s****9
发帖数: 932 | 1 Interspecies is xenogeneic. Allogeneic is same species but different
genetic background. |
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S*****s
发帖数: 242 | 2 You are fine unless you are severely immune deficient
科普一下：
The cancer cells you injected carry allogeneic antigens, and these antigens
could be recognized by immune cells and will be quickly rejected, just like
the rejection of kidney in the transplantation. The number is not an issue
because the rejection for allogeneic antigens is very strong, even entire
kidney, liver etc.
If you injected your own tumor cells, that will be different issue (but it
is obviously you were not doing that). These ... 阅读全帖 |
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w***r
发帖数: 709 | 3 Key points: However, of the 976 citations of the Bellgrau et al. paper,
about 700 were subsequent to publication of the retraction
Why I retracted my Nature paper: A guest post from David Vaux about
correcting the scientific record
David Vaux
In September 1995 Nature asked me to review a manuscript by Bellgrau and co-
workers, which subsequently appeared. I was very excited by this paper, as
it showed that expression of CD95L on Sertoli cells in allogeneic mismatched
testes tissue transplanted u... 阅读全帖 |
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g***r
发帖数: 285 | 4
maybe it's nonmyeloablative transplant,
my understanding is, and correct me if i'm wrong, that allogenic transplant
could be quite toxic in elderly patients, mostly from the myeloablative
chemo prep, so instead, you transplant the cells without high dose intense
chemo as a prep, and the recipient would have both donor cells and his or
her own cells in there, hoping the donor cells will do the trick, at least
slow down the underlying leukemic process, then you can consider allogenic
transplant a |
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s*********s
发帖数: 70 | 5 转载的：
寫給慈濟師姐的一封信
親愛的慈濟師姐，也許妳不認識我，但是我們有一面之緣，很抱歉寫這一封信給您，有
些事情我想讓妳知道。
那天，矽谷的慈濟中文學校辦新春園遊會，每一個班級都有自己班上的攤位。以往的園
遊會，吃吃喝喝的攤位最多，小朋友也很喜歡，但是每次吃完，垃圾桶裡滿滿的免洗餐
具，好不浪費。今年主辦單位決定，不能再有賣吃的攤位，所以今年都是玩一些小遊戲
的攤位，現場也非常熱鬧。我一手牽著兒子，一手牽著女兒，走進了熱鬧烘烘的會場。
在會場的一角，我看到了妳們的攤位，大大的字讓人很難不看到，「慈濟功德會骨髓捐
贈」。我心頭一凜，那塵封已久的往事立刻浮上心頭，下意識的，我帶著兒子向另一邊
走去。妳看到我了，我心裡知道，妳在向我走過來。妳滿臉笑容，我低著頭想逃避。還
是被妳攔住了。
妳迫不及待的告訴我什麼叫白血病，多麼可怕的白血病，大人、小孩、嬰兒、老人、年
輕人都會得到。妳塞給我的小冊子上，印著一張張茫然的臉孔。妳告訴我，他們 唯一
的希望，就是骨髓移植，唯有骨髓移植才能救他們的命。在妳的眼裡，我看到了一個慈
濟人的真誠，妳衷心的希望我能加入骨髓捐贈的資料庫。妳告訴我，連血都不用抽... 阅读全帖 |
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p*******r
发帖数: 21 | 6 寫給慈濟師姐的一封信
親愛的慈濟師姐，也許妳不認識我，但是我們有一面之緣，很抱歉寫這一封信給您，有
些事情我想讓妳知道。
那天，矽谷的慈濟中文學校辦新春園遊會，每一個班級都有自己班上的攤位。以往的園
遊會，吃吃喝喝的攤位最多，小朋友也很喜歡，但是每次吃完，垃圾桶裡滿滿的免洗餐
具，好不浪費。今年主辦單位決定，不能再有賣吃的攤位，所以今年都是玩一些小遊戲
的攤位，現場也非常熱鬧。我一手牽著兒子，一手牽著女兒，走進了熱鬧烘烘的會場。
在會場的一角，我看到了妳們的攤位，大大的字讓人很難不看到，「慈濟功德會骨髓捐
贈」。我心頭一凜，那塵封已久的往事立刻浮上心頭，下意識的，我帶著兒子向另一邊
走去。妳看到我了，我心裡知道，妳在向我走過來。妳滿臉笑容，我低著頭想逃避。還
是被妳攔住了。
妳迫不及待的告訴我什麼叫白血病，多麼可怕的白血病，大人、小孩、嬰兒、老人、年
輕人都會得到。妳塞給我的小冊子上，印著一張張茫然的臉孔。妳告訴我，他們 唯一
的希望，就是骨髓移植，唯有骨髓移植才能救他們的命。在妳的眼裡，我看到了一個慈
濟人的真眨瑠呏孕牡南Ｍ夷芗尤牍撬杈栀浀馁Y料庫。妳告訴我，連血都不用抽，只
要用一... 阅读全帖 |
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h****n
发帖数: 2552 | 7 也不太对头吧，比如我用药物诱导小鼠A长出原发性的肿瘤，然后再把肿瘤移植到小鼠B
上，一样的有几率长出来。
难道不同小鼠身上的肿瘤细胞会没有allogeneic antigens？
antigens
like
and
allogeneic |
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S*********e
发帖数: 127 | 8 Allogeneic T Cells That Express an Anti-CD19 Chimeric Antigen Receptor
Induce Remissions of B-Cell Malignancies That Progress After Allogeneic
Hematopoietic Stem-Cell Transplantation Without Causing Graft-Versus-Host
Disease
Jennifer N. Brudno, Robert P.T. Somerville, Victoria Shi, Jeremy J. Rose,
David C. Halverson, Daniel H. Fowler, Juan C. Gea-Banacloche, Steven Z.
Pavletic, Dennis D. Hickstein, Tangying L. Lu, Steven A. Feldman, Alexander
T. Iwamoto, Roger Kurlander, Irina Maric, Andre Goy, ... 阅读全帖 |
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a**********g
发帖数: 48 | 9 Position: Scientist/Senior Scientist for TRD Process Development
Job Description:
- Develop T-cell proliferation process (USP and DSP) and transfer for
current and future AT (Advanced Therapy = Cell & Gene Therapy) projects.
- Contribute to build development facilities and resources for T-cell
proliferation process development for current and future AT (Advanced
Therapy)projects.
- Contribute to interdisciplinary technical development work for AT projects
in TRD.
- Participate AT process develop... 阅读全帖 |
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a**********g
发帖数: 48 | 10 Position: Scientist/Senior Scientist for TRD Process Development
Job Description:
- Develop T-cell proliferation process (USP and DSP) and transfer for
current and future AT (Advanced Therapy = Cell & Gene Therapy) projects.
- Contribute to build development facilities and resources for T-cell
proliferation process development for current and future AT (Advanced
Therapy)projects.
- Contribute to interdisciplinary technical development work for AT projects
in TRD.
- Participate AT process develop... 阅读全帖 |
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a**********g
发帖数: 48 | 11 A Fortune 500 Healthcare company in New Jersey is hiring Scientist/Senior
Scientist for Biology Process Development
Job Description:
- Develop T-cell proliferation process (USP and DSP) and transfer for
current and future AT (Advanced Therapy = Cell & Gene Therapy)projects.
- Contribute to build development facilities and resources for T-cell
proliferation process development for current and future Advanced Therapy
projects.
- Contribute to interdisciplinary technical development work.
- Partici... 阅读全帖 |
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f****o
发帖数: 2770 | 12 25 yo, why not do allogenic bone marrow transplant?
Approximately 60 to 70 percent of such patients may be cured if you do bone
marrow transplant at young age (<20). 25 is still young.
does pt have other complications?
MD Anderson is the top ranking cancer hospital, but you can also seek for
2nd opionion at other hospitals. |
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p********r
发帖数: 1980 | 13 Here are some opinions from the medical research community:
The Royal College of Obstetricians and Gynaecologists 2006 opinion
states, "There is still insufficient evidence to recommend directed
commercial cord blood collection and stem-cell storage in low-risk
families."
The policy of the Society of Obstetricians and Gynaecologists of Canada
(SOGC) supports public cord blood banking (similar to collection and
banking of other blood products, i.e. altruistic, anyone can use it), as
well as stati... 阅读全帖 |
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n********k
发帖数: 2818 | 14 What an AMAZING woman! seriously!! I vote her to be a next Nobel laureate
and a first Chinese and it is a girl too....
http://english.cas.cn/accessory/twows4th/twowsaward/201006/t20100627_55793.html
Professor Fanyi Zeng was born in 1968. She received her B.A. in University
of California San Diego, CA, USA in 1991. In 2005, she got her Ph.D in
University of Pennsylvania, PA, USA.
Professor Zeng has led a research team that has made substantial and long-
lasting contributions to the developmental ... 阅读全帖 |
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b********h
发帖数: 348 | 15 有些免疫学机制的理论细节有些困扰。很想找人交流学习一下。 |
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m*****y
发帖数: 857 | 16 are you doing interspecies transplantation? |
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o*******a
发帖数: 242 | 17 OK，难得你这么执着，我舍命陪君子吧。
重复一下之前的论述，希望您能放下成见，读一遍，再思考一下。（您的论述我每次都
细读并认真思考的。事实是并不是我忘了common senses，而是你这些所谓的“common
senses”根本就不存在，从根上就错了。）希望你能有耐心把整个帖子读完。
1. 从动物模型结果来说，早先在黑猩猩上的感染实验已经清楚地表明，即使在感染前
及感染后对其实施complete B cell depletion，也就是说无法通过B细胞产生任何抗体
，但是绝大部分的成年黑猩猩还是能够成功的清除病毒，从急性感染中恢复。
Response——你并不知道黑猩猩的细胞和遗传背景。他也许有和人类不一样的蛋白和保
护机制。所以的deplete B cell 在这里不能拿来说事。你能够在人身上找到这样的例
子吗？ 没有吧----
2. 感染后自愈的病人中，有一小部分只能检测到HBcAb，而无法正常产生HBsAb （这部
分人往往对乙肝疫苗也不敏感，即使注射疫苗也不能产生足够滴度的保护性中和抗体）
。但这部分人也在自然感染进程中成功地清除了病毒，并没有转为慢性感染，和能够正
常产生... 阅读全帖 |
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o*******a
发帖数: 242 | 18 OK，难得你这么执着，我舍命陪君子吧。
重复一下之前的论述，希望您能放下成见，读一遍，再思考一下。（您的论述我每次都
细读并认真思考的。事实是并不是我忘了common senses，而是你这些所谓的“common
senses”根本就不存在，从根上就错了。）希望你能有耐心把整个帖子读完。
1. 从动物模型结果来说，早先在黑猩猩上的感染实验已经清楚地表明，即使在感染前
及感染后对其实施complete B cell depletion，也就是说无法通过B细胞产生任何抗体
，但是绝大部分的成年黑猩猩还是能够成功的清除病毒，从急性感染中恢复。
Response——你并不知道黑猩猩的细胞和遗传背景。他也许有和人类不一样的蛋白和保
护机制。所以的deplete B cell 在这里不能拿来说事。你能够在人身上找到这样的例
子吗？ 没有吧----
2. 感染后自愈的病人中，有一小部分只能检测到HBcAb，而无法正常产生HBsAb （这部
分人往往对乙肝疫苗也不敏感，即使注射疫苗也不能产生足够滴度的保护性中和抗体）
。但这部分人也在自然感染进程中成功地清除了病毒，并没有转为慢性感染，和能够正
常产生... 阅读全帖 |
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s****9
发帖数: 932 | 19 1. 你是synergic，还是allogenic？
2. 你可以适当的减少irradiation 的dosage或者separate成2次irradiation
3. 我做过很多用rag1KO的recipient，没觉得和普通的recipient有太大差异。 |
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c********n
发帖数: 67 | 20 Immunologic mechanisms in RCC and allogeneic renal transplant rejection
PMID: 20458329
Thanks for you kindly help.
h***[email protected] |
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s********n
发帖数: 248 | 21 Allogeneic stem cell transplantation in multiple myeloma: immunotherapy and
new drugs.
PMID: 25865214
麻烦请发到[email protected]
/* */，多谢啦！ |
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h******y
发帖数: 351 | 22 我们公司位于马里兰Rockville，是一个startup，方向是细胞治疗。公司现在有一个
opening，需要有免疫学或细胞生物学的背景。具体要求请看下面。
https://onedrive.live.com/redir?resid=BD682A26A4E7C162!11236&au
cm6_q_zSBI&ithint=file%2cpdf
有兴趣的请和我联系。Please submit your resume to [email protected]/* */
公司背景请看 http://www.propagenix.com
Job Description:
We are seeking a highly motivated and creative Staff Scientist, Immunology
to join Propagenix Inc. in Rockville, MD. This exciting opportunity will
focus on regenerative cell therapy and involves extensive ha... 阅读全帖 |
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m********8
发帖数: 314 | 23 这篇论文的提法是co-stimulatory molecule that may be involved in the negative
regulation of cell-mediated immune responses.能算作是“误认为PD-L1(B7-H1)是
抑制T细胞增殖”的论断吗？
https://www.nature.com/articles/nm1299_1365
摘要：The B7 family members B7-1 and B7-2 interact with CD28 and constitute
an essential T-cell co-stimulatory pathway in the initiation of antigen-
specific humoral and cell-mediated immune response. Here, we describe a
third member of the B7 family, called B7-H1 that does not bind CD28,
cytotoxic T-lymphoc... 阅读全帖 |
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f****y
发帖数: 104 | 24 看看陈教授自己的说法：
B7-H1 is a cell-surface glycoprotein belonging to the B7 family of
costimulatory molecules. Stimulation of primary human T cells in vitro with
immobilized B7-H1 in the form of an immunoglobulin (Ig) fusion protein (B7-
H1Ig), along with monoclonal antibody against CD3 as a surrogate antigen,
enhances T-cell growth and IL-10 secretion12. In addition, cell-associated
B7-H1 costimulates T-cell growth, as demonstrated by stimulating
proliferation of resting allogeneic CD4+ T-cells13. Adm... 阅读全帖 |
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d***y
发帖数: 299 | 25 不是很懂，不过最近刚看到这样的一个病人，三个月前被诊断为mds-u,大约二个月前开
始化疗.(decitabine)，后被refer到bone marrow
transplantation unit 做allogeneic stem cell transplantation，正在给他找donor
,同时发现他已经转成aml了, mds-u要担心转化诚aml(acute myeloid leukemia),mds-u
有二
个grade,grade1 blasts 5-10%, grade2, blasts11-20%, blasts 超过20%
就是aml了，不好意思，我也不懂，不想吓你，但愿你朋友长辈病情不会恶化 |
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