m*p
发帖数: 1 | 1 Somewhat agree with EDfan. CADD is good to rationalize the results but it's
terrible to predict the activity. Most of medicinal chemists are very
humble and gave way too much credit to the CADD scientists in the
publications, thus give the impression that the active molecules described
in the paper were designed by the CADD scientists. Having said that, the
CADD tool still useful to provide a rough picture of the potential binding
pockets, then it's medicinal chemist's intution to make the rig |
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U******m
发帖数: 423 | 2 I suppose one of the reasons that modeling do not play their role in some
companies is the modelers do not major in medicinal chemistry or pharmacy.
Though they can use some softwares, they do have very little knowledge in
what is a drug.
Currently, most modelers are from computational chemistry or biophysics, or
structural biology majors. They may publish very fancy papers such as MD
simulation (I really like those beautiful movies from MD) but might be
experts in CADD.
Anyway, CADD is some kin |
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h*******g
发帖数: 23 | 3 不知道有没有XDJM是学CADD方向的。。。国内市场此类人才比较缺乏，有人是否考虑回
国发展 |
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c*****3
发帖数: 17 | 4 My company is hiring a structural CADD Tech. Local candidates only -
Chicago.
Familiar with USACE standards, proficient w/ Microstation, hand-on
experience. The company may sponsor, but due to time, prefer GC, EAC, OPT
who can start working right away. send me your resume to j******[email protected]
w/ salary requirement. |
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h*******g
发帖数: 23 | 5 Dear all,
Anyone wants to know the position about CADD in china.
You can contact Henry.
Email address:h*******[email protected] |
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k**a
发帖数: 284 | 7 这个可是太绝对了，呵呵
目前来看cadd还是有点用的 |
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k**a
发帖数: 284 | 8 cadd还是能压缩部分成本的
适合极其小和极其大的firm |
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发帖数: 1 | 9 The Molecular Informatics department performs molecular design and
informatics support to the small molecules and biologics drug discovery
programs within the R & D center at Shanghai Hengrui Pharmaceutical Inc.
Opening position
Scientist/Senior scientist:
We have an open position for small molecule drug discovery and scientific
computing. This person will actively provide computational support for
various drug discovery projects at different stages independently or under
limited supervision. In... 阅读全帖 |
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z*****g
发帖数: 2 | 10 如果是靶向一个酶的话，可以设计它底物的类似物，从而开发成底物竞争性的
inhibitor，像一些kinase的inhibitor都是ATP的类似物；即Mechanism-based
inhibition，共价和非共价结合的都有，academic groups 开发比较多。但这类
compounds选择性可能不好，对同类型的酶都或多或少有抑制作用。
另外，从已经报道的ligand去设计similar analogs，可能很难跳出别人compound的骨
架(scaffold)，发文章的novelty或专利申请受影响。
如果是靶向protein-protein interaction 的话，尤其是你知道它们的complex
structure，以其中一个为receptor，另一个的peptide为ligand，不断优化（突变和/
或改变长度）这个peptide，使其达到活性达到最优；并且可以再对这个peptide进行化
学modification，提高其透膜性或水溶性。
zjianyun (Four) 提到的假阳性结果，是指Pan Assay Interference Compounds
... 阅读全帖 |
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g**l
发帖数: 169 | 11 我是做道路的，但我知道桥梁制图基本上就是画个草图，然后交给下面专业的CADD制图
，然后再在上面Make up 你的redlines再交给CADD去修改。这就是在这里做engineer和
CADD的区别吧。 |
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g**l
发帖数: 169 | 12 我是做道路的，但我知道桥梁制图基本上就是画个草图，然后交给下面专业的CADD制图
，然后再在上面Make up 你的redlines再交给CADD去修改。这就是在这里做engineer和
CADD的区别吧。 |
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x******i
发帖数: 21 | 13
CADD 在美国已经明显没有7/8年前火热了.国内可能正处在初级兴奋状态.
工作机会不多,一个CADD group 没有几个人, 而且据说只有大的制药公司才买得起整套
专业软件,因为需要与做晶体结构分析的结构生物学同行紧密合作.换句话说, 不能全靠
in silico modeling, 必须拿到药物与receptor or enzyme 共结晶结构才能给做合成
的指出方向. 至于用简单的CADD软件做SAR,恐怕每个well-trained chemist 都会一些.
my two cents. |
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x******i
发帖数: 21 | 14
CADD 在美国已经明显没有7/8年前火热了.国内可能正处在初级兴奋状态.
工作机会不多,一个CADD group 没有几个人, 而且据说只有大的制药公司才买得起整套
专业软件,因为需要与做晶体结构分析的结构生物学同行紧密合作.换句话说, 不能全靠
in silico modeling, 必须拿到药物与receptor or enzyme 共结晶结构才能给做合成
的指出方向. 至于用简单的CADD软件做SAR,恐怕每个well-trained chemist 都会一些.
my two cents. |
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s**********6
发帖数: 1 | 15 CADD和Bioinformatics不一样，CADD主要要求化学以及疾病机理方面的知识，
bioinformatics则是统计和编程上的工作。CADD是很重要的新药研发工具，很多大公司
都在用，Bioinformatics不是很熟，但是也有看到公司招聘的，应该也不算太糟糕吧。
一家之言，抛砖引玉吧。 |
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y****G
发帖数: 38 | 16 我们公司是工程类全美大公司.因为项目原因急需交通,规划,岩土工程,建筑等方面的人
才.
这些职位遍及全美,如有兴趣,欢迎联系
具体职位如下,
Air Quality Scientist
Architectural Historian
Architect
CADD Designer/Technician
CADD Operator
Civil Design Engineer
Civil Engineer
Civil Engineer PM
Civil Engineer
Civil Highway Engineer
Civil Inspector
Civil Superintendent
Contracts Manager
Cost Estimator
Electrical Engineer
Electrical Inspector
Electrical Superintendent
Engineering Manager
Engineer
Environmental Planner
Geotechnical Engineer
Hydraulic/Dr |
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t*******y
发帖数: 2424 | 17 我还真是做了5年吸硫塔和烟道及支撑之后转到输电塔的。其实LNG和吸硫塔设计很像，
不过LNG两层，吸硫塔一层。都是plate + stiffener. 一般ME更合适。
不夸张的说每个月都有recruiter email 或电话。可是找我的95%是transmission. 要
说我做吸硫塔和烟道的公司也都很不错的。
再说transmission这块很偏，就我本硕structure engineering 的经验来说，基本在学
校里没有相对应的课程。招人都得岗上培训。我们是utility, 待遇还行。
说来搞笑，我申请transmission 职位的时候，压根不知道PLS CADD 跟auto CADD 相差
甚远！还直接拿到senior职位。所以我运气好，沒碰到壁垒。 |
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r***y
发帖数: 248 | 18 你以前做的虽不是输电塔，好歹也是高耸构筑物，和输电他算近亲，如果你做的是
房屋或桥梁设计还有戏吗？
我当年还突击过PLS cadd,为准备面试。
我用关键字 “transmission pls cadd”在Boston 地区搜了一下，寥寥无几opening，
难怪你说每个月都有recruiter email 或电话，而不是每周，我就是不干土木了，还
每两个月收到transmission的recruiter email 或电话，大多是短期的合同工。 |
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f*********o
发帖数: 38 | 19 If you or any of your friends who may interested in Chinese positions in
these companies , please feel free to contact with me, available job
openings , eg DMPK, Medichem, Process chemistry, formulation, CADD, Oncology
, Diabetes, Respiratory and inflammation Translational Position.
JD and more information will be provided.
HEADHUNTER
Florence
Head Hunter
TEL: +86 21 3122 9017
Email：f*********[email protected]
Skype: florencehao |
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a*****3
发帖数: 2 | 20 A mid-sized Chelsea-based structural engineering firm, seeks CADD Operators
to join our team. Ideal candidates should have a strong command of AutoCAD
and work experience or internships in designing all types of buildings. We
offer a competitive salary and excellent benefits package, including medical
, dental, disability, life insurance, 401(K) profit sharing plan, paid
vacation and sick leave, and flexible working hours.
Ｗe also need structural engineers!
站内信箱联系！ |
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m****s
发帖数: 18160 | 21 【 以下文字转载自 Pharmaceutical 讨论区 】
发信人: addModules (Apache), 信区: Pharmaceutical
标 题: 诚聘 Computational Chemist for a leading Chinese Pharmaceutical Company (上海)
关键字: 招聘 上海
发信站: BBS 未名空间站 (Mon Jul 8 02:42:08 2013, 美东)
We have an open position in the Computational Chemistry group in the R & D
center at Shanghai Hengrui Pharmaceutical Inc. This person will actively
provide computational support for various drug discovery projects at
different stages independently or under limited supervision. In addit... 阅读全帖 |
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f*********o
发帖数: 38 | 22 by the way more job openings are available, eg Medichem, Process chemistry,
CADD, Oncology, Diabetes, Respiratory and inflammation Translational
Position.
Florence Hao
Skpye: florencehao
TEL: +86 21 3122 9017
Email：f*********[email protected]
please send resume to my email or contact me via skpye |
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f*********o
发帖数: 38 | 23 If you or any of your friends who may interested in Chinese positions in
these companies , please feel free to contact with me, available job
openings , eg DMPK, Medichem, Process chemistry, formulation, CADD, Oncology
, Diabetes, Respiratory and inflammation Translational Position.
JD and more information will be provided.
HEADHUNTER
Florence
Head Hunter
TEL: +86 21 3122 9017
Email：f*********[email protected]
Skype: florencehao |
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d**p
发帖数: 34 | 24 I am a Master's graduate in Mechanical Engineering with 1 year experience in
mechanical/product design. Hands-on experiences of FEA and CADD, engineering
documentation.
Currently I am looking for a position with regard to mechanical engineering,
design or manufacturing, please let
me know if there is anything available around Bay Area.
j*********[email protected]
Thanks! |
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r*******3
发帖数: 10886 | 26 各大药厂的CADD部门几年前就被砍光了吧。。。。。说得跟码工蹲细胞里敲几行代码就
能指挥机器人给人治癌症似的。。。 |
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u****e
发帖数: 99 | 27 Got this email on Dec 20, don't know if it still available. Try it if you are
interested.
Structural Engineer
Our client, an Engineering consulting company, has an immediate need
for a sharp, structural CADD drafter or engineer. The candidate needs to
have 2-5 years experience in vertical structures. Experience with
transportation or roadway engineering would be a plus degree. Any certs
such as PE, EIT or FE is not necessary, but would be an plus. Candidate
would initially be working on a pr |
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l*****y
发帖数: 1 | 28
可以去高校, 也可以找个外企做CADD啊, 这不正好发挥你的专长? |
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n****u
发帖数: 7 | 29 计算机辅助药物设计吗，这专业好找工作？在国内？一般一个公司就设两三个职位，然
后每年国内毕业的博士好歹也有50吧 |
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h*******g
发帖数: 23 | 30 可是国内这一块的需求量不少啊，大公司小公司都在做，而且大公司本身要求就高，需
要的更高端的人才，所以需要国外的大牛们，回国看看 |
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z**l
发帖数: 113 | 31 好像也就罗氏，诺华什么的在上海有几个职位，那还是去年的事了，现在不知道怎么样
？ |
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z*******t
发帖数: 84 | 36 Does he need part-time CADD or structural/bridge engineer to help him?
If so just let me know, hehe.
fresh |
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y*****o
发帖数: 284 | 37 我们公司有个牛人台湾学土木的来美国学神学,生计所迫到一家公司作draft person,就
是现在说的CADD Technician;做了一个月人家说你不是technician而是工程师啊,后来
就工程师了后来考了PE.再后来也成VP级别的人物赫赫不过现在年纪大了不愿意做太累
担太多责任. |
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k******k
发帖数: 475 | 38 microstation用的更多。
不用着急，有CADD画图，你自己大概知道就可以了。 |
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a*****3
发帖数: 2 | 39 A mid-sized Chelsea-based structural engineering firm, seeks CADD Operators
to join our team. Ideal candidates should have a strong command of AutoCAD
and work experience or internships in designing all types of buildings. We
offer a competitive salary and excellent benefits package, including medical
, dental, disability, life insurance, 401(K) profit sharing plan, paid
vacation and sick leave, and flexible working hours.
Ｗe also need structural engineers!
站内信箱联系！ |
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f**h
发帖数: 54 | 40 要用的熟练,正确,还是需要挺长时间.
不过这是cadd的活,engineer知道个大概就行了.
microstation的reference功能真强. |
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j***h
发帖数: 4412 | 41 Local candidates only -Chicago. |
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n**********r
发帖数: 2061 | 42 丑话说前面，如果您拿到这个工作俺是会有奖金的。不要上来就批评俺的动机。俺的动
机是帮着咱自己人找到好工作，顺便也挣点。俺不会藏着掖着，我就是觉得这个公司真
的很好，希望能让您这个人才找到合适的位置。我前一个公司招人的时候我啥都没说，
因为觉得那个公司太烂，不想害您往火坑里跳，虽然排名也很靠前。refer拿奖金这个
是公司内部的政策，好多公司都有这个政策。别上来就骂人。权衡利弊全都靠您，你不
愿意俺帮忙就别给俺发信。
现在介绍一下这个公司，设计公司里排前二十的。在美国有好几十个office。两千多号
人。现在招的从entry level到15年经验的manager都有。设计，规划，施工监理，桥梁
检测，计算机编程，CADD啥都招。每个月都有新opening。最低要求您得有大学本科，
最好有EIT也不是必须的。最好能有PE和n年的工作经验。免费给办H1b，公司给掏钱，
不像有些公司小气的还得自己交律师费。绿卡也可以谈，这要看所在office的经理的意
见。
说说公司待遇和福利。工资和其他专业比如EE，MBA和CS没法比。但在本行业中算中上
。和当地的DOT工资基本持平略高但是没有pensi |
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y******r
发帖数: 2986 | 43 要说PhD也不想找entry level的工作
可惜我要吃饭，只有读这个鸡肋的PhD
对research没有什么感觉，以后还是不想什么faculty的职位了
感觉土木的老师有些“害人害己” ，“孤芳自赏”
始，暂停接收新的refer请求。先把这二十几位老哥老姐安顿妥当再说。以后再有新的
opening会再开帖。谢谢。
动机是帮着咱自己人找到好工作，顺便也挣点。俺不会藏着掖着，俺就是觉得这个公司
真的很好，希望能让您这个人才找到合适的位置。俺前一个公司招人的时候俺啥都没说
，因为觉得那个公司太烂，
号人。现在招的从entry level到15年经验的manager都有。设计，规划，施工监理，桥
梁检测，计算机编程，CADD啥都招。每个月都有新opening。最低要求您得有大学本科
，最好有EIT也不是必须的。
上。和当地的DOT工资基本持平略高但是没有pension和那么多的federal holiday。保
险啥的还不错。有个好处就是稳定。俺所在的office从来没有裁过人。工作氛围特别好
，没有什么bullshit和backst
况给您refer一下。俺不能保证您肯定能拿到工作，只 |
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J***i
发帖数: 541 | 44 T.Y. Lin International's San Francisco Corporate Office has openings for
multiple positions! (San Francisco, CA)
We are currently seeking candidates for the following positions for our San
Francisco office:
Bridge Engineer, Bridge Designer, CADD Technician, and Senior Bridge
Engineer.
Full job descriptions and qualifications are available on our website. If
interested, please apply via our website: http://tylin.com/tyl_career_jobs.html
T.Y. Lin International (TYLI) is a premier, full-service inf... 阅读全帖 |
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h*********r
发帖数: 1940 | 45 【 以下文字转载自 EE 讨论区 】
发信人: hawaiilover (我爱北京天安门), 信区: EE
标 题: 做电塔和传输线设计，前景如何？
发信站: BBS 未名空间站 (Sat Nov 27 19:32:44 2010, 美东)
有个机会去做电塔设计和传输线设计(transmission line and tower design),主要是
使用PLS-CADD, PLS-Pole软件（本人有些这方面的经验），不知道这个方向的工作机会
怎么样？
因为我本科是学土木的，现在土木不景气，所以有这个机会往电力系统方面转，不知道
是不是会好一些？ |
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D*****I
发帖数: 987 | 47 Civil Associate -Surface Water
Location: Irvine, CA
COMPANY:
RBF( A UNIT OF MICHAEL BAKER CORP.)
Requirements include:
• 2-5 years experience in Surface Water Quality
• Engineering degree (B.S. Civil Engineering prefered)
• EIT or PE• CPESC or CPSWQ (or intent to obtain)
• Qualified SWPPP Developer/Practitioner certifications
• Experience and knowledge of construction site inspection, safety,
conduct, and storm water management principles on a construction sit... 阅读全帖 |
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t***r
发帖数: 264 | 48 Bentley Webcast Series:
Every Engineering Project Begins with Data Acquisition
Duration: 1 hour
Cost: Free
Available Credit: 1 PDH*
Topic details:
Join our webcast to see how existing data from virtually any source can be
included in preliminary and final engineering, empowering more informed
decisions. OpenRoads enables use of information from traditional surveys,
GPS, point clouds, CAD graphics, photogrammetry, contour maps and more. Raw
data can be imported, reduced and verified for accuracy... 阅读全帖 |
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b***q
发帖数: 83 | 49 Computer aided drug design, a blessing or a curse?
听起来挺好的专业，可一个师姐正在找工作，说搞这行的根本找不到工作（post-doc除外
），说有人做了8年的post-doc了 |
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