g*********3
发帖数: 177 | 1 文章已经提得很清楚了，GWAS和Regulatory region有很大的overlapping，不知道你有
没有看paper~
个人认为ENCODE可以很好的说明GWAS的价值~
当然了GWAS SNP result到底能explain多少，找到的SNP怎样解释，这个不是GWAS的事
情！ |
|
u*********1
发帖数: 2518 | 2 这个，还是少说点废话空话大话。。。
说个对自己研究最实在的：
我分析exome data，希望寻找可能的disease-causing mutation；目前大家主要关注的
还是exon里面的nonsynonymous mutation，或者frameshift mut （主要还是SNP，然后
加上少数indel）；而且还要通过1000G的筛选找到rare mutation，还要根据疾病的模
型进一步筛选。所以筛选到最后，反正我自己的project就是找不到。
那么我就想问，是不是这个ENCODE出来了以后，等于说更多的genome被annotate了？那
我们的寻找disease mutation的眼光就不用只放在exon上了？。。。可能致病位点就是
在那些regulatory sites上呢。。。当然这样就不能仅限于exome测序了。。。。。但
到底多少疾病是因为regulatory region的SNP导致的呢？我看nature genetics上很多
遗传病或者遗传相关的疾病还是exome的突变导致的 |
|
u**********d
发帖数: 573 | 3 那就得先定义每个stage，每个cell type，离不开靠谱的marker组合，如果没有好用的
表面marker来标记每个细胞类型，那么还得想其它办法来办法富集这些细胞。这项工程
看起来比encode要宏伟得多。 |
|
D****e
发帖数: 14 | 4 这篇文章好几个基本常识都错了。。
。。。A scan over all human chromosomes (22 autosomes + X + Y) reveals that
there are 150,281,981 CpG sites。。
作者到底有没有读过ENCODE那一系列的文章啊。。怎么发表的。。 |
|
M*P
发帖数: 6456 | 5 这些人理论是不是under selection就没有功能。问题是很多human disease，或者是
human specific 功能就未必是under selection。
encode不用进化作为依据就是为了找到靠进化无法理解的功能片段。当然认为所有open
chromatin都是有功能的也是夸张了。 |
|
h**********r
发帖数: 671 | 6 Title:
Bacterial XylRs and synthetic promoters function as genetically encoded
xylose biosensors in Saccharomyces cerevisiae
Biotechnology Journal
最好是把补充材料也帮忙down下来吧。我的email是：[email protected]
(function(){try{var s,a,i,j,r,c,l,b=document.getElementsByTagName("script");l=b[b.length-1].previousSibling;a=l.getAttribute('data-cfemail');if(a){s='';r=parseInt(a.substr(0,2),16);for(j=2;a.length-j;j+=2){c=parseInt(a.substr(j,2),16)^r;s+=String.fromCharCode(c);}s=document.createTextNode(s);l.parentNode.r... 阅读全帖 |
|
b*******a
发帖数: 17 | 7 A Survey of Various Encoding Schemes and Associated Placement Algorithms
Applied to Packing and Layout Problems
Santosh Tiwari, Georges Fadel and Vladimir Gantovnik
[-] Author Affiliations
Santosh Tiwari, Georges Fadel, Vladimir Gantovnik
Clemson University, Clemson, SC
Paper No. DETC2006-99271, pp. 609-618; 10 pages
doi:10.1115/DETC2006-99271
From:
ASME 2006 International Design Engineering Technical Conferences and
Computers and Information in Engineering Conference
Volume 1: 32nd Design Autom... 阅读全帖 |
|
S*********y
发帖数: 261 | 8 我用SAS读一个data包括中文field，这个没有问题，输出的时候用Export proc，想要
设置encoding为utf = 8的csv文件，这个该怎么设置？我在网上找不到。。。
谢谢。 |
|
s*****d
发帖数: 267 | 9 使用ODS，输出到Excel里面，ODS支持Encoding.
到了Excel里面，你想转CSV还不是分分钟的事情。
给包子吧 |
|
u*******n
发帖数: 158 | 10 如此可以省去大家经常需要在浏览器中选择
encoding的麻烦。天天点，都快吐了。 |
|
c****i
发帖数: 2635 | 11 在美实用常用网站网址（下）
http://www.mitbbs.com/pc/pccon_3509_186897.html
●美国官方网址大全
●美国银行网站网址大全
●美国实用商务网站地址大全
●美国汽车网站大全
●国外医学网址大全网站
●美国电视台网址大全
●全球在线电视台网址
●世界各主要船运公司网址 (websites for all major shipping companies)
――――――――――――――――――――――――――――――――――――
美国官方网址大全
1、美国政府官方网站入口 www.firstgov.gov
2、http://lcweb.loc.gov/global/executive/fed.html (可进入美各政府网站)
3、白宫 www.whitehouse.gov
4、美国国务院 www.state.gov
5、美国财政部 www.treas.gov
6、美国司法部 www.usdoj.gov
7、美国商务部 www.doc.gov
8、商务部国际贸易局 www.ita.doc.gov
9、美国内政部 www.doi.gov... 阅读全帖 |
|
f**d
发帖数: 768 | 12 这是一本计算神经科学的优秀著作，全文拷贝这里（图和公式缺），有兴趣的同学可以
阅读
如需要，我可以分享PDF文件（－－仅供个人学习，无商业用途）
From Computer to Brain
William W. Lytton
From Computer to Brain
Foundations of Computational Neuroscience
Springer
William W. Lytton, M.D.
Associate Professor, State University of New York, Downstato, Brooklyn, NY
Visiting Associate Professor, University of Wisconsin, Madison
Visiting Associate Professor, Polytechnic University, Brooklyn, NY
Staff Neurologist., Kings County Hospital, Brooklyn, NY
In From Computer to Brain: ... 阅读全帖 |
|
a********h
发帖数: 245 | 13 转一个相关的博客：
http://www.michaeleisen.org/blog/?p=1179
Blinded by Big Science: The lesson I learned from ENCODE is that projects
like ENCODE are not a good idea
By Michael Eisen | Published: September 10, 2012
When the draft sequence of the human genome was finished in 2001, the
accomplishment was heralded as marking the dawn of the age of “big biology
”. The high-throughput techniques and automation developed to sequence DNA
on a massive scale would be wielded to generate not just genomes, but
refe... 阅读全帖 |
|
l**********8
发帖数: 305 | 14
************************************************************
上个完整的LOG， 谢谢大家了
****************************************************************
NOTE: PROCEDURE PRINTTO used (Total process time):
real time 0.00 seconds
cpu time 0.01 seconds
25
26 *-----------------------------------------------------;
27 %macro process(year,yr,file,first,numobs);
28
29 data cartemp;
30 set loc.carl&year.
31 (firsto... 阅读全帖 |
|
T*******x
发帖数: 8565 | 15 Chrome的字体和encoding设置我一直没搞懂：
应该是中文网页设置为中文字体，英文网页设置为英文字体。
而中文网页或英文网页应该由encoding来区别。
encoding由网页自己给出，或者根据内容自动决定。
所以字体设置应该有两种：
比如western encoding就设为sans-serif，也就是英文字体。
而GB18030 encoding就设为宋体。
这是我理解的字体设置和encoding的关系，不知道对不对。
但是这个chrome的字体设置和encoding设置很奇怪：
就一套，不分情况的：
比如encoding，你只能选一个：utf-8, iso, windows, gb, ...
然后字体分为：standard font, serif font, sans-serif font, ...
每种只能选一个字体。
这跟我对字体和encoding的理解都对不上。不知道怎么选择。
比如我想要中文用宋体，英文用sans-serif字体。怎么选？ |
|
z***b
发帖数: 127 | 16 一种encoding只有1 byte encode或者两byte encode两种形式，如果说第一byte的第一
个bit是0，那么这个bit开始的这个byte encode一个字符；如果第一个byte的第一位是
1，那么他一定是两个byte encode一个字符，并且他的第二个byte的首bit可以是1或者
0. 题目要求，给你一串encode，请问最后一个字符是一个byte encode的还是两个byte
encode的。不允许顺序parse bit串。
这题的考点是啥啊？ |
|
e***y
发帖数: 4472 | 17 Google Chrome Terms of Service
These Terms of Service apply to the executable code version of Google Chrome
. Source code for Google Chrome is available free of charge under open
source software license agreements at http://code.google.com/chromium/terms.html.
1. Your relationship with Google
1.1 Your use of Google’s products, software, services and web sites (
referred to collectively as the “Services” in this document and excluding
any services provided to you by Google under a separate writte... 阅读全帖 |
|
d******i
发帖数: 7160 | 18 多谢。WebGUI终于走起来乐。用的是deluge-web。
不过加了个中文电影torrent之后，
putty得到:
[root@alarm ~]# deluge-web
[ERROR ] 14:42:35 json_api:270 'utf8' codec can't decode byte 0xfd in
position 1: invalid start byte
Traceback (most recent call last):
File "/usr/lib/python2.7/site-packages/deluge/ui/web/json_api.py", line
292, in render
d = self._on_json_request(request)
File "/usr/lib/python2.7/site-packages/deluge/ui/web/json_api.py", line
264, in _on_json_request
return self._send_response(request, response... 阅读全帖 |
|
d******i
发帖数: 7160 | 19 多谢。WebGUI终于走起来乐。用的是deluge-web。
不过加了个中文电影torrent之后，
putty得到:
[root@alarm ~]# deluge-web
[ERROR ] 14:42:35 json_api:270 'utf8' codec can't decode byte 0xfd in
position 1: invalid start byte
Traceback (most recent call last):
File "/usr/lib/python2.7/site-packages/deluge/ui/web/json_api.py", line
292, in render
d = self._on_json_request(request)
File "/usr/lib/python2.7/site-packages/deluge/ui/web/json_api.py", line
264, in _on_json_request
return self._send_response(request, response... 阅读全帖 |
|
w*******s
发帖数: 3417 | 20 【 以下文字转载自 Military 讨论区 】
发信人: wamgjames (胡志明胡志明互助), 信区: Military
标 题: 三中国人？（貌似像中文名字）在密歇根涉信用卡犯罪被捕
发信站: BBS 未名空间站 (Thu Apr 7 16:41:31 2011, 美东)
Zhou Chen
Kang He
Shifu Lin
http://www.mlive.com/news/grand-rapids/index.ssf/2011/03/suspec
How men allegedly used stolen credit cards in $9,500 scheme at Meijer
Published: Friday, March 25, 2011, 8:08 AM Updated: Friday, March 25,
2011, 11:52 AM
By John Agar | The Grand Rapids Press The Grand Rapids Press
Follow
Share17
22
Share close Google Buzz D... 阅读全帖 |
|
w*******s
发帖数: 3417 | 21 【 以下文字转载自 Military 讨论区 】
发信人: wamgjames (胡志明胡志明互助), 信区: Military
标 题: 三中国人？（貌似像中文名字）在密歇根涉信用卡犯罪被捕
发信站: BBS 未名空间站 (Thu Apr 7 16:41:31 2011, 美东)
Zhou Chen
Kang He
Shifu Lin
http://www.mlive.com/news/grand-rapids/index.ssf/2011/03/suspec
How men allegedly used stolen credit cards in $9,500 scheme at Meijer
Published: Friday, March 25, 2011, 8:08 AM Updated: Friday, March 25,
2011, 11:52 AM
By John Agar | The Grand Rapids Press The Grand Rapids Press
Follow
Share17
22
Share close Google Buzz D... 阅读全帖 |
|
w*******s
发帖数: 3417 | 22 Zhou Chen
Kang He
Shifu Lin
http://www.mlive.com/news/grand-rapids/index.ssf/2011/03/suspec
How men allegedly used stolen credit cards in $9,500 scheme at Meijer
Published: Friday, March 25, 2011, 8:08 AM Updated: Friday, March 25,
2011, 11:52 AM
By John Agar | The Grand Rapids Press The Grand Rapids Press
Follow
Share17
22
Share close Google Buzz Digg Stumble Upon Fark
Share
Email
Print
AP File PhotoGRAND RAPIDS – Three men who traveled here from New York and
Pennsylvania are accused of en... 阅读全帖 |
|
w****i
发帖数: 2316 | 23 【 以下文字转载自 Military 讨论区 】
发信人: wamgjames (胡志明胡志明互助), 信区: Military
标 题: 三中国人？（貌似像中文名字）在密歇根涉信用卡犯罪被捕
发信站: BBS 未名空间站 (Thu Apr 7 16:41:31 2011, 美东)
Zhou Chen
Kang He
Shifu Lin
http://www.mlive.com/news/grand-rapids/index.ssf/2011/03/suspec
How men allegedly used stolen credit cards in $9,500 scheme at Meijer
Published: Friday, March 25, 2011, 8:08 AM Updated: Friday, March 25,
2011, 11:52 AM
By John Agar | The Grand Rapids Press The Grand Rapids Press
Follow
Share17
22
Share close Google Buzz D... 阅读全帖 |
|
发帖数: 1 | 24
Download pdf published by SfN (Chapter from 'The History of Neuroscience in
Autobiography, Volume 8' edited by Larry R. Squire)
Yuh-Nung Jan's CV
Lily Jan's CV
Yuh-Nung Jan and Lily Jan
Birth
Family History and Growing Up
National Taiwan University
The Hiking Trip to Shitou in the Spring of 1967
Graduate School Application
Graduate Study at Caltech (1968锟974)
Seymour Benzer Lab (1974锟977)
Steve Kuffler锟絪 Lab at H... 阅读全帖 |
|
t***s
发帖数: 4666 | 25 【 以下文字转载自 Military 讨论区 】
发信人: wamgjames (胡志明胡志明互助), 信区: Military
标 题: 三中国人？（貌似像中文名字）在密歇根涉信用卡犯罪被捕
发信站: BBS 未名空间站 (Thu Apr 7 16:41:31 2011, 美东)
Zhou Chen
Kang He
Shifu Lin
http://www.mlive.com/news/grand-rapids/index.ssf/2011/03/suspec
How men allegedly used stolen credit cards in $9,500 scheme at Meijer
Published: Friday, March 25, 2011, 8:08 AM Updated: Friday, March 25,
2011, 11:52 AM
By John Agar | The Grand Rapids Press The Grand Rapids Press
Follow
Share17
22
Share close Google Buzz D... 阅读全帖 |
|
p*****2
发帖数: 21240 | 26
Some engineers got tired of dealing with all the different ways of encoding
status messages, so they decided to invent their own. In their new scheme,
an encoded status message consists of a sequence of integers representing
the characters in the message, separated by spaces. Each integer is between
1 and M, inclusive. The integers do not have leading zeroes. Unfortunately
they decided to compress the encoded status messages by removing all the
spaces!
Your task is to figure out how many differ... 阅读全帖 |
|
p*****2
发帖数: 21240 | 27
Some engineers got tired of dealing with all the different ways of encoding
status messages, so they decided to invent their own. In their new scheme,
an encoded status message consists of a sequence of integers representing
the characters in the message, separated by spaces. Each integer is between
1 and M, inclusive. The integers do not have leading zeroes. Unfortunately
they decided to compress the encoded status messages by removing all the
spaces!
Your task is to figure out how many differ... 阅读全帖 |
|
g*****g
发帖数: 34805 | 28 In C++, you do use encoding. Let's take it this way, even the simplest
ASCII is an encoding scheme. Everything in computer is encoded, data is
encoded, instruction is encoded. How can a string not encoded?
In most C++ systems, the native char array is OS dependent. For example,
ISO-8859-1 would be the default encoding on windows. If you are using
western characters only, you can call String.getBytes("ISO-8859-1"),
then you can apply your C++ tricks. That being said, Java provides a
strong String |
|
|
x****B
发帖数: 103 | 30 我前些天被老印这么坑过一次。
他说让我写个encoding的算法。
给了我俩个例子。
abc 输出 abc
abbccc 输出 a2*b3*c
写完了，烙印说我算法有bug.我看了半天没看出来。
过了两三分钟。说encode
a2*b3*c我的算法encoding以后也是a2*b3*c。decoding端没有办法decode。
然后这就出问题了。a2*b3*c按照这个例子就需要encode成这个字符串本身。然后他说
你应该自己考虑encode各种字符串让每一个不同的字符串encode结束了有区别。
按照这种模式，要求修改了两三次以后，白板上写的乱七八糟没法看了时间到。
可以参考这种思路。 |
|
t******l
发帖数: 10908 | 31 现在这个 hypothesis 问一个 what if：
What if 这两个娃的所有的 working memory / long term memory 等等等等，如果不
考虑 encoding 的 raw power，都一模一样。连 brain 的 total encoding 的 raw
power 也一样，唯一的差别是 the way of encoding (encoding algorithm) is
different。
也就是说，hyperlexia's encoding algorithm focused on lexicon level, 而 neuro
-typical's encoding algorithm balanced between lexicon to pragmatics to
critical thinking.
So, the question is, (in this hypothetical case), what will happen? |
|
t******l
发帖数: 10908 | 32 第二个问题，是 “intention to learn“ 远远不如 ”novelty to brain“ 更有效。
[quote]
Intention to learn
Studies have shown that the intention to learn has no direct effect on
memory encoding. Instead, memory encoding is dependent on how deeply each
item is encoded, which could be affected by intention to learn, but not
exclusively. That is, intention to learn can lead to more effective learning
strategies, and consequently, better memory encoding, but if you learn
something incidentally (i.e. without intention to ... 阅读全帖 |
|
n********k
发帖数: 2818 | 33 As you folks are discussing Cori, I happened to read his autobiography and
find it both interesting and enlightening:)))...BTW, it sounds Richard Axel
is a lot nicer than what I/we have heard...or in another word, his cruelty
is rooted in his obsession with science and indifference to humanity:))); As
well, it is pretty...he noted Cori but left his ex out...pretty human or
not human?
Autobiography
Richard AxelNew York City is my world. I was born in Brooklyn, the first
child of immigrant parents... 阅读全帖 |
|
p*******m
发帖数: 20761 | 34 猪猪也可以
Most Mac users have an old iPhone or two lying unused in a drawer. One great
way to repurpose these devices is to turn them into security cameras – all
you need is an app that does a good job of capturing and streaming video
from the iPhone’s camera. In this blog post we review a few such apps,
which work with our Mac NVR software SecuritySpy. To turn an iPhone into an
effective CCTV surveillance camera it should be permanently connected to a
power supply, and have access to a good WiFi si... 阅读全帖 |
|
t******l
发帖数: 10908 | 35 我觉得你说的 working memory 可能有一定道理。但这可能不是 working memory 本身
（对应于 simple memory-span test），而是 working memory 的 higher-order
encoding（对应于 complex memory-span test）。
而另一个方面，普通人（neuro-typical）在做 working memory / memory-span test
的时候，受 proactive interference（过去经验）on brain encoding level的影响，
上来做 memory-span test 的时候，可能会有一种 “Holy-crap! I cannot even do
it!” 的感觉（因为跟自己平时的 working memory brain encoding 方式大相径庭）。
但是 proactive interference（过去经验）on brain encoding level 对普通人而言
，是一把双刃剑。在两三天以后，也正是因为 new proactive int... 阅读全帖 |
|
f**********g
发帖数: 4709 | 36 看你闲成这样，我都替你难受。
现在没被攻克的数学猜想还挺多的吧，你要不要划拉一道来玩上个两三年？
: 第二个问题，是 “intention to learn“ 远远不如 ”novelty to brain“ 更
有效。
: [quote]
: Intention to learn
: Studies have shown that the intention to learn has no direct effect on
: memory encoding. Instead, memory encoding is dependent on how deeply
each
: item is encoded, which could be affected by intention to learn, but
not
: exclusively. That is, intention to learn can lead to more effective
learning
: strategies, and conse... 阅读全帖 |
|
f**********g
发帖数: 4709 | 37 看你闲成这样，我都替你难受。
现在没被攻克的数学猜想还挺多的吧，你要不要划拉一道来玩上个两三年？
: 第二个问题，是 “intention to learn“ 远远不如 ”novelty to brain“ 更
有效。
: [quote]
: Intention to learn
: Studies have shown that the intention to learn has no direct effect on
: memory encoding. Instead, memory encoding is dependent on how deeply
each
: item is encoded, which could be affected by intention to learn, but
not
: exclusively. That is, intention to learn can lead to more effective
learning
: strategies, and conse... 阅读全帖 |
|
l*****g
发帖数: 2087 | 38 中国科学院院士李家洋
生平简介
李家洋（1956.7-）安徽肥西人。植物分子遗传学家，中国科学院院士，研究员。
中国
科学院副院长、党组成员。1982年毕业于安徽农学院（现安徽农业大学），1991年获美国
布兰代斯（Brandeis）大学博士学位，1991—1994年在美国康乃尔大学汤普逊（Boyce
Th
ompson）植物研究所进行博士后研究工作。历任中国科学院遗传研究所所长助理、所长，
遗传与发育生物学研究所所长。
李家洋主要从事植物分子遗传学研究，他利用模式植物拟南芥与重要粮食作物水稻探
索植物生长发育的调控机理。近年来的主要研究工作包括：采用图位法克隆了水稻分蘖控
制基因MOC1，开拓了水稻分蘖控制分子机理研究的新领域；利用水稻脆秆突变体分离了
B
C1基因，阐述了水稻机械强度的控制机理；通过获得的拟南芥胆碱生物合成突变体，初步
明确了胆碱合成与植物温度敏感雄性不育性的关系；通过图位克隆法分离出导致细胞死亡
的基因MOD1，明确了初级代谢途径的缺陷会导致植物细胞凋亡；利用转基因技术，创制出
色氨酸与吲哚乙酸合成量改变的转基因植物，从而提出植物生长素吲哚乙酸生物合成途径
的新模... 阅读全帖 |
|
d****n
发帖数: 5 | 39 (1)Java works internally with Unicode, so when compiling source code files
that used a Chinese encoding such as Big5 or GB2312, you need to specify the
encoding to the compiler in order to properly convert it to Unicode.
javac -encoding big5 sourcefile.java
or
javac -encoding gb2312 sourcefile.java
(2)If you read chinese chars from a file or database, most likely it is gb2312
or big5 encoding, then you have to map them to Unicode. |
|
l*****c
发帖数: 1153 | 40 I assume everyone knows what goodbug said, what he said is well known right.
But, there is "raw bytes". What I did not say clear is, it is the raw bytes
of a specific encoding.
Say, you encode the string "今狐冲" in UTF-8, it is actually store in memory
as "E4 BB 8A E7 8B 90 E5 86 B2" (of course, when I paste it here, it is
encoded in another encoding schema). What I need is each of these individual
raw bytes.
C++ or Java. There is only default encoding. |
|
a*******e
发帖数: 3021 | 41 luit -encoding gbk telnet mitbbs.com
Segmentation fault
luit -encoding gb2312是可以，但是还是得把gnome-terminal设成char encoding
gb2312才行，否则还是乱码。。。
其实我用gnome-terminal可以登mitbbs，但是就是没办法用命令行设置character
encoding.要不然就可以做个快捷方式就行了。
gnome-terminal --command="telnet mitbbs.com" +设置char encoding的参数。。。
（可惜找不到）。。。 |
|
w*****s
发帖数: 122 | 42 Can I use GB2312?
Maybe. A conforming XML processor must support UTF-8 and UTF-16 (Unicode). But XML can be encoded using almost
any character set. It is the parser-writer's decision which encodings to support.
Outside the XML processor, the document is encoded in GB2312 (e.g. the EUC encoding of GB2312 and ASCII, also
called cn-euc);
Inside the XML system, the document is encoded as ISO10646. (ISO10646 is the character set that Java uses. It is
the same character set as Unicode. |
|
g*********d
发帖数: 233 | 43 MicroRNA 和病毒
作者：王磊
上海交通大学生命学院研究生
摘要：
microRNA(miRNA)是真核生物体内一组内源性的 21—25nt 长的非编码蛋白质的短序列
RNA，它们能通过碱基配对的方式与生物体中的 mRNA 分子相结合来参与调节基因的表
达。自 2000 年至今，miRNA 的研究发展的速度极快并且影响的范围也非常的广泛，而
且分别在2002年和2003年度中miRNA入选了Science杂志年度十大科技突破。因此，
miRNA是 RNA 研究的又一个突破，被称为 RNA 的第二次革命。目前的研究已发现
miRNA 参与了很多重要的生命活动过程涵盖了发育、凋亡、代谢、人类疾病以及病毒侵
染等方面。在病毒侵染宿主和宿主抵抗病毒的过程中病毒编码的 miRNAs 和宿主编码的
miRNAs 均发挥了重要的作用。这无疑为病毒的侵染以及宿主抵抗病毒的侵染的研究提
供了新的思路和新的领域。因此，本文的主要目的在于阐述 miRNA 的一些基本概况以
及在病毒中主要的研究方向和进展，最后对这个具有跨时代意义的小分子进行展望。
关键词：miRNA vmiRNA 功能 宿主的 miR... 阅读全帖 |
|
z*t
发帖数: 863 | 44 Beutler得奖，Medzhitov会不会有意见？
http://www.sciencedirect.com/science/article/pii/S1074761309002
Ruslan Medzhitov
This year marks the 20th anniversary of a publication (Janeway, 1989) that
in many ways revolutionized our understanding of the immune system. As part
of the proceedings of the Cold Spring Harbor Symposium on Immune Recognition
, the paper authored by the late Charles A. Janeway, Jr. was not a standard
peer-reviewed publication. In fact, Charlie used to refer to it as “the
best paper I've ... 阅读全帖 |
|
r**********e
发帖数: 587 | 45 TFBS在ENCODE project里面已经做烂了
http://www.nature.com/encode/#/threads
如果你关注的是纯计算TFBS prediction，我觉得已经很准确了。如果没记错，ENCODE
用的是MACS这个软件
https://github.com/taoliu/MACS
但是坦白说从纯biology角度，现在大家完全不满足于binding site；
1. Binding doesn't mean function! 好文章现在都要求证明binding后是否调控了
gene expression change
2. 蛋白-DNA和蛋白-蛋白作用非常复杂，所以很多ChIP实验本身就值得质疑，很多猫腻
3. ENCODE project当年豪言说根据他们的研究human genome 80%都有function，当时
受到了批评和质疑
你去看UCSC genome browser里面，一个位点可能有几十个TF在bind；你从单个TF
binding很难预测说，一旦XX TF bind后会有什么作用
对于noncoding human genome... 阅读全帖 |
|
w*******y
发帖数: 60932 | 46 Looking for this model and found it on ebay (usually retails for $130).
Only 10 left so act fast.
LINKY:
http://cgi.ebay.com/Hauppauge-WinTV-HVR-1800-HDTV-Tuner-Capture
Background:
Hauppauge WinTV-HVR-1800 TV Tuner Card PCI-e, Model 78XXX.
Here is the story. I purchased a large quantity of these cards from a
computer intergrator that order the cards special with only the tuners.
That is why you don't see the FM radio, S-video or composite connections.
I will included a CD that has the driv... 阅读全帖 |
|
c*****c
发帖数: 188 | 47 4.When store the binary tree, store (a) structure encoding (b) data, which
is a list containing the content of each internal nodes
For encoding a binary tree, see
http://en.wikipedia.org/wiki/Binary_tree#Methods_for_storing_bi
DB contains that binary tree if it has a record of the exact encoding and
data of the that tree.
DB contains a variant of the binary tree if it has a record of the exact
encoding but the permutation of the data of that tree |
|
g***s
发帖数: 3811 | 48 这个zoom是把每一个2×2扩大到4×4.是不是？
首先可以容易发现，这些字符串都有一个特性：把它分成前后两半，只有最后一位是不
同的。
根据这个特性，我们可以把任何一个2^n位的字符串，一一对应到一个n+1位的字符串
encode(s) = encode( s的前一半）+ s后一半的最后一位
同时，这个逆过程也是存在的。设为decode(s).具体就不列了。
那么现在我们题目可以转化成为，找f(s)的左边。
算法如下：
假设encode(s)=src=x1x2...xn
t[a]=b
t[b]=a
t[c]=d
t[d]=c
string prev(src,n) {
if (n==-1) return '' ; //最左元素的左边元素为同行最右边的；
lastChar = src[n-1];
if (lastChar=='d' || lastChar== 'b‘） return src.substring(0,n-1) + t(
lastChar);
else return prev(src.substring(0,n-1)) + t(lastChar);
}
所以，... 阅读全帖 |
|
y*****i
发帖数: 141 | 49 照着Maxthon的编码解法写了一个：
#include
#include
#include
#include
using namespace std;
bool bool_vec_none(const vector & vec) {
for(auto elem : vec) {
if (elem) {
return false;
}
}
return true;
}
bool bool_vec_all(const vector & vec) {
for(auto elem : vec) {
if (!elem) {
return false;
}
}
return true;
}
string word_abbreviation(string target, vector dict)
{
if (t... 阅读全帖 |
|
