A******y
发帖数: 2041 | 1 Because his mechanism(s) have been validated, and he used to only focus on
basic research. DePinho's science is nothing special and people already did
it just look at AVEO phase II clinical results. Btw, I think he personally
knows that too since several companies already shown his approach only have
limited success unless you hit the absolute target(s).
If you ask DePinho's name to average Americans, do you think they can tell
you who he is? As for the H-index, Brian Druker has H-index of 49... 阅读全帖 |
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a********k
发帖数: 2273 | 2 Thomas M. Roberts
人自己都没claim有啥贡献。。。Druker当时是他实验室唯一做这个的，公司找上门的
时候就和Druker联系了。Gleevec确实也是在他到OHSU之后才做到CML里面的。 |
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d********1
发帖数: 8969 | 3 Donald Shiley
Brian Druker
看这两个人 |
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a******g
发帖数: 13519 | 4 肖邛（中科院生物化学博士）：格列卫应该用来嘲讽药厂，怎么就封神了？
在学界格列卫的发展史是被用来嘲讽诺华的短视和逐利的，怎么电影一出就封神了……
具体到格列卫，简要发展史如下：
1960年，David Hungerford发现在一类白血病人中多出一条染色体，他们把这类现象命
名为费城染色体。当时他们受到无数嘲讽，因为没人相信人会多一条染色体。
1970年，Janet Rowley发现这染色体是怎么出现的，他们发现是第9和第22号染色体发
生了重组，并且因为重组，bcr和abl两个基因融合到了一起，形成了一个新的酶。
图片来源：作者提供，下同
后来到了1990年，David Baltimore等人发现尽管这个新酶在常规致癌实验中不能让细
胞成癌，但是可以让血细胞变成白血病。以上的工作是决定性的，找到了致病的靶点，
好比修车工找到了车哪里出了问题。
接下来的工作是怎么修。这部分工作持续了30年，产生了两个拉斯克奖，完全是学界完
成的。一般来说大家都认为既然是这个酶导致了CML（观察者网注：慢性粒细胞白血病
），那么把这个酶关住，癌细胞就死掉了，这就叫靶向治疗。
而且治疗CML很容易，因为这... 阅读全帖 |
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G***Y
发帖数: 9698 | 5 2016年新政：全美5州居民驾照将不准登机！
Jan 6, 2016, 14:53 PM
【侨报纽约网综合报道】美国国土安全局(DHS)在去年12月29日回绝了伊利诺伊州
提出的延迟实施“真实身份法案”(Real ID Act)的提议，意味著伊州居民今年恐无法
凭借驾照登机。此外，本月10日起，伊州驾照将不能用作进入联邦大楼或军事要地的身
份凭证。
据芝加哥NBC新闻网报道，最早今年4月底开始，有5个州的居民将无法使本州驾照
登机，而必须出示护照才可登机，分别是伊利诺伊州、明尼苏达州、密苏里州、新墨西
哥州和华盛顿州。另外有19到23个州被允许豁免至今年10月，还有22个州的居民不受影
响可继续持驾照在境内乘机。
据悉，国土安全局目前正在审核新法案，预计将在实施前120天通知民众。新规实
施后，民众持伊州驾照也可能会被允许登机，但登机前需要额外安检程序。
据伊州发言人戴维德鲁克尔(David Druker)透露，国土安全局已回绝伊州府提出的
延期实施“真实身份法案”申请。此前，伊州曾于2005年向联邦政府申请延迟实施此“
真实身份法案”，2次均获批，但本次并未获批，国土安全局并没有回应... 阅读全帖 |
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w*********g
发帖数: 10097 | 6 这又不是我的point,point是gleevec是验证确实有效的抗癌药，而且我觉得这东西迟早
是会给诺奖的，只不过三个人都还不算老，按诺奖的给法还要等十几年
我也对彻底攻克癌症的可能性持怀疑态度，但是我觉得让癌症变成一定程度上的
chronic disease从而大幅延长病人存活期还是很有可能做到的，就像Lasker奖给这三
个人的理由：
Druker, Lydon and Sawyers received the Lasker-DeBakey Clinical Medical
Research Award in 2009 for "converting a fatal cancer into a manageable
chronic condition" |
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a********k
发帖数: 2273 | 7 不光是人品问题，Druker还是很有vision的。CML不同于其他cancer，致病机理单一，
最容易成功。他能在90年代初看到这个，并用ATP binding domain的结构来合成文库都
是非常惊艳的。
…… |
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l*******k
发帖数: 361 | 8 You are wrong!
A History of STI 571 by Dr. Brian Druker (Left)
The Unsung Heroes.
As Judy Orem has said, drugs don't just pop off the shelves. As is the case
with any drug, there is a long process before a drug reaches the stage where
STI 571 has arrived. In the case of STI 571, the research effort at began
at Ciba-Geigy (now Novartis) in the early 1990s. Finding a compound that
works in research models is the first stage in identifying a candidate drug.
The next stage, which is referred to as p |
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M*****e
发帖数: 279 | 9 David Baltimore is sure one of the greatest scientists. He made contribution
to the understanding of the aberrant BCR-ABL that was later found to be the target of Gleevec by Brian Druker for the CML (leukemia).
CML patients (not all of them) have an unique chromosome (Philadelpha
chromosome) that is caused by the chromosomal translocations, resulting in the
constitutive activation of ABL kinase (a tyrosine kinase). |
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C******r
发帖数: 790 | 10 一共3天分了6个section，每个section三四个speakers，包括cancer, metabolism,
neuroscience, immunology, plant, 和stem cell。
Keynote: David Baltimore
Cancer: Tony Hunter, Bob Weinberg, Craig Thompson, Brian Druker;
Metabolism: Ron Evens, Bruce Spiegelman, Tamas Horvath, Jeff Gordon, Joe
Goldstein;
Neuroscience: Terry Sejnowski, Susan K. McConnell, Larry Swanson, Bob Wurtz,
Susumu Tonegawa;
Immonology & Virology: Inder Verma, Ruslan Medzhitov, Fiona Powrie, Dan
Littman, Didier Trono;
Plant: Joanne Chory, Elliot Meyer... 阅读全帖 |
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H*****e
发帖数: 120 | 11 They are all excellent labs. They were or are on the top of their fields.
But the title misleading! Best is what they have/had achieved but may not
be the best for you! My comment is followed.
Keynote: David Baltimore
I had been his talk very often. But the most recent one is not that good!
to him! He was such an elegant talker but this time he is just a nice old
man. I did not see the fighter anymore.
Cancer: Tony Hunter, Bob Weinberg, Craig Thompson, Brian Druker;
Except Weinberg's lab,... 阅读全帖 |
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A******y
发帖数: 2041 | 12 Imatinib side effects are not that bad...it also have positive side effects
i.e. restoring nature hair color. Brian Druker is going to win Nobel price
soon... |
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h******y
发帖数: 1374 | 13 新浪科技讯 北京时间9月21日晚间消息，汤森路透9月21日公布了年度汤森路透引文桂
冠得主名单，以预测将于10月公布的诺贝尔奖科学和经济学类得主，名单上的科研人员
将有可能成为各项诺贝尔奖的有力争夺者。
每年，汤森路透都会利用其研究解决方案Web of Knowledge™中的数据，根
据诺贝尔奖的生理或医学、物理、化学与经济分类，使用定量数据来分析和预测最有影
响力的研究人员。根据其发表的研究成果的总被引频次，这些高影响力研究人员被授予
汤森路透引文桂冠得主(Citation Laureates)称号，预示着他们可能成为今年或不久将
来的诺贝尔奖得主。
汤森路透是唯一采用定量数据预测年度诺贝尔奖得主的机构，自2002年起，共有21
位引文桂冠奖得主赢得诺贝尔奖。
汤森路透研究服务引文分析师David Pendlebury说：“在科学社群里，若经过分析
和计算，引文可以作为另一种形式的同行评审。一位科学家发表研究成果的被引用次数
越多，这位学者在其同行之中、从学术角度的受敬重程度越高，而这可以作为如诺贝尔
奖这类奖项的预测指标。汤森路透引文桂冠奖是通过成熟完善的方法评估引用... 阅读全帖 |
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l***d
发帖数: 1828 | 14 生理学或医学
Brian J. Druker 美国奥勒冈州波特兰市奥勒冈健康暨科学大学 (Oregon Health
Science University)医学教授、JELD-WEN血癌研究教授及奈特癌症研究所(OHSU
Knight Cancer Institute)主任、同时也是霍尔休斯医学研究所(Howard Hughes
Medical Institute)研究人员
Nicholas B. Lydon 美国怀俄明州杰克森洞(Jackson Hole, WY)Granite ***a, LLC
创办人；美国加州圣地牙哥AnaptysBio共同创办人兼总监；及美国麻州剑桥Blueprint
Medicines共同创办人兼总监
Charles L. Sawyers 美国纽约州纽约市Memorial Sloan-Kettering癌症中心人类肿
瘤学及病因Marie-Josee and Henry R. Kravis教授、同时也是霍尔休斯医学研究所(
Howard Hughes Medical Institute)研究人员
获奖成就：他们发展出***性慢性骨髓性白血病治疗药物im... 阅读全帖 |
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A******y
发帖数: 2041 | 15 Druker will win one day because he conquered a disease (may not be this year
), plus the study published in NEJM this year further states the important
of his discovery. |
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n*********b
发帖数: 140 | 16 It would be nice that Peter Nowell, Janet Rowley and Brian Druker can share
the price this year.
These three individuals have made most significant contributions to our
understanding of the molecular basis as well as targeted treatment for CML.
Given CML as a model, it should be easy to define targets in hematopoietic
malignancies and soft tissue sarcoma. It is difficult to name targets in
solid tumors since they usually involve multiple clones and each clone
harbors multiple mutations. |
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w***r
发帖数: 709 | 17 知道这些MD吗？
Brian J. Druker,
Bert Vogelstein,
Charles L. Sawyers,
irving weissman,
Stanley B. Prusiner,
Charles Janeway
Even Sydney Brenner was trained as MD.
training |
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O******e
发帖数: 4845 | 18 Brian J. Druker, H-index: 79.
Not 49 .....
did
personally
have
He |
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A******y
发帖数: 2041 | 19 Gleevec Brian Druker breakthrough in CML and target specific therapy. |
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A******y
发帖数: 2041 | 20 I still go for Brian Druker on Gleevec. A drug >>> than theory. And if
they ever going to give a DNA nanotechnology, Peter Dervan is the
grandfather! |
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A******y
发帖数: 2041 | 21 Brian Druker and Carl June are MDs. Look at their researches,way better
than bullshxt big bulls publishing cr@p in CNS. |
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A******y
发帖数: 2041 | 22 Yup, I guess we only have AML and MM to worry about in a few years. Brian
Druker (CML) and Carl June (CLL) will probably win Nobel prize together in a
few years, or they can win individually.
immunotherapy |
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A******y
发帖数: 2041 | 23 Gleevec hasn't won, yet. It won't be them. I still bet on Brian Druker (
and maybe Carl June) for advancement in targeted leukemia therapies because
they are just waiting literally. |
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f*******g
发帖数: 245 | 24 Agree. The discovery should count on Peter Nowell, David Baltimore and
Brian Druker and the guy in Novartis who led the team for STI571
because |
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j********r
发帖数: 156 | 25 everyone knows brian druker, who is his postdoc mentor? It was during his
postdoc stage that the drug was identified based a novel tool that was
developed previously in the lab. sigh~ |
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A******y
发帖数: 2041 | 26 What are you talking about? When STI571 is discovered FOR CML, Brian
Druker is already an assistant professor. He is the one purposed to use
STI571 for CML. Nicholas Lydon has the compound, but he doesn't know what
to do with it. Both said the compound is designed, but we all know it is
from screening and they got lucky.
The dogma at that time I believe was impossible to target Bcr-Abl. |
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f*******g
发帖数: 245 | 27 Dr. Druker developed the first monoclonal anti-phosphotyrosine antibody,
4G10.
Didn't he ? |
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A******y
发帖数: 2041 | 28 One of MD/PhD students in my department has NCS as undergraduate (I think
his MCAT is 39), and my school is not that good. I also interviewed few of
them, one has almost perfect MCAT (43/45) and NCS publications.
However, you don't need Ph.D. to do research. Carl June and Brian Druker
only have MDs. As a MD, you don't have to worry about student debt that
much. Just work in a public hospital and have the debt wiped on the 10th
year. |
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r*****m
发帖数: 3619 | 29 Results: 46
Select item 25597018
1.
Exome-wide Sequencing Shows Low Mutation Rates and Identifies Novel Mutated
Genes in Seminomas.
Cutcutache I, Suzuki Y, Tan IB, Ramgopal S, Zhang S, Ramnarayanan K, Gan A,
Lee HH, Tay ST, Ooi A, Ong CK, Bolthouse JT, Lane BR, Anema JG, Kahnoski RJ,
Tan P, Teh BT, Rozen SG.
Eur Urol. 2015 Jan 14. pii: S0302-2838(14)01396-7. doi: 10.1016/j.eururo.
2014.12.040. [Epub ahead of print]
PMID: 25597018 [PubMed - as supplied by publisher] Free Article
Related citations... 阅读全帖 |
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A******y
发帖数: 2041 | 30 I still think Brian Druker will win the medicine. John List please win for
late boomers. It is almost sad that I don't feel any of the chemist
nominees should win, probably going to give to a biologist this year again..
.Robert Langer maybe. |
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A******y
发帖数: 2041 | 31 The medicine and chemistry committees talk to each other and sometimes award
are linked.
If today's medicine is focusing on tropical diseases, then for chemistry, it
could go to people who are studying tropical diseases such as malaria,
sleeping sickness, or cholera toxin (a lot of x-ray people). If the focus
is on targeted therapy, my prediction still got a shot this year (Gleevec to
Druker et al). |
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w***r
发帖数: 709 | 32 我猜 gleevec 抑癌 Brian druker |
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A******y
发帖数: 2041 | 33 Imatinib is from high throughput screening library. However, if you ask Dr.
Druker, he will tell you it is rationally designed, muhahaha. Yea, it is a
semi-screening effort and a lot of luck.
Btw, if you are in academia and try to write a HTPS grant, good luck to you.
This also apply to other efforts such as combi-chem and computational etc.
And if you are not in the academia, you better hope your collection is
private and is not in the public domain or element of composition patent is
har... 阅读全帖 |
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