s*******e
发帖数: 1389 | 1 我是纯外行，做果蝇发育的。你这两篇加上更早的这两篇：
（Submitted 16 February 2012; accepted in final form 7 May 2012）
Ren G, Kim JY, Smas CM (2012) Identification of RIFL, a novel adipocyte-
enriched insulin target gene with a role in lipid metabolism. Am J Physiol
Endocrinol Metab 303(3):E334–E351.
(Received 8 July 2012, available online 15 July 2012)
Ren Zhang （2012）Lipasin, a novel nutritionally-regulated liver-enriched
factor that regulates serum triglyceride levels。 BBRC
草草看完后，
1，先说命名。
"This gene (RIFL) was variously... 阅读全帖 |
|
s*******e
发帖数: 1389 | 2 我是纯外行，做果蝇发育的。你这两篇加上更早的这两篇：
（Submitted 16 February 2012; accepted in final form 7 May 2012）
Ren G, Kim JY, Smas CM (2012) Identification of RIFL, a novel adipocyte-
enriched insulin target gene with a role in lipid metabolism. Am J Physiol
Endocrinol Metab 303(3):E334–E351.
(Received 8 July 2012, available online 15 July 2012)
Ren Zhang （2012）Lipasin, a novel nutritionally-regulated liver-enriched
factor that regulates serum triglyceride levels。 BBRC
草草看完后，
1，先说命名。
"This gene (RIFL) was variously... 阅读全帖 |
|
T****r
发帖数: 4006 | 3 ANGPTL8 在fat里面表达不少
胖子有更多的ANGPTL8？ |
|
T****r
发帖数: 4006 | 4 ANGPTL8 在fat里面表达不少
胖子有更多的ANGPTL8？ |
|
l**********1
发帖数: 5204 | 5 if not be retracted later
pls refer
PNAS:
Contributed by 3H on October 9, 2012
sent for review August 27, 2012
Cell:
Received: December 28, 2012
Revised: March 28, 2013
Accepted: April 2, 2013
Published: April 25, 2013
发信人: Bostonbio (Rory), 信区: Biology
标 题: 才发现大家热烈讨论的Betatrophin就是Angiopoietin-like 8
发信站: BBS 未名空间站 (Tue May 7 23:39:59 2013, 美东)
Name: Betatrophin vs ANGPTL8
Publication: Cell (04/2013) vs PNAS (11/2012)
Function: increase insulin vs increase triglycerides
Boss: Douglas Melton vs... 阅读全帖 |
|
l**********1
发帖数: 5204 | 6 if not be retracted later
pls refer
PNAS:
Contributed by 3H on October 9, 2012
sent for review August 27, 2012
Cell:
Received: December 28, 2012
Revised: March 28, 2013
Accepted: April 2, 2013
Published: April 25, 2013
发信人: Bostonbio (Rory), 信区: Biology
标 题: 才发现大家热烈讨论的Betatrophin就是Angiopoietin-like 8
发信站: BBS 未名空间站 (Tue May 7 23:39:59 2013, 美东)
Name: Betatrophin vs ANGPTL8
Publication: Cell (04/2013) vs PNAS (11/2012)
Function: increase insulin vs increase triglycerides
Boss: Douglas Melton vs... 阅读全帖 |
|
B*******o
发帖数: 8 | 7 Name: Betatrophin vs ANGPTL8
Publication: Cell (04/2013) vs PNAS (11/2012)
Function: increase insulin vs increase triglycerides
Boss: Douglas Melton vs Helen Hobbs (both in HHMI and NAS)
准备搬小板凳看戏了... |
|
B*******o
发帖数: 8 | 8 又查了一下，乖乖不得了，一个蛋白好多名字，Lipasin/RIFL/ANGPTL8，再加上
Betatrophin，太搞了。
不过三个实验室都说是和Triglycerides相关，参见review：
Biochem Biophys Res Commun. 2013 Mar 15;432(3):401-5.
Emerging roles of Lipasin as a critical lipid regulator.
等着看Cell那篇的后续文章... |
|
B*******o
发帖数: 8 | 9 根据发表的文章，Lipasin/RIFL/ANGPTL8的作用机理是inhibit lipoprotein lipase，
从而提高plasma TG levels, 和SREBP pathway没什么关系吧。 |
|
w***a
发帖数: 4361 | 10 这两个研究可能并不矛盾。
PNAS paper如果用的是adenovirus在liver里面过表达ANGPTL8，
那应该只能是短时间的treatment，比如说一周之内，超过这个时间，老鼠就差不多因为
肝炎要开始挂了。
这么短的时间，beta细胞增殖可能还没完成，所以plasma insulin或者glucose都还看不
到变化。
plasma |
|
z********8
发帖数: 818 | 11 ANGPTL8/Betatrophin Does Not Control Pancreatic Beta Cell Expansion 竟然发
在cell 了。 |
|
