c****l 发帖数: 25 | 1 The MRI shows a cerebellar cystic mass with a large mural nodule associated
with hydrocephalus, most likely representing a pilocytic astrocytoma, a
benign tumor with an excellent prognosis. If the diagnosis is confirmed by a
biopsy, then surgery myself would be curative. Any radiation therapy will
be contraindicated because of the risk of malignant transformation in the
future. |
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O***n 发帖数: 13127 | 2 【 以下文字转载自 Biology 讨论区 】
发信人: albertsmwk (.)(.), 信区: Biology
标 题: 第一批“青年千人计划”生物类@publication列表@
发信站: BBS 未名空间站 (Thu Aug 18 15:04:16 2011, 美东)
花了一个小时,深深的鄙视一下自己的无聊行径!!
125 蔡亮 男 1980年11月 复旦大学 生命
科学 2007年12月毕业于[美国]北卡大学 [美国]加州大学旧金山分校 博士后
Cai L, Mostov K. Polarity is destiny. Cell. 2009 Nov 13;139(4):660-2. PubMed
PMID: 19914162; PubMed Central PMCID: PMC2900917.
Cai L, Makhov AM, Schafer DA, Bear JE. Coronin 1B antagonizes cortactin and
remodels Arp2/3-containing actin branche... 阅读全帖 |
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b*****l 发帖数: 8603 | 3 发信人: joyjoy (joy), 信区: loseweight
标 题: Top 11 Biggest Lies:3. Everybody Should be Eating Grains
发信站: BBS 未名空间站 (Tue Oct 1 23:12:55 2013, 美东)
The idea that humans should be basing their diets on grains has never made
sense to me.
The agricultural revolution happened fairly recently in human evolutionary
history and our genes haven’t changed that much.
Grains are fairly low in nutrients compared to other real foods like
vegetables. They are also rich in a substance called phytic acid which binds... 阅读全帖 |
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j****y 发帖数: 1714 | 4 The idea that humans should be basing their diets on grains has never made
sense to me.
The agricultural revolution happened fairly recently in human evolutionary
history and our genes haven’t changed that much.
Grains are fairly low in nutrients compared to other real foods like
vegetables. They are also rich in a substance called phytic acid which binds
essential minerals in the intestine and prevents them from being absorbed (
10).
The most common grain in the western diet, by far, is wheat… ... 阅读全帖 |
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t******k 发帖数: 553 | 5 我不发表对二人是否结婚事情的任何意见,也不想知道,这个世界为博出位出名,手段多了去了。
裴院士,以前听过报告,有所认识。对于谢欣,这位最年轻的973首席科学家,海龟博士。开红色Audi TT的973兽吸,我还是第一次听说,无聊间,google了一下。
以下是转帖
引用:
这里就是一个学术造诣颇深的院士和一个混迹学术界想要出头的高干千金的两厢情愿的合作。
我们先来看一下一个手里控制着上亿元科研经费的中国最年轻的973首席科学家,973胚
胎发育干细胞项目首席科学家的基本情况:
谢欣研究员, 现任中国财政部长谢旭人之女
现任 中国科学院上海药物所 研究员、 国家新药筛选中心模型建立 II 部主管、 课题
组长 。
下面是她所有的有名字的文章,还算诚实,没用同名同姓的凑数。
可是大家已经要问这样的条件,没有一篇CNS系列的文章,1st-authored paper只有3篇
,够中科院研究员、百人计划择优资助吗?
那些录用的评委和百人计划的专家组,都糊涂了吗?这么一反以“严格”著称之常态了
呢?
1.Chen D, Liao J, Li N, Zhou C, Liu Q, Wang G, Zh... 阅读全帖 |
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z*****e 发帖数: 14786 | 6 挺有教育意义的,请不要轻易终止猫的生命~~
谁能帮改下链接? |
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j*****e 发帖数: 1680 | 10 好呀,你还能找到多一些么?上次RALPH老大妈妈的VIDEO LINK丢失了,都找不到。 |
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j*****e 发帖数: 1680 | 12 1. feline cerebellar hypoplasia |
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s****r 发帖数: 5546 | 13 在LD的张罗下,上周六抢到的。终于又接来一个暹罗,原名Bobby,
三个月大的男猫。这孩子有轻微的cerebellar hypoplasia,平衡能力差,
兴奋的时候摇头晃脑像个小阿三,但是傻高兴,日子过得非常happy.
家里三个大哥开始都不高兴,现在小黑已经对他很不错了,另外俩也都
接受了。 |
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s****r 发帖数: 5546 | 14 他有轻度的Cerebellar Hypoplasia.IQ很低,EQ超高。每天晚上都爬上床
到我们头边又蹭又舔又咬,嗓子里呼噜震天响,还不断地娇声喵喵叫,找到
满意的位置就在脖子上一趴,把我们老两口伺候的眉开眼笑。也顾不上他
不讲卫生,上厕所从来不盖了。 |
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m*******u 发帖数: 6052 | 15 貌似不可以的,按照shelter的说法,是猫妈孕期中出现的问题
The vet thinks that the kitties mother was exposed to Feline Panleukopenia
Virus (FPV), also known as Feline distemper when she was pregnant. The
exposure could've resulted in the disorder in both kitties called Cerebellar
Hypoplasia which causes jerky movements, tremors and generally
uncoordinated motion. |
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m*******u 发帖数: 6052 | 17 黄包和黑包是2014年的春假期间被送到我家的。当时寄养在我家的瞎眼猫熊二刚刚被一
位好心的护士老太太收养,我觉得自己和家里三只原住猫都可以从猫来猫往的状态中歇
一歇了,不料没两天黄包和黑包就被送上门来,大概是shelter觉得我照顾残病猫很有
几下子,于是把这对小儿麻痹猫一块送来了。
小儿麻痹其实是我瞎编的说法,这种病的学名叫Cerebellar Hypoplasia,简称CH, 是
个胎里带的毛病,据说母猫怀孕期间感染了某种白细胞病毒,导致胎儿小脑发育不完全
,于是生出来的小猫就出现四爪不能平衡的问题,通常是两只后腿不能正常行走,拐吧
拐吧的,一不小心就摔个跟头,跟人喝醉了的表现差不多。
黄包和黑包就是这样两只醉猫,区别是黄包比黑包喝得多一点儿,是五步一摔,黑包则
是七步一倒。他们被发现的时候已经冻掉了耳朵尖和尾巴尖,但天生的包子脸还在,所
以虽然shelter给他们起名Baxter和Phoebe, 一到我家就被改成黄包和黑包了。黄包是
哥哥,黑包是妹妹,看个头应该不到一岁,没人知道他们那可怜的老娘(或者小娘)是
不是还在人世。
为了照顾家里三只原住猫的情绪,我把黑包和黄包先安置在了... 阅读全帖 |
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m***i 发帖数: 166 | 18 我们学校没有购买cell research最新的文章,好心的同学可以把下面这个文章发到我
的邮箱吗(h****[email protected])?
非常感谢~
Cell Research 19, 1324-1333 (December 2009) | doi:10.1038/cr.2009.119
Dynamic distribution and stem cell characteristics of Sox1-expressing cells
in the cerebellar cortex
Joelle Alcock and Virginie Sottile |
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U******u 发帖数: 5829 | 19 shyj: 我的考版match路--以此文纪念在美国逝去的10年青春
http://mitbbs.com/pc/pccon_2289_t379_150975.html
发信人: shyj (baobao), 信区: MedicalCareer
标 题: 我的考版match路-以此文纪念在美国逝去的10年青春 (很长很罗嗦,慎入!)
发信站: BBS 未名空间站 (Sat Apr 3 17:31:55 2010, 美东)
Match的结果终于尘埃落定,周1等电邮的时候非常紧张,因为成败就在此了,虽然一直
告诉自己,今年只是热热身,成败都可以接受,但到真的揭晓的时候,还是很紧张,毕
竟一旦卷入其中就身不由己,何况自己也还是有所付出。到周4等match program的时候
虽然也有点紧张,但程度已经大大减少,1个原因是毕竟match上才是头等大事,去哪里
尚在其次,还有1个原因是心理还是有所准备了,虽然希望留在home school,但直觉告
诉我恐怕是非常困难了,在我rank list上第二位的program应该就是我要去的地方,果
不其然。经过几天的等待,发现果然是要搬家了。
对于我... 阅读全帖 |
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g****n 发帖数: 13 | 20 Can anyone help me get this paper?
Astroglial cells in the external granular layer are precursors of cerebellar
granule neurons in neonates,
Molecular and cellular neuroscience (44) 4: 362-373, 2010.
Please e-mail it to y********[email protected].
Thanks a lot. |
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r****t 发帖数: 10904 | 21 Contributions
A.S. designed experiments and performed all the phenotypic characterization
of the mouse mutants, the cortical neuron culture, organotypic slice culture
rescue experiments and electroporation of cerebellar acute slice cultures.
A.A.-P. performed the initial biochemistry on the binding of ephrin B
ligands to Reelin, designed experiments, interpreted results and wrote the
manuscript.
这个 A.A.-P. 干系逃不掉啊。 |
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r****t 发帖数: 10904 | 22 Contributions
A.S. designed experiments and performed all the phenotypic characterization
of the mouse mutants, the cortical neuron culture, organotypic slice culture
rescue experiments and electroporation of cerebellar acute slice cultures.
A.A.-P. performed the initial biochemistry on the binding of ephrin B
ligands to Reelin, designed experiments, interpreted results and wrote the
manuscript.
这个 A.A.-P. 干系逃不掉啊。 |
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a********k 发帖数: 2273 | 23 花了一个小时,深深的鄙视一下自己的无聊行径!!
125 蔡亮 男 1980年11月 复旦大学 生命
科学 2007年12月毕业于[美国]北卡大学 [美国]加州大学旧金山分校 博士后
Cai L, Mostov K. Polarity is destiny. Cell. 2009 Nov 13;139(4):660-2. PubMed
PMID: 19914162; PubMed Central PMCID: PMC2900917.
Cai L, Makhov AM, Schafer DA, Bear JE. Coronin 1B antagonizes cortactin and
remodels Arp2/3-containing actin branches in lamellipodia. Cell. 2008 Sep
5;134(5):828-42. PubMed PMID: 18775315; PubMed Central PMCID: PMC2570342.
Cai L, Makhov AM, Bear JE. F-actin... 阅读全帖 |
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y******a 发帖数: 590 | 24 PMID 11997071
Motor weakness and cerebellar ataxia in Sjögren syndrome--
identification of antineuronal antibody: a case report.
请发到y******[email protected]
多谢,有包子 |
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l**********1 发帖数: 5204 | 25 You sure?
Heine, V. M. et al. (2011)
Small-molecule Smoothened agonist prevents glucocorticoid-induced neonatal
cerebellar injury.
Science Transl. Med. 3: 105ra104
Firestone, A. J. and Chen, J. K. (2010)
Controlling destiny through chemistry: Small-molecule regulators of cell
fate.
ACS Chem. Biol. 15: 15-34.
http://chen.stanford.edu/index.php?option=com_content&view=arti
plus
Zebrafish Protocols
Bleaching Zebrafish Embryos
Genomic DNA Isolation for PCR Analysis
Manual and Enzymatic Dechorionat... 阅读全帖 |
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m***T 发帖数: 11058 | 26 如果只是microarray结果,不一定非常准确(要看用的平台和方法以及最后分析的手段
)另外他们有没有其它的手段来validate这个发现。我粗略查了查我们的数据库,此位
点的duplication和遗传疾病相关的有下面这么几篇,你如果有时间可以读一读。另外
,似乎所有的研究都处于experimental或early studiy in human,所以临床上的意义
不是特别大。我自己没有读这些paper,所以不知道文章里的研究是不是非常match你的
情况。希望能对你有所帮助。
Warburton, D.; Ronemus, M.; Kline, J.; Wigler, M.; Jobanputra, V.; Levy, D.;
Anyane-Yeboa, K.; Chung, W.; Awad, D.
CNVs contributing to the cause of congenital heart defects may include not
only those containing candidate genes but regions more commonly as... 阅读全帖 |
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发帖数: 1 | 27 从思维和执行所需要的计算量考虑,执行需要更多的脑容量。
人脑中,神经细胞约有860亿个。其中约有700亿个为小脑颗粒细胞(cerebellar
granule cell)。 |
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l********z 发帖数: 810 | 28 A fullterm male newborn has enlargement of head circumference.cranial
suitures r separated .U/S shows emlargement of lateral ventricles and
thinning of cerebral cortex.The new born uncle had similar abnormalities....
.....diagnosis?
A.Absence of foramen of luska
B.Cerebellar astrocytoma
C.HOLOPROSENCEPHALY
D.Neurofibromatosis
E.Stenosis of aqeduct of sylvius
F.Tuberous sclerosis |
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l*********e 发帖数: 158 | 29 I guess; Sitting - Deep Venous Thrombosis in the lower limb -Patent foramen
ovale- stroke in deep penetrating arteries that arises directly from the
constituents of the Circle of Willis, cerebellar arteries, and basilar
artery that irrigate posterior limb of the internal capsule-descending
corticospinal tracts- hemiplegia? How can the bilateral lesions happen with
one side of symptoms? |
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d**u 发帖数: 278 | 30 A 69 year old man with Parkinson disease has a progression of his tremor
that is unresponsive to medications.A stereotactic operation is scheduled.To
alleviate the tremor, the needle should be placed in which of the following?
A)Cerebellar hemisphere
B)Frontal lobe of cortex.
C)Globus pallidus.
D)Inferior Olivery Nucleaus.
E)Substantia Nigra.
The answer is C, but why C but not E?
Thanks a lot! |
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i**********d 发帖数: 853 | 31 Hawthrone effect: Hauthrone好手 --> 我们是“好手” --> 知道被研究时好好表现。
Collagen 4型 (部分是从别的同学那里听来的):
1型:老大硬:筋骨皮牙本硬,角膜瞪人,伤口愈合晚不怕
2型:老二软:骨软韧性好,眼睛玻璃软,脊梁髓核软
3型:三妹红彤彤:粉红皮肤,生孩子--> 子宫切,见血管,现胚胎组织,愈合有肉芽
组织
4型:最小,位置最低,住在basement
Hemophilia A (8因子) & B (9因子)--> 阿爸8必救9
Fragile X --> CGG 脆哥哥 --> 脆弱的哥哥注意力不集中 --> ADHD
Spiramycin: given to the mother to prevent vertical transmission of
toxoplasmosis. “弓”黄忠射箭, 披靡-箭是螺旋状 Spiramycin
螺旋霉素
Podophyllin (刨倒树林--把黑树林里的wart给刨了):
1. Remove genital warts; 2. Molluscum... 阅读全帖 |
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i**********d 发帖数: 853 | 32 Hawthrone effect: Hauthrone好手 --> 我们是“好手” --> 知道被研究时好好表现。
Collagen 4型 (部分是从别的同学那里听来的):
1型:老大硬:筋骨皮牙本硬,角膜瞪人,伤口愈合晚不怕
2型:老二软:骨软韧性好,眼睛玻璃软,脊梁髓核软
3型:三妹红彤彤:粉红皮肤,生孩子--> 子宫切,见血管,现胚胎组织,愈合有肉芽
组织
4型:最小,位置最低,住在basement
Hemophilia A (8因子) & B (9因子)--> 阿爸8必救9
Fragile X --> CGG 脆哥哥 --> 脆弱的哥哥注意力不集中 --> ADHD
Spiramycin: given to the mother to prevent vertical transmission of
toxoplasmosis. “弓”黄忠射箭, 披靡-箭是螺旋状 Spiramycin
螺旋霉素
Podophyllin (刨倒树林--把黑树林里的wart给刨了):
1. Remove genital warts; 2. Molluscum... 阅读全帖 |
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p*******g 发帖数: 2976 | 33 【 以下文字转载自 Biology 讨论区 】
发信人: albertsmwk (.)(.), 信区: Biology
标 题: 第一批“青年千人计划”生物类@publication列表@
发信站: BBS 未名空间站 (Thu Aug 18 15:04:16 2011, 美东)
花了一个小时,深深的鄙视一下自己的无聊行径!!
125 蔡亮 男 1980年11月 复旦大学 生命
科学 2007年12月毕业于[美国]北卡大学 [美国]加州大学旧金山分校 博士后
Cai L, Mostov K. Polarity is destiny. Cell. 2009 Nov 13;139(4):660-2. PubMed
PMID: 19914162; PubMed Central PMCID: PMC2900917.
Cai L, Makhov AM, Schafer DA, Bear JE. Coronin 1B antagonizes cortactin and
remodels Arp2/3-containing actin branche... 阅读全帖 |
|
R*******t 发帖数: 367 | 34 Cerebral MRA has pretty standard protocol in terms of imaging acquisition.
When I dictate a report, I always include the following:
Intracranial portion of internal carotids including petreous, clinoid and
siphon
Anterior cerebral arteries, A1 and A2
Acom and pcom, look carefully for aneurysms
Mcas, need to follow at least to trifurcation
Pcas, p1 and p2, if there is fetal origin of pcas
Basilar artery, vertebral, superior cerebellar arteries, pica and Aica.
These arteries should be steadily see... 阅读全帖 |
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R*******t 发帖数: 367 | 35 Cerebral MRA has pretty standard protocol in terms of imaging acquisition.
When I dictate a report, I always include the following:
Intracranial portion of internal carotids including petreous, clinoid and
siphon
Anterior cerebral arteries, A1 and A2
Acom and pcom, look carefully for aneurysms
Mcas, need to follow at least to trifurcation
Pcas, p1 and p2, if there is fetal origin of pcas
Basilar artery, vertebral, superior cerebellar arteries, pica and Aica.
These arteries should be steadily see... 阅读全帖 |
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A*******s 发帖数: 9638 | 36 Cerebellar infarct is tricky. Make sure there is no 4th ventricle
obstruction which is life threatening.
I always put these patients in Snowforest's unit and do a daily CT. I had a
patient found to be in coma and had a wallenberg's syndrome. I called
Neurosurgery who operated him STAT. Amazingly, 2 yrs later, he was able to
go for deer hunting and he sends me greeting card yearly.
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A*******s 发帖数: 9638 | 37 A heterogeneous mass lesion involving right BG, thalamus and superior
cerebellar peduncle/midbrain with surrounding edema and mild midline shift.
MRI would be better than CT though. |
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z*****2 发帖数: 498 | 38 是啊, 我有20多年没有听到 BG, thalamus and superior cerebellar peduncle/
midbrain 这样的名词了,真是亲切。在国内我主要做stereotactic neurosurgery, 来
美国做Gamma unit的fellowship. 后来遇到另外一个CMG电脑高手教我,于是就改了行
了。提到”心术“, 最近我刚刚贴在我新开的网站上,刚看两集:
http://social.cmgforum.net/blog/view/656/-- |
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A*******s 发帖数: 9638 | 39 No, it could be difficult to differentiate cerebellar ataxia and
parkinsonism clinically. But why we differentiate them? SCA-2 or 3 can
overlap with parkinsonism.
for |
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m****9 发帖数: 26 | 40 由于最近几个月来,一直头晕,四肢乏力,四肢发麻,去看了neurologist, 做了头部
,颈椎的MRI,刚拿到报告,医生说没有大的问题,需要进一步去看神经外科,但是我
看到头部MRI的报告显示有问题,这个让我很担心。 然后这个颈椎的问题能引起头晕么
? 报告上写的是没有脊髓和神经压迫。 请帮忙看看怎么回事? 暂时我还没拿到片子
,如果有需要,等拿到片子后,我也可以上传。 谢谢。
头部的报告内容:
MRI BRAIN WITHOUT AND WITH CONTRAST
History: Headaches, unsteady gait, and bilateral leg greater than arm
numbness. Evaluate for demyelinating disease.
Technique: Precontrast T1 axial, DWI axial, GRE T2 axial images were
obtained. Postcontrast 3 mm thick T2 axial, T1 axials, 3-D T1 series and 3-D
T... 阅读全帖 |
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A*******s 发帖数: 9638 | 41 首先声明不是专家。
理论上,每一个疾病都有病因,但不是每一个病都能够明确诊断,事实上不知道的
远比知道的多。应该承认你们的问题已经很专业,你们医生的回答也非常职业,确实值
得你们佩服。代谢病,遗传病基本上说的是一回事,如果这个基因或者那个酶的检查商
业上没有,检查结果就是阴性. 进一步检查也就无从谈起。 举几个例子,Cerebellar
Ataxia的基因检测已经很多了,但很多病人的检测是阴性,这不改变这些病人是基因
变异引起小脑病变的事实, 同样的,hemiplegic migraine的基因也可以查,但大多数
病人都是阴性,这个阴性结果不改变他们有migraine和偏瘫的事实。
非常同情你们的孩子,也非常同情你们的儿科专家。 从有限的材料看,肝移植恐怕是
唯一的解决办法。
★ 发自iPhone App: ChineseWeb 8.2.2 |
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P**k 发帖数: 264 | 42 Looks like this is a cerebellar type MSA, if CoQ10 was recommended. |
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A*******s 发帖数: 9638 | 43 The nystagmus may have little to do with CN 4 palsy. I guess it could be
2nd to congenital cerebellar defect. |
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n****n 发帖数: 5804 | 44 【 以下文字转载自 ChuanYu 讨论区 】
发信人: flmao (SoySauceCat), 信区: ChuanYu
标 题: 生死关头 急求脑外科和神经内科意见帮助! 求转求顶
发信站: BBS 未名空间站 (Thu Feb 21 16:07:01 2013, 美东)
生死关头,急求脑外科和神经内科专业意见帮助
求转贴,求顶贴!多谢!多谢!
患者:女,46岁,无其他病史,96来美。
2013年2月4日在NEW YORK的Presbyterian Hospital做了松果体囊肿pineal gland cyst
的摘除手术,手术本身顺利。术后不到2小时发现继发小脑静脉栓塞post-surgery
cerebellar stroke同时压迫脑干等部位造成 stem stroke,立即进行二次手术,开颅
清除血块,并切除严重受损的小脑扁桃避免脑疝,然后进入深度麻醉状态。为避免进一
步出血、水肿和伤害,2月6日进入亚低温(体温33度)持续到15日,逐步升至正常体温
。目前(2月20日)CT、MRI等诊断意见是依然有主动性出血(脑积液~10ml/hr可见新鲜
粉红色),小脑严重水肿压迫... 阅读全帖 |
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k*****e 发帖数: 22013 | 45 【 以下文字转载自 ChinaNews 讨论区 】
发信人: pipigou123 (鼠姐虎弟), 信区: ChinaNews
标 题: Re: 在美国,学中医的比这里大部分人赚得多
发信站: BBS 未名空间站 (Sun Aug 14 19:55:23 2011, 美东)
INTRODUCTION — The word "acupuncture" is derived from the Latin words "acus
" (needle) and "punctura" (penetration). Acupuncture originated in China
approximately 2000 years ago and is one of the oldest medical procedures in
the world.
Over its long history and dissemination, acupuncture has diversified and
encompasses a large array of styles and techniques. ... 阅读全帖 |
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