b**********5
发帖数: 7881 | 1 【 以下文字转载自 JobHunting 讨论区 】
发信人: beefcurtain5 (beefcurtain5), 信区: JobHunting
标 题: Elite K-8 school teaches white students they’re born racist
发信站: BBS 未名空间站 (Fri Jul 1 17:17:34 2016, 美东)
An elite Manhattan school is teaching white students as young as 6 that they
’re born racist and should feel guilty benefiting from “white privilege,”
while heaping praise and cupcakes on their black peers.
Administrators at the Bank Street School for Children on the Upper West Side
claim it’s a novel approach ... 阅读全帖 |
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s*****a
发帖数: 349 | 2 家里的heat exchanger被查出来crack了，号称会有一氧化碳漏入家里。
检修的人员建议换furnace。家里的已经有10年了。
看了他们给的brochure，比较糊涂，不知道换哪一种的比较好。。。
1. [1999+tax]Latitude series TG8S/TGLS Model ... 80% AFUE
2. [4656+tax]LX Series TM9V Model (LX 2-stage). 96% AFUE... (about 300$ less
than #5)
3. LX Series TM9X Model (LX 1-stage)....... 95.5% AFUE
4. [3299+tax]Affinity Series YPLC Model ... 80% AFUE
5. [5000+tax]Affinity Series YP9C Model ... up to 98% AFUE .. best but most
expensive.
上来问问大家的经验。。。。 |
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s*****a
发帖数: 349 | 3 多谢各位回帖。现在可以先排除#1 and #2 (2-stage)的这两款了。划掉。。。
缩小目标，在#3，#4， #5中选择。
比较了一下，#4和#5的差异在于AFUE。80%和98%的差异。
1. Cost
80% - 3299$
98% - 4699$
差异：1400$
2. heating Operation Costs
80% 每年的heating Operation Costs是$1297
95% 每年的heating Operation Costs是$1091
差异：206$
如果居住7年以上，98%的应该比较合适。
+++++++++++++++++++++
比较#3和#5. 没太看懂。这个是指的什么？看起来应该是affinity serries比较好一些
。。。
大家帮我看看。。。
LX 1-stage : circulation fan uses an average of 200 watts.
Affinity Series: circulation fan uses an average of 83 watts.
Dropped: 1. [1999+t... 阅读全帖 |
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m****r
发帖数: 6639 | 4 bbc2 也就是以前的smash city
宾堂1
ggbc1
affinity
zbtc
ubc
cba
湾区球馆真是比tmd雨后春笋还多呀. 发现居然今天affinity在打华运会. |
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m****r
发帖数: 6639 | 5 打affinity open的时候， 有人在问， affinity愿不愿意承办明年的senior national
。 说不定就办了。 |
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v******s
发帖数: 6949 | 6 一只手打字不给力呀
http://en.wikipedia.org/wiki/Phytic_acid
Phytic acid has a strong binding affinity to important minerals, such as
calcium, iron, and zinc, although the binding of calcium with phytic acid is
pH-dependent.[18] The binding of phytic acid with iron is more complex,
although there certainly is a strong binding affinity, molecules like
phenols and tannins also influence the binding.[19] When iron and zinc bind
to phytic acid they form insoluble precipitate and are far less absorbable
in the... 阅读全帖 |
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s*****d
发帖数: 258 | 7 Luck can only carry you so far. Les Miles will never be on the same level as
NS. His affinity for JJ is unfathomable, no planning what-so-ever the game
that matters is unforgivable, and not give Mett some playing meaningful time
against weak opponent this season will probably ruin 2012.
http://www.tigerdroppings.com/rant/p/31150193/Will-baton-rouge-
I am with those guys:
"Never. Students will tell their grand kids how Miles' affinity for JJ cost
LSU a title in their eyes. Mett doing good will on... 阅读全帖 |
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n****b
发帖数: 744 | 8 Chosen Women Choosing Chinese Men
A tradition of love?
by Jocelyn Eikenburg
Are you Jewish?" I am asked. This is not new to me. I hear this all the time
because my last name ends in "burg," a common Jewish suffix.
So I wasn't surprised when I heard it from Arnold, a new friend of mine from
the local gym in Cleveland Heights, Ohio. He knew my last name because I
had handed him my business card weeks before. And he was, after all, as bold
as the espresso in the coffee shop where I met him.
When he... 阅读全帖 |
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s****k
发帖数: 1384 | 10 x*******[email protected]
(don't reply to this ID)
Item: Squier Affinity Series Stratocaster Electric
Guitar + cable
Color: Metallic Blue Rosewood Fretboard
SN: IC050301808
Year: 2006
Reason for sale: Almost never play since I suck at it and prefer
playing classical and acoustic more
Condition: Like New (there is one tiny scratch,
hardly noticeable)
Pictures:
https://picasaweb.google.com/xieyang/Sale#
Price as listed in Guitar ... 阅读全帖 |
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f*******e
发帖数: 2791 | 11 本帖最后由 jshi6210 于 2010-7-13 11:58 编辑
方舟子美国专利真相调查(ZT)
万维读者网络>教育与学术
美国永久居民、所谓“打假斗士”方舟子常常在中美之间飞来飞去，他经营的美国网站
新语丝，据说每天点击五六十万。他何以为生、维持网站运营，是长期以来大家比较感
兴趣的一个问题。今天因为甘怀远同学的揭露，进行了一番饶有趣味的搜索。
1. 方舟子的博士后在索尔克生物研究院进行 方舟子，本名方是民，1967年9月生于
福建云霄县。1985年考入中国科技大学生物系。1990年本科毕业后赴美留学。1995年获
美国密歇根州立（Michigan State）大学生物化学博士学位，先后在罗切斯特（
Rochester）大学生物系、索尔克（Salk）生物研究院做博士后 …
scitech.people.com.cn/GB/25509/43690/index.html
2. 方舟子本人如此解释他的收入来源 方舟子：我把博士后研究时做的东西（克隆
了一个基因）申请了专利，得到一笔钱，可以维持基本生活费用。同时，我与人合作在
国内开了个专... 阅读全帖 |
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s*******1
发帖数: 191 | 12 www.osifu.net
2010-05-25師父開示
Messages from Osifu：Be Cautious to Acknowledge Someone as Your Master
May 25th 2010
〇sifu 09:17:26
Teachings given by Osifu on the morning of May 25th 2010:
過去心不可得
當下！
The past mind can not be found!
Live in the present moment!
（時有弟子發偈子。）
(At the moment, some follower presents his verse.)
每一個偈子都是大家的心血。
每一個偈子都是大家的心聲。
每一個偈子都是大家的心語。
每一篇妙悟，師父希望大家看到後要珍惜，用心參悟交流，不要有分別心。
Each verse is everyone’s painstaking effort.
Each verse is everyone’s heartfelt wishes.
Each verse is eve... 阅读全帖 |
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q*****i
发帖数: 30 | 13 【 以下文字转载自 CS 讨论区 】
发信人: qiangyi (haha), 信区: CS
标 题: 请教几个image feature detection的问题
发信站: BBS 未名空间站 (Sun Oct 12 05:45:40 2008)
刚开始做一个与图像处理有关的project，想请教几个问题
1. 我现在用的是oxford 的affine covariance detector，想知道一下当每一个affine
region 取出来以后，它是怎么计算sift feature的。是不是基于每一个region的中心的
scale & orientation 来计算？
2. 这个软件怎么计算一个指定区域的sift feature，我看它的input 参数里面有个-p
什么的，但是基于什么原理来计算我还是没有查到。
3.关于这个软件谁有专门的help manual？ 比如我在找region feature的时候，朋友告
诉我-noangle可以使得每个region 只有一个sift feature （-p的情况下）。 但是如果
我直接用hasaff or hesaff找的时候， |
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q*****i
发帖数: 30 | 14 刚开始做一个与图像处理有关的project，想请教几个问题
1. 我现在用的是oxford 的affine covariance detector，想知道一下当每一个affine
region 取出来以后，它是怎么计算sift feature的。是不是基于每一个region的中心的
scale & orientation 来计算？
2. 这个软件怎么计算一个指定区域的sift feature，我看它的input 参数里面有个-p
什么的，但是基于什么原理来计算我还是没有查到。
3.关于这个软件谁有专门的help manual？ 比如我在找region feature的时候，朋友告
诉我-noangle可以使得每个region 只有一个sift feature （-p的情况下）。 但是如果
我直接用hasaff or hesaff找的时候，这个-noangle 没有用。每个点可能有多个sift
feature。
thx in advance。 |
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M****e
发帖数: 70 | 15 talking about de novo peptide-derived drug design, i have an
idea using biosensor for such investigation. basically, i
would like to assess and evaluate the binding affinity of the
peptide to the known receptor as well as its downstream signaling
transductivity. so i may design two chips (biomembrane-based),
both approapriately covered by the receptors, with one linking
to some biosensor that basically detect the affinity, while the
other coupled to the primary downstream signal transducer while |
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r****o
发帖数: 105 | 16 本文献给YL
（十四）anfinsen的疑虑
跑完sephacryl柱子，组分就可以过DNA affinity column。DNA affinity column虽然很重
要，但是这一步技术上来说要求很低。买来CNBR活化好的agarose，然后让特定序列的寡聚核
苷酸固定上去就行了，柱子也是最简单便宜的一次性柱子。
亲合层析是目前最常用也最强大的一种蛋白质纯化技术, 纯化效率比别的层析方法可以高出一
两个数量级。这种方法诞生是六十年代的事情。当时是在NIH的Anfinsen实验室。Anfinsen是一
个诺贝尔奖获得者，可以说是蛋白质折叠研究的老祖宗。他主要贡献是通过研究ribonuclease 的
变性和重折叠证明氨基酸序列就可以决定蛋白质最后的三维结构。他实验室那时侯有一个学生一
个project是从葡萄球菌里面提取大量核酸酶，然后研究enzyme-inhibitor interaction。这个纯
化可是很麻烦的事情，用gel filtration, ion-exchange, hydrophobic interaction, 效率都很
低。有人可能会问，怎么不在E.Coli |
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r****o
发帖数: 105 | 17 本文献给YL
（十五）AP1的活性测定
第二个模块的实验，DNA affinity chromatography之后我们又跑了一个更精细的
Gel filtration，用的是Amersham卖的Superose 6预装柱子。纯化步骤就只有这么多了。
剩下的就是一些活性测定。无论是sephacryl分出来的组分还是DNA affinity column分出
来的组分，我们都测试了AP-1的活性。方法呢就只有两种，一种是凝胶迁移率变动分析
(EMSA)，另一种是DNA水解酶I 足迹分析 (DNase I footprinting assay)，都可以用来分析
蛋白与特定DNA的结合能力。我过去没做过这两种实验，所以感觉很新奇，做的也格外卖
力，结果也还不错。
Gel Mobility-shift assay 原理很简单，把蛋白质样品和P32标记的寡聚核苷酸探针
一起孵育十几分钟, 然后拿去跑一个低浓度acrylamide胶。如果探针结合上蛋白了，速度
会变慢很多，就会停滞在胶的上段；如果没有结合上，探针就会自由的跑到胶的下段去。
然后把胶拿去做放射自显影就行了。跑胶的装置 |
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w******e
发帖数: 1187 | 18 to answer this question, let's do a "simple" math 1st:
Say you generated polyclone antibody which let's say has only two Abs -- X (
the
"nonspecific" one), Y (the "specific" one). the ratio b/w X and Y is 100:1.
the affinity of both abs against the real target P is 1nM, while the
affinity
against the homolog Q is 10nM for X, but 1uM for Y (hence the specificity
difference). You want to add excessive amount of Q to soak off Ab X so that
the final ratio b/w X and Y is 1:10 instead of 100:1, and th... 阅读全帖 |
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j****g
发帖数: 406 | 19 Depending on which company you use, you might not need to do that.
I purified my proteins in denatured condition and the company it is fine for
injection. So I just sent them the protein in 8M urea.
And I got quite good antibodies.
The problem is if you are going to affinity purify your antibody.
If you are, then you will need to get protein in native condition.
In my case, I lowered the IPTG concentration and lowered the temperature for
induction and only got a tiny amount of protein.
But that ... 阅读全帖 |
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l*******1
发帖数: 128 | 20 I think you might need to do consecutive affinity column/pull down. Let's
say you tag your A, B, C, D with GST, V5, His, and HA.
You can start with GST-fused A to pull down the A-containing complexes.
Then pass the elution to V5-tag beads, elute the presumed A&B containing
complexes with V5 peptide. Pass the A&B containing complexes through His-
tag beads, elute the ABC complex with imidazole.
Use Western to probe the original sample and each elution for those 4 tags.
Of course, you can chang... 阅读全帖 |
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w******e
发帖数: 1187 | 21 peptide的affinity方面有新突破吗？还是大多都在uM量级？能不能推荐两篇
经典review？多谢！
另外最近多看了点东西，ms circularization对affinity的改善也有限？ |
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H****s
发帖数: 301 | 22 Not an expert on this topic, but I am willing to share my 2 cents.
For antibody affinity maturation, yeast display is better than other
technologies. FACS sorting, combined with yeast display, increases the
throughput significantly. You can quantify binding affinity and kinetics
with flow cytometry. At the same time, you do not need to work with a
library larger than 10e10, which is still a pain in the field. Dr. Wittrup
established a company in New Hampshire. The name is Adimab. You can check
t... 阅读全帖 |
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w******e
发帖数: 1187 | 23 是有很多工作可以做，但如何入手就是另一回事了呵呵。
比如说，我觉得ultimate goal for affinity reagent development是thermostable,
self-integrated with detection & amplification mechanism, adaptable into
multi-target platform, tunable affinity under enviromental cue，tunable
density to achieve multivalent interaction.
那么怎么去实现这个目标？我脚的on paper aptamer其实是最好的candidate，但
过去二十年都被技术瓶颈限制着呐。最近的breakthrough能把boundary push到
多远？我没本事判断。类似的，protein engineering在thermostability上，
在integrating detection module/scaffolding module上，在molecular
switchin... 阅读全帖 |
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c*****i
发帖数: 1392 | 24 以前做过两个抗体针对同一抗原的competition assay. 一般而言，如果两个抗体
affinity差异10倍以上，low affinity可能被kick off. |
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s******y
发帖数: 28562 | 25 说到这个mechanistic insight,
昨晚我痛定思痛的想了一下，我大概可以做这几个方面：
１。提供该蛋白和pathway B具体某个蛋白的作用证据，这个我其实很粗的做过一些初
步试验，那个蛋白在被修饰之后貌似增强了pathway B里面一个重要成分的活性。当然
这个实验很粗糙，所以这个数据就没有包含到投才出去的文章去。
我可以好好想想，找一个比较好的assay 来证明一下。这个应该不是特别难做，就是会
费点时间。因为相关蛋白的提取和assay很花时间.
但这个如果做出来的话，应该算是比较直接的证据了吧？
２。提供证据说明为什么那个蛋白被修饰之前不能和pathway B 作用，修饰之后就可以
了。比分说是否修饰之后就对pathway A affinity 低了，对pathway B affinity 高了。
但是这个可能会比较复杂，因为pathway A, B 虽然细胞内定位有区别，但是有好几个
公用的蛋白成分，而且都是很大的complex, 还涉及膜什么的，不太可能用简单的co-IP.
我想对于这篇文章，这个大概是可以先搁着不做的吧？ |
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c********b
发帖数: 363 | 26 不知道大家是怎么纯化抗体的，挂IgG的proein A柱子得到的肯定不纯。
如果是用antigen－affinity purification就会好很多。只是有时候那个his－tag还是
会干扰。一个师兄教我先用一个带HIS6的无关蛋白把non-specific的先去掉（比如
sunnyday最喜欢的actin就被我加了his6来干这事），然后再来做antigen－affinity。
如果是intein－tag提出来的这一步都可以省掉，只是intein得到的蛋白量好像没有his
－tag提出来的多。
要提到的是这个protocol在我手上得到的抗体浓度很低，我一般用1：100稀释，但是很
特异。还有就是不太适用于IP。
这个方法不用挂柱子，跑SDS－PAGE，直接转到膜上，block之后先把血清和actin－
his6（in my case）的膜放2hr，然后上清拿出来和block过的antigen的膜泡2hr，
Wash with 1XTBS（contains 0.02％ sodium azide) twice, 10 min each，Elute
with glycine（pH3）... 阅读全帖 |
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c********b
发帖数: 363 | 27 不知道大家是怎么纯化抗体的，挂IgG的proein A柱子得到的肯定不纯。
如果是用antigen－affinity purification就会好很多。只是有时候那个his－tag还是
会干扰。一个师兄教我先用一个带HIS6的无关蛋白把non-specific的先去掉（比如
sunnyday最喜欢的actin就被我加了his6来干这事），然后再来做antigen－affinity。
如果是intein－tag提出来的这一步都可以省掉，只是intein得到的蛋白量好像没有his
－tag提出来的多。
要提到的是这个protocol在我手上得到的抗体浓度很低，我一般用1：100稀释，但是很
特异。还有就是不太适用于IP。
这个方法不用挂柱子，跑SDS－PAGE，直接转到膜上，block之后先把血清和actin－
his6（in my case）的膜放2hr，然后上清拿出来和block过的antigen的膜泡2hr，
Wash with 1XTBS（contains 0.02％ sodium azide) twice, 10 min each，Elute
with glycine（pH3）... 阅读全帖 |
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l**********1
发帖数: 5204 | 29 LZ can try MST
Key Features
NanoTemper's unique MST technology has the following features and benefits:
Sample Preparation Features
measure affinities without surface immobilization, in free solution
measure label-free
measure affinities (KD, dissociation constant) between any (bio)molecules in
10 minutes
measure sub-nM to mM range of dissociation constants
equally applicable to a very large size range of molecules: measure ions,
fragments as well as nucleosomes and liposomes
study multi-compon... 阅读全帖 |
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b******y
发帖数: 627 | 30 What is Maximum stimulation? Since the first points of all three colored
curve have non-zero stimulation, in which I assume there is no or negligible
orthosteric agonist, my conclusion is that the compound is an agonist as
far as stimulation is concerned.
Now that the compound has quite high affinity to the receptor, can you
saturate the receptor with the compound and see whether orthosteric agonist
still has extra stimulation? If so, the compound is a positive allosteric
modulator as far as sti... 阅读全帖 |
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s******9
发帖数: 283 | 31 你是说affinity吧？如果能够不断提高affinity呢？ |
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l**********1
发帖数: 5204 | 32 非植物 或哺乳的数据库区别也 植物的也 一样在完善
关键是楼主有无NGS and HMM （Hidden Markov Models 的背景或能找到那种背景的
合作人
pls refer
PMID 23435661
by Van der Does D et al., (2013).
Salicylic acid suppresses jasmonic acid signaling downstream of SCFCOI1-JAZ
by targeting GCC promoter motifs via transcription factor ORA59.
Plant Cell. 25: 744-61.
Abstract:
ignored
In silico promoter analysis of the SA/JA crosstalk transcriptome revealed
that the 1-kb promoter regions of JA-responsive genes that are suppressed by
SA are significantl... 阅读全帖 |
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l****y
发帖数: 398 | 33 我们做了一批anti-GFP和anti-mCherry的nanobody(15 KDa, single-domain antibody)
, 有两个用来做affinity purification/immunocapture很好用。
有需要的同学请通过站内信提供一个US non-profit research institute 的地址.
vector用e.coli 表达，periplasm加Ni-NTA纯化，一般可以拿到2mg/liter culture.
质量比多抗稳定，成本也低。适合需要做很多affinity purification的情况。 |
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s******c
发帖数: 331 | 34 如果你确定你的小分子结合你想看的target，那么最大的可能是dissociation太快。小
分子和抗体的结合动力学有时候会差很多，描述小分子作用方式的不能仅仅用affinity
或IC50，小分子哪怕affinity在single digit nM range，可能dissociation都是秒级
的，这样在FACS里当然看不到。 |
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发帖数: 1 | 35 Please consider the inhibition effects caused by high affinity unfunctional
metal cations that compete against the functional metal cations. So it's
important to do extensive dialysis after the NgAgo is purified by affinity
chromatography before one carries out the in vitro nuclease activity assay.
Never know what's going on really .
Han has to figure the reason quickly. If other labs figure it out before
they do, the credit will go to that lab.
: PfANgo cuts DNA, by using Mn and Co
: N... 阅读全帖 |
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u**s
发帖数: 384 | 36 Title:Fractionation of the genetic variants of human α1-acid glycoprotein
in the native form by chromatography on an immobilized copper(II) affinity
adsorbent: Heterogeneity of the separate variants by isoelectrofocusing and
by concanavalin A affinity chromatography
Author:Françoise Hervé Corresponding Author Contact Information,
Emmanuel Gomas, Jean-Claude Duché, Jean-Paul Tillement
Journal:Journal of Chromatography B: Biomedical Sciences and Applications
Volume 615, Issue 1, 19 May 1993, ... 阅读全帖 |
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g****n
发帖数: 13 | 37 affine linear
affinely independent
还有simplicial complex, simplex,convex hull
更本不知道是什么东西
这些都是偶在学有限元的是后遇到的，一些数学的动东
请大虾指教
谢谢 |
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Y**e
发帖数: 41 | 38 来自主题: Mathematics版 - 问两个单词 affine function中的affine是什么意思啊？
还有relaxation，是个什么意思啊？ |
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S*********g
发帖数: 7653 | 39
感觉这些东西 在某种意义下 放到更抽象的setting里，好像能"看清楚"是啥东西，比
如Zariski
topology,collection of closed sets. 简单来看，考虑affine的情形（当然affine的
情形
就无论怎么说都简单），对应的是A--->>A/I（collection of strict epimorphism
which
is surjective map) 而一般的collection of strict epimorphism 组成canonical
topology in category of schemes.
这样看上去，好像“清楚”一些 |
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D**o
发帖数: 2653 | 40 注意作者 \author{YHBKJ}
Atiyah-Bott Localization 1
2012-09-05 09:24:19
\documentclass[a4paper,12pt]{article}
\usepackage{amsfonts}
\usepackage{amsmath,amsthm,amssymb}
\usepackage{CJK,graphicx}
\usepackage{amscd}
\usepackage{amssymb}
\newtheorem{theorem}{Theorem}[section]
\newtheorem{corollary}{Corollary}[section]
\newtheorem{definition}{Definition}[section]
\newtheorem{lemma}{Lemma}[section]
\begin{document}
\title{\textbf{\Huge{Atiyah-Bott Localization 1}}}\author{YHBKJ}\date{}\
maketitle
\begin{ab... 阅读全帖 |
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L*m
发帖数: 235 | 41 最近十年在annals of mathematics上发表或合作发表文章的华人全统计（不包括
terrence tao和一位mit本科毕业的abc华人），单位统计以现在作者单位为准
annals
2015年
A proof of Demailly’s strong openness conjecture
关启安（北京大学） 周向宇（中科院）
A solution of an L2 extension problem with an optimal estimate and
applications
关启安（北京大学） 周向宇（中科院）
Finsler metrics and Kobayashi hyperbolicity of the moduli spaces of
canonically polarized manifolds
杨世琪（普渡大学） Wing-Keung To（新加坡国立大学）
Construction of Cauchy data of vacuum Einstein field equations evolving to
black holes
黎俊彬（中山大学）... 阅读全帖 |
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S*****a
发帖数: 190 | 42 漏了不少，孙斌勇和朱程波今年的JAMS：
Conservation relations for local theta correspondence
Authors: Binyong Sun and Chen-Bo Zhu
Journal: J. Amer. Math. Soc. 28 (2015), 939-983
http://www.ams.org/journals/jams/2015-28-04/S0894-0347-2014-008
还有之前 席南华的：
Representations of affine Hecke algebras and based rings of affine Weyl
groups
Nanhua Xi.
J. Amer. Math. Soc. 20 (2007), 211-217 |
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m********e
发帖数: 1156 | 43 我还算有知的，无论深度还是广度，奈何世界上的知识太多。
有人贴出老爱的几百篇论文，我一看大多数是德文，不知道，无法判断。
您瞅一眼，看看有多少是真正的科研论文？
1913 Einige Argumente für die Annahme einer molekular Agitation beim
absoluten Nullpunkt Annalen der Physik(ser. 4), 40, 551–560, link
Some Arguments for the Assumption of Molecular Agitation at Absolute
Zero
1913 Déduction thermodynamique de la loi de l'équivalence
photochimique Journal de physique (ser. 5), 3, 277–282
Thermodynamic Deduction of the Law of Photoche... 阅读全帖 |
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i**w
发帖数: 71 | 44 short rate model里，最简单的Ho-Lee model:
dR(t) = mu*dt + vol*dW(t)
为了缓解负利率的问题，加上mean reversion就得到了Vasicek model:
dR(t) = k*(b-R(t))*dt + vol*dW(t)
面试就可能会问:把上面这个R(t)解出来，是什么distribution?mean和variance是什么
之类的。bond price呢？(记得shreve上有general affine model下discount bond
price的例子)
如果想再扩展，就把参数都变成时间的函数。
到这儿，R(t)始终是个normal variable。我的理解，大家说normal model的时候都是
说distribution是normal的。
如果再扩展，让vol依赖于R(t): vol=sigma*sqrt(alpha+beta*R(t)),就到了affine
model.R(t)就应该不是normal的了。 |
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i**w
发帖数: 71 | 45 short rate model里，最简单的Ho-Lee model:
dR(t) = mu*dt + vol*dW(t)
为了缓解负利率的问题，加上mean reversion就得到了Vasicek model:
dR(t) = k*(b-R(t))*dt + vol*dW(t)
面试就可能会问:把上面这个R(t)解出来，是什么distribution?mean和variance是什么
之类的。bond price呢？(记得shreve上有general affine model下discount bond
price的例子)
如果想再扩展，就把参数都变成时间的函数。
到这儿，R(t)始终是个normal variable。我的理解，大家说normal model的时候都是
说distribution是normal的。
如果再扩展，让vol依赖于R(t): vol=sigma*sqrt(alpha+beta*R(t)),就到了affine
model.R(t)就应该不是normal的了。 |
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C******n
发帖数: 9204 | 46 affine model全都不能很好解释interest rate吧。essentially affine稍好些。quad
model似乎也没好太多。 |
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b******a
发帖数: 704 | 47 Here are some links about this topic. Thanks for sharing such an interesting case!
1. World J Gastroenterol. 2011 November 21; 17(43): 4747–4756.
Pancreatic metastases from renal cell carcinoma: The state of the art
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229623/
"Tumor cells apparently have a high affinity for the parenchyma of the pancreas and only there do they find the conditions they need to mature to manifest metastases. The high affinity of some renal cancer cells for the parenchyma... 阅读全帖 |
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