w**r
发帖数: 134 | 1 CML特效药，印度的gleevec应该效果差不多，只是人家不支持诺华在印度的专利强制仿
制罢了，还有其他国家也强制许可了，疗效应该不会有差别，当初有个中国海龟自己合
成买药被抓，可惜中国没有实施强制许可生产仿制药。
该药用药规范，可以长期活得好好的，一旦断药就可能致命。这样就要长期服用。这笔
费用对家庭不少。考虑下格列卫全球患者援助项目，虽然手续麻烦，但是值得一试，他
们国内也应该知道，不过即使这样，费用还是很高。
该药专利应该2013年到期，江苏正大可能会有仿制药上市,可以大幅降低价格 |
|
y*****o
发帖数: 689 | 2 第一篇是天涯很早的一篇了。《『天涯杂谈』 国内医疗差？？？咱俩换换？——一个
海外华人的由衷感叹》
地址：http://www.tianya.cn/publicforum/content/free/1/2102740.shtml
很长，请耐心看。
-----------------------------------------------------------------------
第二篇是最近看到比较冷静的一篇，原地址找不到，我copy过来啦。
中国就医vs.美国就医 （补充版）
来源： 王晓雯的日志
最近不断的有朋友给我看两篇文章。一篇是讲中国医生多么“丧尽天良”的从癌症病人
身上榨钱（《医生说出了惊天秘密：癌症患者连死都不明白的事》，原文点击这里），
还有一篇是关于说跟美国相比其实中国的医疗制度其实多么好（或者说美国的医疗制度
多么烂）（《科普：国内医疗差？咱俩换换？》原文点击这里）。
其实本来一般别人给我看这种文章，我都会直接无视之，因为不用看也可以大体想象到
会写什么，然后其中的各种误解和偏见只会让自己极不爽，所以索性不看免得心烦。但
是最近分享这两篇文章给我的人如此之... 阅读全帖 |
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y****e
发帖数: 23939 | 3 // k-means helper
static Dict min_dist_real(EMData* image, const vector& data);
static Dict min_dist_four(EMData* image, const vector& data);
static int k_means_cont_table_(int* grp1, int* grp2, int* stb, long int s1,
long int s2, int flag);
// new code common-lines
static vector cml_weights(const vector& cml); |
|
发帖数: 1 | 4 所以說這個版上的人都是外行，但是外行還喜歡評論，這就是我的結論，也是我當初高
看你們啦。。。
首先嘗試看懂那篇文章再提問。這個肯定是第一代產品，未來會通過CCIX連接FPGA或各
種加速器。普通的IVI芯片不需要過AEC-Q100和ASIL-D認證。所以這個肯定是自動駕駛
芯片。最後一個圖裡中間的Safety Island的R52是儀表控制。左邊DSU裡面的A76AE /
A65AE / AIPUAE / MaliAE做自動駕駛。最右邊的C71/D71/V76做視頻採集和顯示。
Reference
http://www.eetrend.com/article/2018-11/100126895.html
Quote Begin
这个框架的计算流是这样的：C71（ASIL-B）把数据从传感器收集，做固定的图像信号
处理，把结果放到DDR；A65AE读取数据，进行车道检测等传统的矢量运算。相对于大核
，A65AE提供了高能效比的运算能力，适合多路并行计算。也可以把任务丢到图形处理
器来运算，延迟稍大，能效比也很高。如果涉及神经网络运算，那A76AE会把任务调度
到AI加速器上，同时在算子不... 阅读全帖 |
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a********k
发帖数: 2273 | 5 不光是人品问题，Druker还是很有vision的。CML不同于其他cancer，致病机理单一，
最容易成功。他能在90年代初看到这个，并用ATP binding domain的结构来合成文库都
是非常惊艳的。
…… |
|
M*****e
发帖数: 279 | 6 多了一条常染色体的遗传疾病，如Down syndrome (21 trisomy)。常有多种身体和智力
发育异常。应当与这多出染色体上的基因表达有关。正常的两条，再加上这多出的一条
，应当导致位于这些染色体上的基因过量表达，然后引起疾病。这些过量表达的蛋白可
能有酶(such as, kinase, phophatase, protease, etc.)和transcription factors，
最终通过复杂机理导致疾病和相应的表现。
有些疾病(如有些肿瘤）是由于染色体易位(translocation)导致正常的基因易位到被强
的promotter控制，导致基因的过量表达。比如CML (BCR-ABL)。有的易位到
immunoglobin的promoter控制。Ig promoter是强的promoter.
应当可以从PubMed查对详细的疾病和致病蛋白的信息的。 |
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o********r
发帖数: 775 | 7 Review
Many different tumor types have polyclonal tumor origin: Evidence and
implications
Barbara L. ParsonsCorresponding Author Contact Information, a, E-mail The
Corresponding Author
aDivision of Genetic and Reproductive Toxicology, National Center for
Toxicological Research, HFT-120, 3900 NCTR Road, USFDA, Jefferson, AR 72079,
United States
Received 7 February 2008;
revised 14 May 2008;
accepted 15 May 2008.
Available online 31 May 2008.
Abstract
Few ideas have gained such strong acceptance i... 阅读全帖 |
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h****g
发帖数: 439 | 8 强人无处不在啊。 Erlotinib 是EGFR的inhibitor， roche产的
500mg的棕红色片剂,其中每片含埃洛替尼250mg。Natco药业有限公司（NPL），是位于
海德拉堡市，资产达9亿5千卢比的一家药业公司，以其研究实力和及时发布技术信息而
闻名。
向性抗癌药。三期临床试验的结果表明它对新诊断慢性粒细胞性白血病（CML）治疗的
有效率超过94%，并且有76%的病人可以得到细胞学的缓解，对加速期和急变期的有效率
也分别达到了71%和31%。伊马替尼对胃肠道间质肿瘤的有效率也高达67%。
胞性白血病。 |
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c**i
发帖数: 6973 | 9 Peter Landers, New Breast Cancer Drug Found Deep in the Sea. Wall Street
Journal, Jan. 4, 2010.
http://online.wsj.com/article/SB1000142405274870411150457605977
("A study found it [Halaven] extended the life of patients with advanced
breast cancer by about two-and-1/2 months, to 13 months")
My comment:
(a) Eisai Co., Ltd. エーザイ株式会社
(a public company; headquarters Tokyo; established in 1941 by Toyoji NAITO
内藤 豊次 as Nohon Eisai Co., Ltd. 日本衛材（衛生材料の略。具体的には絆創膏
や包帯の事))
ja.wikipedia.org
(b) eribulin
htt... 阅读全帖 |
|
g*********d
发帖数: 233 | 10 @ABL:
r u working on CML?
I studied the topic last yr |
|
a****d
发帖数: 1919 | 11 the best protein-tyrosine kinase inhibitor so far being developed to treat
CML and GIST |
|
c****l
发帖数: 1086 | 12 没有一个做癌症的，都在这里瞎说，癌症是无数种疾病的合成，其中被攻克（控制）的
多了。M3 AML, CML, 大部分leukemia,早期癌症等等。
你给攻克下个定义吧。 |
|
K******S
发帖数: 10109 | 13 CML and Gleevec is the only "神话“ in cancer. It totally changed the
paradigm of cancer treatment. However, majority of cancers are not that
simple/easy to treat, especially solid tumors. A lot of stuff are messed up
in solid tumors. |
|
c****l
发帖数: 1086 | 14 This is not correct. I have mentioned another example that Acute
promyelocytic leukemia(M3 AML) can be controled with the introduction of
ATRA before which APL is almost a lethal disease.Of course CML and APL are
relatively simple compared to most other cancers especially solid tumors in
terms of genetic alterations. That is how science and medicine advance, from
simple to complex. I strongly believe human will be able to tackle cancers
one at a time. This is a long-term process however.
up |
|
K******S
发帖数: 10109 | 15 that's still leukemia.
Even for CML and Gleevec, we didn't cure it. we just control it with drugs.
Maybe I'm too pessimistic.
in
from
cancers |
|
n*********b
发帖数: 140 | 16 Gene fusion causes many forms of leukemia, such as BCR-ABL in CML, and some
forms of sarcoma. |
|
n*********b
发帖数: 140 | 17 If the Nobel committee wants to award the target therapy for CML, they need
to figure out how to award both Peter Nowell and Janet Rowley and possibly
others whose contributions not only help the discovery of Gleevec but also
cancer genetics. The Lasker Foundation has grouped the two with Knudson,
which could be one followed by another one to target therapy.
year |
|
z***k
发帖数: 33 | 18 To be fair, if Nobel picks something of "targeted therapy" in cancer, APL,
but not CML, should be the first to think about. Chinese should have a slot
here, too.
share
. |
|
|
p*****n
发帖数: 97 | 20 给坚信生物制药的人泼点冷水：用抗体做药效果并不好。Herceptin到现在还是辅助用
药，EGFR等也会是。Gleevec可以让CML细胞维持在不能被检测出的水平。可见小分子还
是比抗体给力。但是还是不能和放疗化疗比，一个拳头大的肿瘤可以在放疗化疗后彻底
消失。只是副作用太大。将来的方向还是会多管齐下，新老结合。 |
|
b*****u
发帖数: 75 | 21 Even Gleevec cannot CURE a CML patient harboring BCR-Abl fusion gene, not to
mention others likes Herceptin (anti-HER2) or even anti-EGFR. There is no
cure for any type or subtypes of cancer. What all those treatment do in most
case is to hopefully prolong the survival, which varies from a couple of
months to years.
"Papers上说EGFR inhibitor 可作为抗癌药用 (in specific cell lines or animal
models)" does not mean that a good anti-EGFR chemical can be a good drug.
Tons of others issue exist, like the effic... 阅读全帖 |
|
b*****u
发帖数: 75 | 22 Even Gleevec cannot CURE a CML patient harboring BCR-Abl fusion gene, not to
mention others likes Herceptin (anti-HER2) or even anti-EGFR. There is no
cure for any type or subtypes of cancer. What all those treatment do in most
case is to hopefully prolong the survival, which varies from a couple of
months to years.
"Papers上说EGFR inhibitor 可作为抗癌药用 (in specific cell lines or animal
models)" does not mean that a good anti-EGFR chemical can be a good drug.
Tons of others issue exist, like the effic... 阅读全帖 |
|
c****l
发帖数: 1086 | 23 从没治到有治的例子很多，imitinib治疗CML，retinoic acid 治疗 APL ，这样的例子
在不久的几年的到十几年里会层出不穷。
生物信息学目前或者说近几十到一百年内不会成为生物学研究的主流模式，主流仍然是
以假说为基础的的实验科学模式。这是由目前的生物学发展水平决定的。生物体太复杂
，在其主要蛋白质的功能和行为模式被发现完之前，不太可能可以用数学的方法对其建
模和准确的预测，只能作为生物学发现的重要辅助工具。 |
|
P*******e
发帖数: 27 | 24 After reading the comments about NIH, it seems to me people here has a
misunderstanding about the drug discovery process. People seem to believe
the drug discovery has always progressed like this: target---pathway---
cellular model---animal model---human beings. Indeed this is the well
publicized model or paradigm. But years ago, people used a phenotypic
screening to search for drugs without knowing targets, often directly on
animals. For anti-cancer drugs, many old ones were discovered without
... 阅读全帖 |
|
A******y
发帖数: 2041 | 25 Of course the biological research benefits mankind. We actually can cure a
lot of cancer types since the so call War on Cancer. For all researches,
you will always have majority of research that are junks but the 1% is where
the cure come from. The truth is that without that 99% junk, the 1% won't
be there either.
For example, testiclar cancer is almost 100% cure rate...CML is completely
under-control, and it was a death sentence a decade ago. |
|
A******y
发帖数: 2041 | 26 For testicular cancer, yes, its cure rate is very high even when the cancer
spread. CML is a leukemia, it is everywhere. The cure rate is almost 100%,
and it is based on Bcr-Abl inhibitor with no serious side-effect.
Everytime I talk to people about its POSITIVE side effect (yes positive),
people usually find it interesting. Do you know what's the positive side-
effect? I still don't know why Norvatis haven't tried to build a market for
the positive sid-effect. Probably because the drug is... 阅读全帖 |
|
A******y
发帖数: 2041 | 27 Gleevec Brian Druker breakthrough in CML and target specific therapy. |
|
z***d
发帖数: 131 | 28 【 以下文字转载自 Immigration 讨论区 】
发信人: zymed (abcg), 信区: Immigration
标 题: Leukemia审稿机会
发信站: BBS 未名空间站 (Thu Jun 5 01:52:18 2014, 美东)
要出差， 没时间审。有意要推荐的，站内留名,简要经历及e-mail address。
Keyword: CML,nilotinib, targeted therapy.可能是篇review文章。
Journal 暂无 IF。 |
|
A******y
发帖数: 2041 | 29 Yup, I guess we only have AML and MM to worry about in a few years. Brian
Druker (CML) and Carl June (CLL) will probably win Nobel prize together in a
few years, or they can win individually.
immunotherapy |
|
a********k
发帖数: 2273 | 30 Thomas M. Roberts
人自己都没claim有啥贡献。。。Druker当时是他实验室唯一做这个的，公司找上门的
时候就和Druker联系了。Gleevec确实也是在他到OHSU之后才做到CML里面的。 |
|
s********r
发帖数: 312 | 31 想请教下做相关方向的，目前分化的效率怎么样，能够拿到大量的较纯的myeloid
lineage cells吗，再有比如想用iPSC来model leukemia (AML, CML)，有没有可行性。
多谢！ |
|
z*t
发帖数: 863 | 32 还有王振义的ATRA
这个可以和CML的Brain Drunker和Charles Sawyers一起
不过涉及的面没有屠这么广（白血病毕竟相对罕见）不一定能拿到 |
|
z*t
发帖数: 863 | 33 Drucker从治疗疗效上严格来讲是在我们中国后面搞出来的，CML搞了这么多年其实至今
缺一个和imatinib连用的药物。
不过Druck的贡献在于第一个target therapy,我们对砒霜和ARTA的机理是后面药物好使
之后才慢慢搞清楚的 |
|
z*t
发帖数: 863 | 34 Drucker从治疗疗效上严格来讲是在我们中国后面搞出来的，CML搞了这么多年其实至今
缺一个和imatinib连用的药物。
不过Druck的贡献在于第一个target therapy,我们对砒霜和ARTA的机理是后面药物好使
之后才慢慢搞清楚的 |
|
p**t
发帖数: 160 | 35 B-cell lymphoma的几个亚型，比如Follicular lymphoma, Mantle cell lymphoma and
Burkitt lymphoma 的translocation都有Ig heavy chain参与。
CML是BCR-ABL
M3 AML t(15:17)
感觉跟干细胞来源有关，还有就是分化过程中tranlocation易发性有关。 |
|
n******2
发帖数: 971 | 36 额，楼上的讨论太深没看懂。我再冒着汗问一下。
比如BCR-ABL能引发CML而不是乳腺癌，那么到底是因为这个基因易位不能在乳腺细胞里
发生呢，还是因为同样的易位对乳腺细胞没有效果呢？ |
|
|
y*******n
发帖数: 127 | 38 我还见过更严重的情况，比如羧基修饰的PS纳米粒子在pH8时还能吸附双链DNA。我猜是
因为纳米粒子表面的羧基密度不够高，虽然能够部分防止纳米粒子团聚，但是其表面还
是有很多疏水的区域，解决不了根本问题。而且羧基上连接的碳链太长的话，也不利于
其电离。纸上谈兵的说，提高纳米粒子表面羧基或者其他带电基团如磺酸基、磷酸基的
密度，肯定会提高其稳定性。比如，在纳米粒子表面长一层带负电或正电的聚合物刷，
将会极大的改善其稳定性，一个明显的例子是Invitrogen的CML latex的稳定性要比起
carboxyl latex要好得多，原因就是前者表面是聚电解质刷子。PEG改性的纳米粒子稳
定性普遍偏差，毕竟电荷排斥才是王道啊。 |
|
c**i
发帖数: 6973 | 39 Peter Landers, New Breast Cancer Drug Found Deep in the Sea. Wall Street
Journal, Jan. 4, 2010.
http://online.wsj.com/article/SB1000142405274870411150457605977
("A study found it [Halaven] extended the life of patients with advanced
breast cancer by about two-and-1/2 months, to 13 months")
My comment:
(a) Eisai Co., Ltd. エーザイ株式会社
(a public company; headquarters Tokyo; established in 1941 by Toyoji NAITO
内藤 豊次 as Nohon Eisai Co., Ltd. 日本衛材（衛生材料の略。具体的には絆創膏
や包帯の事))
ja.wikipedia.org
(b) eribulin
htt... 阅读全帖 |
|
j*******2
发帖数: 1 | 40 Me : )
Please provide detail information. CML, CIPP, Slip lining, or pipe bursting? |
|
a**i
发帖数: 419 | 41 搜索关于 current mode logic (CML)，injection lock方面的论文 |
|
s********l
发帖数: 35 | 42 每个PLL都有自已的VCO，输出经CML送出。任何两个VCO之间的距离约1mm，VCO间耦合的
可能性很小。
FREQUENCY). |
|
s**g
发帖数: 66 | 43 Try this ckt.
10kHz, resolution 8 bit, ~400ns, shouldn't be a big problem.
prefer CML logic for speed and signal integrity.
In order to lower ripple, lower charge pump current and increase cap.
Make close loop bandwidth at least < 1/5 of your min clk frequency.
Easy to estimate mismatch introduced uncertainty in duty ratio.
good luck |
|
g*****d
发帖数: 210 | 44 第一次做这方面的CIRCUIT
没什么经验
1GHZ .18um CMOS process
请问DESIGN的重点
是让所有DIFF PAIR 的vdsat做的越小越好吗(say 50mV)
还有pre driver 大小该如何决定
请推荐一下参考资料
有SCHEMATIC最好
thanks a lot.. |
|
s**g
发帖数: 66 | 45 Q3: remove rx side cap
you listed one reason: line + cap would have filter effect
I like to push the envelope:
driver normally handles its immediate load better, e.g. linear driver with
voltage mode feedback. Load cap at TX side won't affect output waveform by
much. However, receiver side cap causes delay/ISI/filtering, which can't be
corrected by TX side feedback and thus shall be avoided.
Similar effect can be found in CML/ECL logics. |
|
h***d
发帖数: 2188 | 46 需要一个简单的AC coupling电路变换DC bias就可以了吗？
如果是高频信号>10Gbps 的话，还需要考虑哪些问题？ |
|
|
b***i
发帖数: 3043 | 48 这样看就不难了。
Matlab把数据存文件里面，然后写一个C语言程序，C#程序，用串行通讯发给FPGA。从
来没写过FPGA的应该可以两个星期搞定串行通讯。这是最简单的FPGA设计。
然后，我去年买的Xilinx的就有600MHz的，连内部ARM都是600MHz的，而且最高主频是
800MHz的。你把Matlab发生随机数的程序写出来，说不定我们几分钟就把FPGA直接搞定
，不用串行通讯了。
还有很多种的串并转换的，各种做法，但是基本上，FPGA直接作是没有问题的。电压多
少呢？你需要LVDS还是CML就可以？是否需要这些driver？
data |
|
b***i
发帖数: 3043 | 49 高速电路标准可以相互转换,比如PECL, CML, LVDS等。如果你说的8位就是给8路的输出
，那么就用8个LVDS的差分输出，到8个你的负载。对FPGA而言，这个输出就是数字的输
出，0伏到几伏表示0到1。 |
|
c***z
发帖数: 6348 | 50 【 以下文字转载自 DataSciences 讨论区 】
发信人: chaoz (面朝大海，吃碗凉皮), 信区: DataSciences
标 题: OCR job from recruiter - it is interesting but I can't do it, yet
发信站: BBS 未名空间站 (Fri Jun 20 12:25:07 2014, 美东)
If you would be interested please let me know at h******[email protected] as
early as possible.
Job Title: position for Data Scientist for Machine Learning and Natural
Language Processing Experience
Company: BITS
Task 1: Extend NIST Scientific Text Extraction System
Description of Tasks
I. Implement distributed... 阅读全帖 |
|
