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发帖数: 331 | 2 Insulin: insulin receptor
IGF-I: type I IGF receptor
The presence of the receptors in the tissue suggest that insulin or IGF-I
may stimulate their growth.
The binding of the ligands (insulin or IGF-I) will cause receptor
phosphorylation and activation, which in turn, activate downstream signaling
pathways, such as MAPK and Akt.
Use physiological concentration should be fine.
IGF-I: 5nM
insulin: 10-20 nM
If you want detailed information, search pubmed. There are so many reviews
outthere. |
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