b**u
发帖数: 2761 | 1 JOB DESCRIPTION
Title: Principal Scientist / Manager
Department: Pharmaceutical
Report To: Senior Director
Subordinate: Undetermined
Requirements:
Education: A science degree is required, preferably in
Pharmaceutics or Chemistry. An advanced degree (Pharm D, Masters, or PhD in
a science related discipline) is strongly preferred.
Experience: Minimum of 5 years of experience with
pharmaceutical development programs, preferably with NDA product development.... 阅读全帖 |
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a*********7
发帖数: 180 | 2 请问是New Molecular Entity么?还是new dosage form?？
Based on your limited info, if the obtained clinical data are sufficient to
support the Efficacy and Safety,as justified by the clinical reviewer at FDA
, then no need to file CTAs as IND for Phase I/II. But it sounds like the
data may not be representative to the US demographic info.
However, I really need more information in order to make a conclusion.
p.s. I am a CMC reviewer for pre-market authorization & CTA, not at FDA. 可
以PM. |
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a*********7
发帖数: 180 | 3 请问是New Molecular Entity么?还是new dosage form?？
Based on your limited info, if the obtained clinical data are sufficient to
support the Efficacy and Safety,as justified by the clinical reviewer at FDA
, then no need to file CTAs as IND for Phase I/II. But it sounds like the
data may not be representative to the US demographic info.
However, I really need more information in order to make a conclusion.
p.s. I am a CMC reviewer for pre-market authorization & CTA, not at FDA. 可
以PM. |
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S********Y
发帖数: 55 | 4 恳求各位大牛、前辈们给点指导吧！
情况是这样的：我目前准备申请绿卡，律师说case有点弱，需要提高杂志review。我去
联系了好几个以前发过文章的杂志editor,都很爽快的让我做reviewer，注册也注册了
。可是后来。。。就没有后来了。。。
我这个reviewer当得实在是清闲啊！几个月了一篇文章也没有让我review啊！我试过各
种改变关键词，然并卵。
我想请教一下版上各位有没有相关经验的，怎么才能让杂志发文章给我review啊？或者
手中review多得应付不过来得大牛们，能否让小的帮您分担一些？我的专长偏
formulation、solid dosage.
谢谢大家！ |
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d*****h
发帖数: 61 | 5 我们公司刚刚开始在招 Scientist 和 Sr. Scientist, 还没有看到Job description,
但是HM提了大概的要求：
Ph.D. (0-5 yrs industrial experience)
Solid oral dosage form
Peptide/protein preformulation
如果有意者站内联系，帮忙递简历。 |
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k******o
发帖数: 3328 | 6 其实不是胜任的问题,我觉得比他们更厉害才对.要有这个自信.其实熟能生巧,看到上面
的同学说dosage不记得,那是因为你刚开始学习,你做完1500小时的intern, 你就都记住
了.
我一直都以这样一句话要求自己:我学习不是为了pass exam,二是为了成为一个
knowledgable 的pharmaicst.你考试完了,都应该有这样一个感觉,oh, that is it?
that is the so called test.come on, give me the real one.赫赫,这个话来自我很
尊敬的一个有brain power的pharmacist |
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k******o
发帖数: 3328 | 7 是很简单,比我州的考试简单到几个数量集.apha足够了八,不过有些equipment的题目要
注意以下
dosage, interaction很多,我记得很多都是用patient profile表示的,我用的naplex的
准备材料中,有1章专门测试所有的pt profile. |
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u*****d
发帖数: 1009 | 8 I had a speaker speaking in one of my classes a few years back about his own
compounding pharmacy. His pharmacy compounds prescription drugs for both
humans and animals.
For example, many drugs are very limited in dosage forms, and if you can
find your own way to compound them (or using already available receipes),
then you can really make a business out of it.
Many times insurance companies refuse to cover for compounded prescriptions,
thus the customers will have to pay for it out-of-pocket, m |
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l********8
发帖数: 491 | 9 if you want to teach pharmacy practice, a pharmD + residency (usually 2
years) help you to qualify. if you wanna to teach basic science, phd is fine
. you don't really need a pharmD/phD. I seen a prof with a pharmD/phD , she
teaches the dosage form class, which in my eyes, not the important class in
the curriculum. |
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x**l
发帖数: 113 | 10 临床用药考什么?
考dosage, indication, adverse effects, mechanism, structure?
thanks! |
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s*********t
发帖数: 38 | 11 no dosage, others are all possible |
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A*i
发帖数: 42 | 12 不知怎麽搞得，打出來的居然是繁體，大家湊和看吧。
Mannon Shroff的習題裏提到發錯葯后，patient來complain時，pharmacist要如何對待
，好像說的很輕鬆，要先acknowledge his frustration, 表示同情等等，也沒見書上
有任何地方提到pharmacist會如何被sue.
我就覺得疑惑，難道發錯葯就會那麽輕鬆過關，給病人換一下就可以了？ 我上次看到
本州一些藥劑師的紀錄上都會notes, 比如有個藥劑師把葯發給了同名同姓的另一個病
人，其實這種情況真的挺怨的， 當然藥劑師應該問一下病人拿的是啥葯，但是我平時
自己去藥店取葯時，經常踫到藥劑師只是問我有沒有問題的， 我回答沒，就走了。另
外還有個Pharamcy manager gets notes on her credential because the computer
system allows the pharmacy tech to skip the warning on the dosage, therefore
the pharmacist didn't see the w |
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r********r
发帖数: 352 | 13 医院的central pharmacist 也要接很多电话的。enter order的时候要double check
order是否正确，dosage是否 appropriate. 另一个downside is, you might have to
work 2nd or 3rd shifts. |
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w**r
发帖数: 479 | 14 说实话，我现在想的是如果能上学以后希望有机会去医院，然后在药房工作的同时做些
科研，例如研究一些药物的毒理和相互作用之类的，这是不是就是你说的
Translational Research吧，不知道我这样想的对不对呢？有这种在医院既做科研又发
药的职位吗？是不是就是pharmacist specialist呢？谢谢！
另外关于area of pharmacy practic我可以理解成the discipline of pharmacy which involves developing the professional roles of pharmacists吗？
Areas of pharmacy practice 包括:
Disease-state management
Clinical interventions (refusal to dispense a drug, recommendation to change and/or add a drug to a patient's pharmacotherapy, dosage adjustments, etc.)
Prof |
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j******8
发帖数: 12 | 15 We are working with a top Multinational Pharmacy Company to recruit Clinical
Pharmacologist for their R&D center in China (Beijing or Shanghai),
especially in Phase 1/Clinical Pharmacology/PK/PD studies and Clinical
Pharmacology strategy. This position belongs to Early Research Development
Department.
Primary Responsibilities:
• Both build new and apply known disease and drug models as stated
previously. This will be based on clinical trial information inside Roche as
well as the litera... 阅读全帖 |
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l******k
发帖数: 27533 | 16 EX101 is a buffered, effervescent dosage form of alendronate sodium looking
for approval for treating osteoporosis and Levadex™ is being reviewed
as an orally-inhaled formulation of dihydroergotamine (DHE) for migraine
headaches. |
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l******k
发帖数: 27533 | 17 effervescent dosage form好像就是泡腾片，优点是口感好，对胃刺激小。
alendronate sodium特点是half life特别长，不知道为何要做成泡腾片。。。
大家讨论讨论？！ |
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T*********e
发帖数: 91 | 18 Just want to share my naplex experience, maybe a few of you will take it
this year. I took it on 7/15/11, got my score today, which is 129.
Make sure you get a good night sleep before the exam, I was so anxious the
night before exam that I literally didn't get any sleep, I even thought of
cancelling my test on 7/15/11, but decided to go in the end.
Study math, make sure you can do it quick and accurately, I had at least 20
probably more math questions, a few of them within the last 10 questions.... 阅读全帖 |
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f******k
发帖数: 5329 | 20 高度怀疑第二个儿医开的是200mg/5ml，也许那个妈妈没看全？
另外，immediate release的QD确实不make sense。高度怀疑那个resident当成extended
release说的. |
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l******k
发帖数: 27533 | 21 要么resident说错了，要么你看错了
应该是50mg/kg po qd， maximum 1000 mg per day for 10 days
一天两次已经超过治疗strep throat最大剂量了，用这么高是不是同时treat strep throat
and 手足口？ |
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l******k
发帖数: 27533 | 22 有用高剂量治疗其他症状的，如acute OM, CAP...
第一个医生开的QD，因为当时娃只有strep
第二个医生增加到BID也是make sense的，因为当时娃的病已经发展到strep和手足口了
，这时增加剂量同时treat two infections也是有可能的
extended |
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c****m
发帖数: 626 | 23 clinical pharmacology 是说的divide dose， q12hr.
其它几个资料也说吃两次，中间隔12hr。
那个楼的lz说她儿医说去年的conference说该成每天只吃一次了。
师姐用的哪个reference是50mg/kg po qd？
throat |
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l******k
发帖数: 27533 | 24 我查的lexi-comp
clinical pharmacology确实可能信息比较旧，textbook一般都是要滞后几年的 |
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l******k
发帖数: 27533 | 25 我记得ID module的时候老师介绍过几种不同的方案都可以用的
也许BID和QD都可以用，现在更prefer QD
不过我记不清了，也懒得去找笔记了:P
师妹要有兴趣，可以查查pubmed上有没有clinic trial比较这两种的 |
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f******k
发帖数: 5329 | 26 那你还记不记得老师说为啥更prefer qd? |
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a*****8
发帖数: 2115 | 27 I thought it is 25-50 mg/kd/day in divided doses every 12 hours.
if it is otitis media 80-90 mg/kd/day divided every 12 hours
400 mg bid seems ok to me for kid weight 36 lb. I thought beta-lactam
killing are time above MIC, so I would rather dose more frequently than big
dose once daily though. |
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f****o
发帖数: 2770 | 28 手足口是viral, antibiotics没用的
strep pharyngitis不吃抗生素自己也会好的。。。 |
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w***0
发帖数: 222 | 29 同意第一句。
Strep Throat 用抗生素是对付可能的并发症的，不是治疗Pharyngitis。 所以你所说
的错倒是也没错。 |
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l******k
发帖数: 27533 | 30 去年上的ID课了
当时老师并没有prefer任何一种regimen
所以看到人家residency说儿医们现在更prefer QD，说不定去年的ID课已经out dated
而且lexicomp也只列出了QD
没时间查guideline或者literature呀:(
师妹要有时间帮忙看看，来给我们讲讲就最好了：） |
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l******k
发帖数: 27533 | 31 I agree that for the time dependent ABX like beta lactams, it's better to
have frequent doses to maintain adequate concentration for most time.
However, there are several amoxicillin regimens used for strep throat as my
ID professor introduced in the class. I think either one is ok since there'
s evidence for it.
It's also possible that there's new guideline or clinical study to prefer
the QD amoxicillin regimen over others, which is very interesting:)
big |
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l******k
发帖数: 27533 | 32 ：（（
懒了，没查是viral or bacteria infection
strep throat还是要治疗的，特别是小孩儿，为了prevent complications
你记不记得诊断的方法：先是诊所里做rapid antigen test.如果成人是negative,就不
treat了，如果是小孩，要进一步做culture确认的 |
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w***0
发帖数: 222 | 33 其实不是的。没有那么复杂。
如果一个药可用QD,又可以用BID,在理论上两种方法有效药物浓度是可以维持的。不排
除个体差异的话。剩下的就是毒性问题。这种Strep Throat 的治疗，如果药物可以用
QD，大多药物 没有太多的副作用，安全度比较高。从临床上来说，QD 对孩子比较容易
。没有那么多的考虑。方便有效是主要的。
my
there' |
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l******k
发帖数: 27533 | 34 大家围绕这个case多讨论讨论挺好的，相互share ideas, 也算是课外不错的learning
process吧：）
理论来说，BID还是比QD能cover更多的时间above MIC的
one time large dose对beta lactams确实不常见
不过你说的easy dosing for kids是个很好的理由：） |
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l******k
发帖数: 27533 | 35 uptodate是啥？
你们经常用这个做reference吗？好用不?
有时间我到想看看IDSA上怎么说的。。。
30
MG |
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w***0
发帖数: 222 | 36 99.99% physicians will use Uptodate, once a while, in their life.
almost all the hospital library, college has subscription access.
www. Uptodate.com
普通人用也能受益。 |
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w***0
发帖数: 222 | 37 MIC 是实验室的。临床用的是stead STATe， 介乎于最高浓度和最低浓度之间的一个范
围。通常是3-4个半衰期的药物以后就能达到的。是临床药理学的一部分。
确定是否QD 或 BID,或 TID 是根据半衰期 和 Steady State 的结果定的。
如果两者都能达到Steady State 同样话，你考虑的就是Pulse 峰浓度，因为再上线就
是毒性浓度。
这些是基本药理学里应当提到的。临床上以方便安全第一。
learning |
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l******k
发帖数: 27533 | 38 。。。
我们在说ABX的MIC
dosing frequency for time dependent or concentration dependent ABX
这正是ABX跟其他一般药不同的地方，不是单看一般药代学的AUC或者SS。。。
还有，至少5个半衰期才能达到SS
对了，其实100%的physician用google的 |
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a*****8
发帖数: 2115 | 39 Up to date drug information is copy from Lexi-comp
I don't think IDSA has treatment for strep throat though. |
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J*****0
发帖数: 6 | 40 来这个版上潜水很久了，学了前辈们很多东西，今天也来冒个泡~ 第一次发帖，请多指
教。
先介绍一下自己吧，高中毕业来美，PharmD 6年，今年暑假毕业。想想还是自己年纪有
点小，跟着身边的美国同学吃喝玩乐，当时也不太了解国际学生校外打工的种种手续，
所以一直到P1暑假才开始在药房里实习。虽然常听版上的人说美国学生很笨很懒，但老
实说自己六年的读书生涯里至少有两年颇感辛苦。在国内读书的时候从没惧怕过考试，
来到这里有一段时间考试前夜会焦虑到睡不着觉。还好这样的日子大概只有几个月，之
后也还算顺利。
年初收到两个工作offer,二月去了residency on-site interview，最后选择withdraw
match program，接受工作offer。做决定的时候，也考虑了很久。pharmacy这块的工作
机会是一天一天地少，residency结束后万一没找到工作的话身份的问题很难解决，加
上我本来也比较enjoy retail的工作，所以最后还是选了条安稳的路。
我现在在药店里training，同时在复习准备NAPLEX。如果有准备最近考试的同学，或者
已经考过了的药剂师们，... 阅读全帖 |
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f****o
发帖数: 2770 | 41 复习时间：2.5 weeks
复习材料：protonpass, APhA book, miscellaneous
感觉：考下来感觉难度一般。个别问题觉得没有正确答案，个别问题完全不知道怎么答
。大部分问题还是有底的。
考的范围很广，我的考卷涉及到的题目有：
math 10%(网上有人说会占30%,可能他们错太多，所以naplex系统给他们题目直到做对
为止吧), prescription evaluation, compounding, kinetics, biostatics, heart
failure, arrhythmia, hypertension, anticoagulation, lipids, diabetes,
endocrine, women's health, ADHD, asthma/COPD, ESRD, seizure, oncology
supportive care, basic HIV, opportunitic infection, ID, lots of IDs,
nutrition, electrolytes, gout, GI, pain, p... 阅读全帖 |
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b**o
发帖数: 5769 | 42 ☆─────────────────────────────────────☆
fiorio (那朵花~一定还在某个地方盛开着~) 于 (Sun Jul 8 01:26:21 2012, 美东) 提到:
复习时间：2.5 weeks
复习材料：protonpass, APhA book, miscellaneous
感觉：考下来感觉难度一般。个别问题觉得没有正确答案，个别问题完全不知道怎么答
。大部分问题还是有底的。
考的范围很广，我的考卷涉及到的题目有：
math 10%(网上有人说会占30%,可能他们错太多，所以naplex系统给他们题目直到做对
为止吧), prescription evaluation, compounding, kinetics, biostatics, heart
failure, arrhythmia, hypertension, anticoagulation, lipids, diabetes,
endocrine, women's health, ADHD, asthma/COPD, ESRD, seizure, oncology
sup... 阅读全帖 |
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s*******y
发帖数: 468 | 43 来坛子里看下，发现大家都挺忙的，干脆灌水写下感受。
一晃开学两个月了，我的感觉是，药学院还是挺忙的，尤其我这样拖家带口
读书的，感觉时间还挺紧的。首先，我修了17个学分的课，还当解剖学的助
教，加上家里的两个孩子也都上学，每天忙接送。
这个学期，我修了dosage form, patho, patient care, pharm calculation,
pharm law, pharm lab, biochem，team project, 另外还有门课这周三才
开课。基本每周都有考试，时常一周两个，三个或者四个考试。但是，我除了
教课没有实习。所以自己的时间还是有的。
每天回家先把孩子的学习搞定，等他们上床睡了，我就可以开始忙自己的事
儿了。觉得时间还是够用，压力虽然有，但是也还好。毕竟成绩不再是考核
我们的唯一标准了，我也不会求门门都是A。前辈们说，GPA 3.2就够了，我
想这个还是不难达到的。同学们都挺友好的，大家都愿意互相帮助，班里的
气氛也不错，老师也都很好，所以还挺开心的。大家说p1最忙，到了第二年
就好了。我心里时时盼着时间快点过，早点到p2，我也好抽空看个电影，逛
逛... 阅读全帖 |
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J****S
发帖数: 15 | 44 请有意回国发展的专业人才联系：d******[email protected]
Title: Scientist, Liquid Formulation
Department: Pharmaceutical Sciences, Discovery Center China R&D and
Scientific Affairs
Report to: Head of Formulation in the Centre for Pharmaceutical
Sciences, Discovery Center, China R&D
Subordinates: Up to 2
PRINCIPAL RESPONSIBILITIES:
• Develop liquid, lyophilized, micronized, and nano and sustained
release parenteral formulations of large and small molecules
• Preformulation char... 阅读全帖 |
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b******8
发帖数: 1251 | 45 这学期学完LAW的感觉就是，我还是做TECH好了，我们老师说的，无论TECH烦什么错误
，他都可以get them off the hook:
[8] Pharmacy Error Statistics
• Error rates: 1.5% - 4%
• 5 billion Rxs dispensed
• What if error rate was only 0.1%, how many errors would there be? &#
61664; 5 million
[9] Drug Topics Survey
• 53% admitted to error within past 60 days
• 36% admitted to making 2 errors
• 28% admitted to making > 2 errors
• 80% of errors wrong drug or dosage
我还是现在 chain pharmacy把该犯的错误都犯了来吧 |
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P*******D
发帖数: 523 | 46 刚刚查了naplex分数，过了，分数居然还不错。 考完觉得要fail了。我的考题是rare
diseases，rare drug names and dosage forms 占据的了整个考试。其他的常见的东
西也都有，但是都是蜻蜓点水的考一下，一两题的样子。计算也不多。虽然我没好好复
习，只是看了常见的内容，但感觉就是我再复习一个月也没可能看到考试中遇到的东西
。考完看了些别的论坛的帖子，发现每个人的考的侧重点可能完全不一样。真不知道该
怎么复习了。唯一的一点经验是不要panic，如果有题不会的话，随便选一个就move on
。把握好时间，做完所有的题。尽量保证计算全做对。我就只用了rxprep。 |
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r********r
发帖数: 352 | 48 1. AST/ALT 只是 mildly elevated, 不足以说明是肝功能异常。单纯CK elevation 也
和心衰没有关系。CK其实也不算很高了，我觉得这三个lab偏高主要是 rosuvastatin的
副作用 － LFT elevation, muscle break down. 其实CK也没有高太多，病人有没有肌
肉疼痛的症状呢？我觉得应该再查一下scr, 以及lipid panel。不过既然你有AST/ALT
了，说明做了CMET, 那creatinin 你没有列出来说明不高对吗？那说明还没有发展到
rhabdomyolysis。这个时候如果LDL不太高，可以暂停 rosuvastatin. 针对lipid
profile 选择合适的降脂药。
2. calcium channel blockers may decrease the metabolism of statins. but the
dosage for rosuvastatin is not high. 如果一定要用其他statin可以试试
pravastatin or atorvastatin，这样可以s... 阅读全帖 |
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u*******s
发帖数: 688 | 49 Hctz requires no hepatic impairment dosage adjustment and is less potent
than Lasix. Lasix causes increased sensitivity to hypokalemia and increased
volume depletion in cirrhosis pts. Pt is hypotensive. Also with the hctz the
pt may not even need potassium supp any more.
Protonix 40 mg given in a 2 min infusion is on formulary at the hospital I
work at. Different places may have different practice... |
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M****S
发帖数: 33 | 50 this is hard...
easiest way just borrow a hand hold uv meter and you can read the dosage
right away. |
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