y***g
发帖数: 1375 | 1 想买adefovir这种药，处方拿到了，但是由于买的insurance card是iso的med2，不是
prescription card，所以从网
上找了一个可以75%off的card打印出来，但也不包括我想买的这种药，一个月的量原价
900多刀，打折后还要700多
刀，有没有哪个好心人能介绍哪种对这个药可以打折比较多的，还有3天就吃完了，急
死了，万分感谢！ |
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d***y
发帖数: 195 | 2 我个人觉得两者不可相比，Icotinib在仿制规避上很成功，me-too类的药物。Adefovir
，简单baidu了一下，就发现国内有不少厂家在做，申请不同晶型专利等。Adefovir分
子结构可能已经过期了，某些厂家如GSK掌握了关键晶型的专利，但还没获得授权。一
旦授权，随后的纠纷就会产生。
另外，关于晶型专利，我感觉可以在专利上搞一些手脚并宣称拥有自主知识产权等，但
制备方法上可能还是避不开其他人的一些关键专利。
楼上说第三个分子靶向药物，不清楚这个“第三个”是什么意思。
另外，中国在一定期间内仍不可能出现大的generic，但如浙江贝达，江苏恒瑞，正大
天晴等药企很有潜力。关键在于这些药企向外发展的情况，立足国内没错，但不出去就
不可能变大。 |
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s*********e
发帖数: 77 | 3 interferon (IFN)α
lamivudine
adefovir dipivoxil
all requires prescription and all are expensive. |
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l****l
发帖数: 91 | 4 ☆─────────────────────────────────────☆
azuremoon (azure) 于 (Fri May 20 00:09:15 2005) 提到:
我父亲在国内患有乙肝疾病
现在需要这种药：adefovir dipivoxil。这种药只有美国有卖，并且是处方药。
请问有没有什么办法能买到这种药？
或者有没有可能来美国治疗？如果有可能应该怎么做？
我自己是F1身份
谢谢
☆─────────────────────────────────────☆
dashabi (大沙比) 于 (Fri May 20 00:20:13 2005) 提到:
阿德福韦酯2000年12月就批准了，国内怎么会没有卖？ 没有卖的话只能说明这药还是有
很多问题
☆─────────────────────────────────────☆
oboi (人穷志短 龟瘦壳软) 于 (Fri May 20 02:01:41 2005) 提到:
大傻逼说的精辟
☆─────────────────────────────────────☆
dicky |
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F**********8
发帖数: 36 | 6 来美前已知携带乙肝病毒，但其他指标正常。最近体检发现情况不妙，两转氨酶（ALT,
AST)都超出正常范围，表面抗原(HBsAg)和e抗体(Anti-HBe)阳性，乙肝病毒DNA含量4*
10^6,显示病毒复制活动。心中焦虑。有两个问题诚心求教各位有经验的兄弟姐妹：
1. 我年纪不小了，正打算要小孩子，没想到节骨眼上来了这个问题捣乱。请问目前我
的情况，是不是要赶紧治疗，这两年不能考虑怀孕了？
2. 我在美国见医生的感觉不太好，家庭医生根本不懂那些指标。请问是否有必要回国
治疗？但似乎网上资料显示国内的治疗方法也与美国大同小异，不外乎抗病毒药如
lamivudine(拉米夫定）和adefovir,以及干扰素（interferon）。请问国内还有比较有
效的办法吗？
焦虑惶急中，请百忙中提供您的意见。多多感谢！！ |
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f******I
发帖数: 769 | 7
sorry to hear that,
in addition to the antiviral agent lamivudine, there are a bunch of other
antiviral medicines such as
adefovir which has advantage against lamivudine-resistent strains of hep b;
entecavir, telbivudine,tenofovir are other antiviral drugs,
there are some anti-viral drugs in trials, include emtricitabine,
famciclovir, clevudine, val-d-cytosine and valtorcitabine, alamifovir,
pradefovir, i didn't read into the details andnot sure if you could get
those in china, in general |
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g*****j
发帖数: 1211 | 8 Hepatitis b treatment depends on the stage of disease. Newly infected
patients are treated with anti-HBV immunoglobulin. Chronic infection
treatment depends on severity of liver damage. If minimal liver injury and
viral titer is low, patient is usually monitored. If infection is more
active, interferon alpha as well as several reverse transcriptase inhibitor
can be used (such as Iamiudine, adefovir, entecavir). In severe cirrhosis,
liver transplantation is the only treatment. The bottom lin |
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w**********9
发帖数: 242 | 9 乙肝 can be treated with interferon in combination of anti-viral drugs such
as entecavir and adefovir. some people can be cured.
肝硬化is no cure. |
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m**********s
发帖数: 117 | 10 前面有人提到‘努力吃药’，这里努力吃药的意思是。。。虽然没有药物可以杀死HBV
病毒,但是可以通过一些抗病毒核苷类药物或者干扰素来抑制病毒的复制，降低病毒在
人体的活性，有名的有 lamivudine (拉米夫定), adefovir （阿德福林） 和
entecavir （恩替卡韦）, 以及 telbivudine. 一旦有需要开始服药，就是长期性的，
所以要‘努力’。
忽略 |
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c********p
发帖数: 322 | 11
治愈率 is still O
Although none of the available drugs can clear the infection, they can stop
the virus from replicating, thus minimizing liver damage. Currently, there
are seven medications licensed for treatment of hepatitis B infection in the
United States. These include antiviral drugs lamivudine (Epivir), adefovir
(Hepsera), tenofovir (Viread), telbivudine (Tyzeka) and entecavir (Baraclude
) and the two immune system modulators interferon alpha-2a and PEGylated
interferon alpha-2a (Pegasys). ... 阅读全帖 |
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d*******g
发帖数: 8992 | 12 不能吧
即使是Adefovir之类的也就是控制吧，拉米夫定就更容易反复啦。 |
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J********n
发帖数: 534 | 13 HBV have a virally-encoded DNA polymerase, AKA reverse transcriptase. That
is the target of most of the approved HBV drugs
1.Epivir (lamivudine): GlaxoSmithKline
2.Hepsera (adefovir): Gilead
3.Baraclude (entecavir): Bristol-Myers Squibb
4.Tyzeka (telbivudine): Novartis |
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J********n
发帖数: 534 | 14 HBV have a virally-encoded DNA polymerase, AKA reverse transcriptase. That
is the target of most of the approved HBV drugs
1.Epivir (lamivudine): GlaxoSmithKline
2.Hepsera (adefovir): Gilead
3.Baraclude (entecavir): Bristol-Myers Squibb
4.Tyzeka (telbivudine): Novartis |
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c**i
发帖数: 6973 | 15 Doctors in China defraud to enrich themselves. "转氨酶高，白蛋白低." Well
they are borderline.
Do not waste money on Adefovir (trade name: Hepsera). |
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z**h
发帖数: 153 | 16 I am not a hepatology specialist. But as I understand, interferon is not the
first line anti-vrial therapy for HepB because of its side effects,
inconvenience to take and the availability of many other oral meds with mild
side effects like, Lamivudine, Adefovir, Tenofovir, Entecavir ect. |
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w****r
发帖数: 90 | 17 such as?
To my knowledge, there are two drugs currently on market for Hepatitis B:
Hepsera (adefovir dipivoxil) by Gilead
Baraclude (entecavir) by BMS
side effects are silimar to placebo according to PDR |
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p*******e
发帖数: 143 | 18 The drugs works by slowing the growth of the virus. It is not a cure for
hepatitis B.
Decompensated cirrhosis is characterized by severe scarring of the liver
caused by chronic liver inflammation,the median survival rate in
decompensated patients is two to three years,
BARACLUDE or Adefovir (another one in same class) should be taken lifelong.
patients often require liver transplant. |
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