T********e
发帖数: 1025 | 1 朋友在国内，09年乳腺癌做了手术，想咨询下美国这边是怎么治疗的，以下是朋友从有
病以来的一些具体情况描述，请帮忙看看这样治疗可以吗？
最开始手术时病理的癌基因检测结果是：
ER(+ ,85%)
PR(+ ,50%)
HER2(-)
病理会诊报告是：乳腺导管内癌（ductal carcinoma in situ，DCIS）及少许浸润性导
管癌（Infiltrating ductal carcinoma）
2009年5月份做的手术，2009年9月份完成了6六次化疗，之后开始吃Tamoxifen citrate
tablets（他莫西芬片），每天两片，每半年复查一次，并且每半年做一次
bioremediation（生物治疗）。
前几天体检，即在生理周期结束的第一天（黄体期）检查结果：Estradiol（雌二醇）
是257.43pg/ml,黄体期的参考范围是（22.4-256），国内的医生说，正常我吃
Tamoxifen citrate tablets（他莫西芬片），Estradiol（雌二醇）的范围应该是绝经
期的值（0-44.5），因此医生建议不吃Tamoxifen citrate t... 阅读全帖 |
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l**u
发帖数: 2 | 2 我朋友在中国，患有乳腺癌。年龄37岁
她2009年5月份做的手术，手术时病理的癌基因检测结果是：
ER(+ ,85%)
PR(+ ,50%)
HER2(-)
病理会诊报告是：乳腺导管内癌（ductal carcinoma in situ，DCIS）及少许浸润性导
管癌（Infiltrating ductal carcinoma）
2009年9月份完成了6六次化疗，之后开始吃Tamoxifen citrate tablets（他莫西芬片
），每天两片，每半年复查一次，并且每半年做一次bioremediation（生物治疗）。
前几天体检，即在生理周期结束的第一天（黄体期）检查结果：Estradiol（雌二醇）
是257.43pg/ml,黄体期的参考范围是（22.4-256），国内的医生说，正常我吃
Tamoxifen citrate tablets（他莫西芬片），Estradiol（雌二醇）的范围应该是绝经
期的值（0-44.5），因此医生建议不吃Tamoxifen citrate tablets（他莫西芬片），
而是用诺雷德 zoladex (别名是戈舍瑞林，goserelin)和... 阅读全帖 |
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l**u
发帖数: 2 | 3 我朋友在中国，患有乳腺癌。年龄37岁
她2009年5月份做的手术，手术时病理的癌基因检测结果是：
ER(+ ,85%)
PR(+ ,50%)
HER2(-)
病理会诊报告是：乳腺导管内癌（ductal carcinoma in situ，DCIS）及少许浸润性导
管癌（Infiltrating ductal carcinoma）
2009年9月份完成了6六次化疗，之后开始吃Tamoxifen citrate tablets（他莫西芬片
），每天两片，每半年复查一次，并且每半年做一次bioremediation（生物治疗）。
前几天体检，即在生理周期结束的第一天（黄体期）检查结果：Estradiol（雌二醇）
是257.43pg/ml,黄体期的参考范围是（22.4-256），国内的医生说，正常我吃
Tamoxifen citrate tablets（他莫西芬片），Estradiol（雌二醇）的范围应该是绝经
期的值（0-44.5），因此医生建议不吃Tamoxifen citrate tablets（他莫西芬片），
而是用诺雷德 zoladex (别名是戈舍瑞林，goserelin)和... 阅读全帖 |
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l*****o
发帖数: 26631 | 4 Long-Term Health Risks and Benefits Associated with Spay / Neuter in Dogs
Laura J. Sanborn, M.S.
May 14, 2007
Precis
At some point, most of us with an interest in dogs will have to consider
whether or not to spay / neuter our pet. Tradition holds that the benefits
of doing so at an early age outweigh the risks. Often, tradition holds sway
in the decision-making process even after countervailing evidence has
accumulated.
Ms Sanborn has reviewed the veterinary medical literature in an exhaustive
a... 阅读全帖 |
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l**********1
发帖数: 5204 | 5 if cancer cell
'sox9'
pls refer
PMID 23201164
by Kopp JL et al.
Identification of Sox9-dependent acinar-to-ductal reprogramming as the
principal mechanism for initiation of pancreatic ductal adenocarcinoma.
(2012).
Cancer Cell. 22: 737-50.
PDF link:
HttP: //cmm.ucsd.edu/sander/sander/Home_files/Kopp_CancerCell_2012.pdf
>>
>>>
发信人: wdgca (全是骗银地), 信区: Biology
标 题: Re: genes in controlling cell morphology
发信站: BBS 未名空间站 (Wed Apr 10 16:44:27 2013, 美东)
做了啥treat，用的啥细胞都不说，那就木法猜。
> |
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b**********y
发帖数: 326 | 6 医生诊断为：浸润性导管癌，肿瘤大小为直径3厘米。两周前手术切除了肿瘤，并作了
病理切片。
给这边一位做breast cancer research 的朋友看了病理切片，诊断为
invasive carcinoma with ductal lobular feature, high grade; With DCIS and
lymphovascular invasion
手术完立刻作了chemo,这周六做left breast mastectomy并切除左腋下淋巴。
想问问，有没有可能在这边联络到医生，给看看片子，并讲讲美国这方面的一般做法及
最新进展，术后及化疗期间的恢复和药。 我知道没有检查过病人不能给诊断，但能给
点information, 介绍有哪些药也好啊！国内的医生问这边的药，他们如果知道也会适
量使用。谢谢！！
另外，医生没有作穿刺（穿刺是biopsy吗？还是特指needle biopsy? 什么是surgery
biopsy?),认为穿刺准确率低（约60%），只能作为参考。是这样吗？ |
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s********1
发帖数: 8 | 7 我的肿块体积不大1.5-2.0cm，估计属1期或2a期。病理分型是ER/PR阳性，HER2阴性。
是invasive ductal carcinoma, diagnosed by core biopsy, confirmed by
mammograph and MRI.Genetic test showed no BRCA1/2 mutation.
由于感觉肿块长大了，伴有钝痛，今天又见了医生，想提前手术。但医生觉得没有明显
变大，手术排满了，不能reschedule. 真得很着急，希望术前这两周时间千万别转移，
扩散。
谢谢祝福！
is |
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s********o
发帖数: 3 | 8 今天早上接到医生的电话说 在我的右乳房分泌物发现 rare papillary-like cluster
of ductal cells， 建议立即约医生手术， 医生的语气很沉重的样子， 请问这是
breast cancer 的前兆吗？ 我生了两娃， 每个孩子母乳喂养大概九个月，老二刚满3
岁。 两娃断奶后乳头用手积压有透明和乳壮物出来，身体无任何异样症状， 一直以为
是断奶没断干净， 把这症状给忽略了。 孩子还太小，要是真是癌症可怎么办啊！ 请
教大家约医生的时候注意问些什么问题和需要注意的事项， 谢谢大家了。 |
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M****0
发帖数: 877 | 9 Bless!
首先祝福全家，勇敢面对。The course is challenging but I believe your wife
definitely can go through, with the whole family's support. The management
of side effects of chemo makes it more tolerable now.
Wait for the pathological report first. Certain type breast cancer, such as
mucinous adenocarcinoma, has a better prognosis as it is less aggressive and
responding to chemo well.
Currently, we treat breast cancer with multimodality measures. Local therapy
with surgery and radiation therapy plus system... 阅读全帖 |
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m*******2
发帖数: 152 | 10 谢谢大家的短信。有同学指出 就这孩子的情况看来，袁医生不是最适合的医生。
小孩越来越严重了，主要就是腹胀的严重，特别是吃饭之后越来越涨，而且不停的胀气
打嗝（打嗝非常非常的频繁，几乎可以说是每秒钟都在打嗝！），小孩非常的痛苦。父
母决定尽快到美国就诊，请求大家有了解波士顿儿童医院或麻省总院的朋友给推荐几个
水平高不错的专家。
上个月B超报告：
1. pancreas obscured, no peripancreatic fluid colleciton seen.
2. mildly echogenic portal triads, otherwise unremarkable sonographic
appearance the liver. Increased echogenicity of the portal triads is
nonspecific and of unclear clinical significance in this age group
上个星期的MRI 报告：
1. The gallbladder is moderately distended wi... 阅读全帖 |
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t****u
发帖数: 836 | 11 What It Is:
EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) are two principal
fatty acids found in fish and krill. They belong to a family of nutrients
known as omega-3 fatty acids. DHA can also be obtained from other marine
sources, such as algae (algal oil). EPA and DHA are polyunsaturated fats ("
good" fats, as opposed to saturated fats which are thought to increase the
risk of heart disease). The body can only manufacture limited amounts of EPA
and DHA from the essential fatty aci... 阅读全帖 |
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c******n
发帖数: 5697 | 12 我平时看大纪元时报，大纪元还是挺靠谱的，比很多砖家要靠谱的多，那个乳腺导管原
位癌（DCIS)就是病理切片才确诊的，很多女人的乳房就这样莫名其妙的被割了，很多
男人的床上生活就这样莫名其妙的被剥夺了
【大纪元2013年07月30日讯】（大纪元记者林南编译报导）美国癌症研究专家建议，彻
底改变癌症的定义、诊断和治疗，并从一些常见的诊断中完全消除癌症这一术语。
《纽约时报》报导，这一建议由美国国家癌症研究所的一组癌症研究专家提出，于7月
29日（周一）发表在美国医学协会杂志上。 他们说， 一些癌前病变的病例，比如，一
个名为乳腺导管原位癌（ ductal carcinoma in situ）的疾病， 很多医生认为其不是
癌症，应该将其换名，把“癌”字去掉，则可使患者少些惊吓，也少寻求可能是不必要
的治疗，甚至是潜在的有害的治疗，包括手术切除乳房。 |
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h********n
发帖数: 4079 | 13 Who has done intra-ductal injection of virus into mouse mammary gland?
Thank you. |
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c**l
发帖数: 319 | 14 Hyperlipidemia Causes Pancreatic Inflammation and Ductal Proliferation in
Apolipoprotein E Deficient Mice
Mallen-St. Clair, J.; Joaquin, V. A.; Fisher, E. A.; Bar-Sagi, D.
Pancreas, November 2007,35(4):414-415
请发pdf到g*****[email protected]
包子奉上, Thanks |
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w**f
发帖数: 38 | 17 To define MMTV-Cre expression pattern, I crossed MMTV-Cre mice with Rosa-YFP
reporter mice. Very nice GFP fluorescence signal was seen in ductal trees
of Cre-postive/Rosa-YFP (+/-) mouse mammary glands. I then isolated mammary
epithelial cells using the Stem Cell kit (Collagenase/Hyaluronidase
digestion). No GFP-positive cells were detected using FACS analysis. Can
anyone give some suggestions on how to preserve GFP for FACS? Or can anyone
recommend one good protocol to cut sections from frozen ... 阅读全帖 |
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b**k
发帖数: 1585 | 19 Radiofrequency ablation for advanced ductal pancreatic carcinoma: is this ap
proach beneficial for our patients? A systematic review
[email protected]
/* */
非常感谢! |
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发帖数: 1 | 20 读了一下这篇文章，不喜欢这种研究思路，不能够称之为科学。
该实验室主页上面所挂出来的以下一些文章中，有很多引用率非常的低。
ROCKII inhibition promotes the maturation of human pancreatic beta-like
cells. Nature Communications. 2017 Academic Article GET IT
High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates
that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain.
Cell Stem Cell. 2017 Academic Article GET IT
A Modular Platform for Differentiation of Human PSCs into All Major
Ectodermal Lineages. Cell Stem Cell. ... 阅读全帖 |
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l**x
发帖数: 296 | 22 III score 8 is high grade, not good
Low grade: score 3-5
Intermediate grade: score 6,7
High grade: score 8,9
This is histological grading of invasive ductal carcinoma of breast, based on tubular formation, mitotic count, and nuclear grade.
The link is about cancer staging, which means how extensive the tumor is involved, eg if there is axillary lymph node involved, if there's distant metastasis. |
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i*****r
发帖数: 265 | 23 帮个朋友问的，57岁，下面是病理报告：
Examination Findings
Specimen of right breast mass 4X2X3CM was sent for inspection. A grey nodule
with size of 2.5X2CM was found in the section. Endoscope finding: The tumor
cells were in nest shape and glandular tube. The cells arranged solidly and
grew invasively. Nuclear fission was easy to see, and nuclear atypia was
obvious. No cancer metastasis was found in the 3 pieces of lymph nodes in
the right paracardial region for inspection.
ER(++70%) PR(-) P35(++75%) C-erbB-... 阅读全帖 |
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v*****e
发帖数: 30 | 24 国内的好朋友最近诊断乳腺癌。她有一个年幼的孩子，真的很替她着急担心。最近化疗
两个疗程之后，白细胞下降得很厉害。这里附上她的诊断和问题，这里哪位好心的大侠
能给回答一下？ 她已经把问题翻译成了英文.
Specimen Type: Specimen of modified radical mastectomy right breast
Tumour Site/Location: 2.5 cm from the top of the nipple
Size of Tumour: 2.5 x 2.3 x 1.4 cm
Tumour Type: Mucinous carcinomas, ductal carcinoma in situ was seen around
the surrounding area (low and intermediate grade)
Histologic Grade: (blank)
Intravenous Tumor Thrombus: (+) Nerve Invasion: ( - )
Nipple: no cancer cell ... 阅读全帖 |
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v*****e
发帖数: 30 | 25 感谢Icetea!
Here is the info:
patient age: 41
Family history: no breast cancer family history
medical history: no
Breast cancer with modified right radical mastectomy (right breast) and
axillary lymph node
dissection on 20th of May, 2011.
A lump under her right armpit was self-found but it was not checked out
until 1 and a half months later.
Her histopathology report has revealed that a tumour which was noted to be
at 2.5cm from the top of the nipple, 2.5 cm from the nipple.
It is also rep... 阅读全帖 |
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R*******t
发帖数: 367 | 26 I am a strong advocate for annual screening from the age 40, or earlier if
there is strong family history of family cancer. Screening MRI should also
be considered when calculated Gail score of lifetime breast cancer risk more
than 25%.
A Sweden study with 30 years trial has proven screening mammogram does save
lives, and they only used one-view screening mammogram rather than The two-
views that we use here as standard protocol.
Now there are lots of debates if we should start from 50 or do it ... 阅读全帖 |
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yf
发帖数: 272 | 27 Your mother has stage IIIA(T3N0M0) ER positive/PR positive/HER2 positive
Invasive ductal carcinoma. There is discrepancy regarding the PR status and
Ki 67 percentage. Ki 67 is usually not so reliable. PR status is considered
positive in the second hospital pathology but negative in the first hospital
pathology. Anyway the cancer is high risk, your mother needs chemotherapy,
radiation therapy, 1 year of trastuzumab(Herceptin), and at least 5 years of
aromatase inhibitor. Every part of the treatme... 阅读全帖 |
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i*****r
发帖数: 265 | 28 【 以下文字转载自 MedicalCareer 讨论区 】
发信人: integer (integer), 信区: MedicalCareer
标 题: 关于乳腺癌，大牛看看
发信站: BBS 未名空间站 (Wed Feb 4 02:49:02 2015, 美东)
帮个朋友问的，57岁，下面是病理报告：
Examination Findings
Specimen of right breast mass 4X2X3CM was sent for inspection. A grey nodule
with size of 2.5X2CM was found in the section. Endoscope finding: The tumor
cells were in nest shape and glandular tube. The cells arranged solidly and
grew invasively. Nuclear fission was easy to see, and nuclear atypia was
obvious. No cancer met... 阅读全帖 |
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a******2
发帖数: 143 | 29 之前在这里得到很多帮助，我妈妈在天津肿瘤医院的乳腺癌治疗进行的还算顺利，刚做
完第7期化疗，我妈妈身体好又用了好的保护的药，反应不太大。现在化疗快做完了，
大夫说化疗完需要做放疗，但我妈妈对放疗很抵触认为伤害太大不需要，现在还没同意
做放疗，我在这里想问问这个放疗有多大必要？大夫说〉5厘米就要放疗。非常感谢！
！！
下面是我妈妈的情况
- 作了手术 Completely removed the right breast and removed nearby lymph
nodes.
- 在做化疗 共8期（4x4),已作了7期，第一个四期：5% 表柔吡星(Epirubicin)+ 环磷
酰胺（Cyclophosphamide）；第2个四期：多西他赛Docetaxel + Herceptin
- 大夫说化疗完我妈妈得作放疗（25times, 5times/week for 5 weeks)和一年的靶向
(Hercepti年），然后吃来曲唑(Letrozole) 2.5mg once every day for 5 years. 现
在我妈妈就对这个放疗抵触：（
我妈妈病例：
- 65岁，... 阅读全帖 |
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