l*h
发帖数: 4124 | 1 since it's adenocarcinoma, it appears there was a justification to have
surgery, if it was to reduce tumor burden without much adverse effects on
lung functions.
the pleural invasion itself is sufficient to put it into stage IV, M1a. in
the US, about 40% non-small cell patients are at stage IV at the time of
diagnosis. the 5-yr survival is around 2%.
future treatment depends on various factors. generally speaking, it should
center on improving the quality of life unless the patient him/herself
s... 阅读全帖 |
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M****0
发帖数: 877 | 2 Bless!
首先祝福全家，勇敢面对。The course is challenging but I believe your wife
definitely can go through, with the whole family's support. The management
of side effects of chemo makes it more tolerable now.
Wait for the pathological report first. Certain type breast cancer, such as
mucinous adenocarcinoma, has a better prognosis as it is less aggressive and
responding to chemo well.
Currently, we treat breast cancer with multimodality measures. Local therapy
with surgery and radiation therapy plus system... 阅读全帖 |
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c*********0
发帖数: 923 | 3 The Center for Infectious Diseases and Vaccinology at the Biodesign
Institute at Arizona State University is seeking applications for
postdoctoral investigators.
An expanding innovative vaccine development research program http://cidv.biodesign.asu.edu is focused on the design, construction, and evaluation of recombinant attenuated Salmonella antigen and DNA vaccine delivery vaccines to induce mucosal, systemic and/or cellular immune responses, as appropriate, to confer protection to agricultur... 阅读全帖 |
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g****e
发帖数: 1426 | 4 Current: $3.80
Target: $5 (in 2-4 months)
Agenus Inc., a biotechnology company, engages in developing and
commercializing technologies to treat cancers and infectious diseases. Its
technology portfolio consists of saponin adjuvant based technologies and
heat shock protein based technologies.
Bullish reasons.
1. 5 key catalysts near term during the second half of 2013 and into 2014
a>the Phase 3 data read-out at GSK MAGE-A3 program for melanoma.
b>the Phase 2 data read-out for HerpV for t... 阅读全帖 |
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P********6
发帖数: 709 | 5 Dynavax Announces Acceptance of Two Data Abstracts for SD-101 in Combination
with KEYTRUDA® for Presentation at the 2018 Ameri
2018-03-15 10:30:02.354 GMT
Dynavax Announces Acceptance of Two Data Abstracts for SD-101 in Combination
with KEYTRUDA® for Presentation at the 2018 American Association for
Cancer Research (AACR) Annual Meeting
Data from Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
(HNSCC)
Durability Data in... 阅读全帖 |
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G*******1
发帖数: 137 | 6 still need one more，please someone with related majors to send CV to me。
Thanks. |
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n******i
发帖数: 374 | 7 您好，希望能把这次机会给我，谢谢了
Yarong Liu
2623 Ellendale Pl.
Los Angeles, CA 90007
(213) 249-2419
y*******[email protected]
www.linkedin.com/pub/yarong-liu/2b/a36/65b/
PUBLICATIONS
1. Yarong Liu, April Tai, Kye-Il Joo and Pin Wang. “Visualization of DC-
SIGN-mediated entry pathway of engineered lentiviral vectors in target cells
” 2013, PLoS One 8(6): e67400.
2. Liang Xiao, Kye-Il Joo, Yarong Liu, Jinxu Fang and Pin Wang. “
Injectable thermo-sensitive hydrogel as an adjuvant: in vivo modulation of
dendritic ... 阅读全帖 |
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a*********0
发帖数: 268 | 8 转medicine的审稿。 需要英文background 介绍和email，姓名以便推荐。
Adjuvant Chinese herbal medicine in patients with ischemic heart disease
diagnosed after type 2 diabetes in Taiwan |
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p********3
发帖数: 5750 | 9 再让你看看这几句话： 多了怕你看不懂， 这个只是一个综述里面的一段。
This approach was assessed in a double-blind, placebo-controlled trial, in
which 120 patients receiving adjuvant chemotherapy for breast or colon
cancer were evaluated by a qualified Chinese herbalist [34]. Treatment was
prescribed and the active herbs or a matched control were dispensed in a
blinded fashion. There was no difference between the two groups in
hematologic toxicity, which was the primary end point. Among 16 non-
hematologic parameters assessed, th... 阅读全帖 |
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o**s
发帖数: 3412 | 11 Thanks for the feedback everyone.
Our city requires every pet to be licensed, and license need to be renewed
every year, with proof of Rabies vaccination.
For those of you who vaccinate the three year one, my research says it is
not as safe as the one year vaccine because it uses chemical called adjuvant
to purposely cause inflammation.
The only "safe" one for cats is called "Purevax". Science suggests that it
is effective for at least three years or longer but legally it is only good
for a year... 阅读全帖 |
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o**s
发帖数: 3412 | 12 I didn't check all the facts, just read a couple websites, one is this:
http://www.catinfo.org/?link=vaccines
There is a risk I selectively read what I want to read:).
Rabies:
-The only non-adjuvanted is called PureVax by Merial. Their own study showed
it protected cats from rabies for three years. I suspect it could be even
longer because cats are like us, their immune system have memories. Legally
PureVax only good for one year. Unless your city law requires, I would only
vaccinate at most eve... 阅读全帖 |
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R******0
发帖数: 6158 | 13 还真不知道HEB有呢~~
一年的是不加佐剂adjuvant的，比较安全，三年的往往是加了佐剂的killed virus做的
疫苗，佐剂有较高概率引起sarcoma，最好还是能不要over-vaccination |
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R******0
发帖数: 6158 | 14 ！！！你也去Westbury Animal Hospital？？那我们岂不是很近？你去BARC不是很远？
我本来准备带可乐雪碧去Westbury打rabies，但问了他们也是用adjuvanted疫苗，有点
失望呢 |
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L******u
发帖数: 3412 | 15 是啊！我去BARC超级远的。。其实去Westbury也不近，开车得10迈呢。。
至于疫苗啥的，只要不乱打就行了，没法要求更高。我不知道non-adjuvanted的疫苗有
啥区别。。 |
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R******0
发帖数: 6158 | 16 我家过去才不到3迈~~当初还是看你推荐用yelp搜索才找到这家vet，没想到你也去同一
家~~
non-adjuvanted的疫苗就是不用killed virus，不加佐剂，而这个佐剂会增加sarcoma
风险，所以尽量避免吧，当然整体来说还是不打不必要的疫苗最好 |
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L******u
发帖数: 3412 | 17 这种疫苗的普及率如何？看似不高啊。。价格跟adjuvanted疫苗一样吗？
疫苗这东西能不打当然还是不打啦~~我家离那也不近，会选他是因为有24小时
emergency。。
sarcoma |
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L******u
发帖数: 3412 | 18 那你可以平时去Westbury，打rabies就去Maryland AC嘛。。
狗的疫苗我确实是没找到Non-adjuvant的。。Westbury的硬件条件很强大
大厅看着像度假酒店一样 |
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R******0
发帖数: 6158 | 19 嗯，前段时间也仔细研究过，最后决定还是遵守法规每年打rabies，确保用不加
adjuvent的疫苗（目前好像只有PureVax一种，我当时问了一圈才找到家附近一家vet有
），并且每三年打FVRCP |
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R******0
发帖数: 6158 | 20 我家indoor猫三只，都是每年打rabies，隔三年打一次FVRCP（只有第一年和第二年是
连续两年打），专门找的副作用小的non-adjuvanted vaccine，平均每针每猫二十多刀。
leukemia的不了解，一般indoor肯定是不需要，经常往外跑可能接触别的猫的话还是谨
慎一些吧，不过leukemia的疫苗不像前面两种那样有效，就是打了也仍然可能会感染。
。。 |
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A***l
发帖数: 302 | 21 . Discussion and conclusion
These four approaches are among the most popular approaches in the design of
synthetic peptide vaccine. Of course, they are not incompatible with each
other. For example, synthetic peptide combinatorial libraries offer a
convenient way to find epitopes, which are basic components of Gamete
antigens and MAPs. The two-epitope MAP could be looked as highly branched
covalently attached T- and B-cell epitopes. Adjuvants have been connected to
MAP to make more powerful mala |
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n******u
发帖数: 2121 | 22 The application of his project sounds closer to 治疗, e.g. staging,
monitoring effect of neoadjuvant, adjuvant procedures |
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C******n
发帖数: 941 | 23 A self-assembling peptide acting as an immune adjuvant
PNAS 2010 107:622-627
c***********[email protected]
thank you. |
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a******u
发帖数: 211 | 24 Curr Drug Deliv. 2006 Oct;3(4):379-88.
Particulate systems as adjuvants and carriers for peptide and protein
antigens.
Liang MT, Davies NM, Blanchfield JT, Toth I.
Please send it to e*********[email protected]
thanks so much!!!!!!!! |
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a******u
发帖数: 211 | 25 1. Int Arch Allergy Appl Immunol. 1982;68(4):377-81.
Chitin: an immunological adjuvant and a polyclonal B-lymphocyte activator.
Diamantstein T, Klos M, Osawa H, Chen ZC.
2. Arch Immunol Ther Exp (Warsz). 1991;39(1-2):127-32.
Immunoadjuvant properties of chitosan.
Marcinkiewicz J, Polewska A, Knapczyk J.
Please send the papers to e*********[email protected]
Thanks so much!!!! |
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a******u
发帖数: 211 | 26 J Liposome Res. 2010 Jun 16. [Epub ahead of print]
Relationship between the adjuvant and cytotoxic effects of the positive
charges and polymerization in liposomes.
Gasparri J, Speroni L, Chiaramoni NS, Valle Alonso SD.
Please send the paper to e*********[email protected]
Thanks so much!! |
|
z*t
发帖数: 863 | 27 from nature research highlight
How 大牛 in this board view this study?
Once upon a time, around 1,800 years ago, there was a Chinese medicine known
as Huang Qin Tang. It was based on four different herbs and was used to
treat gastrointestinal symptoms such as diarrhoea, nausea and vomiting.
Today, PHY906, a compound derived from this medicine, is in clinical trials
to evaluate its effect as an adjuvant to chemotherapy in metastatic
colorectal carcinoma (CRC). But how does it work? A group led by Y |
|
a******u
发帖数: 211 | 28 J Liposome Res. 2009;19(1):2-11.
Liposome-based cationic adjuvant formulations (CAF): past, present, and
future.
Christensen D, Agger EM, Andreasen LV, Kirby D, Andersen P, Perrie Y.
please send the paper to e*********[email protected]
Thanks so much! |
|
a******u
发帖数: 211 | 29 Expert Rev Vaccines. 2007 Oct;6(5):785-96.
Cationic liposomes as vaccine adjuvants.
Christensen D, Korsholm KS, Rosenkrands I, Lindenstrøm T, Andersen P,
Agger EM.
please send the paper to e*********[email protected]
Thanks so much! |
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s*******e
发帖数: 1544 | 30 我觉得你怎个被孟山都洗脑了。你讲的那些转基因理由都是孟山都的宣传语。请问你是
不是拿着拿孟山都或其他外国种子公司的资助或为这些公司工作？美国现在很喜欢给中
国学农的奖学金，有些人就能成为以后打入中国粮食种子市场的先锋。退一步，就算你
和这些公司没有瓜葛，作为一个有农学背景的人，讲话基本上都是想当然，什么“我们
不发展自己的转基因工业，不意味着我们的绿色产品能竞争
得过国外的转基因食品”， 拜托多读点文献，了解一下已经有转基因工业的阿根廷，
巴西，印度这些国家的粮食主权怎么被孟山都吞噬再来说教行吗？
听听你讲的“用国外的经费，做本国的科研，总体是件挺好的事”
---在位的官员、科学家拿着外国公司的俸禄，他该替谁服务呢？你连基本的conflict
of interest 概念都没有。所有拿了外国公司俸禄的在转基因方面的意见都要被
discount。但是现在是这帮人掌握的话语权，在缺乏论证和透明的情况下要强行推进转
基因。
“转基因是很安全的抗病虫杂草的方式了。”
孟山都的剧毒除草剂根本不安全。 在《体外毒理学》杂志上发表的一项最新研究发现
，即使在非常低的水平，孟山都的除草剂配方综述破坏睾... 阅读全帖 |
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s*****g
发帖数: 7857 | 31 http://en.wikipedia.org/wiki/Bevacizumab
Bevacizumab (trade name Avastin, Genentech/Roche) is a drug that slows
angiogenesis, the growth of new blood vessels. It is licenced to treat
various cancers, including colorectal, lung, breast (outside the USA),
glioblastoma (USA only), kidney and ovarian.
Bevacizumab is a humanized monoclonal antibody that inhibits vascular
endothelial growth factor A (VEGF-A).[1] VEGF-A is a chemical signal that
stimulates angiogenesis in a variety of diseases, especia... 阅读全帖 |
|
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n***3
发帖数: 663 | 33 Nat Biotechnol. 2012 Aug 26. doi: 10.1038/nbt.2344. [Epub ahead of print]
Polyethyleneimine is a potent mucosal adjuvant for viral glycoprotein
antigens.
please send the paper to e*********[email protected]
Thanks! |
|
S***a
发帖数: 257 | 34 Please send to xjxia at hotmail.com
Thanks a lot!
J Liposome Res. 2006;16(3):205-13.
Liposome-based systems for anti-tumor vaccination: influence of lipopeptide
adjuvants.
Heurtault B, Thomann JS, Jedrzejewska J, Wels WS, Schuber F, Frisch B.
Source
Institut Gilbert Laustriat, UMR 7175-LC01 CNRS/Université Louis Pasteur, D
épartement de Chimie Bioorganique, Faculté de Pharmacie, Illkirch, France. |
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y*********8
发帖数: 37 | 35 对, 越早诊断越好, 更好的是Cancer Prevention, 你自己保持快乐的心情,加强锻炼,
不吸烟,提高免疫能力,
癌症不一定得完全治好了才行，quality of life, survive with cancer 都是可以的,
其实如果人到了80岁, 不得癌症也或可能或不了多少年了吧?
小瘤子没转移之前切了最好,然后再加以药物辅助治疗, 比如breast cancer的adjuvant
treatment Tamoxifen等,效果很好,http://en.wikipedia.org/wiki/Tamoxifen.
Overall, the current cancer research is very exciting. Novel treatment
strategy and drugs are continuing emerging.... |
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y*********8
发帖数: 37 | 36 对, 越早诊断越好, 更好的是Cancer Prevention, 你自己保持快乐的心情,加强锻炼,
不吸烟,提高免疫能力,
癌症不一定得完全治好了才行，quality of life, survive with cancer 都是可以的,
其实如果人到了80岁, 不得癌症也或可能或不了多少年了吧?
小瘤子没转移之前切了最好,然后再加以药物辅助治疗, 比如breast cancer的adjuvant
treatment Tamoxifen等,效果很好,http://en.wikipedia.org/wiki/Tamoxifen.
Overall, the current cancer research is very exciting. Novel treatment
strategy and drugs are continuing emerging.... |
|
t**l
发帖数: 109 | 37 我刚想说JAMES CHEN又发了一篇Science。昨天他又发了。
哈哈。
他和feng zhang一样，2013大灌水
Published Online August 29 2013
< Science Express Index
Read Full Text to Comment (0)
Science DOI: 10.1126/science.1244040
REPORT
Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune
Adjuvant Effects |
|
c******r
发帖数: 3778 | 38 好像确实有人这么干。但是效率非常低。一般会加点儿adjuvant啥的。
但是这么干有几个问题。第一是效率实在太低了。第二十基本没有特异性。好像多数都
是被macrophage给吃掉了。刚开始做gene therapy就有这样尝试的，后来发现不行，所
以主要还是得用各种东西包裹一下。即使如此，效率仍然非常低下，跟病毒deliver没
法比。
研究这个包裹方式的人也不少，目前不知道有什么突破没有？ |
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j********8
发帖数: 1 | 39 大家好，真诚求审稿机会，我的研究领域如下：
1, Virology
2, Immunology
3, Vaccine and Adjuvant
4, Veterinary Medicine
请站内发信给我，我将提供详细信息和CV。
感谢您的帮助！ |
|
d*p
发帖数: 534 | 40 CIK: Cytokine induced Killer
就是抽点你的血，用cytokine+cd3/cd28 在体外激活一下，养1周左右，基本就是 T
cell+NK cell. 再输回去。
可能的作用：
1. adjuvant: 激活的细胞输回去以后，分泌一些cytokine, 或许对肿瘤免疫反应有点
帮助。问题在于这些细胞不能主动进入肿瘤，因此效果可以忽略。
2. 降低 T cell激活的 threshold, 可能激活一些能对肿瘤有反应的细胞。 问题在于
血液里面肿瘤特异性细胞数量太少了，而取的那点血里就少之又少了，效果同样可以忽
略。
个人观点：忽悠为主。 |
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g*****j
发帖数: 1211 | 43 You can find adverse effect on everything. The question is about how
often do you see adverse effect, and what is the consequence if you do
not treat. It is all about risk and benefit. That is why you need a
doctor to prescribe insulin.
For the side effect you sited:
1. 低血糖反应
This is not a side effect of insulin, but a side effect of inappropriate
use.
2. 过敏反应
Every drug on this planet has this side effect. So, what the hell ..
3. 胰岛素性水肿
As you said, it is an evidence of improvement. And it... 阅读全帖 |
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x********i
发帖数: 905 | 44 http://www.israelnationalnews.com/News/News.aspx/135820
Winners of Prestigious Wolf Prize Announced
by Malkah Fleisher
(IsraelNN.com) Israeli Minister of Education and Wolf Foundation Council
Chair, Mr. Gideon Sa'ar, has announced the recipients of the 2010 Wolf
Prizes.
The Wolf Prize in Medicine will be awarded to Axel Ullrich of Germany for
groundbreaking cancer research that has led to development of new targeted
biologic drugs such as Herceptin, for both adjuvant care and metastatic
treatmen |
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I****a
发帖数: 407 | 45 In general, post mastectomy radiation for stage IIB ER/PR + breast cancer probably adds 8% survival in 10 years when combined with chemo and or hormonal therapy. According to adjuvant online, adding Tam/AI adds 8% survival, chemo further adds about 2% in 10 years. Patient needs be be educated about those number and makes the decision. If you look at numbers, it seems that hormonal tx and radiation give the best bang for the long term survival although a lot of patients also choose chemo in addit... 阅读全帖 |
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d******a
发帖数: 127 | 46 Please provide detailed and precise history, pathology report, stage and
adjuvant treatment (you mentioned chemo). But cytotoxic chemo is no effect
in mRCC.
You can see late recurrence in RCC. The longest one was 45 yearsper
literature.
You didn't answer my question. 对各种西医的治疗没有什么效果 What kind of 西
医的治疗?
Why中医? You have evidence that mRCC patient will benefit from 中医? |
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d****y
发帖数: 2180 | 47 选A还是E？
Paracentesis 虽说是比较general 的抽液，在这题可以理解为心包抽液吗？
18. A 50-year-old woman has had progressive dyspnea over the past 2
weeks
and constant, sharp chest pain for 4 days. The pain is localized to the
center of the chest and is worse while supine. She underwent a right,
modified radical mastectomy and adjuvant chemotherapy for breast cancer
3
years ago. She has a history of hypothyroidism treated with thyroid
replacement therapy. She has smoked one pack of cigarettes daily for 30
years and drinks t... 阅读全帖 |
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yf
发帖数: 272 | 48 If it's R0 resection, no need for chemo, if it's R1 or R2 resection,
adjuvant chemoradiation(fluopyramidine based chemo with concurrent radiation)
R0= No cancer at resection margins, R1= Microscopic residual cancer, R2=
Macroscopic residual cancer or M1 resection,
1 cycle before and 2 cycles after chemoradiation
Capecitabine 750-1000 mg/m PO BID on Days 1-14
Cycled every 28 days
With radiation
Capecitabine 625-825 mg/m PO BID on Days 1-5 or 1-7
Weekly for 5 weeks |
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yf
发帖数: 272 | 49 If it's R0 resection, no need for chemo, if it's R1 or R2 resection,
adjuvant chemoradiation(fluopyramidine based chemo with concurrent radiation)
R0= No cancer at resection margins, R1= Microscopic residual cancer, R2=
Macroscopic residual cancer or M1 resection,
1 cycle before and 2 cycles after chemoradiation
Capecitabine 750-1000 mg/m PO BID on Days 1-14
Cycled every 28 days
With radiation
Capecitabine 625-825 mg/m PO BID on Days 1-5 or 1-7
Weekly for 5 weeks |
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y******7
发帖数: 17 | 50 The following is what I collected when I was a student doing capstone in a
local hospital. Not sure if it is useful.
Lidocaine topical is a amide-type local anesthetic. for production of
topical anesthesia, relief of pain associated with postherpetic neuralgia,
reduction of gagging during dental procedures, prevention and control of
urethral pain, anesthetic lubricant for endotracheal intubation, and relief
of hemorrhoidal pain.
Polyethylene glycol(Miralax) is a nonabsorbed solution used to trea... 阅读全帖 |
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