J***2
发帖数: 444 | 1 Scott Blanchard
WEILL CORNELL MEDICAL COLLEGE
Structures of the Bacterial Ribosome in Classical and Hybrid States of tRNA
Binding
Paul Driscoll
UNIVERSITY COLLEGE LONDON
Tracking death domain complex assembly with NMR
Qing Fan
COLUMBIA UNIVERSITY
Structural studies of human GABA(B) receptor
Evripidis Gavathiotis
ALBERT EINSTEIN COLLEGE OF MEDICINE
Tracing a Killer's Path: Structural insights into the Activation Pathway of
Pro-Apoptotic BAX
Wayne Hendrickson
COLUMBIA UNIVERSITY
Structural Analysi... 阅读全帖 |
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a********k
发帖数: 2273 | 2 花了一个小时，深深的鄙视一下自己的无聊行径！！
125 蔡亮 男 1980年11月 复旦大学 生命
科学 2007年12月毕业于[美国]北卡大学 [美国]加州大学旧金山分校 博士后
Cai L, Mostov K. Polarity is destiny. Cell. 2009 Nov 13;139(4):660-2. PubMed
PMID: 19914162; PubMed Central PMCID: PMC2900917.
Cai L, Makhov AM, Schafer DA, Bear JE. Coronin 1B antagonizes cortactin and
remodels Arp2/3-containing actin branches in lamellipodia. Cell. 2008 Sep
5;134(5):828-42. PubMed PMID: 18775315; PubMed Central PMCID: PMC2570342.
Cai L, Makhov AM, Bear JE. F-actin... 阅读全帖 |
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d*p
发帖数: 534 | 3 I am talking about general cell therapy. Oncogenic is only one part of the
safety issue. For example, one major concern of T cell therapy is over-
activated T cell might cause autoimmune disease, which is a very common
problem in stem cell and organ transplant, including cancer immunotherapy.
Rosenberg, a big name in cancer immune therapy, killed one patient due to
the infused Her2/neu targeting T cell were activated in lung.
Stem cell therapy actually only account for a small part of cell thera... 阅读全帖 |
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s****9
发帖数: 932 | 4 What is your control, Wild type mice control or no antibody control?
It does not looks positive from my view. It is unlikely that all of these
cells in this layer are uniformly positive. In addition, the cell size of
positive cells in your picture look pretty round and uniform, while the size
of true positive apoptotic cells are quite heterogeneous and look different
from healthy cells. |
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j***x
发帖数: 1469 | 5 1.EMBO J. 2012 Mar 30;31(9):2207-21. doi: 10.1038/emboj.2012.63.
EBV and human microRNAs co-target oncogenic and apoptotic viral and human
genes during latency.
Riley KJ, Rabinowitz GS, Yario TA, Luna JM, Darnell RB, Steitz JA.
2.Cell Mol Life Sci. 2012 May 1. [Epub ahead of print]
Virus-mediated inhibition of natural cytotoxicity receptor recognition.
Seidel E, Glasner A, Mandelboim O.
3
RNA Biol. 2012 Jun 1;9(6). [Epub ahead of print]
Battle of the midgets: Innate microRNA Networking.
Elias S,... 阅读全帖 |
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A******d
发帖数: 571 | 6 我的一个细胞系，用药物处理之后annexinV/PI染色作facs,annexinV+/PI+（necrosis)
的增多，但是annexinV+/PI-(apoptosis)的没有变化，可是我的microarray结果显示很
多和apoptosis相关的基因上调了。如果说药物作用时间太长导致apoptotic的necrotic
,那我处理4小时也是同样的结果。
请问，会不会apoptosis 在某些细胞里就会引起细胞膜破裂？ |
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s****l
发帖数: 395 | 7 还是搞点non-apoptotic cell death吧，这个是热点 |
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u**********d
发帖数: 573 | 8 这……
non-apoptotic 死法应该有很多种吧？能否科普一下 |
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C********4
发帖数: 308 | 9 假如下面的文章都是同一个人发表的。
请问在这个领域算是上等，还是中等，还是比较差的？
＝＝＝＝＝＝＝＝
1.
Metallic gold slows disease progression, reduces cell death and induces
astrogliosis while simultaneously increasing stem cell responses in an EAE
rat model of multiple sclerosis.
Pedersen DS, Fredericia PM, Pedersen MO, Stoltenberg M, Penkowa M, Danscher
G, Rungby J, Larsen A.
Histochem Cell Biol. 2012 Jul 22. [Epub ahead of print]
2.
Metallic silver fragments cause massive tissue loss in the mouse brain.
Locht LJ, Pedersen MØ, Markhol... 阅读全帖 |
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w***7
发帖数: 1637 | 10 source：http://bbs.netbig.com/thread-2491712-1-2.html
看了一下，今年不错啊，和清华并驾齐驱。
而且下半年我知道的还有两篇NS。
~~~~~~~~~~~~~~~~~
1.
Yuan W, Wu T, Fu H, Dai C, Wu H, Liu N, Li X, Xu M, Zhang Z, Niu T, Han Z,
Chai J, Zhou XJ, Gao S, Zhu B
Dense Chromatin Activates Polycomb Repressive Complex 2 to Regulate H3
Lysine 27 Methylation
Science, DOI: 10.1126/science.1225237, Aug. 24, 2012
2.
Liu B, Du H, Rutkowski R, Gartner A, Wang X
LAAT-1 Is the Lysosomal Lysine/Arginine Transporter That Maintains Amino
Acid Homeostasis
S... 阅读全帖 |
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a*****x
发帖数: 901 | 11 主要是明确的定义，以及pathway是什么? 谢谢！ |
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b***8
发帖数: 31 | 12 链接后面的一串数字其实是DOI
Quantitative image based apoptotic index measurement using multispectral
imaging flow cytometry: a comparison with standard photometric methods
APOPTOSIS
Volume 13, Number 8 (2008), 1054-1063, DOI: 10.1007/s10495-008-0227-4 |
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j*******g
发帖数: 10 | 13 thanks a lot!
Current Neurovascular Research
ISSN (Print): 1567-2026
ISSN (Online): 1875-5739
VOLUME: 9
ISSUE: 1
DOI: 10.2174/156720212799297100
PDGF Receptor β Signaling in Pericytes Following Ischemic Brain Injury
Author(s): Koichi Arimura, Tetsuro Ago, Masahiro Kamouchi, Kuniyuki Nakamura
, Koji Ishitsuka, Junya Kuroda, Hiroshi Sugimori, Hiroaki Ooboshi, Tomio
Sasaki and Takanari Kitazono
Pages 1-9 (9)
Abstract:
Platelet derived growth factor (PDGF)-B plays a neuroprotective role in
brain dam... 阅读全帖 |
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o**4
发帖数: 35028 | 14 代表性科研论文:
1. Song Y. and Lu B. Notch signaling modulator Numb's interaction with α-
Adaptin regulates endocytosis of Notch pathway components and cell fate
determination of neural stem cells. Journal of Biological Chemistry 2012,
287(21):17716-28.
2. Song Y. and Lu B. Regulation of cell growth by Notch signaling and its
differential requirement in normal vs. tumor-forming stem cells in
Drosophila. Genes & Development, 2011, 25(24):2644-2658.
3. Ouyang Y.*, Song Y.* and Lu B. p53 restrains ectopic... 阅读全帖 |
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C**S
发帖数: 522 | 15 http://www.mcw.edu/Hemonc/faculty/Anderson-Marshall.htm
The third project is based on our identifying several small chemicals that
inhibit the activation of NF-kB induced by chemotherapeutic agents. This
activation of NF-kB induces anti-apoptotic proteins which reduces the
efficacy of cancer drugs. We are now testing the compounds in cell lines to
compare the induction of apoptosis with chemotherapeutic agents alone and in
combination with curcumin or our test compounds.
Our goal is to test at l... 阅读全帖 |
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m******g
发帖数: 467 | 16 PNAS 13.12.17
本周似乎没有碰到那种令人眼前一亮的文章，下面几篇可以稍微看一下。
1. Codon 104 variation of p53 gene provides adaptive apoptotic responses to
extreme environments in mammals of the Tibet plateau
2. Repeated elevational transitions in hemoglobin function during the
evolution of Andean hummingbirds
3. The Burmese python genome reveals the molecular basis for extreme
adaptation in snakes
4. The king cobra genome reveals dynamic gene evolution and adaptation in
the snake venom system |
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m******g
发帖数: 467 | 17 PNAS 13.12.17
本周似乎没有碰到那种令人眼前一亮的文章，下面几篇可以稍微看一下。
1. Codon 104 variation of p53 gene provides adaptive apoptotic responses to
extreme environments in mammals of the Tibet plateau
2. Repeated elevational transitions in hemoglobin function during the
evolution of Andean hummingbirds
3. The Burmese python genome reveals the molecular basis for extreme
adaptation in snakes
4. The king cobra genome reveals dynamic gene evolution and adaptation in
the snake venom system |
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h******x
发帖数: 2 | 18 哪位大侠能否帮忙下载这篇文章，十分感谢。
[email protected]
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/* ]]> */
Increased expression of Bim contributes to the potentiation of serum
deprivation-induced apoptotic cell death... 阅读全帖 |
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p*******l
发帖数: 10 | 19 千人彭金荣担任动物科学学院和生命科学学院两个院长, 从2008年回国后发表的SCI论
文（说明：IF标注的是2013的），包括综述。
1: Zhu Z, Chen J, Xiong JW, Peng J. Haploinsufficiency of Def activates p53-
dependent TGFβ signalling and causes scar formation after partial
hepatectomy. PLoS One. 2014 May 6;9(5):e96576. （IF=3.534）
2: Ou Z, Yin L, Chang C, Peng J, Chen J. Protein interaction between p53 and
Δ113p53 is required for the anti-apoptotic function of Δ113p53. J Genet
Genomics. 2014 Feb 20;41(2):53-62.
(IF=2.924)
3: Tao T, Shi H, Huang D, Peng J. Def... 阅读全帖 |
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d****i
发帖数: 360 | 20 One paper, please! Thanks a lot! E-mail: x**********[email protected]
Molecular pharmaceutics!
ASAP paper!
Selective Apoptotic Killing of Solid and Hematologic Tumor Cells by Bombesin
-Targeted Delivery of Mitochondria-Disrupting Peptides
Huawei Cai, Hao Yang, Bin Xiang, Shengfu Li, Shan Liu, Lin Wan, Jie Zhang,
Youping Li, Jingqiu Cheng and Xiaofeng Lu |
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b******8
发帖数: 55 | 21 Dihydro-1,3-oxazines as antitumor agents , Kuehne, M. E.; Konopka, E. A.
Journal of Medicinal & Pharmaceutical Chemistry (1962), 5, 257-80.
Highly Selective Apoptotic Cell Death Induced by Halo-Salane Titanium
Complexes, Timo A. Immel, Malgorzata Debiak, Ulrich Groth, Alexander Bürkle
, Thomas Huhn, ChemMedChem
Volume 4, Issue 5, pages 738–741, May 11, 2009
Thanks! |
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c******6
发帖数: 928 | 22 Ying Zhang，Hang Chen，Ju-Guang Han，Insight into the binding modes of Lassa
nucleoprotein complexed with ssRNA by moleculardynamic simulations and free
energy calculations，Journal of Biomolecular Structure & Dynamics，2015，33
（1）：946-960
Run-Ning zhao，S. Fan，Ju-Guang Han，Guang Liu，Molecular dynamics study of
segment peptides of Bax,Bim, and Mcl-1 BH3 domain of theapoptosis-regulating
proteins bound to the anti-apoptotic Mcl-1 protein，Journal of Biomolecular
Structure and Dynamics，2015，33（1）：1067-10... 阅读全帖 |
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发帖数: 1 | 23 ==
The risk of cancer is increasing significantly nowadays, which is a serious
social and health problem threatening human being. Hence, numerous
scientists continuously endeavor on this imperative issue for conquering the
malignant disease and declining the cancer incidence. Due to over 60% of
currently used anticancer agents are derived from natural sources directly
or indirectly, the discovery and development of new effective and safe
cancer inhibitors from folk medicines still is important r... 阅读全帖 |
|
发帖数: 1 | 24 ==
The risk of cancer is increasing significantly nowadays, which is a serious
social and health problem threatening human being. Hence, numerous
scientists continuously endeavor on this imperative issue for conquering the
malignant disease and declining the cancer incidence. Due to over 60% of
currently used anticancer agents are derived from natural sources directly
or indirectly, the discovery and development of new effective and safe
cancer inhibitors from folk medicines still is important r... 阅读全帖 |
|
发帖数: 1 | 25 ==
The risk of cancer is increasing significantly nowadays, which is a serious
social and health problem threatening human being. Hence, numerous
scientists continuously endeavor on this imperative issue for conquering the
malignant disease and declining the cancer incidence. Due to over 60% of
currently used anticancer agents are derived from natural sources directly
or indirectly, the discovery and development of new effective and safe
cancer inhibitors from folk medicines still is important r... 阅读全帖 |
|
发帖数: 1 | 26 ==
The risk of cancer is increasing significantly nowadays, which is a serious
social and health problem threatening human being. Hence, numerous
scientists continuously endeavor on this imperative issue for conquering the
malignant disease and declining the cancer incidence. Due to over 60% of
currently used anticancer agents are derived from natural sources directly
or indirectly, the discovery and development of new effective and safe
cancer inhibitors from folk medicines still is important r... 阅读全帖 |
|
p*******g
发帖数: 2976 | 27 【 以下文字转载自 Biology 讨论区 】
发信人: albertsmwk (.)(.), 信区: Biology
标 题: 第一批“青年千人计划”生物类@publication列表@
发信站: BBS 未名空间站 (Thu Aug 18 15:04:16 2011, 美东)
花了一个小时，深深的鄙视一下自己的无聊行径！！
125 蔡亮 男 1980年11月 复旦大学 生命
科学 2007年12月毕业于[美国]北卡大学 [美国]加州大学旧金山分校 博士后
Cai L, Mostov K. Polarity is destiny. Cell. 2009 Nov 13;139(4):660-2. PubMed
PMID: 19914162; PubMed Central PMCID: PMC2900917.
Cai L, Makhov AM, Schafer DA, Bear JE. Coronin 1B antagonizes cortactin and
remodels Arp2/3-containing actin branche... 阅读全帖 |
|
b******a
发帖数: 704 | 28 Lampl, C. and K. Yazdi (2002). "Central pontine myelinolysis." Eur Neurol 47
(1): 3-10
The etiology and pathogenesis of this disorder are unclear and will be
discussed. Chronic alcoholism is still the most common underlying condition
of CPM patients. In the literature, 174 cases of CPM have been reported in
alcoholics since 1986, which is equivalent to an incidence of 39.4%.
Likewise, 95 cases of CPM following the correction of hyponatremia have been
documented since 1986 (21.5%). The role of h... 阅读全帖 |
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