c******n
发帖数: 16403 | 1 Volume 50, 1998, Pages 343-376
Chapter 9 Synthesis of the Aspidosperma Alkaloids
J. Edwin Saxtona
我们这只有01年以后的。 多谢 |
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p********3
发帖数: 5750 | 2 50， 70， 71； 大家注意一下和这几篇文献相关的话题。 另外， 73-75我本人没有看，确实是谈的印度药材， 我在查阅参考文献的时候在搜索Chinese Medicine的时候， 显示有这些文献，我本人没有亲自看这些文献， 也许其中有讲中药的地方。不过这不影响我要表达的意思。
慢慢看：
INTRODUCTION — Plants have been used for medicinal purposes for thousands
of years. All major cultures including Native American, European, South
American, Asian, and African cultures have used botanicals for healing
purposes. As an example, saw palmetto was used for urinary symptoms in men
from Egypt in the 15th century BC [1]. Hippocrates documented... 阅读全帖 |
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p********3
发帖数: 5750 | 3 以下有文献是讲中药Lead中毒的：我懒得去筛选， 先发这个。 还有很多其他的比如癌
症的， 肾脏毒性的， 单个疾病双盲单盲科研的。我就不一一列举了。
参看50， 51， 70， 73-75.
REFERENCES 1 Wilt TJ, Ishani A, Stark G, et al. Saw palmetto extracts for treatment of benign prostatic hyperplasia: a systematic review. JAMA 1998; 280:1604.
2 Blumenthal M (Ed). The ABC Clinical Guide to Herbs. American Botanical Council/Thieme, New York 2003.
3 Kaptchuk TJ. Acupuncture: theory, efficacy, and practice. Ann Intern Med 2002; 136:374.
4 Farnsworth NR, Akerele O, Bingel AS, et al. Med... 阅读全帖 |
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w********9
发帖数: 8613 | 4 以下是第12001到第13000的word families的开头：
ABATTOIR 0
ABATTOIRS 0
ABBESS 0
ABBESSES 0
ABEYANCE 0
ABSOLUTION 0
ABSOLUTIONS 0
ACADEME 0
ACERBIC 0
ACERBITY 0
ACETIC 0
ACETYLCHOLINE 0
ACQUISITIVE 0
ACQUISITIVELY 0
ACQUISITIVENESS 0
ACROPOLIS 0
ACTIN 0
ADDER 0
ADDERS 0
ADENOCARCINOMA 0
AERODROME 0
AERODROMES 0
AFFECTATION 0
AFFECTATIONS 0
AGAPE 0
AGONIST 0
AGONISTIC 0
AGONISTS 0
AGRIBUSINESS 0
AIRBRUSH 0
AIRBRUSHE... 阅读全帖 |
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r********y
发帖数: 2540 | 5 请立即停止使用微波炉加热或烹煮的食物
如果您用『微波炉煮热的食物』把癌细胞养得肥肥壮壮的，保证癌细胞会很高兴吃，
但不会说谢谢。而且，连您的身体也会一起吃掉。也许还可以让您散尽家产及痛不欲生。
所以呢 …… ，为了自己的健康，请详细阅读以下的说明以下的内容摘录
首先令我们好奇的是何以微波炉有害？倘若有害，为什么政府不回收呢？
有个很有意思的比喻，或者可比拟这个情况，当你将一只青蛙放上一个开着大火的
热锅时，牠会立刻跳走，但如果你用一根蜡烛慢慢加温，刚开始时，青蛙并不觉得有任
何烫感，但逐渐的等到牠觉得热了，再也无力气跳走。
如今微波炉就像那根蜡烛，使用它的人就像那只青蛙，什么时! 候! 会被困住，或
许是十或二十年之后，但迟早有可能被困住。
在医院中输血，需将从冰箱拿出的血加以温热才可输入人体，曾有护士为了急救病
人节省时间，使用微波炉加温血液，一输入体后病人立即死亡，以后医院中严格规定，
绝不可用微波炉去温热血液。
专门调制给婴儿服用的奶粉，盒上说明文字，明白写出绝不可用微波炉去煮热，因
为它会破坏所有的营... 阅读全帖 |
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c**i
发帖数: 6973 | 6 Peter Landers, New Breast Cancer Drug Found Deep in the Sea. Wall Street
Journal, Jan. 4, 2010.
http://online.wsj.com/article/SB1000142405274870411150457605977
("A study found it [Halaven] extended the life of patients with advanced
breast cancer by about two-and-1/2 months, to 13 months")
My comment:
(a) Eisai Co., Ltd. エーザイ株式会社
(a public company; headquarters Tokyo; established in 1941 by Toyoji NAITO
内藤 豊次 as Nohon Eisai Co., Ltd. 日本衛材（衛生材料の略。具体的には絆創膏
や包帯の事))
ja.wikipedia.org
(b) eribulin
htt... 阅读全帖 |
|
r********y
发帖数: 2540 | 7 发信人: rockjohnny (肉夹馍), 信区: Food
标 题: Re: 微波炉热饭致癌
发信站: BBS 未名空间站 (Wed Feb 20 18:29:16 2013, 美东)
请立即停止使用微波炉加热或烹煮的食物
如果您用『微波炉煮热的食物』把癌细胞养得肥肥壮壮的，保证癌细胞会很高兴吃，
但不会说谢谢。而且，连您的身体也会一起吃掉。也许还可以让您散尽家产及痛不欲生。
所以呢 …… ，为了自己的健康，请详细阅读以下的说明以下的内容摘录
首先令我们好奇的是何以微波炉有害？倘若有害，为什么政府不回收呢？
有个很有意思的比喻，或者可比拟这个情况，当你将一只青蛙放上一个开着大火的
热锅时，牠会立刻跳走，但如果你用一根蜡烛慢慢加温，刚开始时，青蛙并不觉得有任
何烫感，但逐渐的等到牠觉得热了，再也无力气跳走。
如今微波炉就像那根蜡烛，使用它的人就像那只青蛙，什么时! 候! 会被困住，或
许是十或二十年之后，但迟早有可能被困住。
在医院中输血，需将从冰箱拿出的血加以温热才可输入人体，曾有护士为了急救病
人节省时间，使... 阅读全帖 |
|
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g***e
发帖数: 14217 | 9 番茄的枝叶和青果子都含有毒素。狗都会中毒，兔子免不了吧。
From wikipedia:
tomato leaves and stems contain atropine and other tropane alkaloids that
are toxic if ingested. Ripened fruit does not contain these compounds. Leaves, stems, and green unripe fruit of the tomato plant
contain small amounts of the poisonous alkaloid tomatine.
Tomato plants can be toxic to dogs if they eat large amounts of the fruit,
or chew plant material. |
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g***e
发帖数: 14217 | 10 From Wikipedia:
Like many other nightshades, tomato leaves and stems contain atropine and
other tropane alkaloids that are toxic if ingested. Ripened fruit does not
contain these compounds. Leaves, stems, and green unripe fruit of the tomato
plant contain small amounts of the poisonous alkaloid tomatine. Use of
tomato leaves in tea (tisane) has been responsible for at least one death.
However, levels of tomatine are generally too small to be dangerous. |
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F*********k
发帖数: 11739 | 11 刚刚以前科普过：
From Wikipedia:
Like many other nightshades, tomato leaves and stems contain atropine and
other tropane alkaloids that are toxic if ingested. Ripened fruit does not
contain these compounds. Leaves, stems, and green unripe fruit of the tomato
plant contain small amounts of the poisonous alkaloid tomatine. Use of
tomato leaves in tea (tisane) has been responsible for at least one death.
However, levels of tomatine are generally too small to be dangerous. |
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R***a
发帖数: 41892 | 12 Many poison dart frogs secrete lipophilic alkaloid toxins through their skin.
你以为alkaloid是啥东西？ |
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c**i
发帖数: 6973 | 13 Peter Landers, New Breast Cancer Drug Found Deep in the Sea. Wall Street
Journal, Jan. 4, 2010.
http://online.wsj.com/article/SB1000142405274870411150457605977
("A study found it [Halaven] extended the life of patients with advanced
breast cancer by about two-and-1/2 months, to 13 months")
My comment:
(a) Eisai Co., Ltd. エーザイ株式会社
(a public company; headquarters Tokyo; established in 1941 by Toyoji NAITO
内藤 豊次 as Nohon Eisai Co., Ltd. 日本衛材（衛生材料の略。具体的には絆創膏
や包帯の事))
ja.wikipedia.org
(b) eribulin
htt... 阅读全帖 |
|
c**i
发帖数: 6973 | 14 Peter Landers, New Breast Cancer Drug Found Deep in the Sea. Wall Street
Journal, Jan. 4, 2010.
http://online.wsj.com/article/SB1000142405274870411150457605977
("A study found it [Halaven] extended the life of patients with advanced
breast cancer by about two-and-1/2 months, to 13 months")
My comment:
(a) Eisai Co., Ltd. エーザイ株式会社
(a public company; headquarters Tokyo; established in 1941 by Toyoji NAITO
内藤 豊次 as Nohon Eisai Co., Ltd. 日本衛材（衛生材料の略。具体的には絆創膏
や包帯の事))
ja.wikipedia.org
(b) eribulin
htt... 阅读全帖 |
|
w********9
发帖数: 8613 | 15 这是Shorter Oxford American English Dictionary第五版列出的与德语或者日耳曼语
相关的英语词根或词汇。
-at, suffix2. + -dom, suffix. + -ed, suffix1. + -ed, suffix2. + -en, suffix1
+ -en, suffix2 + -en, suffix5 + -en, suffix6 + -er, suffix1. + -er, suffix3
. + -er, suffix5. + -est, suffix1. + -est, suffix2. + -et, suffix2. + -eth,
suffix1. + -hood, suffix. + -ing, suffix1. + -ing, suffix3. + -ish, suffix1.
+ -kin, suffix. + -le, suffix1 + -le, suffix3 + -less, suffix. + -ling,
suffix1. + -ling, suffix2 + -ly, suffix1. + -ly, s... 阅读全帖 |
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h***i
发帖数: 89031 | 16 傻逼
every potato will turn green when exposed to light. most will sprout.
Alkaloid will raise and make it bitter, But it is still safe to eat.
Even it taset so badly, it is still safe.
只要味道还能吃，安全绝对没有问题
family
properties,
isolated
, |
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h***i
发帖数: 89031 | 17 傻逼
long before salonine will harm you, the substance and other alkaloid will ru
in the taste first. |
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q*******u
发帖数: 3435 | 18 Government-owned companies of India"
A
Air India
Airline Allied Services
Airports Authority of India
Allahabad Bank
Andaman & Nicobar Islands Forest and Plantation Development Corporation
Antrix Corporation
Artificial Limbs Manufacturing Corporation of India
Ashok Group
B
Balmer Lawrie
Bank of Baroda
Bank of India
Bank of Maharashtra
Bharat Earth Movers
Bengal Chemicals and Pharmaceuticals
Bharat Bhari Udyog Nigam
Bharat Coking Coal
Bharat Dynamics Limited
Bharat Electronics Limited
Bharat Heavy... 阅读全帖 |
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S*******d
发帖数: 1 | 19 在历史上它曾拯救了无数生灵，得到医家的推崇。尽管金鸡纳树主要出产在印度尼西亚
，但是它的故乡却是在美洲的厄瓜多尔。 [5-6]
疟疾，
酋长送药
酋长送药
又称为“打摆子”，是由蚊子传播的一种急性传染病，人们一旦感染了这种疾病，就会
突然发冷、打寒战，之后又发高烧、说胡话、神志不清，若不及时治疗，就会有生命危
险。在从前，中国南方特别是气候潮湿的地区很多人得这种病，那时候，人们对这种病
毫无办法，往往坐以待毙。 [5-6]
根据传说，在厄瓜多尔南部山区洛哈省的马拉卡托斯地方，某位印第安人有一次患上了
疟疾，全身发热口渴难当，他就爬到密林深处的一口小池塘边，喝了许多凉水，顿觉病
情减轻，他发现这个池塘里的水竟是苦的。后来才知道原来池塘旁边生长着许多金鸡纳
树，其中有些倒在水中，那苦味正是树皮的浸出液呢！从此以后，当地的印第安人遇到
疟疾时，就会用这种含苦味的树皮来进行自我医治。由于屡试屡效，被当地土著视作神
药，世代相传。 [5-6]
哥伦布发现新大陆后，欧洲人大量涌入美洲，一位名叫贝德罗·莱依瓦的酋长，出于友
谊，向传教士胡安·洛佩斯透露了金鸡纳树的药用价值，并送他一块金鸡纳树皮留作纪... 阅读全帖 |
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l****u
发帖数: 8729 | 20 颠茄是地球上毒性最大的植物之一，里面含有托烷类生物碱(tropane alkaloid)，一旦
剂量足够多，会致成年人于死地。托烷类生物碱主要活性剂阿托品(atropine)会攻击副
交感神经系统，扰乱其负责调节诸如呼 吸等潜意识活动的能力。鉴于它的致命性，科学
家发现阿托品在医学方面的有益用途恐怕会令许多人大吃一惊。在作为乙酰胆碱酯酶抑
制药用以阻滞过度活跃的神经 细胞时，阿托品有助于缓解沙林和炭疽等神经毒剂的致命
作用。神经毒剂会令受害者失去对身体功能的控制。阿托品还被用于治疗青光眼，使心
跳骤停的患者恢复知觉。
稀奇古怪、魅力十足的真菌
在自然界中，真菌是一个相当庞大的家族，约有12万多种，而我们最常见到的不过是平
菇、香菇之类的，没什么特色。现在有一批稀奇古怪、魅力十足的真菌。相信大多数你
都没有看见过。
http://www.9999ya.com/upfiles/201102/20110212225557760.jpg
这种真菌是澳大利亚真菌的某一代表种属，橙黄色，相当漂亮。菌伞直径约为5厘米
，柄上覆盖着一些长长的羊毛状的毛发。
“地星”？
这些真菌在幼年的时候和马勃菌差不... 阅读全帖 |
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s******y
发帖数: 17729 | 21 杂志Molecular Genetics and Genomics
Tropane alkaloids (TAs) 途径相关的，植物分子生物领域相关的谁要的话，请站内我
，付上邮箱和CV，先来先得 |
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n****r
发帖数: 5801 | 22 hehe
http://en.wikipedia.org/wiki/California_Poppy
California poppy leaves were used medicinally by Native Americans, and the
pollen was used cosmetically. The seeds are used in cooking.[1]
An aqueous extract of the plant has sedative and anxiolytic action.[8] The
extract acts as a mild sedative when smoked. The effect is far milder than
that of opium. California poppy contains a different class of alkaloids:[9][
10]
"An aqueous alcohol extract of Eschscholzia californica has been
evaluated ... 阅读全帖 |
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r**z
发帖数: 1793 | 24 这个做了同时口服脂质和咖啡因对糖耐量的影响，作者认为能降低糖耐量
J Nutr. 2011 Apr 1;141(4):574-81. Epub 2011 Feb 23.
An oral lipid challenge and acute intake of caffeinated coffee additively
decrease glucose tolerance in healthy men.
Beaudoin MS, Robinson LE, Graham TE.
SourceDepartment of Human Health and Nutritional Sciences, University of
Guelph, Guelph, Ontario N1G 2W1, Canada.
Abstract
Lipid-induced insulin resistance has been investigated primarily with i.v.
infusions, and caffeine-induced insulin resistance, with alkalo... 阅读全帖 |
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h*t
发帖数: 42 | 25 更多文献,有兴趣看看?
Peer-Reviewed Research References
Bosello, O., & Zamboni, M. (2000). Visceral obesity and metabolic syndro
me.Obesity reviews, 1(1), 47-56.
Merat, S., Casanada, F., Sutphin, M., Palinski, W., & Reaven, P. D. (199
9). Western-type diets induce insulin resistance and hyperinsulinemia in LDL
receptor-deficient mice but do not increase aortic atherosclerosis compared
with normoinsulinemic mice in which similar plasma cholesterol levels are a
chieved by a fructose-rich diet. Arter... 阅读全帖 |
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g***e
发帖数: 14217 | 26 "The whole plant is poisonous but especially the bulbs. It contains two
alkaloids, narcissine (lycorine) and galantamine as well as the glycoside
scillaine (scillitoxin)." |
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m***y
发帖数: 14763 | 27 The bitterness of most fruits/veggies are caused by Alkaloid, you know, the
stuff contain mostly basic nitrogen atoms. So, if there is an over supply of
N fertilizer, that tends to make the fruits/veggies more bitter.
I don't think the bitter melon is the cause, in LZ's case. |
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c******n
发帖数: 5697 | 29 http://online.wsj.com/article/SB1000142405274870369920457501697
4.html?mod=WSJ_hpp_LEFTTopStories
Pick Your Poison
From deadly snakes to toxic mushrooms, a look at history's poison
garden.
The hemlock plant, which contains a potent alkaloid, that causes
convulsions, paralysis and death—was a favored method of execution in
ancient Greece. The most famous victim of hemlock executive is the
philosopher Socrates, who died in 399 B.C.
So many people believed that the sudden death of U.S. President Za... 阅读全帖 |
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l**********9
发帖数: 42 | 30 Cool! 問了一下賣家. 說絕對合法,通得過drug test (great!), 因為含的是
Alkaloids,不含DMT (失望..).
誰用了上來寫個心得謝謝 Orz |
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s******9
发帖数: 283 | 33 传统的natural product discovery一般需要好的bioassay。Fractionation of plant
extracts比较简单，但找到活性成分不容易，一般情况都是多种成分共同起作用。植物
的次级代谢产物diversification十分显著，一个pathway可能有很多结构相似的产物，
其中多少都有些相似的活性。
不管是多肽和其他小分子化合物，结构鉴定相对容易。多肽也不能靠简单测序，很多都
有修饰：hydroxylation，methylation，disulfide bond，cyclization,
incoporation with other building blocks, such as fatty acids, alkaloids...
这个学科历史悠久，但远未成熟。 |
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a***n
发帖数: 1152 | 34 NMR spectral assignments of a new chlorotryptamine alkaloid and its
analogues from Acacia confuse; Magnetic Resonance in Chemistry; Volume 45
Issue 4, Pages 359 – 361
Please email to h****[email protected]
Thanks a bunch! |
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d****i
发帖数: 360 | 37 Carbon-13 and Proton Nuclear Magnetic Resonance Spectra of Veratrum
Alkaloids
First PageHi-Res PDF[420 KB]Citing ArticlesWilliam Gaffield, Mabry Benson,
Robert E. Lundin, Richard F. Keeler
J. Nat. Prod., 1986, 49 (2), pp 286–292
Thanks a lot! |
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c******n
发帖数: 16403 | 39 Tan, Min-Jia; Yin, Chun; Tang, Chun-Ping; Ke, Chang-Qiang; Lin, Ge; Ye, Yang
Antitussive Indole Alkaloids from Kopsia hainanensis
Planta Med 2011; 77: 939-944
DOI: 10.1055/s-0030-1250631
thanks！ |
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d*****3
发帖数: 65 | 40 1. Wu, Zhimeng; Guo, Zhongwu. Sortase -Mediated Transpeptidation for Site-
Specific Modification of Peptides, Glycopeptides, and Proteins. J.
Carbohydrate Chem.2012, 31(1): 48-66.
http://www.tandfonline.com/doi/pdf/10.1080/07328303.2011.635251
2. Oh, Ki-Bong; Mar, Woongchon; Kim, Sanghee; Kim, Ji-Yun; Lee, Tae-Hoon;
Kim, Jae-Gyu; Shin, Daehyun; Sim, Chung J.; Shin, Jongheon. Antimicrobial
activity and cytotoxicity of bis(indole) alkaloids from the sponge
Spongosorites sp. Biological & Pharma... 阅读全帖 |
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e*l
发帖数: 585 | 41 看你头像，alkaloid 205B是你做的吧，牛人，敬仰敬仰。
Scripps |
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h*d
发帖数: 19309 | 43 土豆果子看起来不能吃
Potato fruit contains large amounts of the toxic alkaloid solanine and is
therefore unsuitable for consumption. |
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