发帖数: 1 | 1 有一种抗癌药物 Bortezomib 国内叫做万科。效果奇好。国内最近刚刚纳入医保项目。
医疗上的进步还是要靠这些美国药。救了不少人的命。 |
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ri 发帖数: 56 | 2 【 以下文字转载自 Biology 讨论区 】
发信人: ri (ri), 信区: Biology
标 题: 求一篇文章下载 谢谢
发信站: BBS 未名空间站 (Wed Mar 1 17:11:23 2017, 美东)
The p53-independent induction of apoptosis in breast cancer cells in
response to proteasome inhibitor bortezomib
Yerlikaya A1, Okur E, Ulukaya E.
Tumour Biol. 2012 Oct;33(5):1385-92. doi: 10.1007/s13277-012-0386-3. Epub
2012 Apr 4.
请回复此贴或发邮件至[email protected]/* */
谢谢! |
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f****o 发帖数: 2770 | 3 国内有velcade (bortezomib)么
z这个也很新很流行 |
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m*********s 发帖数: 12 | 4 借这个版问问。我一个同学的爸爸(60多岁)在国内得了多发性骨髓瘤(二期了,一共
三期)。
据说治愈的几率非常低,但是她还是想问问美国这边有没有什么更好的治疗方法。
(1) 目前他的用药是 注射用硼替佐米(Bortezomib for Injection)
中文名称:来那度胺
中文别名:雷利度胺
是1.3乘以身体的面积,最后是2.5毫克每次,第1、4、8、11天使用,这样为一个疗程
另外老的方法还有MPT、TD、TAD、PAD等方案,都是老方案
万珂TM(Velcade),现在皮下注射疗效和静脉注射疗效差别大不,据说皮下注射的疗效
也还好,但是比静脉注射对神经的影响较小
万珂TM(Velcade),其实是神经毒药,用者会产生神经炎,神经痛,那么国外在治疗这
个副作用的过程中有没有什么更好的方法,很多用户不是万珂打不起,而最后是痛死,
不肯打了
另外,这个病最怕的是肾脏,那么在保护肾脏的时候,国外有什么更加先进的方法吗
(2)她现在听说有种新的治疗办法:用热疗法来对抗癌细胞
据说是热疗完了以后,马上注入树突细胞,树突细胞是寻找定位癌细胞的,树突细胞本
身是从本人身体抽取的睡眠状态,不起作用... 阅读全帖 |
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s********h 发帖数: 85 | 5 爸爸69岁,被诊断出患有多发性骨髓瘤。现在是high risk smoldering myeloma,
因为骨头还没有受损伤。但是不幸的是细胞遗传学的结果不好,13和17号染色体都有变
异。骨髓穿刺也发现浆细胞比例有40%。其他验血验尿的结果都不太好。
现在进行化疗刚刚一个月,用的药是lenolidomide和Dexamethasone。但是医生担心治
疗效果不会太好,因为染色体的问题。所以以后非常可能会用到例如Bortezomib之类的
更厉害的化疗的药。
但是现在爸爸就已经有了很严重的副作用。他不想再把化疗进行下去了。我们也不知道
该怎么办。我看到在 MD Anderson 好像还有一个免疫疗法,不知道这种方法可行吗?
难道真的只有化疗吗?爸爸现在已经非常痛苦,我简直不敢想象以后的日子怎么过。 |
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f****o 发帖数: 2770 | 6 multiple myeloma has no cure right now
bortezomib is different from lenolidomide, your father may tolerate it well
immunotherapy 免疫疗法 can have intolerable side effects as well
consult palliative care/symptom management to improve qualify of life |
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b****r 发帖数: 17995 | 7 除了常规化疗,也有靶向治疗的专门药物
http://www.mayoclinic.org/diseases-conditions/multiple-myeloma/
Targeted therapy. Targeted drug treatment focuses on specific abnormalities
within cancer cells that allow them to survive. Bortezomib (Velcade) and
carfilzomib (Kyprolis) are targeted drugs that block the action of a
substance in myeloma cells that breaks down proteins. This action causes
myeloma cells to die. Both medications are administered through a vein in
your arm. |
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i********n 发帖数: 171 | 8 有审稿意愿的请发送你的CV到[email protected]/* */并告知你希望审稿的文章编号
请有时间愿意多审几篇的也可以,只要你能保证质量,之前有些审稿人有些敷衍,希望
大家能认真对待。谢谢合作。
1. Comparative assessment of cytotoxic effect of Cuban and Brazilian
propolis in human laryngeal epidermoid carcinoma cells
2. Role of PI3K/AKT/mTOR signaling pathway in ostearthritis by regulating
articular chondrocytes autophagy in rats
3. CREB knockdown inhibits growth and induces apoptosis in human pre-B
acute lymphoblastic leukemia cells through inhibition of prosurvival sig... 阅读全帖 |
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e********s 发帖数: 93 | 9 I am not sure about the source of that resume, but it might potentially get Dr.Xu into some troubles:)
Dr. Xu was a student/postdoc in David Scheinberg's lab at Cornell/Sloan
Kettering, but I don't think he ever got a faculty position there. Dr.Xu might have made some contribution to the CD33 projects, his main work was about the regulation of CD13/aminopeptidase N.
While David's work has pushed Lintuzumab (humanized monoclonal antibody
against CD33) into several clinical tests, trials for AML w... 阅读全帖 |
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p********t 发帖数: 411 | 10 In multiple myeloma, the magic drug "bortezomib" is based on Ubiquitin. |
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ri 发帖数: 56 | 11 The p53-independent induction of apoptosis in breast cancer cells in
response to proteasome inhibitor bortezomib
Yerlikaya A1, Okur E, Ulukaya E.
Tumour Biol. 2012 Oct;33(5):1385-92. doi: 10.1007/s13277-012-0386-3. Epub
2012 Apr 4.
请回复此贴或发邮件至[email protected]/* */
谢谢! |
|
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m*********s 发帖数: 12 | 13 【 以下文字转载自 Medicine 讨论区 】
发信人: manymembers (manymembers), 信区: Medicine
标 题: 询问关于“多发性骨髓瘤”
发信站: BBS 未名空间站 (Thu Jun 20 22:39:29 2013, 美东)
借这个版问问。我一个同学的爸爸(60多岁)在国内得了多发性骨髓瘤(二期了,一共
三期)。
据说治愈的几率非常低,但是她还是想问问美国这边有没有什么更好的治疗方法。
(1) 目前他的用药是 注射用硼替佐米(Bortezomib for Injection)
中文名称:来那度胺
中文别名:雷利度胺
是1.3乘以身体的面积,最后是2.5毫克每次,第1、4、8、11天使用,这样为一个疗程
另外老的方法还有MPT、TD、TAD、PAD等方案,都是老方案
万珂TM(Velcade),现在皮下注射疗效和静脉注射疗效差别大不,据说皮下注射的疗效
也还好,但是比静脉注射对神经的影响较小
万珂TM(Velcade),其实是神经毒药,用者会产生神经炎,神经痛,那么国外在治疗这
个副作用的过程中有没有什么更好的方法,很多用户不是万珂打不起,而最... 阅读全帖 |
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W********g 发帖数: 610 | 14 税收五年一直处于增长状态...cash充足,我觉得风险相对于BPAX小一些
James S. J. Manuso
Thank you, Tim. Good afternoon, and thank you for joining us for Astex
Pharmaceuticals 2012 First Quarter Conference Call. During the quarter, we
made considerable operational progress on many fronts in discovery, research
and in the clinical and regulatory development of our drugs. Our balance
sheet remains sound and our financial performance was excellent. We ended
the quarter with $126 million in cash and marketable securities and we
po... 阅读全帖 |
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