n***d 发帖数: 8857 | 1 【 以下文字转载自 NextGeneration 讨论区 】
发信人: Jiushibu (948), 信区: NextGeneration
标 题: 紧急求助治疗方案:老公得了胃癌晚期,孩子才半岁 (转载)
发信站: BBS 未名空间站 (Mon Mar 2 21:53:54 2015, 美东)
发信人: Jiushibu (948), 信区: Medicine
标 题: 紧急求助治疗方案:老公得了胃癌晚期,孩子才半岁
发信站: BBS 未名空间站 (Mon Mar 2 21:51:33 2015, 美东)
紧急请求大家提供信息和治疗方案。先感谢大家!
老公半年前被确诊胃癌晚期,腹腔转移(但未转移到要害器官比如肝肾肺等),伴有严
重腹水,在纽约的 Memorial Sloan Kettering 治疗。开始用Xeloda,效果很好,腹水
也得到控制,但3个月后失效;于是换用Docetaxel,但是基本上没用,腹水会在抽掉后
2天内迅速回来。但是医生仍然坚持继续用这种药,而没有给我们吧开常用的复合化疗
药。就这样用了一个多月,两个疗程。10天前本来我们要去医院接受第三个疗程的
... 阅读全帖 |
|
W*****d 发帖数: 4196 | 2 【 以下文字转载自 NextGeneration 讨论区 】
发信人: Jiushibu (948), 信区: NextGeneration
标 题: 紧急求助治疗方案:老公得了胃癌晚期,孩子才半岁 (转载)
发信站: BBS 未名空间站 (Mon Mar 2 21:53:54 2015, 美东)
发信人: Jiushibu (948), 信区: Medicine
标 题: 紧急求助治疗方案:老公得了胃癌晚期,孩子才半岁
发信站: BBS 未名空间站 (Mon Mar 2 21:51:33 2015, 美东)
紧急请求大家提供信息和治疗方案。先感谢大家!
老公半年前被确诊胃癌晚期,腹腔转移(但未转移到要害器官比如肝肾肺等),伴有严
重腹水,在纽约的 Memorial Sloan Kettering 治疗。开始用Xeloda,效果很好,腹水
也得到控制,但3个月后失效;于是换用Docetaxel,但是基本上没用,腹水会在抽掉后
2天内迅速回来。但是医生仍然坚持继续用这种药,而没有给我们吧开常用的复合化疗
药。就这样用了一个多月,两个疗程。10天前本来我们要去医院接受第三个疗程的
... 阅读全帖 |
|
J******u 发帖数: 26 | 3 【 以下文字转载自 Medicine 讨论区 】
发信人: Jiushibu (948), 信区: Medicine
标 题: 紧急求助治疗方案:老公得了胃癌晚期,孩子才半岁
发信站: BBS 未名空间站 (Mon Mar 2 21:51:33 2015, 美东)
紧急请求大家提供信息和治疗方案。先感谢大家!
老公半年前被确诊胃癌晚期,腹腔转移(但未转移到要害器官比如肝肾肺等),伴有严
重腹水,在纽约的 Memorial Sloan Kettering 治疗。开始用Xeloda,效果很好,腹水
也得到控制,但3个月后失效;于是换用Docetaxel,但是基本上没用,腹水会在抽掉后
2天内迅速回来。但是医生仍然坚持继续用这种药,而没有给我们吧开常用的复合化疗
药。就这样用了一个多月,两个疗程。10天前本来我们要去医院接受第三个疗程的
Docetaxel化疗,先抽了腹水,但抽掉腹水后情况恶化:心率升高,呕吐,腹痛。于是
医院没化疗而是转入病房观察,就这样过了3天心率仍然没降下来,医生才姗姗来迟说
化疗推迟,但是2天后就下了病危通知。老公入院前还可以吃东西,但入院后就滴水未
进,全靠输液... 阅读全帖 |
|
J******u 发帖数: 26 | 4 紧急请求大家提供信息和治疗方案。先感谢大家!
老公半年前被确诊胃癌晚期,腹腔转移(但未转移到要害器官比如肝肾肺等),伴有严
重腹水,在纽约的 Memorial Sloan Kettering 治疗。开始用Xeloda,效果很好,腹水
也得到控制,但3个月后失效;于是换用Docetaxel,但是基本上没用,腹水会在抽掉后
2天内迅速回来。但是医生仍然坚持继续用这种药,而没有给我们吧开常用的复合化疗
药。就这样用了一个多月,两个疗程。10天前本来我们要去医院接受第三个疗程的
Docetaxel化疗,先抽了腹水,但抽掉腹水后情况恶化:心率升高,呕吐,腹痛。于是
医院没化疗而是转入病房观察,就这样过了3天心率仍然没降下来,医生才姗姗来迟说
化疗推迟,但是2天后就下了病危通知。老公入院前还可以吃东西,但入院后就滴水未
进,全靠输液维持,医生解释说是巧合,说是病情恶化恰好和抽腹水凑一起了。这样一
周内滴水未进的老公体重骤减,身体虚弱,医生说因为老公身体虚弱,所以无法继续化
疗,连本来预计的实验中的药都不能用了。我问医生为什么当初看到Docetaxel没效果
却没有给我们换复合药,医生说老公当时身体... 阅读全帖 |
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J******u 发帖数: 26 | 5 紧急请求大家提供信息和治疗方案。先感谢大家!
老公半年前被确诊胃癌晚期,腹腔转移(但未转移到要害器官比如肝肾肺等),伴有严
重腹水,在纽约的 Memorial Sloan Kettering 治疗。开始用Xeloda,效果很好,腹水
也得到控制,但3个月后失效;于是换用Docetaxel,但是基本上没用,腹水会在抽掉后
2天内迅速回来。但是医生仍然坚持继续用这种药,而没有给我们吧开常用的复合化疗
药。就这样用了一个多月,两个疗程。10天前本来我们要去医院接受第三个疗程的
Docetaxel化疗,先抽了腹水,但抽掉腹水后情况恶化:心率升高,呕吐,腹痛。于是
医院没化疗而是转入病房观察,就这样过了3天心率仍然没降下来,医生才姗姗来迟说
化疗推迟,但是2天后就下了病危通知。老公入院前还可以吃东西,但入院后就滴水未
进,全靠输液维持,医生解释说是巧合,说是病情恶化恰好和抽腹水凑一起了。这样一
周内滴水未进的老公体重骤减,身体虚弱,医生说因为老公身体虚弱,所以无法继续化
疗,连本来预计的实验中的药都不能用了。我问医生为什么当初看到Docetaxel没效果
却没有给我们换复合药,医生说老公当时身体... 阅读全帖 |
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J******u 发帖数: 26 | 6 【 以下文字转载自 Medicine 讨论区 】
发信人: Jiushibu (948), 信区: Medicine
标 题: 紧急求助治疗方案:老公得了胃癌晚期,孩子才半岁
发信站: BBS 未名空间站 (Mon Mar 2 21:51:33 2015, 美东)
紧急请求大家提供信息和治疗方案。先感谢大家!
老公半年前被确诊胃癌晚期,腹腔转移(但未转移到要害器官比如肝肾肺等),伴有严
重腹水,在纽约的 Memorial Sloan Kettering 治疗。开始用Xeloda,效果很好,腹水
也得到控制,但3个月后失效;于是换用Docetaxel,但是基本上没用,腹水会在抽掉后
2天内迅速回来。但是医生仍然坚持继续用这种药,而没有给我们吧开常用的复合化疗
药。就这样用了一个多月,两个疗程。10天前本来我们要去医院接受第三个疗程的
Docetaxel化疗,先抽了腹水,但抽掉腹水后情况恶化:心率升高,呕吐,腹痛。于是
医院没化疗而是转入病房观察,就这样过了3天心率仍然没降下来,医生才姗姗来迟说
化疗推迟,但是2天后就下了病危通知。老公入院前还可以吃东西,但入院后就滴水未
进,全靠输液... 阅读全帖 |
|
k*******2 发帖数: 4163 | 7 【 以下文字转载自 NextGeneration 讨论区 】
发信人: Jiushibu (948), 信区: NextGeneration
标 题: 紧急求助治疗方案:老公得了胃癌晚期,孩子才半岁 (转载)
发信站: BBS 未名空间站 (Mon Mar 2 21:53:54 2015, 美东)
发信人: Jiushibu (948), 信区: Medicine
标 题: 紧急求助治疗方案:老公得了胃癌晚期,孩子才半岁
发信站: BBS 未名空间站 (Mon Mar 2 21:51:33 2015, 美东)
紧急请求大家提供信息和治疗方案。先感谢大家!
老公半年前被确诊胃癌晚期,腹腔转移(但未转移到要害器官比如肝肾肺等),伴有严
重腹水,在纽约的 Memorial Sloan Kettering 治疗。开始用Xeloda,效果很好,腹水
也得到控制,但3个月后失效;于是换用Docetaxel,但是基本上没用,腹水会在抽掉后
2天内迅速回来。但是医生仍然坚持继续用这种药,而没有给我们吧开常用的复合化疗
药。就这样用了一个多月,两个疗程。10天前本来我们要去医院接受第三个疗程的
... 阅读全帖 |
|
k*******2 发帖数: 4163 | 8 【 以下文字转载自 NextGeneration 讨论区 】
发信人: Jiushibu (948), 信区: NextGeneration
标 题: 紧急求助治疗方案:老公得了胃癌晚期,孩子才半岁 (转载)
发信站: BBS 未名空间站 (Mon Mar 2 21:53:54 2015, 美东)
发信人: Jiushibu (948), 信区: Medicine
标 题: 紧急求助治疗方案:老公得了胃癌晚期,孩子才半岁
发信站: BBS 未名空间站 (Mon Mar 2 21:51:33 2015, 美东)
紧急请求大家提供信息和治疗方案。先感谢大家!
老公半年前被确诊胃癌晚期,腹腔转移(但未转移到要害器官比如肝肾肺等),伴有严
重腹水,在纽约的 Memorial Sloan Kettering 治疗。开始用Xeloda,效果很好,腹水
也得到控制,但3个月后失效;于是换用Docetaxel,但是基本上没用,腹水会在抽掉后
2天内迅速回来。但是医生仍然坚持继续用这种药,而没有给我们吧开常用的复合化疗
药。就这样用了一个多月,两个疗程。10天前本来我们要去医院接受第三个疗程的
... 阅读全帖 |
|
h*w 发帖数: 20 | 9 LMH 您好!
多谢回复!
我父亲有做X-ray。现上传给您:左侧的是4/3/13 HERCEPTIN/DOCETAXEL 化疗前的X-
ray;右侧是的 经HERCEPTIN/DOCETAXEL 两次化疗,出现呼吸困难后于5/3/13拍的X
ray, 并附有图像分析报告,还请您请多赐教。 非常感谢!
secretion |
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b**********e 发帖数: 531 | 10 Let me know if you are familar and willing to review the following paper,
thanks
Preparation and Characterization of Self Emulsified Docetaxel
Abstract
The main goal of this work was to prepare a self-microemulsifying docetaxel
(Dtx) using PLGA, Tetraglycol, Labrasol, and Cremophor ELP. The prepared Dtx
-loaded SMES showed the size of the range of 80–90 nm with narrow size
distribution and the negative zeta-potential values. Its morphology was a
spherical shape by atomic force microscopy. In exp |
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d*******6 发帖数: 58 | 11 专家们怎么都只潜水啊。 我这外行去看期刊太费劲了。
查到两种标准的药物
Iressa (gefitinib) tablets
platinum-based and docetaxel chemotherapy
还有
Bevacizumab (Avastin).
Erlotinib (Tarceva).
还请专家们有时间介绍一下药性及用药之类的。
另外有人用树状高分子做药物定向投递吗? |
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p**********l 发帖数: 1160 | 12 我的朋友乳腺癌II期 ( 大约2cm多一点, 没有淋巴结转移,低分化癌,但是ki-67 很
高: 60-70%)。手术切除了肿块及部分组织,没有做全切。
因为不到40,属于年轻比较high risk, 目前有个临床试验用来比较两个不
同的方案。医生还说两个方案副作用也差不多,哪个更有效也不知道。极力建
议朋友参加clinical trial, 让电脑随机选一个方案。临床试验对病人要求做很多检
查和随访。另外,朋友觉得医生有点更关心为临床试验找更多的参加者
。但是朋友更关心的是哪个是已经证实了疗效稍好的,因为孩子还小,比较害怕将来复
发。
Regime 1:
Doxorubicin + Cyclophosphamide :every 2 weeks for 4 cycles
then Paclitaxel every 2 weeks for 4 cycles
Regime 2:
Docetaxel + Cyclophosphamide every 3 weeks for 6 cycles
请问这种情况,哪个方案更常用?请不吝赐教。
多谢了。 |
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h*w 发帖数: 20 | 13 Hello Simon:
Thank you very much for the suggestion.
My father did receive two weekly-dose of herceptin plus docetaxel. After
this combination of regimen his symptom got worsening...though hard to tell
the exact cause.
How about lapatinib, could you please give your insight and advice. Thanks! |
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f****o 发帖数: 2770 | 14 她想打听下,美国肺癌1B期手术切除一页肺之后,是否会建议病人再做化疗?
-NCCN guideline说都可以。具体是否化疗看肿瘤是否在变大。
cisplatin + vinorelbine or etoposide or vinblastine or gemcitabine or
docetaxel
如果不化疗,会用什么药?--不化疗就观察 |
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f****o 发帖数: 2770 | 15 手术放疗二选一,你既然手术切除了前列腺,就没必要放疗
PSA上升的非常快, 确定了骨转移就是荷尔蒙治疗先
最新的证据表明可以荷尔蒙+docetaxel x 6 cycles(化疗)
骨转移要考虑加denosumab or zometa |
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l********i 发帖数: 2503 | 16 肺癌的IIb期结果挺怪异的,他们用的P值我不懂,我只知道小于0.05才是有统计学
差异
In the phase IIb lung cancer study, the combination of vintafolide and
docetaxel met the primary endpoint of progression-free survival with a p
value of 0.0696. Endocyte uses a more forgiving statistical hurdle in the
phase II than you'd typically see in a large phase II study, which explains
why a p value of greater than 0.05 was considered statistically significant. |
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b********w 发帖数: 37 | 17 Int J Oncol. 2010 May;36(5):1235-41.
Altered DNA methylation is associated with docetaxel resistance in human
breast cancer cells.
Kastl L, Brown I, Schofield AC.
可发到b************[email protected]
Thanks. |
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d********n 发帖数: 1013 | 18 晚期肺癌,手术目前是不要考虑了.如果是非小细胞(NSCLC),有活检组织能测个序吗
,看看有没有EGFR, KRAS, ALK mutation.有些基因型一些比较贵药效果会比较好,比
如tarceva之类的.如果没有办法测序,目前估计docetaxel, cisplatin+pemetrexed
(Altima)好像用得比较多.不直接做临床,只知道这点. |
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t*d 发帖数: 1290 | 19 IMHO, to find novel drug delivering methods might be better ways to conquer
cancer comparing to studying the mechanisms of cancer initiation and
progression.
Nature 491, S58–S60 (22 November 2012)
Nanotechnology: Carrying drugs
When Joseph DeSimone makes nanomedicines, he compares himself to a baker. He
mixes drugs with different chemical 'batters', puts them in tiny moulds,
cures them and then turns them out. He can mould almost any shape: discs,
cubes, long sticks, roughened doughn... 阅读全帖 |
|
S*********s 发帖数: 304 | 20 plasma cancer gene detection一直就有,尤其是EGFR mutation.
这个系列有很多文章。只是sensitivity和false negative的问题。
如JCO上的这篇。是北大肿瘤医院王洁做的。
EGFR mutations detected in plasma are associated with patient outcomes in
erlotinib plus docetaxel-treated non-small cell lung cancer.
http://www.ncbi.nlm.nih.gov/pubmed/19414683
可以解决一些病人不做穿刺(实在是很痛苦)。
study |
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r******0 发帖数: 357 | 21 BMC终于在最近做了一件值得尊敬的事情。我敢说下面的狗屎99%都是所谓的个性化生物
“信息”“润色”的畸形怪胎。一般以所谓的Meta分析或者随便下载一套狗屎基因芯片
数据,然后做一些似是而非的烂分析,发一堆垃圾,一篇文章卖给忙于召妓的医生5万
到10万。
1.
Retraction Note Open Access
Retraction Note: Impact of guidewire selection and operator expertise on
radiation exposure in transradial angiography
Jianmin Yang, Ningfu Wang, Xiaoshan Tong, Xianhua Ye, Liang Zhou, Guoxin
Tong, Yun Shen, Shuzheng Lv
Journal of Cardiothoracic Surgery 2015, 10:42 (27 March 2015)
Full text | PDF
2.
Retraction Note Open Access
Retracti... 阅读全帖 |
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o******u 发帖数: 60 | 22 The second line hormonal therapy abiraterone (Zytiga) completed a phase 3 trial for CRPC patients who have failed chemotherapy in 2010. Results were positive with overall survival increased by 4.6 months when compared to placebo. On April 28, 2011, the U.S. Food and Drug Administration approved abiraterone acetate in combination with prednisone to treat patients with late-stage (metastatic) castration-resistant prostate cancer who have received prior docetaxel (chemotherapy)
Alpharadin
add two m... 阅读全帖 |
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t*d 发帖数: 1290 | 23 【 以下文字转载自 Biology 讨论区 】
发信人: ttd (oldcat), 信区: Biology
标 题: better way to conquer cancer
发信站: BBS 未名空间站 (Wed Jan 16 14:57:14 2013, 美东)
IMHO, to find novel drug delivering methods might be better ways to conquer
cancer comparing to studying the mechanisms of cancer initiation and
progression.
Nature 491, S58–S60 (22 November 2012)
Nanotechnology: Carrying drugs
When Joseph DeSimone makes nanomedicines, he compares himself to a baker. He
mixes drugs with different chemical 'batters', ... 阅读全帖 |
|
v*****e 发帖数: 30 | 24 Thanks a lot for previous answer and help!
My friend now is undergoing "decreased WBC" problem. Here is her question:
I went to cancer cnter and TCM hospital yesterday. this is my rountine
visit right before each chemo cycle. (I will start my 3rd course soon)
I may be very sensitive to the Docetaxel(T agent), so my WBC got extremely
low in the second course already. My TCM doctor was very concerned. She even
suggested me to change the chemo plan! She is a surgery and TCM doctor
specialized in ... 阅读全帖 |
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yf 发帖数: 272 | 25 I guess they used dose dense AC, so it's every two weeks protocol and it's
standard. Neulasta is a must for dose dense AC, or neupogen. AC is Q 3wks,
the dose is different from dose dense AC. But dose dense AC is a little
more effective than AC and is the standard now.
The doctors in Tianjing are doing the right thing.
If your mother has weak heart which is proven by ECHO or MUGA scan, then you
can consider TCH(Docetaxel (Taxotere) 75 mg/m2 iv d1 q3w x 6 cycles
Carboplatin (Paraplatin) AUC 6 iv... 阅读全帖 |
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s***s 发帖数: 25 | 26 我不是医生,只是在药厂工作的统计师
晚期二线胃癌获批的还有ramucirumab+docetaxel的联合治疗。
三线没有标准治疗,在中国获批的有江苏恒瑞自主研发的小分子靶向药阿帕替尼 |
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a******2 发帖数: 143 | 27 之前在这里得到很多帮助,我妈妈在天津肿瘤医院的乳腺癌治疗进行的还算顺利,刚做
完第7期化疗,我妈妈身体好又用了好的保护的药,反应不太大。现在化疗快做完了,
大夫说化疗完需要做放疗,但我妈妈对放疗很抵触认为伤害太大不需要,现在还没同意
做放疗,我在这里想问问这个放疗有多大必要?大夫说〉5厘米就要放疗。非常感谢!
!!
下面是我妈妈的情况
- 作了手术 Completely removed the right breast and removed nearby lymph
nodes.
- 在做化疗 共8期(4x4),已作了7期,第一个四期:5% 表柔吡星(Epirubicin)+ 环磷
酰胺(Cyclophosphamide);第2个四期:多西他赛Docetaxel + Herceptin
- 大夫说化疗完我妈妈得作放疗(25times, 5times/week for 5 weeks)和一年的靶向
(Hercepti年),然后吃来曲唑(Letrozole) 2.5mg once every day for 5 years. 现
在我妈妈就对这个放疗抵触:(
我妈妈病例:
- 65岁,... 阅读全帖 |
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y*****l 发帖数: 5997 | 28 T-DM1 Significantly Improved Progression-Free Survival in Randomized Phase
II Trial
3 hours 20 minutes ago - BIZ via Comtex
BusinessWireImmunoGen, Inc. (Nasdaq: IMGN), a biotechnology company that
develops targeted antibody-based anticancer products, today announced that
Roche has disclosed positive top-line results from the first randomized
trial assessing trastuzumab emtansine (T-DM1, previously known as
trastuzumab-DM1) in HER2-positive metastatic breast cancer (MBC). T-DM1
consists of Immuno... 阅读全帖 |
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y*****l 发帖数: 5997 | 29 好像射天狼也是ANX专家,如果FDA能过的话,潜力巨大。
http://seekingalpha.com/article/267816-adventrx-poised-for-run-
Adventrx Pharmaceuticals (ANX) is a specialty pharma company developing two
novel formulations of anti-cancer drugs that are designed to result in less
side effects in addition to a compound in late-stage clinical development
for the treatment of a blood disorder known as sickle cell anemia.
On 3/10/11, ANX reported its 4Q10 and full-year 2010 financial results,
including:
As of 3/1/11, had 23.7 mill... 阅读全帖 |
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f**********g 发帖数: 2252 | 30 来自主题: _pennystock版 - 生拉启动了 有没有人玩ARRY?
http://finviz.com/screener.ashx?v=341&t=ARRY
As we look at the BioMedReports Trade Catalyst Calendar, we see that ARRY
had three milestones listed this year. One Pahse Ib trial result for ARRY543
with Docetaxel (Advanced Solid Tumors), Another Phase Ib trial result, this
time for ARRY543 with Gemzar for the treatment of Solid Tumors and finally
a Phase I trial end status update for ARRY 403 for the treatment of Type II
Diabetes. We began to track these events after they were discussed... 阅读全帖 |
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y*****9 发帖数: 43 | 31 感谢版主邀请,既然进来了,怎么也得贡献一点心得。这个就再这里首发了~~
这两个股票目前都还是低价股,但是都属于同一类股票。都是与血液肿瘤(癌症)相关
的BIO公司。
医药股的特点不是EPS,不是REV,(当然这些仍是成熟BIO的特点)对于研发阶段的BIO
,最重要的是它的实验数据(trial data).每次关键的data公布都会成为股价的催化剂。
SNTA: 最近两日的大涨都源自于本月底前后的data
Preliminary results from the GALAXY trial are expected in the second quarter
of 2012, and additional results from the GALAXY trial together with
preliminary results from the ALK+ lung cancer and breast cancer trials are
expected in the second half of 2012. In addition to the company-sponsored
tr... 阅读全帖 |
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E****e 发帖数: 315 | 32 from SeekingAlpha
The recent news announcing Genentech’s (DNA) receipt of a “Refuse to File
(RTF)” letter from the FDA for the accelerated approval of the Biologic
License Application (BLA) for trastuzumab-DM1 (T-DM1) has caused a sell-off
in Immunogen, the owner of the technology and partner on the drug with Roche
. According to the FDA letter, the refusal to give the early approval was
because “the trials had not yet exhausted all available drugs approved for
metastatic breast cancer, regardle... 阅读全帖 |
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E****e 发帖数: 315 | 33 from SeekingAlpha
The recent news announcing Genentech’s (DNA) receipt of a “Refuse to File
(RTF)” letter from the FDA for the accelerated approval of the Biologic
License Application (BLA) for trastuzumab-DM1 (T-DM1) has caused a sell-off
in Immunogen, the owner of the technology and partner on the drug with Roche
. According to the FDA letter, the refusal to give the early approval was
because “the trials had not yet exhausted all available drugs approved for
metastatic breast cancer, regardle... 阅读全帖 |
|