E**********y
发帖数: 991 | 1 is that why clonogenic survival assay becomes a standard assay to assess
therapeutic agents?
differently
give
SAHA, |
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y******6
发帖数: 294 | 2 irreversible growth arrest 可以用clonogenic 来说明吗？
irreversible |
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s****l
发帖数: 395 | 4 这玩意儿不是测量cell survival最直接的证据吗 |
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A******y
发帖数: 2041 | 6 The differences is not at the detection method. The cells grow differently
in cell culture (liquid) verses colongenic method (semi-solid). I can give
you a perfect example which is not reported anywhere. HDAC inhibitor, SAHA,
inhibits leukemia cell growth in cell culture (many papers). However, it
is useless against leukemia growth in colongenic assay. |
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A******y
发帖数: 2041 | 7 Yes, you need it before in-vivo. |
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e*****6
发帖数: 278 | 8 Cytotherapy. 2010 Nov;12(7):951-60.
Clonogenic assays measure leukemia stem cell killing not detectable by
chromium release and flow cytometric cytotoxicity assays.
请发到[email protected]
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谢谢！ |
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