c*******o
发帖数: 8869 | 1 需要判断一个STRING里是否有"ACDD" 或者"FADS", 怎么写, 谢了 |
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b******n
发帖数: 592 | 2 normally "(ACDD|FADS)" will do. Which langauge is it? |
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t****a
发帖数: 1212 | 3 对于你说的这个OO更符合人类习惯的论调表示怀疑，我没看到研究证据表明你说的这点。
如果真想OO，前面提到的那些多态相关的方法可以在FP语言里实现这点。
common-lisp也实现了CLOS的OO方式，看各人喜好用吧。
我倒是看到一堆大牛在批评的OO：
Luca Cardelli wrote a paper titled "Bad Engineering Properties of Object
-Oriented Languages".[32]
Richard Stallman wrote in 1995, "Adding OOP to Emacs is not clearly an
improvement; I used OOP when working on the Lisp Machine window systems, and
I disagree with the usual view that it is a superior way to program."[33]
A study by Potok et al.[34] has shown no... 阅读全帖 |
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p*****2
发帖数: 21240 | 4
看来我的感觉有可能是对的。刚刚看到这段话。Java这么强调DP，确实有先天不足的原
因。其他语言如果强大的话，很多东西都很自然，没必要这么强调DP了。所以Java总是
把DP挂在嘴边make sense的，但是没有必要把DP抬那么高。因为其他语言里可能是很简
单就搞定了的事情。
The GoF Design Patterns are perhaps the most popular design fads of Software
ever. However some people argue that they are more or less solutions to the
deficiencies of Language itself (particularly C++/Java) and if the language
is powerful enough they are redundant. |
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g****t
发帖数: 31659 | 5 GooG,FB应该是世界上最大的两家广告公司了。
你说人家FB是渣，这说明你没有商业常识。
而且我认为，很可能，FB其实在创造信息给用户的原理上是比GooG要更高一代的。
你查查他家最近一个2.4亿人的软件实验什么的一个资料,看看你能看明白么。
简单的说，从GooG来的东西，一般不如从fb来的让人觉得更新鲜。
(不算GooG+)
AG还有点过硬产品带来真正收入，FL就是FAD渣。 |
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g****t
发帖数: 31659 | 6 GooG,FB应该是世界上最大的两家广告公司了。
你说人家FB是渣，这说明你没有商业常识。
而且我认为，很可能，FB其实在创造信息给用户的原理上是比GooG要更高一代的。
你查查他家最近一个2.4亿人的软件实验什么的一个资料,看看你能看明白么。
简单的说，从GooG来的东西，一般不如从fb来的让人觉得更新鲜。
(不算GooG+)
AG还有点过硬产品带来真正收入，FL就是FAD渣。 |
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m******t
发帖数: 635 | 7 如果连你这样比较高水平的都觉得复杂的话，那么Scala可能真的没有前途，就跟
MongoDB一样，等这一波吃螃蟹的吃出问题了，就算热过去了。大家再跳下个热点，简
历上多了一堆类似CORBA, DCOM那样的鸡肋。
追过太多的东西，对这些FAD（和时装差不多）免疫了。Clojure倒是真的不错，可能永
远就是小众了，小众就小众吧，哈哈 |
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m******t
发帖数: 635 | 8 如果连你这样比较高水平的都觉得复杂的话，那么Scala可能真的没有前途，就跟
MongoDB一样，等这一波吃螃蟹的吃出问题了，就算热过去了。大家再跳下个热点，简
历上多了一堆类似CORBA, DCOM那样的鸡肋。
追过太多的东西，对这些FAD（和时装差不多）免疫了。Clojure倒是真的不错，可能永
远就是小众了，小众就小众吧，哈哈 |
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g*********e
发帖数: 14401 | 9 技术含量高不一定赚钱，原子弹比bit钱币难搞吧，照样不如卖茶叶蛋的。
fb 这种 取得一时fad的能成功，说明了人类社会的一个根本道理，情商高的，懂得如
何manipulate人的感情的，控制人心的，玩各种plot的，能够rule智商高的。而且智商
高的人清高，喜欢内讧。 |
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z****g
发帖数: 75 | 10 1. 简单好用，上手快，特别是对熟悉javascript的FE programmers
几行程序就能搞个HTTP server出来，做个原型真是很快、方便
想想如有用C++，Java这得多麻烦
这是很多startup选择nodejs的原因
2. 性能还行
异步编程，做request processing，这个效率比起 one thread per request(TPR)的
model
效率提高很多。
这种单线程实现 10k／sec 的request processing很轻松
其实目前所有的高性能network server都是异步实现的，只是用C++／Java实现一直很
繁琐
因为没有比较好用的lib来支持。在牛x公司里这样的c++库一直是有的， 只是多数人无
法接触到。
这个估计是ebay，linkedin之类公司选择nodejs的主要考虑。
这些公司显然内部没有牛x的在Java／c++上的异步库
Facebook自己有一个还凑合的异步库，所以它们不需要
后来linux kernel thread 性能提高以后，TPR model实现10k／sec的处理速度也行了
但是由于每个t... 阅读全帖 |
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c*********e
发帖数: 16335 | 11 5年之后会不会被别的新贵给取代？
programming和fashion太象了，一年一个样，谁也说不清为啥流行这个。
cloud大公司用还行，小公司没那个必要。但是，大公司担心隐私被nsa查，为了技术而
牺牲公司安全性，是一个问题。 |
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e******0
发帖数: 291 | 12 这种在大公司貌似还是能提高生产力的，能用5年应该说明还是不错的了，lol |
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c*********e
发帖数: 16335 | 13 angularjs的老版本可以支持ie8,但是有很多没fix的bug. angularjs,不支持ie8的版本
，fix了这些bug,但是不能支持ie8. |
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w***g
发帖数: 5958 | 15 "Functional style programming seems new, almost like a fad, but functions ar
e a key part of (almost) every computer language."
作者完全不懂啊。
不管大人小孩，都不应该选FP作为入门语言。 |
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n****l
发帖数: 1739 | 16 quantum computing is probably a fad, as the previous AI. anyone really
understand how this shit works besides someone in China? |
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p*******r
发帖数: 4048 | 17 I didn't say it's useless. I just say the current fad is overblown.
Thank you for your paper suggestion. |
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p*******r
发帖数: 4048 | 18 偏激的哲学观点 is a good sign, because it means he knows how to think for
himself, instead of following fad. |
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h*******o
发帖数: 4884 | 19 BACE was not found to be hyper-active or over-express in either FAD or SAD...
My point is that target at Amyloid generation could be wrong from the
begining. |
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h*******o
发帖数: 4884 | 20 Most of the vaccine candidate worked beautifully in animal models, which are
transgenic models (in a sense more similar to FAD). None of them worked in
human trials so far. They did reduce amyloid load or plaques (thanks to PIBS
compound and PET image), but no improvement in cognitive function. |
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k*****o
发帖数: 1486 | 21 阿...我别把别人家误导了.
一般molecular biology lab存细胞或者enzyme的时候用普通冰箱(不是frost-free的),
这样会使它们更稳定.
Reagent如ATP,NAD(P)H,FAD(P)H为了严格的enzymatic assay,也会放在里面.
其他东西能4度放着的,比如说抗生素什么的就放有defrost功能的冰箱里也无所谓.
另外,frost-free冰箱可以随便开关,普通冰箱不suppose你经常这么做的..| |
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C*********m
发帖数: 213 | 22
自闭症这种复杂的疾病，希望能找到一个基因确定病因这种研究套路未必能走上正确的
方向。比如Alzheimer's disease，根据FAD病例中找到APP, presenilin突变，从而认
为Abeta是致病因素。但是据此做了几十年，结果基本走进死胡同。现在新的观点认为
Abeta是次生因素，可能是AD的结果而不是原因。原生因素依然在探索中。很可能是多
种因素协同作用的结果。 |
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z*h
发帖数: 773 | 23 I do not trust the credibility of FAD and USDA. Most of scientists are
stupid. I used to trust them before. When I did more research and become a
first class scientit, I start realizing how stupid they are .
Let me give an example. Cotton seed oil. In a short term, you cannot see any
negative impact on human. In a long term, some compounds can keep serum. |
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u*********1
发帖数: 2518 | 24 Once a jolly pyruvate enters the matrix
Of a mitochondrion, so they say,
A decarboxylating, complex dehydrogenase
Converts it to acetyl coenzyme A
Waltz around the cycle,
Waltz around the cycle,
Waltz around the TCA cycle today,
A decarboxylating, complex dehydrogenase
Turns pyruvate to acetyl CoA
Oxaloacetate looking for a partner
Thinks "active acetate" looks OK,
Condensing enzyme arranging a merger
Makes a new citrate, and kicks out CoA.
Waltz around the cycle,
Waltz around the cycle,
Waltz a... 阅读全帖 |
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H**O
发帖数: 89 | 26 早上起来在C&EN上看到一则新闻说百济神州(Beigene)以2.33亿美元的价格向德国Merck
转让了BGB-283的除中国外的全球范围内的研发和销售。除此，协议还包括了未来在销
售上可能取得净销售收入基础上可达两位数百分比的提成(原文)。 BGB-283是一种用于
治疗癌症的第二代BRAF inhibitor，目前处于临床前开发阶段，准备明年进入临床测试
期，有效针对黑色素瘤和大肠癌。BRAF蛋白是MAPK通道的下游成分，与细胞内的信号传
导有关，能促进细胞生长，2002年发现在人类癌症细胞里有突变(DOI: 10.1038/
nature00766)。而目前市面上的BRAF inhibitor类的药物有罗氏的Vemurafenib，Brand
name是Zelboraf，FAD 2011年批准通过的。
另外一个上个星期刚被FDA批准用于黑色素瘤晚期治疗的BRAF inhibitor类药物则是葛
兰素史克Dabrafenib，Brand name是Tafinlar。
百济神州这回可算是一夜变身高富帅，这也是近两年来第二次跨国制药公司获取中国研
发的药物。第一次是由和记黄埔向阿斯康... 阅读全帖 |
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k*******1
发帖数: 187 | 27 企业管理总是一个潮流引领着另一个潮流，一个新概念接一个的出现。
有很多都是曾经被追捧过的，现在已经逐渐普及或者没落。例如 TQM，ISO，6 sigma
等等。
大家能不能尽量的告诉我你所知道的这些有一定影响的概念或者潮流？
谢谢。 |
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s*****w
发帖数: 2065 | 28 你能不能先简单解释一下你说的这几个呢？没准能理出点思路，呵呵。 |
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l***r
发帖数: 233 | 31 Trash research, just a fad |
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q**i
发帖数: 174 | 32 There is an article in a recent Fortune magazine featuring Fama on the
efficient market hypothesis vs. behavioral finance / economics.
It was quite an entertaining read, especially for those "experts" among us who
regarded behavioral finance / economics as fad or even BS. |
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k****u
发帖数: 1 | 33 有无搞错？ 科技和金融能一样？ wall street 永远都不可能成为 silicon valley。 金
融博士吃香的很呢。要不profile
能那么疯？ 哈哈。 |
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q**i
发帖数: 174 | 34 I would have said that you were right back 10 years ago when
derivatives were the rage.
Now? go to blumberg and count how many "quant" headhunters
there are - you can do that with one hand, in ease too.
It is just so last millenium, to say the least. |
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p****a
发帖数: 32 | 35 Emm...
It is nice to see qili on this board after a long time.
If we refer to the whole investment industry, my opinion is that demand for
new financial products still exists and should be stable, hence financial
engineering should be a stable field. However, there is a VAST supply for the
potential financial engineers. During the last millenium, the job market have
already been quite over supplied.
However, I hold the opinion that demand for financial engineers still exists
but will not be expl |
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h*******l
发帖数: 359 | 36 mit empirical io牛人辈出，从老的joskow，Schmalensee到nancy rose，只不过他们
的方法和berry，pakes那帮人的方法不同。现在structural io还属于比较早的发展阶
段，大概很少人真的相信strutural io的结论，这个领域目前主要看谁解决了一个
更难的问题，谁就更牛。很难说给人类对于经济生活的理解留下什么，到底是不是一个
fad只有时间才能说明。
这个星期levitt和list上传了一篇nber工作论文，其实更像一篇战斗檄文，很明显他们的目标就是要灭掉strutural io，就像当年princeton那帮人灭掉strutrual labor一样。当然他们的方法entry barrier更高，因为很少人象levitt这样可以接近公司高层，这场仗最后怎样也只有时间才能说明。
ebay
io |
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r***l
发帖数: 298 | 37 These days, it is getting harder to get into law school. Although the number
of test takers and applicants are going down, each school is becoming more
selective, some even announced enrollment cuts.
These days, it is a lot harder to get a firm job, even for law students with
science or engineering undergraduate degrees, including EE.
This correlates with the reality that clients are cutting budgets, firms are
competing furiously by underbidding each other.
Patent law practice in my area took of... 阅读全帖 |
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F****3
发帖数: 1504 | 38 请问板上各位大神啊！
从000到255有256个数字，把这256个数字进行转换用字母a到j表示成密码，但是是三位
。请问可以知道每个数字对应哪个吗？谢谢！！！！
aaa
aab
aad
aag
aah
aai
abb
abc
abh
abj
aca
acg
adi
aea
aec
aed
aef
afc
afg
afh
agd
ahb
ahf
aib
aic
aie
aig
aje
aji
baf
baj
bbb
bbg
bbi
bbj
bcb
bcf
bci
bcj
bdc
bdf
bdh
beh
bfb
bfc
bff
bgd
bge
bgg
bgj
bhf
bhg
bhi
bib
bic
bid
bif
bjc
bjg
bjh
caa
cah
cca
ccg
cci
cdg
cef
ceh
cej
cfg
cfh
cga
chi
chj
cib
cih
cjb
cjf
cjj
daa
dac
dad
dae
dce
dcg
dda
ddd
ddh
deb
dec
ded
def
dff
dfh
dgb
dge
dgf
dhe
dia
dif
dii
djb
djc
eac
eai... 阅读全帖 |
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l********y
发帖数: 2295 | 39 【 以下文字转载自 Pre_Resident_Club 俱乐部 】
发信人: lovelypony (lovelypony), 信区: Pre_Resident_Club
标 题: steps学习的口诀
发信站: BBS 未名空间站 (Fri Oct 22 21:56:46 2010, 美东)
响应老刀的号召，冒个小泡。有很多难记的东西，编过一些口诀，先贡献一个，回头有
空了再慢慢添。大家有好的口诀也都来分享，这样大家都省时省力。
先贡献一个pony比较经典的口诀，认识pony的都会的，呵呵。
for step1:
trinucleotide repeat expansion diseases:
My Ex is Hungry on Fri.
My (大家都Call Tall Girl, CTG)=Myotonic dystrophy
Ex (比较肉麻的Call Ge Ge, CGG)=fragile X syndrome
Hungry (点了个鸡蛋Call An Egg, CAG)=Huntington's disease
Fri (大家AA制的，Go AA, GAA)=Fried... 阅读全帖 |
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l********y
发帖数: 2295 | 40 做题中场，贡献一下小宝的故事。这个貌似答应了kaye斑竹的。pony压箱底的，呵呵。
小宝的7个LP：
大LP（VitB1,thiamine）
二LP(VitB2,riboflavin)
三LP（Vit B3, niacin）
四不吉利，没有四老婆。
五LP（Vit B5, pantothenate）
六LP（Vit B6, pyridoxine）
七LP（Vit B7, biotin）
小LP（Vit B12, cobalamin）
大LP（VitB1,thiamine）:派（Pyruvate dehydrogenase）阿铜（alpha-ketoglutarate
dehydrogenase）从侧门（branched-chain AA dehydrogenase）搬运铜（
transketolase）换私房钱。好像大LP都喜欢攒私房钱，嘻嘻。
二LP擅长flirt（联想到riboflavin,中间有个fla，还联想到FAD/FMN）。flirt太多了唇干裂（Cheilosis），媚眼抛多了角膜都血管化了（Corneal vascularization）。
三LP是lesbian，p... 阅读全帖 |
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g********n
发帖数: 4054 | 41 Cash rich large pharma are now purchasing biotechs just to get their
products. They slashed and outsourced their research section as the fad.
. |
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s******1
发帖数: 239 | 42 Just came back from a small conference on China. Everything was generally fine
under the context of the "potato strategy of presentation."
Afer presentation on Chinese foreign policy, a senior professor from UC Berkey
asked, "Why all you guys study Chinese foreign policy from a social
constructivism perspective?As some scholars think that China has lots of
realpolitk thoughts. How about a realist approach on China?" |
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w***t
发帖数: 404 | 43 right; I like his work a lot. A really smart guy. But cannot think of many
others. |
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w***t
发帖数: 404 | 44 right; I like his work a lot. A really smart guy. But cannot think of many
others. |
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k***g
发帖数: 7244 | 45 Alastair Johnston? I think he is most popular IR + SC guy in recent years. |
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w***t
发帖数: 404 | 46 right; I like his work a lot. A really smart guy. But cannot think of many
others. |
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h****t
发帖数: 632 | 47 Suisheng Zhao, in DU.His written work is not bad, but his spoken English is
really unbearable. |
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