m*********D
发帖数: 1727 | 1 这是网友孙不露（sunblue)给我出的难题。那天聊到女性更年期有什么对应的药物，就
说到男性更年期。我虽然在雌激素这个领域作了20年研究，和雄激素相关的研究就少多
了，大约接触过4-5年吧，当时是实验室一个学生的课题和雄激素有关，就读过一些相
关的文献。总起来讲，两者都是steroid这个种类的激素，分子水平上的机制是很相似
的。
男女都有更年期。这是由于身体里雌雄激素水平随年龄变化而出现的生理现象。但男女
有不同：男性的雄激素水平在20多就到了顶峰，然后就慢慢下降；女性的雌激素水平下
降则在45岁前后出现快速下降。所以，这个不同导致的症状就很不一样：男性更年期症
状不明显，女性的就反过来了。所以（加上乳腺癌），针对雌激素的研究就比雄激素的
研究多得多。
其实，仅仅是激素水平下降，补一点不就行了？是，很多症状在补一点激素后就会好转
或消除。这就是当年女性Hormone-replacement-therapy的基本思路。这个流行了几十
年，一直到后来发现更年期后女性乳腺癌和雌激素有关，才在2008（可能有误）前后正
式停止使用。
有没有激素替代品呢？要知道这个，就要知道一点分子水平的机... 阅读全帖 |
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b*****d
发帖数: 7166 | 2 【 以下文字转载自 Pharmaceutical 讨论区 】
发信人: sir ( 郎), 信区: Pharmaceutical
标 题: 淫羊藿做药了
发信站: BBS 未名空间站 (Tue Sep 23 07:49:00 2014, 美东)
http://seekingalpha.com/news/1994445-plandai-firms-up-plans-to-
Plandai Biotechnology (OTCQB:PLPL -3%) plans to develop and test an all-
natural product for erectile dysfunction (ED). The compound, called icariin,
is an extract from the plant Epimedium, also called the horny goat weed.
Icariin is a phosphodiesterase type 5 (PDE5) inhibitor similar to sildenafil
, the active... 阅读全帖 |
|
s*r
发帖数: 2757 | 3 来自主题: Pharmaceutical版 - 淫羊藿做药了 http://seekingalpha.com/news/1994445-plandai-firms-up-plans-to-
Plandai Biotechnology (OTCQB:PLPL -3%) plans to develop and test an all-
natural product for erectile dysfunction (ED). The compound, called icariin,
is an extract from the plant Epimedium, also called the horny goat weed.
Icariin is a phosphodiesterase type 5 (PDE5) inhibitor similar to sildenafil
, the active ingredient in Viagra.
The company has begun cultivating and cloning epimedium and expects to begin
testing on a potential E... 阅读全帖 |
|
s*r
发帖数: 2757 | 4 来自主题: Pharmaceutical版 - 淫羊藿做药了 http://seekingalpha.com/news/1994445-plandai-firms-up-plans-to-
Plandai Biotechnology (OTCQB:PLPL -3%) plans to develop and test an all-
natural product for erectile dysfunction (ED). The compound, called icariin,
is an extract from the plant Epimedium, also called the horny goat weed.
Icariin is a phosphodiesterase type 5 (PDE5) inhibitor similar to sildenafil
, the active ingredient in Viagra.
The company has begun cultivating and cloning epimedium and expects to begin
testing on a potential E... 阅读全帖 |
|
d*******u
发帖数: 5337 | 5 Hi reviewers,
I wish you all have a happy new year.
Please check the following manuscripts to Biomedicine and pharmacotherapy.
If you are interested in reviewing these manuscripts, send your background
and Ms #. Feel free to pass this information to your friends and collogues.
Best regards,
xxxx
Executive editor
Biomedicine and Pharmacotherapy
1. Antiproliferative activity of Corylus avellana L. extracts against
human cancer cell lines
2. Poloxamer Surface modified Trimethyl Chitosan Nano... 阅读全帖 |
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r**k
发帖数: 1402 | 6 Icariin 不便宜呀，我吃一次 USD $8 就没了 |
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