j***k
发帖数: 2719 | 1 what qualification does one need to be called 爷叔?
for me, a 爷叔 must be an urban dweller, someone who really understands what
comsmoplitan life style is all about, someone who has a fancy taste (does
not have to be expensive), someone who understand literature and music, a
car is not needed, but if one has one, it has to be somewhat of german
ancestry. As true to all old-schoolers, a leica camera (from M3 - M7, no M9!
) is a must for any 爷叔, a rollie or Hassle would also be nice.
爷叔 must also hav... 阅读全帖 |
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j***k
发帖数: 2719 | 2 what qualification does one need to be called 爷叔?
for me, a 爷叔 must be an urban dweller, someone who really understands what
comsmoplitan life style is all about, someone who has a fancy taste (does
not have to be expensive), someone who understand literature and music, a
car is not needed, but if one has one, it has to be somewhat of german
ancestry. As true to all old-schoolers, a leica camera (from M3 - M7, no M9!
) is a must for any 爷叔, a rollie or Hassle would also be nice.
爷叔 must also hav... 阅读全帖 |
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s******o
发帖数: 298 | 3 Researchers begin to trace the ancestry of massive galaxies.
by Elesa Janke
By studying quasars and their host galaxies with the Hubble Space Telescope
(HST), a team of astronomers has begun to trace the “family tree” of giant
elliptical galaxies. The group's findings reveal that 10 billion years ago,
when the universe was one third of its present age, these galaxies were
already forming, converting large amounts of gas into luminous families of
stars.
Among the most luminous objects ever found, |
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c*****a
发帖数: 1046 | 4 Mauna Kea在当地人心中可是相当的神圣，很多人用到了
那的望远镜最后致谢都要加上这么一段：
We wish to extend special thanks to those of
Hawaiian ancestry on whose sacred mountain we are privileged
to be guests.Without their generous hospitality, many
of the observations presented herein would not have been
possible.
LBT那块在70年代找到了千八百只本来以为早已灭绝了的小松鼠，
原来那块打算建好多镜子，最后搞来搞去只能建3面，建LBT的时
候官司一直打到国会才拿到permit，而且这个permit要隔个几年
再通过国会更新一下，理论上就是说，指不定哪天国会抽风就能
把LBT关掉。现在去LBT，人和车都要permit。
Arizona这块的山也很多是印第安人的神山，比如kitt Peak
好像就是什么雷电之神的山，（听着怎么这么不吉利，不怪
观测的时候总阴天... 阅读全帖 |
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g**p
发帖数: 32 | 5 official definition from textbook:
genes sharing common ancestry are called homologs.
if genes are homologs and there's no evidence of gene duplication, they're
called othologs.
if there is evidence of gene duplication, genes derived from one copy of the
duplicate are also called othologs.
Genes derived from two respective copies of the duplicate are called paralogs. |
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e*n
发帖数: 1511 | 6 Walgreens on Tuesday said it will begin selling personal genetic testing
kits on Friday, the first major retail chain in the U.S. to offer the home
tests.
The Deerfield, Ill.-based drugstore chain has an agreement with Pathway, a
startup that offers genetic health and ancestry reports.
But the U.S. Food and Drug Administration told the Chicago Tribune it is
investigating claims made by the San Diego-based company and Walgreens in
marketing its genetic test, which has not been approved by U.S. re |
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y****i
发帖数: 1265 | 7 发信人: Isaiah (SKIASONARANHR), 信区: Emprise
标 题: 据说哈利波特上nature了
发信站: 水木社区 (Thu Jan 6 09:19:54 2011), 站内
http://blog.renren.com/share/225423167/4622536314
刚看了《哈利波特7上》，无聊的在PubMed里面用"Harry Potter"做关键词搜索文献，
得到32篇文献，居然还有发在Nature上的文章两篇 还有其他牛文若干篇。灰常的欢乐。
附该文章链接： http://www.ncbi.nlm.nih.gov/pubmed/16094345
以免大家以为是我胡诌。最近真是闲的蛋疼。
==========================神==作==分==割==线==========================
在下面第一篇nature文章中，在2005年《哈里波特与混血王子》出版后，来自澳大利亚
皇家儿童医院的Graig等人，同样对哈里波特中描述的有超能力的巫师wizards and
witches与麻瓜muggle结合后，后代属性问... 阅读全帖 |
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P****d
发帖数: 564 | 8 化石是真的，但从性状推断ancestry是用猜的，因为无法排除是旁系祖先，同时还要假
定不是趋同进化。 |
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z*t
发帖数: 863 | 9 Beutler得奖，Medzhitov会不会有意见？
http://www.sciencedirect.com/science/article/pii/S1074761309002
Ruslan Medzhitov
This year marks the 20th anniversary of a publication (Janeway, 1989) that
in many ways revolutionized our understanding of the immune system. As part
of the proceedings of the Cold Spring Harbor Symposium on Immune Recognition
, the paper authored by the late Charles A. Janeway, Jr. was not a standard
peer-reviewed publication. In fact, Charlie used to refer to it as “the
best paper I've ... 阅读全帖 |
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s**u
发帖数: 9035 | 10 Postdoctoral Fellowships in Tobacco Control Research
The purpose of the fellowship is to attract diverse individuals from a
wide variety of backgrounds in medical, biological, social,
behavioral, and policy sciences to develop a new generation of
academic leaders in tobacco control. Upon completion of training,
fellows will be well positioned to be active participants in crucial
policy debates about the future development and implementation of
tobacco control interventions. The need for tobacco... 阅读全帖 |
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e*******e
发帖数: 1837 | 11 For African-American, the proportion of African/European ancestry could vary
significantly among individuals. You can label them as a population/group,
although genetically they are not homogenous. |
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o**4
发帖数: 35028 | 12 还有这个人，文章也一般
1. Driscoll CA, Luo SJ, MacDonald D, Dinerstein E, Chestin I, Pereladova O
and O'Brien SJ (2011). Restoring tigers to the Caspian region. Science 333:
822-823. [Letter to Editor]
2. Luo SJ, Johnson WE, and O’Brien SJ (2010). Applying molecular genetic
tools to tiger conservation. Integrative Zoology 5: 351-362. [Invited Review]
3. Luo SJ, Johnson WE, Martenson J, Antunes A, Martelli P, Uphyrkina O,
Traylor-Holzer K, Smith JLD and O’Brien SJ (2008). Subspecies genetic
assignments of w... 阅读全帖 |
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p*****c
发帖数: 20445 | 13 Michael Rape, Ph.D.
University of California, Berkeley
Michael Rape’s love of science began in the basement of his parent’s house
, where he used to conduct rudimentary biochemistry experiments. Today, he
uses far more sophisticated methods to understand a complex process critical
to nearly all organisms: ubiquitylation. The term describes the attachment
of a regulatory protein called ubiquitin—named for its ubiquity—onto other
proteins. Ubiquitin tags communicate a wealth of information to the ... 阅读全帖 |
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l**********1
发帖数: 5204 | 14 >只有千万分之三?
are they sure?
即使覆盖了 除了港澳台的 CN 所有地域的 地下 和地上的基因测序
也不算完整
n.b. 秦末的 徐福东渡日本的 说法 还有三国归晋之前后 曹操家族 也可能东渡或东
跨 韩日
更不要说外逃南洋的客家 很大一部分是黄河以北 魏国之后裔呢
即使后面唐宋 的音声更接近客语而不是元和清之后的后清 普通话:
pls refer,
>唐宋漢語之入聲調(收-p,-t,-k塞音尾)，今之普通話已完全消失，客語卻完整保留，
如：「合喝核」「接節跡」「業熱>逆」…又如雙唇鼻音尾(閉口ｍ尾)的字，北京音系
消失，併入舌尖鼻音尾(ｎ尾)，如「新心」「因音」「干甘」「山>衫」「鄰林」「煎
尖」「攤貪貪」「真針」等原來韻尾有別的字(ｍ/ｎ不同)，北京話卻都混同了，這些
收ｍ尾的字不僅保留在客語中，也留存於韓語中，可說是「禮失而求諸野」。客語的鼻
韻尾-m,-n,-ng和入聲尾-p,-t,-k對應整齊(如:斬展整、敢揀哽；眨舌石、磕刻揢)，韓
語也一樣(韓語的輔韻尾「終聲」有-m,-n,-ng，-p,-t,-k,-l七個)，因此學會客語，... 阅读全帖 |
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m******g
发帖数: 467 | 15 Nature 14.01.02
稍微了解一下：
1. N6-methyladenosine-dependent regulation of messenger RNA stability
m6A: most prevalent internal modification in mRNA
Recognized by human YTH domain family
From translatable to mRNA decay
小知识：
1. Low investment in sexual reproduction threatens plants adapted to
phosphorus limitation
2. Upper Palaeolithic Siberian genome reveals dual ancestry of Native
Americans
3. The complete genome sequence of a Neanderthal from the Altai Mountains |
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m******g
发帖数: 467 | 16 Nature 14.01.02
稍微了解一下：
1. N6-methyladenosine-dependent regulation of messenger RNA stability
m6A: most prevalent internal modification in mRNA
Recognized by human YTH domain family
From translatable to mRNA decay
小知识：
1. Low investment in sexual reproduction threatens plants adapted to
phosphorus limitation
2. Upper Palaeolithic Siberian genome reveals dual ancestry of Native
Americans
3. The complete genome sequence of a Neanderthal from the Altai Mountains |
|
m******g
发帖数: 467 | 17 PNAS 14.2.18
稍微了解一下：
1. Ancient west Eurasian ancestry in southern and eastern Africa
Two admixture events
Some ancentry related to Europeans and Middle Easterners
2. Population genomics of the honey bee reveals strong signatures of
positive selection on worker traits |
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m******g
发帖数: 467 | 18 Nature 14.03.20
稍微了解一下：
1. The genomic landscape of Neanderthal ancestry in present-day humans
2. Two independent transcription initiation codes overlap on vertebrate core
promoters
小知识：
1. How proteins find their DNA target
trials and errors
2. Hominin explorers were poor planners
3. Melanosome evolution indicates a key physiological shift within feathered
dinosaurs |
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k*****2
发帖数: 135 | 19 生物PhD（遗传进化方向），双修统计硕士，会Python、Perl和R编程，今年12月份毕业
。Publication还可以。
想花半年时间找工作，如果找不到合适的工作再读博后。
不考虑申请难度的话，现在能想到的公司有genentech, Illumina, PacBio, ancestry.
com, 23&me, verily，还有默克、辉瑞等等。其他咨询公司也打算投一圈试试看。
打算从5月份起一个个投过去，如果大神有可能内推的话也请站内信联系我，感谢！
会持续更新这个贴，感谢大家的帮助和鼓励。
准备面试有什么建议和特别要注意的地方吗？第一次找工作经验不足。 |
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m*********e
发帖数: 533 | 20 How about Natera?
ancestry. |
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g***o
发帖数: 31 | 21 我跟你有几乎一样的学位和研究背景。当年找工作的体会，直接申请那些药厂
scientist职位难度很大。R&D里面这个方向的组普遍规模比较小。genentech，merck，
pfizer，novartis等都有相关opening，但是一般招的人都有几年博后经验或者工业界
经验。fresh phd如果有业界关系运气也比较好，也有可能拿offer。这些公司也都有
postdoc program，门槛低一些。
那些小biotech公司，也会找很多statistical geneticist，bioinfo scientist，
computational biologist。相对容易拿到面试的机会，但是很多小公司面试流程不规
范，不好把握。关键看onsite面试的情况。
ancestry. |
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e*******o
发帖数: 4654 | 22 你学长学姐去了哪
问问是否可以内推
ancestry. |
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发帖数: 1 | 23 【 以下文字转载自 JobMarket 讨论区 】
发信人: JuneEight (), 信区: JobMarket
标 题: 【波士顿】全职技术员/博后-药物研发相关的小鼠实验
发信站: BBS 未名空间站 (Mon May 9 14:25:30 2016, 美东)
主要工作是小鼠脑中接种肿瘤细胞及后续的监控、监测。Title可以是技术员，也可以
是博后。
本项目是与药企合作项目，对于申请者之后找工业界的工作会有帮助。
项目启动时间紧迫，所以优先当地的申请者，且只考虑有相关经验的申请者。
工作单位：Brigham and Women's Hospital
工作地点：Longwood medical area。
有意者请直接通过BWH申请，申请链接：
https://partners.taleo.net/careersection/jobdetail.ftl?job=3017
Vy0Utcf5HhI.gmail
详细说明：
Job Description
TECHNICAL RESEARCH ASSISTANT II / 40 HOURS / DAY / BWH - NEUROLO... 阅读全帖 |
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发帖数: 1 | 24 23andme 将客户的数据卖给其他公司。如果查出有什么遗传病，到时候保险公司买了你
的数据然后知道了就不给保险。类似这样的情况都有可能发生。还不如在自己lab用公
共平台给自己测测。 |
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g*****x
发帖数: 3283 | 25 拿着自己最重要的信息交钱给别人高价卖？
现在人的智商啊。。。
report |
|
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e********h
发帖数: 694 | 27 如果只是拿数据进行研究，和医院没有两样。没看出来有什么问题啊。一般录入后名字
，ssn都给隐藏了。和卖给保险公司性质完全不同吧 |
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g****u
发帖数: 252 | 28 医院的consent是，do you want to participate in this study?
23andme的客户都是在无知的情况下被利用的。
很简单的假设，如果他们在他们的广告页面上，除了什么35medical reports，加上一
句，contribute to scientific discovery，或者加上一句，will be shared to
other universities/research insitute.你觉得还会有多少智力正常的人用他们的
service么？本来就是不可告人的秘密。加上一群急功近利，不知廉耻的所谓scientist
。噁心。 |
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发帖数: 1 | 29 你用过23andme吗？
买kit的时候只要提供姓名，根本不需要提供SSN或者DOB这种personal identifier。你
用假名都可以。
保险公司怎么知道你信息？
scientist |
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|
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w***a
发帖数: 4361 | 32 开玩笑，无论是23andme还是保险公司，干这个事情都要take huge risk，
脑子要进多少水才会这么干？ |
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发帖数: 1 | 33 还有，美国已经立法禁止了这种行为。
The Genetic Information Nondiscrimination Act of 2008 (Pub.L. 110–233, 122
Stat. 881, enacted May 21, 2008, GINA, pronounced Gee-na), is an Act of
Congress in the United States designed to prohibit the use of genetic
information in health insurance and employment. The Act prohibits group
health plans and health insurers from denying coverage to a healthy
individual or charging that person higher premiums based solely on a genetic
predisposition to developing a disease in the fu... 阅读全帖 |
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w***a
发帖数: 4361 | 34 照你这个逻辑，Framingham Heart Study，Dallas heart study
这几千号人把家里三代人的数据都贡献出来了，人家都是白痴就你不是？ |
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w***a
发帖数: 4361 | 37 医院测个BRCA mutation就要charge你好几百刀好不好。 |
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b********w
发帖数: 334 | 38 为啥不考虑Genos?
$399 CLIA Certified Whole exome sequencing
You own your own data.
What does a true ownership should mean to you
1. You have the access to the data
2. you control your data, people can only assess your data with your
consent
3. you are free to export and download and port your data to other
provider and we are building the partnership to make the process easier
4. you are entitle to receive financial benefit when your data get access
5. You can leave the platform if y... 阅读全帖 |
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e********h
发帖数: 694 | 39 医院的consent不是那么简单呢。。。和23andme大同小异。
scientist |
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b********w
发帖数: 334 | 40 try Genos 吧
我们给原始数据，现在beta中，bam, fastq你要也会给。 |
|
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g*****n
发帖数: 241 | 42 Genos 给health related reports吗？ |
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b********w
发帖数: 334 | 43 关于GINA
保险公司是不能依据你的遗传信息拒绝你的HEALTH INSURANCE。
但是保险公司有权让你disclose你的遗传信息决定你的LIFE Insurance，和Long term
disability insurance.
122
genetic |
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g*****n
发帖数: 241 | 44 如果不提供报告的话是不是意味着现阶段只能我们自己分析数据？
CLINVAR |
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b********w
发帖数: 334 | 45 对一般消费者
1. 我们会提供一个界面去浏览你的variant信息，我们会报告你的exome里面和CLINVAR
数据库匹配的结果，一般大致有1000-1500 个位点， 按照pathogenic, likely
pathogenic, VUS, likely benign, 和benign分类。忠实反映CLINVAR的结果没有多余
的解读。关联相关文献。同时按照CGD疾病把variant分类。再有就是一些
entertainment的traits
2. Genos给VCF文件，VCF包括所有位点的信息，不仅仅是界面展示的位点。你自己下载
了VCF文件，你有自由去其他的解读服务。未来Genos会引入第三方提供深度解读的
partner. （目前有在谈，10刀左右吧）
3. 不排除以后我们给报告。
如果你是bioinformatician, 我强烈推荐Genos
现在是beta, Genos可以提供更原始的数据 比如，bam文件。分析自己的数据比分析别
人的数据好玩多了。
可以私信一下email， 我给你发内测VIP invitation. |
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g*****n
发帖数: 241 | 46 谢谢解释，我再考虑一下。如果需要的话就给您写信。
CLINVAR |
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H*Q
发帖数: 725 | 47 https://career012.successfactors.eu/career?company=merckgroup&career_job_req
_id=159751&career_ns=job_listing&navBarLevel=JOB_SEARCH
A career with us is an ongoing journey of discovery: our 50,000 people are
shaping how the world lives, works and plays through next generation
advancements in healthcare, life science and performance materials. For 350
years and across the world we have passionately pursued our curiosity to
find novel and vibrant ways of enhancing the lives of others.
Your role:
W... 阅读全帖 |
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z*******6
发帖数: 679 | 48 帮朋友招个博后，台湾朋友，人非常好，博后五年两篇Cell，绝对牛人。
Postdoctoral Associate – Immunometabolism and Immunotherapy
Tracking Code
6934
Job Description
The Chang Lab at The Jackson Laboratory (JAX) is seeking a Postdoctoral
Associate to investigate metabolic
regulation of immune cells in the tumor microenvironment. We are especially
interested in dissecting how metabolic
events coordinate tumor-infiltrating T cells and control cancer progression
in order to benefit immunotherapy. The
project involves molecular/cellul... 阅读全帖 |
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发帖数: 1 | 49 【 以下文字转载自 Faculty 讨论区 】
发信人: CornucopiaX (VE RI TAS), 信区: Faculty
标 题: Re: 大家来认祖归宗 (转载)
发信站: BBS 未名空间站 (Thu Dec 21 18:58:25 2017, 美东)
发信人: CornucopiaX (VE RI TAS), 信区: Joke
标 题: Re: 大家来认祖归宗
发信站: BBS 未名空间站 (Thu Dec 21 18:58:10 2017, 美东)
这个国内有了吗？
我公司创业何不搞这个？
https://www.ancestry.com/ |
|
