f*********s
发帖数: 792 | 1 两种孕期维生素，一种有iron (ferrous fumarate)，另外一种没有iron (ferrous fumarate)，
只有iron, elemental (carbonyl iron)。谁知道这个区别在什么？哪一种比较好？ |
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l********8
发帖数: 491 | 2 iron usually comes in ferrous sulfate or ferrous fumarate. ferrous sulfate
is more commonly used because ferrous sulfate is better absorbed than
ferrous fumarate. but iron supplements are irritating to the stomach, so
ferrous fumarate is an alternative if ferrous fulfate is too harsh for the
stomach. |
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p****u
发帖数: 239 | 3 Dimethyl fumarate has won FDA approval to treat relapsing-remitting forms of
multiple sclerosis and will be sold under the name Tecfidera, the agency
said Wednesday.
Manufactured by Biogen Idec, the drug is also known as BG-12. It becomes the
third oral disease-modifying medication available to treat MS. Others
include fingolimod (Gilenya) and teriflunomide (Aubagio).
Dimethyl fumarate has a novel mechanism of action relative to existing MS
drugs. It is believed to activate the nuclear factor-li... 阅读全帖 |
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p****u
发帖数: 239 | 4 http://www.medpagetoday.com/Neurology/MultipleSclerosis/38122?i
Dimethyl fumarate has won FDA approval to treat relapsing-remitting forms of
multiple sclerosis and will be sold under the name Tecfidera, the agency
said Wednesday.
Manufactured by Biogen Idec, the drug is also known as BG-12. It becomes the
third oral disease-modifying medication available to treat MS. Others
include fingolimod (Gilenya) and teriflunomide (Aubagio).
Dimethyl fumarate has a novel mechanism of action relative to exi... 阅读全帖 |
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v**********m
发帖数: 5516 | 5 临床试验无效？你是挖坑的吧。
http://www.fda.gov/ForConsumers/byAudience/ForPatientAdvocates/
Nucleoside Reverse Transcriptase Inhibitors (NRTIs)
Brand Name Generic Name Manufacturer Name Approval Date Time to Approval
Combivir2 lamivudine and zidovudine GlaxoSmithKline 27-Sep-97 3.9 months
Emtriva3 emtricitabine, FTC Gilead Sciences 02-Jul-03 10 months
Epivir4 lamivudine, 3TC GlaxoSmithKline 17-Nov-95 4.4 months
Epzicom5 abacavir and lamivudine GlaxoSmithKline 02-Aug-04 10 months
Hivid6 zalcitabine, dideoxycy... 阅读全帖 |
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s******a
发帖数: 472 | 6 http://www.philly.com/philly/health/HealthDay668074_20120827_FD
MONDAY, Aug. 27 (HealthDay News) -- A new pill to treat HIV infection that
combines four medicines and only has to be taken once a day was approved by
the U.S. Food and Drug Administration on Monday.
Stribild, which will be marketed by maker Gilead Sciences, contains the HIV
drugs elvitegravir, cobicistat, emtricitabine and tenofovir disoproxil
fumarate. It will be prescribed to people who have never been treated for
HIV infection, ... 阅读全帖 |
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j*******1
发帖数: 266 | 7 “作为FDA，没有任何incentive去为了降低industry的cost，而降低他们的标准和要求。
正常的思路应该是在达到FDA的标准的情况下，怎么采取更好的办法，去降低R&D的成本
.”
FDA 要怎么做是它的事，我只是说如此一来很多病治不了。正常的思路应该FDA认清自
己的问题，想办法解决问题。FDA 的规矩是人定的，是为人服务的，人是可以改规矩的。
“Gilead最新的HIV药，他们称为Quad，一共四个有效成分，其中两个是NCE，分别为
Elvitegravir和cobicistat。另外两个成分是emtricitabine和tenofovir disoproxil
fumarate。这个NDA已经被FDA接受，而且很可能会批准。这不只是个例，只要愿意找，
可以找到更多。
HIV是我说的2类病，另外两个成分emtricitabine和tenofovir disoproxil
fumarate 已证明对它有效，在加上Elvitegravir和cobicistat 有多少benefit。 而且
这种是两个NCE的有几列？更不要说更多的NCE了。而3类病，没有人知道需几个NCE。... 阅读全帖 |
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z*******4
发帖数: 285 | 8 算了，你脑子大概也被活摘过
懒得跟你解释，贴个清单吧：
累计研究数量 注册号 注册日期 研究者单位 研究者单位（英文） 注
册题目 注册题目（英文) 预计纳入参试者日期
1 ChiCTR2000029308 1/23/2020 武汉市金银潭医院（武汉市传染病医院）
Wuhan Jinyintan Hospital (Wuhan Infectious Diseases Hospital) 一项评价
洛匹那韦/利托那韦和干扰素-α2b联合治疗武汉新型冠状病毒肺炎(COVID-19)住院患者
的疗效和安全性随机、开放、空白对照的研究 A randomized, open-label, blank-
controlled trial for the efficacy and safety of lopinavir-ritonavir and
interferon-alpha 2b in hospitalization patients with novel coronavirus
pneumonia (COVID-1... 阅读全帖 |
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s**c
发帖数: 34339 | 9 我去年吃zyrtec,没用，今年吃allegra,还是没用。
眼药是ketofifen fumarate。
跟鼻子痒，眼睛痒比起来，那种咳嗽起来要吐血的感觉更让人难受 |
|
s**c
发帖数: 34339 | 10 allegra
我前几天也是咳嗽的都快吐血了，这两天开始慢慢的好起来，基本上没有那么撕心裂肺
的咳嗽了。
上周眼睛痒的恨不得扣出来，用那个ketotifen fumarate eye drops坚持滴，现在也基
本上不怎么痒了 |
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s**c
发帖数: 34339 | 11 推荐allegra D ＋ ketotifen fumarate ophthalmic solution |
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f*********s
发帖数: 792 | 12 是什么？
iron (ferrous fumarate)是什么？
这两种铁对人的身体有什么不同作用吗？
多谢。 |
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g**********e
发帖数: 416 | 13 我吃anti bi-polar 药 -- Lamotrigine , Quetiapine Fumarate..从去年9月开始吃，
大概四个月后，月经开始不正常了，现在不正常已经两个月。原来是31-32天（就算一
个月吧）来一次；现在仍然是31-32天，但是这中间会多来一次。每31-32天来的那次，
仍然跟以前一样，月经量很大。而这中间多来的一次，月经是棕色发黑，会持续一个多
礼拜。很担心，闭经这些。 |
|
g*********o
发帖数: 20357 | 14 侄子23岁心脏病，请见附件诊断
现在的用药如下，请专家们给看看这个用药行不行，多谢！
根克通（盐酸曲美他嗪片）20mg
trimetazidine hydrochloride tablets 一天3次 一次一片
安博维（厄贝沙坦片）0.15g
Irbesartan tablets 一天一次 一次半片 晚上服用
阿司匹林肠溶片（aspirin enteric-coated tablets) 100mg 一天一次，一次一片 晚
上服用
康忻（富马酸比索洛尔片）bisoprolol fumarate tablets 5mg 一天半片 早服用
地高辛（Davoxin）0.25mg 早半片
呋塞米（Furosemide tablets) 20mg 一天一片早服用
螺内酯20mg或氨苯蝶啶50mg半月交替 一天一片
辅酶q10 100mg一天一个(doctor's best high absorption) |
|
t********n
发帖数: 82 | 15 ☆─────────────────────────────────────☆
vanillahf (annie) 于 (Tue Aug 18 15:56:34 2009, 美东) 提到:
有没有孕妇非孕妇之分，或者含量的要求，一天吃几片？
今天见完OB，后来打电话说我缺铁，电话是我lg接的，当时他见老板呢，所以也没有听
太清楚，说是一回让我回电，结果电话号码太多，也不知道是谁给我打的，有一个人说
什么牌子都性，去walmart买就行，不知道有没有什么特殊要求对孕妇？
☆─────────────────────────────────────☆
oxhorn (^_^) 于 (Tue Aug 18 16:04:12 2009, 美东) 提到:
我的是医生开的，缺铁也分缺哪种铁
盒子上有：Ferrous Asparto Glycinate, Ferrous Fumarate
OB说我需要补的是后者
我还问过prenatal里已经含铁了，够不？OB说即使吃prenatal，还得吃这个
另外，平时多吃牛肉等含铁的食物，一是补铁，二是防止便秘，吃铁剂最大的副作用是
便秘， |
|
e*****3
发帖数: 137 | 16 如果要吃铁剂，试试 ferrous fumarate 吧, less constipating than Ferrous
sulfate.
还有吃 cherry 也挺好的，含铁。 |
|
u*****e
发帖数: 917 | 17 有DHA的那个是有red 40的，你要看ingredients
costco网上查到的：
Ingredients:
Fish Oil, Calcium Carbonate, Gelatin, Soybean Oil, Ascorbic Acid, Ferrous
Fumarate, Water, Glycerin, Zinc Oxide, Niacinamide, Soy Lecithin, dl-Alpha
Tocopheryl Acetate, Yellow Beeswax, Titanium Dioxide (artificial color),
Pyridoxine Hydrochloride, Thiamin Mononitrate, Beta Carotene, Riboflavin,
Red 40, Folic Acid, Yellow 6, Blue 1, Cyanocobalamin, Cod Liver Oil, Vitamin
D3 (Cholecalciferol). |
|
t******g
发帖数: 17520 | 18 @@ 我往国内带过不下1打善存，上次有朋友用我的卡到costco 买了10瓶
现在看到这个文章
One of the most popular supplements on the market is the multi-vitamin
Centrum. What many people don’t realize is that this multi-vitamin is
probably doing more harm than good. Is Centrum a vitamin supplement of
synthetic chemical cocktail? (Tweet it!)
A Few Centrum Facts:
Centrum is a product produced by the company Pfizer, one of the largest
pharmaceutical companies in the world.
The dosages of most of the nutrients in Centrum are negligi... 阅读全帖 |
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u*********1
发帖数: 2518 | 19 Once a jolly pyruvate enters the matrix
Of a mitochondrion, so they say,
A decarboxylating, complex dehydrogenase
Converts it to acetyl coenzyme A
Waltz around the cycle,
Waltz around the cycle,
Waltz around the TCA cycle today,
A decarboxylating, complex dehydrogenase
Turns pyruvate to acetyl CoA
Oxaloacetate looking for a partner
Thinks "active acetate" looks OK,
Condensing enzyme arranging a merger
Makes a new citrate, and kicks out CoA.
Waltz around the cycle,
Waltz around the cycle,
Waltz a... 阅读全帖 |
|
l********k
发帖数: 14844 | 20 La cucaracha, la cucaracha, The cockroach, the cockroach,
ya no puede caminar can't walk anymore
porque le falta, porque no tiene because it's lacking, because it doesn'
t have
marihuana pa' fumar. marijuana to smoke.
Ya murió la cucaracha The cockroach just died
ya la llevan a enterrar now they take her to be buried
entre cuatro zopilotes among four buzzards
y un rató... 阅读全帖 |
|
H********g
发帖数: 43926 | 21 可能是说富马酸干 fumaric acid，因为是反式构象，所以自己一个分子不能成酸酐
它的顺式异构体是马来酸，可以自己环化形成马来酸酐
富马酸酐这个不错，晚上发奖。 |
|
g**********e
发帖数: 416 | 22 我吃anti bi-polar 药 -- Lamotrigine , Quetiapine Fumarate...从去年9月开始吃
，大概四个月后，月经开始不正常了，现在不正常已经两个月。原来是31-32天（就算
一个月吧）来一次；现在仍然是31-32天，但是这中间会多来一次。每31-32天来的那次
，仍然跟以前一样，月经量很大。而这中间多来的一次，月经是棕色发黑，会持续一个
多礼拜。很担心，闭经这些。 |
|
u*********1
发帖数: 2518 | 23 Once a jolly pyruvate enters the matrix
Of a mitochondrion, so they say,
A decarboxylating, complex dehydrogenase
Converts it to acetyl coenzyme A
Waltz around the cycle,
Waltz around the cycle,
Waltz around the TCA cycle today,
A decarboxylating, complex dehydrogenase
Turns pyruvate to acetyl CoA
Oxaloacetate looking for a partner
Thinks "active acetate" looks OK,
Condensing enzyme arranging a merger
Makes a new citrate, and kicks out CoA.
Waltz around the cycle,
Waltz around the cycle,
Waltz a... 阅读全帖 |
|
s******a
发帖数: 252 | 24 The golden age of metabolism is coming again.
The signaling roles of metabolites have been unappreciated for too long,
even prominent examples like cAMP are everywhere.
Stability and low concentration limit the study of many of them. We may know
less than half of metabolites in our body right now.
High resolution mass spectrometers and systems biology will power the next
wave of discoveries. The fist half of 20th century was the first golden age.
Pasted below are Nobel prizes related to metaboli... 阅读全帖 |
|
s******a
发帖数: 252 | 25 The golden age of metabolism is coming again.
The signaling roles of metabolites have been unappreciated for too long,
even prominent examples like cAMP are everywhere.
Stability and low concentration limit the study of many of them. We may know
less than half of metabolites in our body right now.
High resolution mass spectrometers and systems biology will power the next
wave of discoveries. The fist half of 20th century was the first golden age.
Pasted below are Nobel prizes related to metaboli... 阅读全帖 |
|
A******y
发帖数: 2041 | 26 A lot of successful drugs are hard to publish in good journal because
sometimes the mechanism is not exactly known. Gleevec's first paper was
published in cancer research (IF ~8). The compound itself with its target
was published in Structures (IF~2). How about dimethyl fumarate for MS? It
was published in journal I have never heard of. Just imagine that you tell
the editors and reviewers that a glutathione depleting agent is going to
work in MS. They will laugh at you.
Btw, NIH still fund... 阅读全帖 |
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w********h
发帖数: 12367 | 27 这个帖子是勾引我回帖阿。。。
PMMA有很多不好的地方：
（1）不可降解；
（2）聚合散发大量的热；
（3）残余单体有毒；
（4）比较硬，不匹配骨组织。
PMMA可以临床使用是因为历史原因。战争不允许苛刻的条件。
现在的替代产品主要是可交联固化可降解的材料，
其中以polypropylene fumarate (PPF)为代表。 |
|
J**********i
发帖数: 925 | 28 http://www.netherlandscorporatenews.com/archive/en/2006/08/14/f046.htm
TORONTO, Ontario--(BUSINESS WIRE)--Aug. 14, 2006--Gilead Sciences,
Inc. (Nasdaq:GILD) today announced that the company has signed
non-exclusive license agreements to provide generic versions of
tenofovir disoproxil fumarate (sold by Gilead under the brand name
Viread(R)) to three generic manufacturers in India. These license
agreements grant to Emcure Pharmaceuticals Ltd., Hetero Drugs Ltd. and
Strides Arcolab Ltd. the rights |
|
L******r
发帖数: 522 | 29 作为FDA，没有任何incentive去为了降低industry的cost，而降低他们的标准和要求。
正常的思路应该是在达到FDA的标准的情况下，怎么采取更好的办法，去降低R&D的成本.
Gilead最新的HIV药，他们称为Quad，一共四个有效成分，其中两个是NCE，分别为
Elvitegravir和cobicistat。另外两个成分是emtricitabine和tenofovir disoproxil
fumarate。这个NDA已经被FDA接受，而且很可能会批准。这不只是个例，只要愿意找，
可以找到更多。
不过你要抬杠说要三个4个，那我就没办法了。但是这些例子你不知道，并不意味着你
的想法正确。当然，你爱怎么想怎么想，那是你的自由。
trials, |
|
y*****l
发帖数: 5997 | 30 http://seekingalpha.com/article/315312-biotech-companies-promis
Exelixis' (EXEL) advanced PI3K-delta research and development preclinical
program attracted Merck (MRK), known as MSD outside of the United States and
Canada. PI3K-delta is a therapeutic target that academic researchers and
the drug industry are racing to develop, therapeutic antagonists for both
inflammatory diseases and cancer. To get to the Exelixis program, Merck
agreed to pay $12 million in an upfront payment in addition to pot... 阅读全帖 |
|
