v********a
发帖数: 646 | 1 点击fulltext，只有这么多内容：
http://cancerdiscovery.aacrjournals.org/content/5/7/OF20.abstra
Chimeric antigen receptors (CAR) link antigen-binding domains with T-cell
signaling domains and represent potential anticancer agents. However, only
CARs targeting CD19 in hematologic malignancies have demonstrated
significant clinical efficacy. To identify the mechanisms underlying the
poor efficacy of CARs targeting other tumor antigens, Long and colleagues
compared the in vivo antitumor activity of CD19 CAR T ... 阅读全帖 |
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z*y
发帖数: 84 | 2 有好办法（相对简单快速）分辨GD2和o-acylated GD2（乙酰化在末端糖基唾液酸9位的
O上）
吗?比如说TLC，或简单的修饰一下然后检测。别说做NMR，没现成的条件，行不通。样
品是细胞，我的设想是先萃取分离带电荷的脂类分子，然后跑TLC。但是担心成分太杂
，分辨率不好，而GD2和o-acylated GD2的分子量又相差不大。
GD2的结构可以在wiki找到，这里是链接
https://en.wikipedia.org/wiki/GD2
或者怎样上图？
另外GD2和o-acylated GD2都是2个净正电荷，对吧？
谢谢！ |
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z*y
发帖数: 84 | 3 Posted this in the Chemistry board, but few people responded. See if can get
more suggestions here.
有好办法（相对简单快速）分辨GD2和o-acylated GD2（乙酰化在末端糖基唾液酸9位的
O上）吗?比如说TLC，或简单的修饰一下然后检测。别说做NMR，没现成的条件，行不通
。样品是细胞，我的设想是先萃取分离带电荷的脂类分子，然后跑TLC。但是担心成分
太杂，分辨率不好，而GD2和o-acylated GD2的分子量又相差不大。
GD2的结构可以在wiki找到，这里是链接
https://en.wikipedia.org/wiki/GD2
或者怎样上图？
谢谢！ |
|
e****u
发帖数: 17 | 4 My answer:
1. SELECT EP1.id
FROM EMP EP1
WHERE EP1.sal>(SELECT AVG(EP2.sal)
FROM EMP EP2
WHERE EP1.department=EP2.department)
2. SELECT vendor_id
FROM GOODS
GROUP BY vendor_id
HAVING COUNT(*)>=(SELECT COUNT(*)
FROM GOODS GD2
WHERE GD2.vendor_id='002') |
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t********6
发帖数: 43 | 5 谢谢ls两位.我估计我没把问题说清楚.
总体的population:
cluster1
D+ D-
E+ a1 b1
E- c1 d1
cluster2
D+ D-
E+ a2 b2
E- c2 d2
OR(ture)=(a1+a2)(d1+d2)/(b1+b2)(c1+c2)
在我的sample里:
cluster1
D+ D-
E+ a1 fb1
E- c1 fd1
cluster2
D+ D-
E+ a2 gb2
E- c2 gd2
OR(sample)=(a1+a2)(fd1+gd2)/(fb1+gb2)(c1+c2)
OR(sample) not equal to OR(ture), because f not equal to g;
Bias就是这样产生的.
f,g已知,分别是每个cluster里sample的control的百分比.
我用的是inverse probability=1/f or 1/g for control group. |
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t****y
发帖数: 168 | 6 祝福。希望是治愈率好的类型
听到这类消息总是很伤心。
Gd2抗体治疗？ |
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s****n
发帖数: 489 | 8 想买个地方做论坛.php+ mysql
php最好4.x以上支持gd2.0+ 因为论坛要有大量照片.GD库可以自动缩放图片
所以这个功能很重要
其次是解析的域名国内要能访问到.以前registerfly注册的域名国内访问不到
mysql最好可以创建2个以上数据库.
其他容量价格方面到不是问题.
有哥们推荐一个吗? |
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b*******g
发帖数: 1309 | 9 Carbohydrate-based vaccines are widely used to prevent infectious diseases,
but their use to fight cancer has so far proved problematic. To increase the
chance of success, researchers are pursuing a number of avenues that have a
common goal: enhance carbohydrates’ ability to induce the human immune
system to mount an effective fight against cancer.
Carbohydrates are studded all over the surfaces of human cells, where they
help with essential functions ranging from protein transport and cell-cell... 阅读全帖 |
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