j***z
发帖数: 105 | 1 It is true that so far molecular biomarkers have not reached people's
expectation in cancer diagnosis.The only example I can think of is BRCA1/2.
Perhaps deep sequencing of circulating tumor DNA will reach clinic someday
and transform the early diagnosis. Cancer research is heavily skewed towards
treatment, which in my view is wrong.
But I think it is unfair to say "癌症分子水平研究对近年的癌症治疗的进展
贡献微小". There are already impressive examples like Gleevec and PD-1/CTLA
-4. I think in next decade we will see... 阅读全帖 |
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a**********2
发帖数: 3726 | 2 Thank you for your fair comment.
BRCA is not used for screening for breast cancer or ovarian cancer in
general population. For breast cancer screening, still mammography for older
than 50 yo. For ovarian cancer, no screening markers. BRCA test is only
used when there is strong family history of breast/ovanrian cancers.
As for treatment, Gleevec is one of the very few molecules that are targeted
for therapy. Compared with the numbers of known molecules in signal
transuction, the successful molec... 阅读全帖 |
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l****b
发帖数: 400 | 3 well, 看看PCR，ELISA,FISH的发明对诊断的贡献。看看Avastin, anti-CD20,gleevec
对治疗的贡献。当然这里更多的是涉及制药，但是生物方面的概念对这些药物的开发起
到重要的作用。
Prostate |
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T******l
发帖数: 13 | 4 google一下Gleevec (Imatinib) 治疗慢性粒细胞白血病的历史，你就知道自己的无知
了。 |
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T******l
发帖数: 13 | 5 google一下Gleevec (Imatinib) 治疗慢性粒细胞白血病的历史，你就知道自己的无知
了。 |
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A******y
发帖数: 2041 | 6 Gleevec Brian Druker breakthrough in CML and target specific therapy. |
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A******y
发帖数: 2041 | 7 I still go for Brian Druker on Gleevec. A drug >>> than theory. And if
they ever going to give a DNA nanotechnology, Peter Dervan is the
grandfather! |
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A******y
发帖数: 2041 | 8 A lot of successful drugs are hard to publish in good journal because
sometimes the mechanism is not exactly known. Gleevec's first paper was
published in cancer research (IF ~8). The compound itself with its target
was published in Structures (IF~2). How about dimethyl fumarate for MS? It
was published in journal I have never heard of. Just imagine that you tell
the editors and reviewers that a glutathione depleting agent is going to
work in MS. They will laugh at you.
Btw, NIH still fund... 阅读全帖 |
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B******f
发帖数: 2489 | 9 最近几天看到生物版又有人讨论起来cancer research方向来，不由挠动俺的一点点小
想法。
俺曾经做过几年癌症研究，也发过几篇说的过去的cancer课题论文，应该说对癌症还是
有一点点皮毛的了解的。现就自己一点点局限的认识，跟大家交流几句。因为俺已经离
开基础研究领域了，要是谁从这点交流中得到一点灵感，万一得了炸药奖或将来卖个牛
x的抗癌药，千万要pm俺一下，好替你高兴。
单刀直入说吧，一句话概括：俺觉得现在癌症基础研究方面有个很大的缺陷，即对分化
（differentiation)投入的力量过于薄弱，而主要精力仍然盯在proliferation和
apoptosis上。
怀疑是不是很多纯生物专业毕业的同仁不太了解癌症的病理分级分期。在病理上，定性
一个癌凶猛与否的最重要指标就是differention程度，而proliferation和apoptosis的
markers如Ki67，p53等只在很少数的癌症诊断中使用。一般而言，分化越低，
prognosis越差。
人类现在治疗癌症的基本或主要手段是什么？绝大多数都是能切则切，首选手术；然后
是放疗，化疗；生物制剂如Gleev... 阅读全帖 |
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A******y
发帖数: 2041 | 10 Gleevec hasn't won, yet. It won't be them. I still bet on Brian Druker (
and maybe Carl June) for advancement in targeted leukemia therapies because
they are just waiting literally. |
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a********k
发帖数: 2273 | 11 Thomas M. Roberts
人自己都没claim有啥贡献。。。Druker当时是他实验室唯一做这个的，公司找上门的
时候就和Druker联系了。Gleevec确实也是在他到OHSU之后才做到CML里面的。 |
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A******y
发帖数: 2041 | 12 That's not the problem. The problem is that the treatment life extension is
marginal. Also, it is for prostate cancer. Also, if you have prostate
cancer, you are more likely died of old age than the cancer. If you can
curve a cancer, you can set crazy amount of money. Look at Gleevec, the
price has doubled over last few years but you have to buy it or you die. |
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A******y
发帖数: 2041 | 13 I won't cite a site that spells drug name wrong. If you look into those FDA
approved drugs, they are all have a lead molecule (already known or exist)
to work with or already exist in a HTS library (Gleevec). If you found a
new target and there is absolute no lead, you are in trouble. Btw, sometime
understanding the biology of the target will help because the substrate of
the target usually will give you some lead. |
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o*******a
发帖数: 242 | 14 青蒿素作为一类新药，得奖希望比gleevec大。
上个月，好几篇讲青蒿素耐药的，都发的是science. |
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A******y
发帖数: 2041 | 15 The medicine and chemistry committees talk to each other and sometimes award
are linked.
If today's medicine is focusing on tropical diseases, then for chemistry, it
could go to people who are studying tropical diseases such as malaria,
sleeping sickness, or cholera toxin (a lot of x-ray people). If the focus
is on targeted therapy, my prediction still got a shot this year (Gleevec to
Druker et al). |
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O**********a
发帖数: 317 | 16 Gleevec 的话，张亭栋也应该有戏
[在 ArtyArty (Art Lover!) 的大作中提到：]
：The medicine and chemistry committees talk to each other and sometimes
award are linked.
：
：........... |
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a*******5
发帖数: 50 | 17 自从美国开始加大投入，现在基本一枝独秀了。就说肿瘤治疗吧， 都是在美国做出来
的。
化疗： cisplatin, taxol....
靶向药物： gleevec, herceptin....
免疫治疗： ctla4, pd1. |
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A******y
发帖数: 2041 | 18 Exactly,if you ever read prologue of some statistics text or program (i.e.
Prism). The author literally said that if you have to use the program to
tell you if you hypothesis is significant or not; it is likely NOT in the
real life. For example, Gleevec phase I is 100% effective! Do you really
need a program to tell you that it works? |
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A******y
发帖数: 2041 | 19 Some of you are confusing Nature, Science, and Cell publications and Western
medicine. How many chemicals published in NSC actually made it all the way
through clinical trials. Let me guess...almost none. Gleevec first
publication is in Structures (IF ~ 2). It finally made it to Cancer
Research because no one believes that targeting Bcr-Abl is possible and is
the right target.
Clinical trials just a way to approach a medical issue using scientific
methods. Does a medicine work and benefit t... 阅读全帖 |
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A******y
发帖数: 2041 | 20 It is about hype...CNS is very good at doing that. Very good for academia,
but poorly for industry. When Gleevec was first discovered, the guy cannot
get it published in CNS at all (including sub-journal) and finally settled
for Cancer Research (its crystal structure with Bcr-Abl was first, it
published in a IF 2 journal).
of
that
However
Just |
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g****1
发帖数: 261 | 22
To scientists who developed Gleevec also known as Imatinib. |
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A******y
发帖数: 2041 | 23 As always, it will be for bio-chemist for chemistry. I do not think any
current material chemist deserve a Nobel prize unless they have a product to
justify it. Who cares about your H-index?
Medicine: Gleevec |
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w***r
发帖数: 709 | 24 我猜 gleevec 抑癌 Brian druker |
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A******y
发帖数: 2041 | 25 I thought we are talking about natural products. If we are talking about
small molecule chemotherapy, Gleevec works very well for CML with limited
side-effects. You literally live a normal life today comparing to a decade
ago that it is literally a death sentence if you have CML. It costs about $
160K/yr today though...also retinoic-acid don't have much side-effects for
PML.
I don't have Pinyin on my computer, but toxins can be used safely as long as
you know how and how much to use. Allerga... 阅读全帖 |
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g*****j
发帖数: 1211 | 26 您有听说过Gleevec吗？
如果你认为现代医学就是抗生素加手术刀，那真的应该再学习啊！ |
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i**o
发帖数: 1161 | 27 作者：倪海厦 文章来源：本站蒐集 点击数：1169 更新时间：2009-2-1
二位肝癌与骨髓癌的比较
2008/09/28，近日来因为浩费较多的时间思考如何将中医的精神传播下去，所以就
没有多余的时间写些诊疗日志，今天适逢周末，因此利用清晨时间写下这几个案例，除
了给未能来参加跟诊的同学看之外，也给西医师们看一看，请不要再继续闹下去了。
第一位是68岁左右的美国白人，去年他因为得到胃癌，之后被西医切除75%的胃，
接着继续做化疗，直到西医告诉他，其癌症已经扩散开了之后，他才来找我治疗，经过
服用中药一段时间后，他被本地西医证明，已经找不到任何胃癌细胞了。
但是今年六月时，我正好赴大陆山西，他又因为身体不适，而去医院做检查，这次
却被查出又得到肝癌了，当时我不在美国，加上他太太给他许多压力，于是他只好先服
用美国西医开的Gleevec，服用这种魔药后，让他双腿水肿，腹水增加，全身发黯黄，
我返国后，他来诊时，双眼袋已经出现卧蚕状，望诊可见其面色黯黄又黯青，已经是危
症了，经过几周的治疗后，前天他来复诊时，水肿全退，体重下降约20磅，胃口与体力 |
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a*******e
发帖数: 253 | 28 达人们，您们好。我爸的病经过北大医院的骨髓化验，他们结论是嗜酸粒细胞白血病。
我有一位生物学专家朋友告诉我，慢性粒细胞白血病(chronic myeloid leukemia)美国
已有药治疗，是Novartis公司生产的，叫作Gleevec(named "Glivec" in Europe)，主
要成分是imatinib。
请问哪位达人了解这种药？它对嗜酸粒细胞白血病有疗效吗？
即使这药有用，也要美国癌症医生开处方才可买到。
先叩谢了！！ |
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d******a
发帖数: 127 | 29 Agree! Iressa 没什么用.
I don't like the trials. Compared to Gleevec for CML and GIST, Iressa is a
garbage. Target Tx for lung cancer? There is a looooooooooooooooong way to
go. |
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i***e
发帖数: 32 | 30 来自主题: Pharmaceutical版 - 买药求助 90 tablets of this Gleevec 100 mg drug that you're asking about is around $
2500.
Also, you do need a prescription, and physicians will not just simply write
one for you without seeing a real patient, cuz that's illegal and they don't
want to lose their precious license. |
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r********0
发帖数: 22 | 32 Should try to contact NOVARTIS BEIJING first, don't use any generic drugs.
Many Chinese patients join a charity program called "GAPIP" launched by the
Max Foundation and Novatis company. Try to contact the Gleevec office in
Beijing: 86-10-67119500 to see if your sister can join this program.
It is said the program requires patients to pay for 3-6 months of treatment
at regular price, then life-time free medication afterwards. |
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L******r
发帖数: 522 | 36 这个我还真不知道，可以尝试下，去chinatown找个中国医生问问，也许需要打点下（
如果你自己掏钱不要保险cover，其实医生不那么担心，但是如果你要保险cover，医生
不会干的，因为那是真正犯罪了），要救命，那只能什么办法都要用了， 只要拿到医
生处方，其余很简单，去药房拿就是。这个药在全世界范围内，比如欧洲，美国，日本
（不知道中国有没有）都有批，如果欧洲有朋友，也可以去那里尝试下，感觉欧洲管得
没美国严。
还有就是老印医生也愿意干这种事情，不过就是代价比较高，要是花1-2千块钱能从此
随要随开，也许值得,就是别被骗了。目前这个药便宜的generic是没有的，如果有，都
是假的，如果国内有合法的，不是太离谱，也许还是在国内比较好。
国内现在有很多Phase IV的follow up study，如果你的朋友能参加，会便宜很多，甚
至免费。我一个朋友他妈得了血癌，就是参加Novartis Gleevec在中国的Phase IV。但
是我不知道Nevaxar是否在中国也有类似的program，可以打电话到Bayer (Bayer
license这个药）或者Onyx Pharmace... 阅读全帖 |
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d*******2
发帖数: 397 | 37 治慢粒白血病的特效药 Gleevec 在国内应该是今年专利失效，一般药厂仿制的信息哪
能知道，没什么信息呢？一年7万多药费家人很吃力，盼着仿制药生产。或者国内哪个
论坛是这个专业的论坛？谢谢 |
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d******e
发帖数: 1424 | 38 Why Gleevec goes off patent earlier in China than in US?
"In the USA, the patent protecting the active principal will expire on 4
January 2015 while the patent protecting the beta crystal form of the active
principal ingredient will expire on 23 May 2019" |
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c*********7
发帖数: 26 | 39 楼主说的是对的。忘了具体的原因了，但是记得在某个时间段上，印度是可以仿制一些
药。不过楼主一定不要买到假药。诺华的Gleevec实在是太贵了。 |
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y******a
发帖数: 590 | 40 Eosinophilia: lots of causes, parasitic infection, malignancy (
HES, very good response to Gleevec), vasculitis, TB,
etc. Better go to a big hospital in Beijing or Shanghai, and have a full
workup. |
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R*******t
发帖数: 367 | 41 是腺癌吗？如果是GIST，现在有Gleevec，很快就能让肿瘤在PET上失去代谢活性，人称
魔术子弹。 |
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R*******t
发帖数: 367 | 42 是腺癌吗？如果是GIST，现在有Gleevec，很快就能让肿瘤在PET上失去代谢活性，人称
魔术子弹。 |
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b********p
发帖数: 45 | 43 你的论点基本上跟中医一样，形而上学，空洞无物，没有诊断，没有药物。
我跟你说现在cancer targeted therapy, 从lapatinib, 到gefitinib, 到avastin, 到
gleevec,哪个不是从机理出发，你非要说我是自己家里的玩法。你真相是一个典型的中
医，哦，此人气血不足，你分的出疾病了，然后又怎么样了？然后你连nih都扯出来了
，你知道nih是怎么回事吗。你的论点充分暴露出你的问题，说了半天有很多观点，却
没啥证据，非常的虚弱 |
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