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全部话题 - 话题: caloric
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c****1
发帖数: 5654
1
the BB founder just passed away in SF at age of 96 last year!
there is no scientific proof that BB lives shorter than average joe...

recommen
long
calor
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mutati
the
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M*****a
发帖数: 7122
2
原文 http://www.sherdog.net/forums/f15/fat-weight-loss-techniques-risk-vs-benefits-366419/
http://www.buildingbodies.ca/Cardio/...fat-loss.shtml
High Risk Fat Loss
Risk To Benefit Ratios of Extreme And Controversial Fat Loss Techniques
THE RATING SYSTEM
In Kinakin’s book, he outlined a simple three-point rating system with low
(1), medium (2) and high (3) risk-benefit ratings, which I have adopted here
for fat loss techniques. An exercise that is low risk (1), low benefit (1)
might safely provide ... 阅读全帖
s*********x
发帖数: 1923
3
可能你原来的intensity太低了,trainer让你减少时间,加大intensity, burn more
calories. 就是说,同样一个mile, 快跑所消耗的卡路里比慢跑多很多。
http://thechart.blogs.cnn.com/2011/09/23/which-burns-more-calor
J***n
发帖数: 210
4
来自主题: Fitness版 - 这样会有什么效果?
It is just his style. Flip back to his posts a year and you can see how he
did extreme cutting, crazy ass daily cardio with very low caloric intake.
J***n
发帖数: 210
5
Your raw strength depends mostly on how much muscles you have and your CNS -
to what percentage and how hard you can activate your muscles.
So the answer to your question comes down how to keep your muscles and CNS
level while on a cutting phase. It is cliche but that depends on your diet
and training.
Diet wise, you need to keep your protein intake high (1-1.2g per lb is the
consensus) even if you are on a caloric deficit diet. Training wise, in
addition to P90x style training I believe you nee... 阅读全帖
m******i
发帖数: 9479
6
来自主题: Fitness版 - 练肌肉对健康有利还是有弊?
有study的结果是,从standard american diet转成ketogenic diet之后,受测试的人的
caloric intake从平均3200自动变成了2100。自动自发的,没有要求节制饮食。因为食
物的满足感太强,不需要多吃了。
btw,ketogenic diet的macro nutrient的比例很极端。50g以下碳水(含fiber以及一
切碳水),体重(in kg)乘1.5g到2.5g的protein,其余的都是fat
J***n
发帖数: 210
7
http://www.today.com/news/lolo-jones-gobbling-9-000-daily-calor
27lbs of muscle gain? I would not believe it.
f*******n
发帖数: 5241
8
来自主题: Fitness版 - 大家帮我看看问题在哪里?
我倒觉得长肌肉不见得一定长很多肥肉,只要不吃过量就好,
但是也不能吃太少,保持一个小caloric surplus。但是同时
也不能求速成。吃得少的话,变化也小。力量练习尽量上大
重量是根本。
LZ这种应该是吃太少了。另外150克的蛋白质是怎么算的,是
看label的吗?一般来说中国人的饮食很难吃到这么多。
150g蛋白质基本上等于一斤多纯瘦肉。
500g火鸡胸脯
576g三文鱼
600g瘦肉
420g瘦牛肉
25个鸡蛋
a***a
发帖数: 40617
9
来自主题: loseweight版 - 公主应该懂的...
这些东西我是花了10小时以上的时间去研究的
您有兴趣可以去研究一下人类过去200年caloric sweetener的消耗是如何
增加20倍的
以及儿童typeII diabetes发病率
a***a
发帖数: 40617
10
来自主题: loseweight版 - 饮食习惯和基因的区别
还有各种caloric sweetener
现在美国人吃上述这玩意儿(特别是HFCS)是200年前美国人食谱的20倍
不过我以前写keto那篇小综述就明确说过,keto/atkins不是适合所有人
适合胰岛素耐受的
P*******y
发帖数: 40
11
来自主题: loseweight版 - 健康减肥123...
My caloric intake is much less than yours, and I workout more (insanity
everyday). Haven't lost a single pound for over 2-3 weeks already. Maybe I
should eat more.
Keep up the good work.
l*******p
发帖数: 683
12
来自主题: loseweight版 - 问个怀孕饮食的事儿
我目前孕26周,长了18磅了。从11周开始就在本版做饮食记录了,你可以去看,吃的都
是健康食品,牛奶鸡蛋坚果蔬菜瘦肉之类的,垃圾油榨食品完全不碰,每天的总卡路里
一般保持在1800卡左右。
“自己的体重加宝宝的体重”这个想法太天真了,就是孕期还象减肥期一样吃的时尚版
宝驴妹妹也长了20磅呢。而且,每个人的priority不一样,选择也不一样,我自己是不
会为了一出月子就能瘦回孕前体重这样的目标而在怀孕期间吃减肥餐的。Remember,
first of all you are growing a human being! 别一味地追求身材而deprive your
baby and yourself of good nutrition.
下面是给你引用的American Pregnancy Association提供的一些guidelines和数据参考:
Facts about weight gain:
For women who were a normal weight before pregnancy with a BMI of 18.5-24.9
the recommended ... 阅读全帖
h*********r
发帖数: 10182
13
那篇文章最后有这样的话
Meanwhile, there is a dearth of evidence that caloric restriction slows
ageing in humans. Observational studies have found that people of average
weight tend to live longest3. Nir Barzilai, a gerontologist at Albert
Einstein College of Medicine in New York, says that the centenarians he
studies have led him to believe that genetics is more important than diet
and lifestyle. “They’re a chubby bunch,” he says
G***a
发帖数: 27294
14
我一看你给的abstract,就笑了。原来根本没有任何神秘之处 ~
关键句子在:Exercise time was adjusted to maintain caloric expenditure (400
kcal per session).
这句话什么意思? 意思就是,不管你的intensity level,控制的不是时间,而是总卡
路里燃烧
这不是一个fair comparison。因为high intensity training,一个特征是post-
burning。
因为high intensity里面,你把肌肉搞到了潜力上限,运动完了,氧债还要还,肌肉疲
劳也要缓解,这些东西,还要继续燃烧热量。增加的肌肉也需要大量ATP来maintain(
这点很多人不知道,就是肌肉静止也耗大量能量)
而low intensity不用。
所以控制卡路里,low intensity吃亏了。
实际生活中,情况不是这么简单的。最大问题就是,如果你fitness level不够,一上
来high intensity就会受伤。
受伤啥都别练了
还有一个问题是low intensity能保存体力,... 阅读全帖
G***a
发帖数: 27294
15
我一看你给的abstract,就笑了。原来根本没有任何神秘之处 ~
关键句子在:Exercise time was adjusted to maintain caloric expenditure (400
kcal per session).
这句话什么意思? 意思就是,不管你的intensity level,控制的不是时间,而是总卡
路里燃烧
这不是一个fair comparison。因为high intensity training,一个特征是post-
burning。
因为high intensity里面,你把肌肉搞到了潜力上限,运动完了,氧债还要还,肌肉疲
劳也要缓解,这些东西,还要继续燃烧热量。增加的肌肉也需要大量ATP来maintain(
这点很多人不知道,就是肌肉静止也耗大量能量)
而low intensity不用。
所以控制卡路里,low intensity吃亏了。
实际生活中,情况不是这么简单的。最大问题就是,如果你fitness level不够,一上
来high intensity就会受伤。
受伤啥都别练了
还有一个问题是low intensity能保存体力,... 阅读全帖
p*********l
发帖数: 26270
16
来自主题: loseweight版 - how to 增肥!!! (转载)
【 以下文字转载自 Tri 讨论区 】
发信人: pecanlover (SheRox), 信区: Tri
标 题: 冒着会被群殴的危险发这个
发信站: BBS 未名空间站 (Wed Sep 26 16:07:27 2012, 美东)
For Skinny Athletes: How to Gain Weight Healthfully
http://www.beginnertriathlete.com/cms/article-detail.asp?articl
Five tips for boosting calories
Although you cannot change your genetics and your tendency to fidget, you
can boost your calorie intake. Here are five tips to help you bulk-up
healthfully.
1. Eat consistently. Do NOT skip meals; doing so means you'll miss out on
im... 阅读全帖
p*********l
发帖数: 26270
17
Q. One topic that almost always seems to cause debate and controversy is the
issue of calories. Some claim that there is some kind of 'metabolic
advantage' associated with low-carbohydrate diets?
A. Okay, this is going to be a very long-winded answer since there's a lot
to cover. I want to point out that more detailed discussions of most of this
(everything except the more recent studies) are in my first book The
Ketogenic Diet.
The metabolic advantage of low-carbohydrate diets is an idea that h... 阅读全帖
s*******t
发帖数: 7746
18
来自主题: loseweight版 - 新目标,2个月减8lb
学习了!现在我最大的问题是晚上回家吃太多了,早上不觉得饿。
我发现我睡眠不足的时候确实特想吃,也许就是这里面说的
inadequate sleep can lead to excessive levels of cortisol, the stress
hormone, which can induce insulin resistance and (especially in the belly)
weight gain, but we also know that sleep deprivation has been linked to
lowered serum leptin.
这个也许是减肥反弹的原因吧
Too much dieting inhibits leptin secretion. In fact, drastic reductions in
caloric intake reduce leptin levels, faster than could be explained by body
fat losses (the same goes for overfeedi... 阅读全帖
s*******t
发帖数: 7746
19
来自主题: loseweight版 - 新目标,2个月减8lb
学习了!现在我最大的问题是晚上回家吃太多了,早上不觉得饿。
我发现我睡眠不足的时候确实特想吃,也许就是这里面说的
inadequate sleep can lead to excessive levels of cortisol, the stress
hormone, which can induce insulin resistance and (especially in the belly)
weight gain, but we also know that sleep deprivation has been linked to
lowered serum leptin.
这个也许是减肥反弹的原因吧
Too much dieting inhibits leptin secretion. In fact, drastic reductions in
caloric intake reduce leptin levels, faster than could be explained by body
fat losses (the same goes for overfeedi... 阅读全帖
v******s
发帖数: 6949
20
来自主题: loseweight版 - 啥时候该从减脂进入增肌?
你也不能老减阿,3个月以后效果就基本无了,你就得正常吃饭吃上个半年再减。无数
人血淋淋的例子,一直caloric deficit 身体会适应那个能量摄入的。(大胖子不在此
类大胖子就该饿着。)
k***a
发帖数: 335
21
来自主题: loseweight版 - [转]No simple road to weight loss
THE STAR PHOENIX 今天发的一篇。回答了几个版上经常讨论的问题. Highlights:
-"Weight loss requires significant changes in intake and expenditure".
- "those who set ambitious goals often get better results.
- "our heredity and genetics are not our destiny. Anyone can lose weight"
-There has to be sufficient intensity and duration to accompany frequency
for one to lose weight.
- sticking with meal structuring, especially on weekends, is important to
greater weight loss.
***************************************************... 阅读全帖
w********9
发帖数: 132
22
来自主题: loseweight版 - 刚开始,大家给点意见吧
心肺水平的问题。要慢慢加量。头一个礼拜可以玩一样的慢慢跑20min,不要指望多少
的calore deficit,先让身体适应运动再说。过一两个礼拜慢慢加到40min,再加到
60min.
如果很多年不运动了话,刚上来是比较艰难的。我本科的时候练长跑的,后来两三年没
运动再开始也是一次只能呼哧呼哧20分钟。坚持跑了一个月就恢复到原先的心肺水平了。
当你可以保持80%最大心率持续运动一个小时的时候,就可以正式开始cut了。
祝好运!
i*********5
发帖数: 19210
23
【 以下文字转载自 Tri 讨论区 】
发信人: ironman2015 (IMMT 2013), 信区: Tri
标 题: 220 lbs lighter and Ironman 70.3 ready
发信站: BBS 未名空间站 (Wed Sep 11 11:04:02 2013, 美东)
Gary Steeves was eating himself to death. Now he’s turned his life around
and ready to race in the IRONMAN 70.3 Sunshine Coast.
http://www.ironman.com/triathlon/news/articles/09/a-weighty-sub
When Gary Steeves lines up in next weekend’s IRONMAN 70.3 Sunshine Coast in
Australia he may not think about the fact that most of the athletes around
him weig... 阅读全帖
B*Q
发帖数: 25729
24
来自主题: loseweight版 - 这回是减肥餐了吧?
你哪里看来的?我看http://nutritiondata.self.com/
Caloric ratio:
Quinoa cooked: 71% Carb, 14% fat, 15% protein
White Rice Cooked: 90% Carb, 2% fat, 8% protein
Brown Rice Cooked: 87% Carb, 6% fat, 7% protein
k***a
发帖数: 335
25
来自主题: loseweight版 - 三娃妈减肥日记
DAY 25 - 129.9 LB
早餐(181cal):一片自产multigrain面包抹butter
AM Snack (53cal):一个半小橘子(烂了半个;(
午餐(245cal): 1.5杯烫蔬菜, 半杯烧豆腐
PM Snack(61cal):150克希腊酸奶
晚餐(cal):
---------
(cal)
运动:今天休息
虽然很早就醒了,想了想还是休息一天,给肌肉一个恢复的机会。昨天一天走路拖着两
条腿,谁谁见了都问。加上今天冰雨加暴雨,正是偷懒的好机会。
昨天吃的有点多。最主要的是下午加餐instead of yogourt吃了granola.又快到月底了
,生理期前正是嘴馋的时候。今天不运动,打算把caloric intake也降低。
k***a
发帖数: 335
26
来自主题: loseweight版 - 三娃妈减肥日记
DAY 25 - 129.9 LB
早餐(181cal):一片自产multigrain面包抹butter
AM Snack (53cal):一个半小橘子(烂了半个;(
午餐(245cal): 1.5杯烫蔬菜, 半杯烧豆腐
PM Snack(287cal):150克希腊酸奶, 一个煮鸡蛋,一块手工杂粮饼干
晚餐(370cal):两杯烫蔬菜,一杯煮豆腐
---------
(1136cal)
运动:今天休息
虽然很早就醒了,想了想还是休息一天,给肌肉一个恢复的机会。昨天一天走路拖着两
条腿,谁谁见了都问。加上今天冰雨加暴雨,正是偷懒的好机会。
昨天吃的有点多。最主要的是下午加餐instead of yogourt吃了granola.又快到月底了
,生理期前正是嘴馋的时候。今天不运动,打算把caloric intake也降低。
k***a
发帖数: 335
27
来自主题: loseweight版 - 三娃妈减肥日记
DAY 45 (Thu. Mar 13) - 130.3 LB
早餐(301cal):一片 半面包加花生酱
AM Snack (55cal): 一个小苹果
午餐(380cal): 10个饺子
PM Snack(0 cal): 没吃
晚餐(266cal): 两个饺子, 一杯Brussels sprouts, 21只虾
---------
(1002cal)
运动:没动
早上准时起床,洗完穿好,喝了口水,拿着包准备去GYM。走到门口,想起没拿今天要
做的几项的list, 回头上楼,拿了List。忽然不想去GYM了。。。没什么原因,也不困
。回到厨房,烧咖啡,做早饭。
今天翻了翻The Biggest Loser的菜谱。终于领悟了我为什么快两个月了体重没减多少
- 还是吃太多了! 书里说给那些contestants规定的食谱daily caloric intake 是(
150-300LB间的话)体重乘7。不足150磅按150磅做起始。那我不是要控制在1050卡/日
才能掉秤?还有15天,打算按这个目标试一试。
A******u
发帖数: 1279
28
来自主题: loseweight版 - [nytimes] the fat trap
http://www.nytimes.com/2012/01/01/magazine/tara-parker-pope-fat
长文慎入。
“I think many people who are anxious to lose weight don’t fully understand
what the consequences are going to be, nor does the medical community fully
explain this to people,” Rudolph Leibel, an obesity researcher at Columbia
University in New York, says. “We don’t want to make them feel hopeless,
but we do want to make them understand that they are trying to buck a
biological system that is going to try to make it hard for th... 阅读全帖
G*********s
发帖数: 6786
29
来自主题: loseweight版 - 标示的热量能完全吸收么?
想减肥,就按照最高值来算就对了
大多数计算就是根据吸收来的
In this system, calories are not determined directly by burning the foods.
Instead, the total caloric value is calculated by adding up the calories
provided by the energy-containing nutrients: protein, carbohydrate, fat and
alcohol. Because carbohydrates contain some fiber that is not digested and
utilized by the body, the fiber component is usually subtracted from the
total carbohydrate before calculating the calories.
w***n
发帖数: 9040
30
嗯,应该是因为误差,因为脂肪和糖所占的百分比是从RQ测试值换算出来的,RQ测试值
每档的差距也就0.01-0.02左右,难免出现误差。
The respiratory quotient (or RQ or respiratory coefficient), is a unitless
number used in calculations of basal metabolic rate (BMR) when estimated
from carbon dioxide production. Such measurements, like measurements of
oxygen uptake, are forms of indirect calorimetry. It is measured using
Ganong's Respirometer.
Calculation
The respiratory quotient (RQ) is calculated from the ratio:
RQ = CO2 eliminated / O2 consumed
where the te... 阅读全帖
w***n
发帖数: 9040
31
嗯,应该是因为误差,因为脂肪和糖所占的百分比是从RQ测试值换算出来的,RQ测试值
每档的差距也就0.01-0.02左右,难免出现误差。
The respiratory quotient (or RQ or respiratory coefficient), is a unitless
number used in calculations of basal metabolic rate (BMR) when estimated
from carbon dioxide production. Such measurements, like measurements of
oxygen uptake, are forms of indirect calorimetry. It is measured using
Ganong's Respirometer.
Calculation
The respiratory quotient (RQ) is calculated from the ratio:
RQ = CO2 eliminated / O2 consumed
where the te... 阅读全帖
g*2
发帖数: 658
32
EXERCISE-RELATED TRANSIENT ABDOMINAL PAIN — Exercise-related transient
abdominal pain (ETAP) is commonly referred to as a "stitch." It occurs
frequently during long distance running (particularly during training and
racing) but also with swimming, cycling, horseback riding, and team sports.
The reported incidence varies widely: 6 to 68 percent.
Clinical manifestations — Exercise-related transient abdominal pain is
often described as a side ache, side cramp, sharp or stabbing pain, cramping
, ach... 阅读全帖
g*2
发帖数: 658
33
来自主题: Running版 - 有人拉肚子吗?
ACUTE DIARRHEA — Diarrhea and the urge to defecate in long distance runners
(colloquially referred to as "runner's trots") are common, and frequently
interrupt exercise and impact performance. Exercise-associated diarrhea
ranged from 14 to 38 percent in long distance runners and marathoners, while
urgency to defecate during exercise ranged from 24 to 54 percent. Fecal
incontinence is relatively uncommon (4 percent).
Athletes have described an association with the intensity of exercise, pre-
race... 阅读全帖
m*****i
发帖数: 2325
34
来自主题: Running版 - 腿老心不老
这是版的诊断:
参看: http://www.mitbbs.com/article_t/Running/31646495.html
EXERCISE-RELATED TRANSIENT ABDOMINAL PAIN — Exercise-related transient
abdominal pain (ETAP) is commonly referred to as a "stitch." It occurs
frequently during long distance running (particularly during training and
racing) but also with swimming, cycling, horseback riding, and team sports.
The reported incidence varies widely: 6 to 68 percent.
Clinical manifestations — Exercise-related transient abdominal pain is
often described ... 阅读全帖
w*****3
发帖数: 1582
35
来自主题: Running版 - 版主小变有什么建议?
对拉,我对你特别推荐fasting (节食), 我是做肿瘤, 还有衰老研究的, 我知道节
食可以降低肿瘤的发生,更新免疫系统,还有延长寿命(小鼠延长20-30%)。
我刚查了一下文献,发现最新的在顶级杂志cell 发表了fasting 还可以扭转糖尿病的
发病。
这是新闻
http://www.collective-evolution.com/2017/04/06/a-fasting-diet-could-reverse-diabetes-repair-the-pancreas-new-research-shows/
这是nature 的介绍
http://www.nature.com/nrendo/journal/v13/n5/full/nrendo.2017.28.html
The reprogramming of pancreatic β cells to restore insulin production has
been proposed as a potential therapeutic strategy for type 1 diabetes
mellitus (T1... 阅读全帖
j*j
发帖数: 5564
36
原作者Yann Martel在写了《Life of Pi》不久之后,又写了一部作品,
《We ate the children last》
可见他对吃人这个话题耿耿于怀,难以摆脱。这暗示他写《Life of Pi》的真实意图
中确实有写人吃人那一层意思,这层意思起码占50%吧。
说白了,写小说就是一个游戏,他故意要写得亦真亦幻,让那些经历不同信仰不同的读
者们对此作不同的解读。
-------------------------------------------------
We ate the children last
Yann Martel
The Guardian, Friday 16 July 2004
The first human trial was on Patient D, a 56-year-old male, single and
childless, who was suffering from colon cancer. He was a skeletal man with
white, bloodless skin who could no longer ... 阅读全帖
G******t
发帖数: 1782
37
Immigrants to the United States often ditch their ethnic diets for high-
calorie American fare, partly because it is cheap and easy to find but also
as a way to fit in, a new study shows.
新研究显示,移民美国的人,常常放弃他们的传统饮食,改吃高卡路里的美国饮食,部
分是因为美国食物便宜好找,不过也因为这是一种融入的方式。
Immigrants who eat American are consuming, on average, 182 extra calories
and seven additional grams of saturated fat compared to immigrants who stick
to their traditional diet, leaving the fast-food immigrants more likely to
become obese and s... 阅读全帖
m***j
发帖数: 9290
38
话是这么说,但是我觉得代谢减慢也是一个长期的过程。
AFU是六个月KC的,我也没减粮,但是从那时起他的生长速度就迅速减慢了。到了8个月
之后就几乎没怎么长了。
我想一方面这和年纪有关,另一方面也说明,KC之后,只要正常的运动量,也不用怎么
担心体重的问题。所以到现在我还是再按照DRY FOOD BAG上的指示来喂,没觉得有什
么问题。
但是象ORIJEN这样HIGH PROTEIN的,CALORE DENSITY太高,我不知道孩子会不会吃不
饱,总觉得肚子饿。因为AFU什么时候吃饭都是那么大兴致,所以我也无法分辨他到底
有多饿。
MM是喂多少量呢?
l*****a
发帖数: 38403
39
来自主题: Wisdom版 - 地中海饮食- 老人篇
After the age of 60 caloric requirements tend to decrease, while the
quality of nutrients must, on the contrary, increase. Physiologically
the body undergoes changes due to aging: the mass of bone and muscle
diminishes, the liver decreases in weight, body fat tends to increase.
Eating during this stage of life is tied to various factors:
environment, solitude, physical activity, mental condition, social
status, money, the ability to chew. Persons not particularly attracted
by food will choose, w
D*a
发帖数: 6830
40
来自主题: Biology版 - paper help, thanks!
Moderate caloric restriction initiated in rodents during adulthood sustains
function of the female reproductive axis into advanced chronological age.
Selesniemi K, Lee HJ, Tilly JL.
Aging Cell. 2008 Oct;7(5):622-9. Epub 2008 Jul 24.
多谢!
x********[email protected]
w***j
发帖数: 88
41
来自主题: Biology版 - SIRT3如何战胜衰老
CR在monkey上的作用
Caloric restriction delays disease onset and mortality in rhesus monkeys.
Science 2009;325:201-204
争论的焦点在于是否是SIRT家族起了最关键的作用,而不在于CR是否有作用
另外,CR领域里火的就那么几个东西:IGF-1,AMPK,mTOR,SIRT1,SIRT3
D*a
发帖数: 6830
42
: "most animals at wild die long before they reach the beginning of their
====
This is true
小鼠在自然界中平均寿命也就六个来月,不可能活到两年多。中国古代女子15岁及笄(
可以嫁人),加上解放前平均寿命30岁的数据,所以能作用于reproduction的基因肯定
是跟寿命有这样那样的联系的。
现在说得通的寿命理论(evolutionary theory of aging),我觉得并不是突变积累和
抗氧化,而是kirwood的disposal soma,由willarms的antagonistic pleiotropy发展
而来,中心思想是能量的分配,这个理论认为,机体soma是用来支持生育的,现在的长
寿实际上是要求用更多的能量来维持机体的功能,所以不可避免要从其他地方(例如生
育能力)调出能量,从这个角度可以理解抑制growth hormone/IGF-1通路,或者
caloric restrition,可以影响机体的能量分配方式。
突变积累和抗氧化,我认为只是作用方式
reproduct... 阅读全帖
h*******o
发帖数: 4884
43
Again, small mammals most die from accidents or predation, not die of aging.
Large mammals have a much longer life span which surely is longer than
reproductive competent period.
As for caloric restriction, personally this is one sick way to extend life
span at the expense of life quality. This is particularly true at younger
ages.
D*a
发帖数: 6830
44
你这个思想还是programmed aging的思想。
其实可以这样倒过来想。如果evolution不需要 aging,那么某个基因对aging有没有影
响,都无关紧要,没有选择压力,那么就不会被evolution 选择掉。
那么假设一个种群平均寿命是5岁,死亡原因是要么掉到沟里摔死,要么被天敌吃掉。
那么如果一个基因的结果是造成心脏在六年之后挂掉,那么这个基因有没有都无所谓。
所以这样的基因就没有选择压力,从而可能在种群中慢慢散布开来。
那么这个基因散布开之后,有另一个突变造成肝在七岁的时候挂掉,那么也没有什么关
系,同理,这个基因也会慢慢散布开来。那么长此以往,“aging”就在不需要aging的
群体中建立了。
当然最有可能的是这些基因并非炸弹定时器,而是影响其fonction从而慢慢发挥作用,
比如让心脏供血能力提升,肝代谢毒物速度加快。。。(从而引起exhausting of stem
cell pool?)
所以如果再次把这个种群放到人工环境中,我们发现他们活六年就死了,作出结论说这
个种群的平均寿命是六年。 同时,人工环境中这些基因的优势就又没有优势了。因此
我们通过基因... 阅读全帖
D*a
发帖数: 6830
45
做衰老的一抓一大把吧。
这几年的rapamycin treatment, s6k1 KO, Methionine-deficient diet,snell,ames
dwaft,GHR KO,IGF1R KO, IRS KO,p66 Shc, klotho 都是在正常老鼠里面做的,还
有各种KO加caloric restriction的(老鼠活到1000天了都)而且这些实验室经常是
survival的实验再重复一次,当然重复也是因为dispute,后续的重复实验经常就发到
plos one之类的地方了。
不知道为啥大家突然一窝蜂的去搞早衰模型的rescue了。原来正常衰老模型,也有寿命
延长到60%甚至更多的,也有没发到CNS上的,人家也没差这一年。
再说不是加一个早衰转基因进去就一定省时间的,后续很多事情要考虑。
l**********1
发帖数: 5204
46
来自主题: Biology版 - yeast synthetic rescue 怎么分析?
Alleviating interactions.
Please go to AMPK(Sip2) Nature paper:
Functional dissection of lysine deacetylases reveals that HDAC1 and p300
regulate AMPK (2012)
link:
//www.ncbi.nlm.nih.gov/pubmed/22318606
its pp251
called both as
[synthetic lethal (negative/aggravating) and rescue (positive/alleviating)
interactions]
more reference:
Acetylation of yeast AMPK controls intrinsic aging independently of caloric
Cell 146: 969-
//www.ncbi.nlm.nih.gov/pubmed/21906795
x**4
发帖数: 112
47
来自主题: Biology版 - paper help
http://www.ncbi.nlm.nih.gov/pubmed/22787140
Diabetes. 2012 Jul 10.
Caloric Restriction Chronically Impairs Metabolic Programming in Mice.
Thanks
d*********w
发帖数: 6
48
这个Lin YY 很高产啊,三年内三篇CNS。高度怀疑其他paper的可信度。。。那个Lu JY
好像是他老婆。
Functional dissection of lysine deacetylases reveals that HDAC1 and p300
regulate AMPK.
Lin YY, Kiihl S, Suhail Y, Liu SY, Chou YH, Kuang Z, Lu JY, Khor CN, Lin CL,
Bader JS, Irizarry R, Boeke JD.
Nature. 2012 Feb 8;482(7384):251-5. doi: 10.1038/nature10804.
Acetylation of yeast AMPK controls intrinsic aging independently of caloric
restriction.
Lu JY, Lin YY, Sheu JC, Wu JT, Lee FJ, Chen Y, Lin MI, Chiang FT, Tai TY,
Berger SL, Zhao Y, Ts... 阅读全帖
y****y
发帖数: 123
49
我不是做这个的就是随便看看nature而已
有懂行的详细说说么
Impact of caloric restriction on health and survival in rhesus monkeys from
the NIA study
Julie A. Mattison,
George S. Roth,
T. Mark Beasley,
Edward M. Tilmont,
April M. Handy,
Richard L. Herbert,
Dan L. Longo,
David B. Allison,
Jennifer E. Young,
Mark Bryant,
Dennis Barnard,
Walter F. Ward,
Wenbo Qi,
Donald K. Ingram
& Rafael de Cabo
Affiliations
Contr... 阅读全帖
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