x**********o
发帖数: 142 | 1 Cell Physiol Biochem. 2013;31(1):113-22. doi: 10.1159/000343354. Epub 2013
Jan 25.
External Qi of Yan Xin Qigong inhibits activation of Akt, Erk1/2 and NF-&#
312;B and induces cell cycle arrest and apoptosis in colorectal cancer cells.
Yan X, Shen H, Jiang H, Hu D, Wang J, Wu X.
Background/Aims: Colorectal cancer (CRC) is the second leading cause of
cancer death in the Western countries. Novel approaches of treatment are
needed for CRC. The purpose of the present study was to investigate
cytotox... 阅读全帖 |
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E**********t
发帖数: 56 | 2 Xuebiao Yao, Dasheng Li and Gang Pei recently wrote an essay to Nature
Review in MCB Which is entitled “In focus: molecular and cell biology
research in China”. Here is the link: http://www.nature.com/nrm/journal/v14/n9/full/nrm3638.html In this article, they discussed the past, present and future of molecular and cell biology research in China. One part which interested me is the key MCB discoveries in China. Although most of the work are nice and likely solid work, few of them are breakthrough... 阅读全帖 |
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m******g
发帖数: 467 | 3 Science 14.01.03
新年快乐！P.S. 这周又没有遇到“推荐”的paper。
稍微了解一下：
1. Two Y Genes Can Replace the Entire Y Chromosome for Assisted Reproduction
in the Mouse
另外，
complex and multilayered palindromic structure of the Y chromosome
may facilitate internal pairing of nucleotide bases
2. Break-Induced Replication Repair of Damaged Forks Induces Genomic
Duplications in Human Cells
小知识：
1. A Cascade of Histone Modifications Induces Chromatin Condensation in
Mitosis
2. A Neural Mechanism Underlying Mating Preference... 阅读全帖 |
|
m******g
发帖数: 467 | 4 Science 14.01.03
新年快乐！P.S. 这周又没有遇到“推荐”的paper。
稍微了解一下：
1. Two Y Genes Can Replace the Entire Y Chromosome for Assisted Reproduction
in the Mouse
另外，
complex and multilayered palindromic structure of the Y chromosome
may facilitate internal pairing of nucleotide bases
2. Break-Induced Replication Repair of Damaged Forks Induces Genomic
Duplications in Human Cells
小知识：
1. A Cascade of Histone Modifications Induces Chromatin Condensation in
Mitosis
2. A Neural Mechanism Underlying Mating Preference... 阅读全帖 |
|
s******a
发帖数: 10 | 5 Bob Weinberg的理论是CSC也可分成induced的和非induced的 要是所有普通cancer
cell都具有induce成CSC的可能那针对CSC的治疗和研究又有多大呢
★ 发自iPhone App: ChineseWeb 8.6 |
|
P**F
发帖数: 18 | 6 谢谢楼上各位的建议和讨论！
我的设想如下：
1. 用已有的启动子（较弱）驱动一个报告基因，然后在此基础上构建一个library，
把random序列（6～8 bp ？）放在这个较弱启动子的前面并用某种化学物质（inducer
）处理，然后在in vivo筛选报告基因表达增强的克隆。目的是找到对此inducer有特异
反应的DNA序列。
2. 根据此DNA序列，寻找能够在体内情况下结合的蛋白，然后通过调节这些蛋白的表达
进一步增强报告基因的活性。
3. 最终目的是建立一个全新的系统，包括synthetic promoter和上游调控因子，能对
特殊的inducer（可以是任何环境影响，不限于化合物）具有超灵敏的反应。
不知大家对此设想有何高见？ |
|
c********e
发帖数: 215 | 7 很多paper说用了各种autophagy inducer，然后看到了p62 upregulation, LC3-II
upregulation, induced autophagy, 也有很多paper说抑制了autophagy看到p62的
accumulation。这个p62上调到底是说induced还是suppressed autophagy。越看越糊涂
。 |
|
w*********1
发帖数: 27 | 8 之前一直用的四质粒系统包装慢病毒。包括shRNA和普通的DNA表达。但都不是tet
inducible的。最近需要换成Tet inducible的。我想包装系统就不用变了。但需要重新
购买用于包装上shRNA和DNA的tet inducible的表达载体。老板让我去addgene上去搜。
请问各位老师有何推荐的比较好用的载体？谢啦。 |
|
v*******e
发帖数: 11604 | 9 先申明一下，我不是业界大牛，只是因为感兴趣所以读了不少这个方面的文章。所以我
说的话都不一定是对的。
看了一批文章，总结这个故事最make sense。修改下不准确的地方。加reference。
细胞在G2的时候，由于各种因素造成DNA损坏（过氧化，辐射，端粒太短，某些致癌基
因表达导致SSB或者DSB等），引起P53表达，P53表达引起P21表达，P21的水平高到一定
程度就会把cyclin B1关进细胞核不出来【Krenning 2014】，加上其他P21影响的其他
途径（cdk1（次要）, RB（比前者重要）， 等）导致细胞跳过M，直接进入G1【Ye
2013, Johmura 2014】或者某些别的致癌基因表达，虽然没有DNA损坏，但是只要引起
DDR，也可以导致细胞跳过M，直接进入G1。或者，强制引起P53表达，或者强制P21表达
，或者什么别的原因导致细胞跳过M，直接进入G1
【Krenning 2014, Johmura 2014, Sussman 2014】。这样的细胞是4倍体，如果继续细
胞周期则会先8倍体然后分裂；因为多个centrosome或者其他原因会导致细胞染... 阅读全帖 |
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s******y
发帖数: 28562 | 10 他们的意思是，神经突触的形成和记忆无关？
Reinstatement of long-term memory following erasure of its behavioral and
synaptic expression in Aplysia
Shanping Chen, Diancai Cai, Kaycey Pearce, Philip Y W Sun, Adam C
Roberts, David L GlanzmanCorresponding Author
DOI: http://dx.doi.org/10.7554/eLife.03896Published November 17, 2014 Cite as eLife 2014;10.7554/eLife.03896 Download PDF
Abstract
Long-term memory (LTM) is believed to be stored in the brain as changes in
synaptic connections. Here, we show that LTM storage... 阅读全帖 |
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r******0
发帖数: 357 | 11 BMC终于在最近做了一件值得尊敬的事情。我敢说下面的狗屎99%都是所谓的个性化生物
“信息”“润色”的畸形怪胎。一般以所谓的Meta分析或者随便下载一套狗屎基因芯片
数据，然后做一些似是而非的烂分析，发一堆垃圾，一篇文章卖给忙于召妓的医生5万
到10万。
1.
Retraction Note Open Access
Retraction Note: Impact of guidewire selection and operator expertise on
radiation exposure in transradial angiography
Jianmin Yang, Ningfu Wang, Xiaoshan Tong, Xianhua Ye, Liang Zhou, Guoxin
Tong, Yun Shen, Shuzheng Lv
Journal of Cardiothoracic Surgery 2015, 10:42 (27 March 2015)
Full text | PDF
2.
Retraction Note Open Access
Retracti... 阅读全帖 |
|
n**e
发帖数: 2026 | 12 【 以下文字转载自 WaterWorld 讨论区 】
发信人: nile (nile), 信区: WaterWorld
标 题: 美国科学促进会《科学》大旗下的转基因谎言
发信站: BBS 未名空间站 (Fri Oct 30 10:18:45 2015, 美东)
今年初，美国科学促进会（AAAS）和皮尤研究中心（Pew Research Center）联合公布
的一项调查显示，88％的科学家认为转基因食品可安全食用，持这一看法的公众只有37
％。报告认为差距如此之大的一个可能原因是，三分之二的公众认为科学家对转基因食
品的健康后果没有清晰认识。这就是真正的原因吗？
根据报告全文，皮尤中心给19，984名科学家发出了调查问卷，3748人（18.8%）完成了
问卷调查。其中生物医学学科背景的科学家占50%。报告没有说明50%的生物医学背景是
否能够代表科学家总体的学科构成。更大问题是在这50%的科学家人群中，有多少人的
工作是与转基因作物的研究有关，以什么样的方式相关。报告没有提供任何信息。
由于这些关键信息缺失，88%的科学家相信转基因安全的说法毫无意义。在一个没有代
表性并且无法排除... 阅读全帖 |
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N*********6
发帖数: 2302 | 13 人在国内，有11篇文章。有兴趣的PI, 请email me ：：[email protected]
/* */
谢谢！
1. Kang H, Cao S, Chen T, Jiang Z, Liu Z, Li Z, Xu Q, Lin Q, WeiS. The poor
recovery of neuromyelitis optica spectrum disorder is associated with a
lower level of CXCL12 in the human brain. J Neuroimm, 289:56-61, 2015.(co-
first author)
2. Chen T, Li Z, Jiang Z, Liu Z, Xu Q, Huang D, Lin Q, Wei.S (2015) Changes
of CXCL12, CXCL14 and PDGF levels in the brain of patients with idiopathic
demyelinating optic neuritis and neuromyeliti... 阅读全帖 |
|
z*t
发帖数: 863 | 14 inducible目前不好做
可以稳转Cas9+ inducible sgRNA，这个是目前我觉得最靠谱的.
至于inducible Cas9之前有兄弟说了不一定work，我们的经验是还会有Cas9的leakness. |
|
v********a
发帖数: 646 | 15 面对这个1979年的单身女郎，从中专毕业，到参加成人自考拿到同等学历，然后一路逆
袭，最后傲然在苏州大学就职。
只有两个字：佩服
http://hlxy.suda.edu.cn/jiaoxuekeyan/yanjiushengdaoshiminglu/20
王丽，女，教授，硕士研究生导师
研究方向
慢性病运动康复：重症病者包括心脑血管疾病、骨关节系统疾病和终末期肾病等患者的
运动康复。
体能与疾病：体能水平与疾病发生和预后之间的关系；
社区康复：糖尿病、骨质疏松等的社区康复护理干预。
联系方式
电话：0512-65221499 (办公室); 138-1486-1702 (手机)
邮a class="__cf_email__" href="/cdn-cgi/l/email-protection" data-cfemail="3dd99e875154104a5c535a100c7d4e48595c13585948135e53">[email protected]/* */; [email protected]/* */
地址：苏州市十梓街1号苏州大学护理学院本部20... 阅读全帖 |
|
s*********y
发帖数: 579 | 16 找到一篇
(1) administration of high Tm doses leads to extended CreER nuclear
localization; (2) Tm administration induces reporter gene recombination for
several days or weeks after Tm treatment is completed, depending on the
original dose administered; and (3) Tm treatment induces side effects that
may have physiologic consequences in Tm-inducible models.
: 诱导后多久又成为wt野生型了？实验要在几天内完成？
: 有的模型周期长，难道中间还要再注射几次？
|
|
G****n
发帖数: 145 | 17 Justin Lin of CCER
[BOOK] The China miracle: Development strategy and economic reform[PDF] from
socialsecurity.orgJY Lin, F Cai… - 2003 - books.google.com
The Hong Kong Centre for Economic Research The Centre was set up as a
research and educational
trust under a trust deed signed in 1987. It supports research and publishes
studies on public
policy issues to promote understanding of economic affairs and provide
alternative policy ...
Cited by 462 - Related articles - Library Search - All 18 vers... 阅读全帖 |
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S******w
发帖数: 195 | 18 No.
Set rings R=Q, S=Z, T=Z/nZ;
u: S->R: a->a, v: S->T: a->a mod n;
X=Spec R, Y=Spec S, Z=Spec T.
Then u induces dominant f: X->Y, v induces morphism g: Z->Y;
f' is induced by T->(R tensor T over S, which is 0). So f' is not dominant. |
|
e****0
发帖数: 678 | 19 Endometrial hyperplasia types. Risk of cancer treatment
simple 1% Cyclic progestin
complex 3% Cyclic progestin
Simple atypical 8% THA or progestins
Complex atypical 29% THA or progestins
• Prolatinoma and hypothyroidism galactorrhea
• Anesthesia can reduce uterine activity if in the latent phase
• Contraceptive for lactating mother
Progestin-only oral contraceptive
• Pregnancy luteoma
African-ameri... 阅读全帖 |
|
y******7
发帖数: 17 | 20 The following is what I collected when I was a student doing capstone in a
local hospital. Not sure if it is useful.
Lidocaine topical is a amide-type local anesthetic. for production of
topical anesthesia, relief of pain associated with postherpetic neuralgia,
reduction of gagging during dental procedures, prevention and control of
urethral pain, anesthetic lubricant for endotracheal intubation, and relief
of hemorrhoidal pain.
Polyethylene glycol(Miralax) is a nonabsorbed solution used to trea... 阅读全帖 |
|
g*2
发帖数: 658 | 21 刚看到有趣病例活动，想到 broken heart syndrome。 在我短短的几个月住院第一年
中，居然看到了2例。 一例是copd induced, 例外一例可能是GBS induced.
basically broken heart syndrome is transient stress induced cardiomyopathy,
aka Takotsubo cardiomyopathy/apical ballooning syndrome
a sudden onset of congestive heart failure associated with ECG changes
suggestive of an anterior wall myocardial infarction. in my 1st case, pt's
ECHO when admitted showed basal segment thickening w/ remaining hypokinetic
ventricle walls, severely decreased LV systolic ... 阅读全帖 |
|
f**d
发帖数: 768 | 22 这是一本计算神经科学的优秀著作，全文拷贝这里（图和公式缺），有兴趣的同学可以
阅读
如需要，我可以分享PDF文件（－－仅供个人学习，无商业用途）
From Computer to Brain
William W. Lytton
From Computer to Brain
Foundations of Computational Neuroscience
Springer
William W. Lytton, M.D.
Associate Professor, State University of New York, Downstato, Brooklyn, NY
Visiting Associate Professor, University of Wisconsin, Madison
Visiting Associate Professor, Polytechnic University, Brooklyn, NY
Staff Neurologist., Kings County Hospital, Brooklyn, NY
In From Computer to Brain: ... 阅读全帖 |
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c*********d
发帖数: 9770 | 23 【 以下文字转载自 Military 讨论区 】
发信人: chinabbsdad (张果老他爹), 信区: Military
标 题: 论林彪反党集团的社会基础（汉英对照）
发信站: BBS 未名空间站 (Fri Nov 22 09:43:14 2013, 美东)
论林彪反党集团的社会基础
On the Social Basis of the Lin Piao Anti-Party Clique
姚文元
by Yao Wen-yuan
[This article is reprinted from Peking Review, #10, March 7, 1975, pp. 5-10.]
毛主席在讲到必须搞清楚无产阶级对资产阶级专政的问题时明确指出：“林彪一类如上
台，搞资本主义很容易。因此，要多看点马列主义的书。”这就提出了一个极其重要的
问题：即“林彪一类”的阶级本质是什么？林彪反党集团产生的社会基础是什么？把这
个问题弄清楚，对于巩固无产阶级专政、防止资本主义复辟，对于坚定地执行党在社会
主义历史阶段的基本路线，一步一步地造成资产阶级既不能存在也不能再产生的条件，
无疑是十分... 阅读全帖 |
|
M*****8
发帖数: 17722 | 24 【 以下文字转载自 TraderSuccess 俱乐部 】
发信人: MB80528 (肥猫(Contrarian)[食MM而肥]), 信区: TraderSuccess
标 题: 今天 TraderSuccess(tm) 电子信的内容 (March 22, 2011)
发信站: BBS 未名空间站 (Wed Mar 23 13:02:39 2011, 美东)
有免费的 eMail Newsletter:
欢迎订阅。
http://StockCounsel.com/pm/user/subscribe.php
=================================================
MCP Now Bearish (March 22, 2011)
We now confirm that MCP is over-extended and bearish.
http://yhoo.it/eEiguu
Here is the latest forecasts (as of last night, March 22, 2011):
SYMBOL, DATE... 阅读全帖 |
|
o**********e
发帖数: 18403 | 25 Remember some background: before Eastern Han Dynasty, old Chinese books
were not originally written on paper, they were painstakingly carved into
bamboo sticks. They weigh a lot were very expensive. That's why old
written Chinese were so succinct. Most of the books had only a few copies.
Writers lived short lives and spent their lifetime to write. If other
literary Chinese found these
writing good, they in turn would spend a lot of time and money to make a
copy. It was a darwinian evol... 阅读全帖 |
|
o**********e
发帖数: 18403 | 26 蒙古元朝有一个特点就是100年统一中国而摧残中国文化，这种情况史无前例。
这事秦始皇也干过， 但是他只有15年统一的时间。 他残杀六国贵族学者, 销毁民间
藏诸子百家典籍， 将孤本存在自己私人图书馆。 他干得这一系列都让他问鼎中国文
明第一罪人。 他登天以后， 看看反秦人物的履历吧。
项羽年轻人“愤青新三届”，学的是家传楚国兵法，有领导力但不是理论上的好学生。
他看见秦始皇的私立图书馆就把它当秦始皇的财产一把火烧解气, 这把火成就
了中华文明第二罪人。 项羽的很多决策错误，小半是性格，大半绝对是他理论功
底薄弱造成。
刘邦，此人年轻时是战国末期的游侠可能在当地的大学里上过一些学（老三届），曾经
想追随信陵君。 社会履历丰富。 40多岁起兵。 萧何， 年纪跟刘邦差不多，也是
受惠先秦教育的老三届。 他哥俩合伙干的很多事都是在恢复被秦始皇唾弃摧毁的先秦
文化： 约法三章， 寻访诸子百家孤本 （很多已经失传）， 保存秦朝残余的census
data.
韩信与张良都比刘邦萧何年轻一大截。 但是张良出身韩国贵族在民间秘密Chinese
School学得太公兵法。 ... 阅读全帖 |
|
o**********e
发帖数: 18403 | 27 Remember some background: before Eastern Han Dynasty, old Chinese books
were not originally written on paper, they were written on
collated sheets of bamboo sticks. They weigh a lot were very expensive.
That's why old
written Chinese were so succinct. Most of the books had only a few copies.
Writers lived short lives and spent their lifetime to write. If other
literary Chinese found these
writing good, they in turn would spend a lot of time and money to make a
copy. It was a darwinian ... 阅读全帖 |
|
d*b
发帖数: 21830 | 28 food dye不induce cancer啊。你这个苏丹红要induce cancer要日日吃月月吃年年吃才
行。 |
|
M*****8
发帖数: 17722 | 29 【 以下文字转载自 TraderSuccess 俱乐部 】
发信人: MB80528 (肥猫(Contrarian)[食MM而肥]), 信区: TraderSuccess
标 题: 今天 TraderSuccess(tm) 电子信的内容 (March 22, 2011)
发信站: BBS 未名空间站 (Wed Mar 23 13:02:39 2011, 美东)
有免费的 eMail Newsletter:
欢迎订阅。
http://StockCounsel.com/pm/user/subscribe.php
=================================================
MCP Now Bearish (March 22, 2011)
We now confirm that MCP is over-extended and bearish.
http://yhoo.it/eEiguu
Here is the latest forecasts (as of last night, March 22, 2011):
SYMBOL, DATE... 阅读全帖 |
|
s********n
发帖数: 26222 | 30 方舟子在此文中说“虫子不吃的， 人能吃吗”是中国人的质疑， 而美国人是不会问这
样的问题的， 这显然是骗人的。见下文和其中引用的文献， 其中不少是美国人的科研
。
"Comments on the human health impact of Bacillus thuringiensis toxin gene
product in genetically modified crops"
EPA Review Docket Number OPP-00678B
Professor Joe Cummins
Professor Emeritus of Genetics
University of Western Ontario
I have studied the Environment Protection Agency (EPA) document "Bt Plant-
Pesticides Biopesticides Registration Action Document B. HUMAN HEALTH
ASSESSMENT" and comment in the following ... 阅读全帖 |
|
J*****l
发帖数: 252 | 31 SYSTEMS FOR INDUCING CHANGE IN A HUMAN PHYSIOLOGICAL CHARACTERISTIC
United States Patent Application, August 18, 2011
By Bank of America
Patent Abstract
Systems and methods for inducing a change in a human physiological
characteristic. The physiological characteristic may correspond to an
emotional state of a dialogue participant. The dialogue participant
may be
an individual participating in a conversation. The outcome of the
conversation may be related to a business objective, such as providin... 阅读全帖 |
|
w*********g
发帖数: 30882 | 32 中文译文：
疫苗中的抗HCG荷尔蒙可导致人类绝育？
http://organichealthadviser.com/archives/does-a-hormone-found-i
Does A Hormone Found In Some Vaccines, Human Chorionic Gonadotrophin (hCG),
Cause Infertility In Humans?
A couple of comments by our readers and an article over at tetrahedron.org
are causing us to ask some hard questions about a hormone called "human
chorionic gonadotrophin" (hCG) and vaccines. Apparently, when the hormone
hCG is added to a vaccine, the human body not only develops antibodies
against what... 阅读全帖 |
|
M*****8
发帖数: 17722 | 33
..........................
Does A Hormone Found In Some Vaccines, Human Chorionic Gonadotrophin (hCG),
Cause Infertility In Humans?
A couple of comments by our readers and an article over at tetrahedron.org
are causing us to ask some hard questions about a hormone called "human
chorionic gonadotrophin" (hCG) and vaccines. Apparently, when the hormone
hCG is added to a vaccine, the human body not only develops antibodies
against what it is being vaccinated for, it also develops antibodies again... 阅读全帖 |
|
h******i
发帖数: 661 | 34 你们学校ap能发这么多paper?
1989
Cosmological implications of quasar-galaxy associations, L.Z.Fang, Y.Q.Chu
and X.F. Zhu, Mod. Phys. Lett., 4, 887.
Geometrical optics in an inhomogeneous universe, L.Z.Fang and X.P.Wu,
Chinese Phys. Lett., 6, 233.
Quasar clustering and its cosmological implication, L.Z.Fang, Inter. J. Mod.
Phys. A4, 3477.
L'Osservatorio astronomico di Pechino: la sua storia, il presente, L.Z.Fang,
Scienza e Tecnica, Annuario della EST 88/89 404.
Overview on the frontier of high energy astr... 阅读全帖 |
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k****z
发帖数: 1863 | 35 Yan, SD, Yan, S-F., Chen, X., Fu, J., Chen, M., Kuppusamy, P., Smith, M.A.,
Perry., G., Godman,G.C., Nawroth, P., Zweier, J.L., and Stern, D. Non-
enzymatically glycated tau in Alzheimer’s disease induces neuronal oxidant
stress resulting in cytokine gene expression and release of amyloid ß-
peptide. Nature Medicine, 1(7):693-699, 1995
Yan SD, Chen X, fu J, Chen M, Zhu H, Roher A, Slattery T, Nagashima M,
Morser J, Migheli A, Nawroth P, Goodmand G, Stern D, and Schmidt AM. RAGE in
Alzheimer... 阅读全帖 |
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k****z
发帖数: 1863 | 36 他妈怎么把它生出来的？
Yan, SD, Yan, S-F., Chen, X., Fu, J., Chen, M., Kuppusamy, P., Smith, M.A.,
Perry., G., Godman,G.C., Nawroth, P., Zweier, J.L., and Stern, D. Non-
enzymatically glycated tau in Alzheimer’s disease induces neuronal oxidant
stress resulting in cytokine gene expression and release of amyloid ß-
peptide. Nature Medicine, 1(7):693-699, 1995
Yan SD, Chen X, fu J, Chen M, Zhu H, Roher A, Slattery T, Nagashima M,
Morser J, Migheli A, Nawroth P, Goodmand G, Stern D, and Schmidt AM. RAGE ... 阅读全帖 |
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k****z
发帖数: 1863 | 37 发信人: pangduer (白飞飞), 信区: WaterWorld
标 题: Re: 傅瑾教授：已经把在哥大的学习经历说明和学位证书复印件提
发信站: BBS 未名空间站 (Mon Jul 23 14:03:45 2012, 美东)
对，这篇1997年的nature paper，列在第一位的yan shidu其实是唯一的通讯作者，列
在最后一位的本该是通讯作者的David Stern其实就是当时部门里的大牛。估计情况就
是David Stern是大老板，但是对这个project其实没啥贡献，然后是作为通讯作者的
Yan shidu是小老板，带领Fu Jin等一干人做出来的，才会有这样奇怪的authorship。
这样看来，Fu JIn实质上是真正干活的第一作者，凭这样一篇nature paper获得博士
也就没啥稀奇的了。Fu Jin是1999年拿的博士，1997年的paper正好对景。
凭什么方肘子要看学位证明人家就亮给这个傻逼看啊。他家菊花不是都拒绝出示学位证
明吗？人家Fu Jin教授把学位亮给学校看就好了，气死方教主及其教徒们！
Yan, SD, Yan, S-F., C... 阅读全帖 |
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k****z
发帖数: 1863 | 38 Yan, SD, Yan, S-F., Chen, X., Fu, J., Chen, M., Kuppusamy, P., Smith, M.A.,
Perry., G., Godman,G.C., Nawroth, P., Zweier, J.L., and Stern, D. Non-
enzymatically glycated tau in Alzheimer’s disease induces neuronal oxidant
stress resulting in cytokine gene expression and release of amyloid ß-
peptide. Nature Medicine, 1(7):693-699, 1995
Yan SD, Chen X, fu J, Chen M, Zhu H, Roher A, Slattery T, Nagashima M,
Morser J, Migheli A, Nawroth P, Goodmand G, Stern D, and Schmidt AM. RAGE in
Alzheimer... 阅读全帖 |
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J**X
发帖数: 2433 | 39 从福建医学院83年毕业的SD Yan去了美国（哥大？），做了postdoc，
然后在哥大的大老板手下做了小老板，
找了同是福建医学院89年毕业的Fu J做了她的tech./postdoc.
SD Yan的确做得不错，Fu J干活应该也不错，但哥大的博士学位应该是没有的。
连SD Yan都只是说自己是哥大postdoc，Fu J就敢说自己是哥大博士。
区别就在一个在美国，一个在中国。
另外一点就是SD Yan应该在福建科研界有些影响，所以Fu J的问题也可能会不了了之。
下面是一些关于prof. Yan的信息，和她们共同发的文章。
http://www.pharmtox.pharm.ku.edu/index.php?page=content:faculty
Dr. Yan received her M.D. from Fujian Medical University in 1983 and
completed Postdoctoral training at the Physicians & Surgeons College of
Columbia University in New ... 阅读全帖 |
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C****g
发帖数: 2220 | 40 真是“大道之行简也”。。。
Summary
Differentiated cells can be reprogrammed to an embryonic-like state by
transfer of nuclear contents into oocytes or by fusion with embryonic stem (
ES) cells. Little is known about factors that induce this reprogramming.
Here, we demonstrate induction of pluripotent stem cells from mouse
embryonic or adult fibroblasts by introducing four factors, Oct3/4, Sox2, c-
Myc, and Klf4, under ES cell culture conditions. Unexpectedly, Nanog was
dispensable. These cells, which we desi... 阅读全帖 |
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m**********n
发帖数: 27535 | 41 After our house burned down in Wisconsin a few months ago, my husband and I
packed our four young kids and all our belongings into a gold minivan and
drove to my sister-in-law’s place, just outside of Atlanta. On the back
windshield, we pasted six stick figures: a dad, a mom, three young girls,
and one baby boy.
That minivan was sitting in the front driveway of my sister-in-law’s place
the night a SWAT team broke in, looking for a small amount of drugs they
thought my husband’s nephew had. Some ... 阅读全帖 |
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S******8
发帖数: 24594 | 42 老方到美国后发的文章列表，你自己看吧：
1990
174. Biased clustering in a universe with hot dark matter and a cosmic
string, L.Z.Fang, S.P.Xiang and L.Yan, Astr. & Astrophys. 233, 1.
175. Periodicity of redshift distribution in a T-3 universe, L.Z.Fang, Astr.
& Astrophys. 239, 24.
176. An upper limit to quasar's peculiar velocity, L.Z.Fang, Y.Q.Chu, X.F.
Zhu and L.F. Wang, Inter. J. Mod. Phys., 5, 2993.
177. Quasar pair and quasar's peculiar velocity, L.Z.Fang, Developments in
general relativity, astrophysics and qu... 阅读全帖 |
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g******4
发帖数: 6339 | 43 What is a safe level of radon gas?
This is the simpler of the two questions. A safe level of radon gas is no
radon gas. Radon gas is a carcinogen which causes lung cancer. The US EPA
has put it plainly, stating, "Any radon exposure has some risk of causing
lung cancer. The lower the radon level in your home, the lower your family's
risk of lung cancer." The average person receives a higher dose of
radiation from the radon levels in their home than from their combined
exposure to all other radiat... 阅读全帖 |
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x********i
发帖数: 905 | 44 Intel STS 2015 Finalists
Anandapadmanaban, Eswar
Dr. Ronald E. McNair Academic High School, Jersey City, NJ
The ThereNIM: A Touch-less Respiratory Monitor
Ashkin, Emily Lorin
Providence Day School, Charlotte, NC
A Novel Synergistic Approach for Enhancing Immunotherapy in the Treatment of
Melanoma
Chemparathy, Augustine George
Dougherty Valley High School, San Ramon, CA
Accumulation of the Biodiesel Precursor Triacylglycerol Offsets Oxidative
Stress in the Model Alga Chlamydomonas reinhardtii
Cui... 阅读全帖 |
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b********n
发帖数: 38600 | 45 http://journal.frontiersin.org/article/10.3389/fpsyg.2014.00852
Introduction
Access to highly palatable and calorically rich foods is a major
contributing factor to the increasing rates of obesity worldwide (Caballero,
2007). Eating is essential for survival and is underpinned by the
fundamental physiological need to consume energy. However, our basic
requirements for nutrients and energy to maintain physiological homeostasis
are often exceeded by an abundant source of readily available and conv... 阅读全帖 |
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f**e
发帖数: 3343 | 46 Al+NaOH确实有H2产生，但是(跟我说的一样)不是金属球持续运动的原因
However, bubbles are observed on the uncoated surface without occurrence of
the motion. NaOH solution with higher concentration accelerates the bubble
generation, but the
sphere stays still, demonstrating that the force from the bubble recoil is
insuffi cient to actuate the autonomous locomotion of a rigid bead
金属球运动真正的mechanism
Figure 3. Working mechanism for the self-fueled liquid metal motor. a) The
fl ow fi eld of the solution in the channel induced by t... 阅读全帖 |
|
f**e
发帖数: 3343 | 47 Al+NaOH确实有H2产生，但是(跟我说的一样)不是金属球持续运动的原因
However, bubbles are observed on the uncoated surface without occurrence of
the motion. NaOH solution with higher concentration accelerates the bubble
generation, but the
sphere stays still, demonstrating that the force from the bubble recoil is
insuffi cient to actuate the autonomous locomotion of a rigid bead
金属球运动真正的mechanism
Figure 3. Working mechanism for the self-fueled liquid metal motor. a) The
fl ow fi eld of the solution in the channel induced by t... 阅读全帖 |
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q********u
发帖数: 15519 | 48 人物简介
编辑
美国疼痛学专家 阮秀禄(Xiulu Ruan)医生简介： 生于济南，1982 年就读于山东医科
大学医学系(英语班),88 年毕业. 1989年赴美深造，接受了临床医生全面正规的训练,
先后在美国麻省Worcester Medical Center内科任实习医生(internship),在威斯康星
医学院(Medical College of Wisconsin)附属医院理疗与康复科任住院医生(residency
), 在密执根大学University of Michigan (Ann Arbor) Health Systems 麻醉科-介入
治疗疼痛医学中心接受了研究生专科培训(Fellowship)，通过了八项医学专业/亚专业
特考文凭考试，成为美国医学界持有最多特考文凭的医生， 激励着海外医学学子为实
现自己的梦想而奋斗。
2人物生涯
编辑
创立并刷新世界纪录
学无止境，是阮秀禄医生的座右铭. 基于对病人的高度责任感及对技术精益求精的工作
作风, 阮医生刻苦学习，努力钻研, 以惊人的毅力,通过了艰辛的考试，以其拿下8项美
国医学专业/亚专业特考文凭(Board/S... 阅读全帖 |
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d**z
发帖数: 3577 | 49 【 以下文字转载自 man 讨论区 】
发信人: dmjz (东门虎西门豹), 信区: man
标 题: Re: 得知女朋友曾经被包养过，我不知道该不该和她继续下去
发信站: BBS 未名空间站 (Fri Jun 5 05:29:39 2015, 美东)
NEW HPV CANCER CONCERNS
DERRY TOWNSHIP, Pa.-The Human Papillomavirus, or HPV has long been
associated with cervical cancer, a cancer that strikes 12 thousand women a
year. Now, there's new concern, as researchers begin to link HPV to head
and neck cancers.
Why should you listen? Because HPV is the most common sexually transmitted
disease. Doctors say nearly every sin... 阅读全帖 |
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d*b
发帖数: 4184 | 50 【 以下文字转载自 Gay_Pathology_and_Therapy 俱乐部 】
发信人: dcb (奉钻风之命删除), 信区: Gay_Pathology_and_Therapy
标 题: gay基因如果存在，对女性也是有害的
发信站: BBS 未名空间站 (Sun Jul 26 23:12:55 2015, 美东)
1993年，一个骗子提出gay基因的概念并将之定位在Xq28，后来无数学者都证明题其研
究是无法重复的，但gay基因的概念不断被无良政客用来欺骗就缺乏常识的民众。 稍微
有点遗传学常识的人都会有个疑问，在遗传上极其不利的gay基因如果存在也应该在进
化中被淘汰，于是其它骗子为了圆谎有抛出gay uncle 理论，即gay 基因会对女性携带
者繁衍有利所以能够通过女性隐性遗传。
本研究通过对gay的女性长辈（有gay 子/侄者，虚构的gay 基因携带者非发病者）研究
，得出其与非gay亲属女性的区别：
1. 较少妇科病
2. 较少复杂怀孕（多胞胎等）
3. 对生育不感兴趣（解释1）
4. 不太重视夫妻间浪漫的爱情
5，缺少社会生活
6. 家庭的稳定降低
7. 更外向（... 阅读全帖 |
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