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c****n
发帖数: 33 | 2 Isolated second isotopic peak |
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y*****s
发帖数: 1047 | 3 广告都多得很
Posted/Revised: 5/2/2012
Company/Institute: Pfizer Inc
Department:
Position: 2 Year Postdoctoral Fellow – Protein Quantitation in Tissues
by Mass Spectr
Job Location: Andover, MA United States
Description: 2 year Postdoctoral Fellow – Protein Quantitation in
Tissues by Mass Spectrometry and Immunoanalytical Techniques A Postdoctoral
Fellowship is available in Pfizer’s Pharmacokinetics Dynamics and
Metabolism New Biological Entities (PDM-NBE) in Andover, MA. The PDM ... 阅读全帖 |
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o******e
发帖数: 284 | 4 if>1
1 CHEM REV 40.197
2 NAT MATER 32.841
3 CHEM SOC REV 28.760
4 ACCOUNTS CHEM RES 21.640
5 NAT CHEM 20.524
6 ALDRICHIM ACTA 16.091
7 NANO TODAY 15.355
8 ANNU REV PHYS CHEM 14.130
9 ADV MATER 13.877
10 ANGEW CHEM INT EDIT 13.455
11 NANO LETT 13.198
12 COORDIN CHEM REV 12.110
13 SURF SCI REP 11.696
14 ACS NANO 10.774
15 MED RES REV 10.700
16 J PHOTOCH PHOTOBIO C 10.360
17 ADV FUNCT MATER 10.179
... 阅读全帖 |
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b*******g
发帖数: 1309 | 7 here is our strategy:
try higher resolution MS,like FT-MS and Obri, to get more accurate m/z less
than 1ppm or even smaller and better isotope pattern-->this will help you to
predict the formula
second, did you try MS/MS search in Metlin or other database? you may find
some possible functional group from the MS/MS fragment. Together with
formula, you may propose a structure.
With UV information, refine you structure and synthesize the
compound. Then try MS/MS again, to see whether it matches wi... 阅读全帖 |
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b*******g
发帖数: 1309 | 8 here is our strategy:
try higher resolution MS,like FT-MS and Obri, to get more accurate m/z less
than 1ppm or even smaller and better isotope pattern-->this will help you to
predict the formula
second, did you try MS/MS search in Metlin or other database? you may find
some possible functional group from the MS/MS fragment. Together with
formula, you may propose a structure.
With UV information, refine you structure and synthesize the
compound. Then try MS/MS again, to see whether it matches wi... 阅读全帖 |
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u**s
发帖数: 384 | 9 Title:A novel method for selective isotope labeling of bacterially expressed
proteins
Authors:Lee KM1, Androphy EJ, Baleja JD.
Journal:J Biomol NMR. 1995 Jan;5(1):93-6.
Link:http://www.ncbi.nlm.nih.gov/pubmed/7881274
Thanks! |
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u**s
发帖数: 384 | 10 Title:A novel method for selective isotope labeling of bacterially expressed
proteins.
Journal:J Biomol NMR. 1995 Jan;5(1):93-6.
Authors:Lee KM1, Androphy EJ, Baleja JD.
Link:http://www.ncbi.nlm.nih.gov/pubmed/7881274
Title:Assignment of amino acid type in 1H-15N correlation spectra by
labeling with 14N-amino acids.
Journal:J Magn Reson B. 1994 Sep;105(1):88-90.
Authors:Shortle D.
Link:http://www.ncbi.nlm.nih.gov/pubmed/7921674
3x! |
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k******6
发帖数: 7 | 11 Purpose
The Center for Nanophase Materials Sciences (CNMS) at Oak Ridge National
Laboratory (ORNL) is seeking a Postdoctoral Research Associate with
experience and expertise in organic spintronics, with a strong emphasis on
the design, fabrication and characterization of organic spintronic device.
The CNMS http://cnms.ornl.qov/ is a nanoscience research facility supported by the Office of Science, U.S. Department of Energy (DOE). The CNMS has a diverse spectrum of nanoscience activities includ... 阅读全帖 |
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l*******t
发帖数: 1016 | 12 人体有三大系统：
能量系统: 包括经络，NMR Spectroscopy, IR spectroscopy，已经用isotope证明了。
信息系统：包括CNS，PNS，肠胃NS。
营养系统：包括CVS,淋巴。
现代医学使用的 NMR Spectroscopy, IR spectroscopy 都没有解剖基础。
的。 |
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c*****t
发帖数: 198 | 13 【 以下文字转载自 Biology 讨论区 】
发信人: compact (support), 信区: Biology
标 题: how to measure the spatial distribution of amino acids, like lysine
发信站: BBS 未名空间站 (Tue Jul 1 13:42:59 2008)
other than C14 isotope measurement. Thank you. |
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a*****0
发帖数: 3 | 14 能不能下到这篇老的硕士论文：
DJ Campbell, 1985, Fractionation of stable chlorine isotopes during
transport through semipermeable membranes.
Please send to l*******[email protected] if available, thanks a lot! |
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t*****a
发帖数: 40 | 15 请教一下各位：地质学上经常有δ13C (C13 Isotope Concentration)，请问这些术语是怎么定义的？用什么做参照标准?
哪里有相关介绍？
谢谢! |
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a***a
发帖数: 5 | 16 Generally, every lab produces its own standards for routine analyses. But
all the published data should have been calibrated relative to the
international standard (PDB for stable C isotopes).
default |
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c*****e
发帖数: 238 | 17 If I remember correctly, the radical is usually represented by a dot,
I hardly remember anything related with an asterisk, maybe an asymmetric
carbon atom, or an isotopic carbon.
steric effect译为位阻效应吧.
It is generally caused by the hindrance of large groups. |
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C***S
发帖数: 175 | 19 No, she can not get a faculty position there. if you are in NMR, especially in
solid-state NMR field, check whom her husband is.
She should mention that in her addressing.
for
Mei
my
as
NMR
biological
the
Research
these
enhancement
isotopic
these |
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x*****d
发帖数: 427 | 20 王老师的这个讲稿应该是配合道具的, 所以看起来有些费劲. 而且
他谈的是在生物, 化学中的应用, 这些并非是扭结的真正意义. 记得
当时我出国, 好多亲友问我学的东西有什么用, 我总是说, 可以用来
设计立体交通. 现在看来当然是扯淡.
三维空间中的一个闭合的圈, 可能根本没打结, 但是仍然可以看上去很
复杂, 比如把它揉成一团. 一个自然而根本的问题是, 如果不动手去解,
单凭观察, 怎么能判断它到底有没有打结? 这个问题到现在还没有解决.
这个问题在数学上就是不变量的问题. 我们想找一个量, 数量或者更广泛
的量, 这个量在 "解结" 这个过程中是不变的. "解结" 是个怎么样的过程
呢? 就是一种变形, 而在变形过程中保持某种"连续性", 简单来说, 就是
不能剪断绳圈. 圈在空间的形态在拓扑上叫做从圆到三维空间的一个"嵌入"
(imbedding). 如果一个形态可以通过连续变形成为另一个形态, 我们就说
这两个"嵌入"是"同痕的"(isotopic). 这个连续变形就叫一个"同痕"(isotopy).
直观上, 两个同痕的嵌入当然是同一个扭结, 因为跟打结有关的性质是不会
在 |
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e****0
发帖数: 678 | 21 • leukemia
ALL AML CLL
child adult elderly
BM lymphoblasts 25%myeloblasts
lab Lymphocyte 5000, mature-appearing cells
• Osgood-schlatters disease
Adolescent male athletes
Traction apophysitis—quadriceps tendon put the traction on the
apophysis of the tibial tubercle where patellar tendon inserts.
A firm mass =heterotopic bone formation
Pain can be reproduced by extending the kne... 阅读全帖 |
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l******u
发帖数: 2314 | 22 也不知道翻译的对不对。
今天看到Hongjie Dai组的JACS的ASAP: "Multiplexed Multicolor Raman Imaging of
Living Cells with Isotopically Modified SWNTs"。见附件。今年春天ACS和这位
Zhuang Liu兄弟有幸有一面之缘。
最后有多大用不谈，单单从science角度讲，抛开SWNT不谈，如果这是第一次用C12/C13
的G-band shift做Raman Imaging的话，真是灰常creative、灰常amazing了。大家看看
吧。 |
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k******6
发帖数: 7 | 23 Purpose
The Center for Nanophase Materials Sciences (CNMS) at Oak Ridge National
Laboratory (ORNL) is seeking a Postdoctoral Research Associate with
experience and expertise in organic spintronics, with a strong emphasis on
the design, fabrication and characterization of organic spintronic device.
The CNMS http://cnms.ornl.qov/ is a nanoscience research facility supported by the Office of Science, U.S. Department of Energy (DOE). The CNMS has a diverse spectrum of nanoscience activities includ... 阅读全帖 |
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w********g
发帖数: 447 | 24 Outsourcing M&A Year In Review
By Michael A. Martorelli
Several large outsourcing firms made important tuck-in acquisitions, many
mid-sized firms expanded their platforms with strategic acquisitions, and
one outsourcing firm successfully tapped the equity market for an Initial
Public offering (IPO). But the big stories in the pharmaceutical outsourcing
industry in 2009 involved seven “going private” transactions and fifteen
separate divestitures. During the past few years, both in these annual
r... 阅读全帖 |
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c*******n
发帖数: 1214 | 25 Yes. Most isotope that is used is Tc-99, which has short half-life, and it
is used during the day. So the drugs have to be compounded the night before.
That is why nuclear pharmacists have to work overnight shift. Maybe not all
the time, but you have to work overnight in some weeks per month. At least
that is what I know about nuclear pharmacy. |
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c*****t
发帖数: 198 | 26 【 以下文字转载自 Biology 讨论区 】
发信人: compact (support), 信区: Biology
标 题: how to measure the spatial distribution of amino acids, like lysine
发信站: BBS 未名空间站 (Tue Jul 1 13:42:59 2008)
other than C14 isotope measurement. Thank you. |
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s*****n
发帖数: 1279 | 27 我不是搞NMR的，不过最近在看一篇文章（也不是NMR方面的），不过其中有一句话介绍
NMR：
Nuclear magnetic resonance analysis techniques are based on the principle
that all isotopes with an odd-
numbered atomic number (Z) have an intrinsic spin when subjected to a
magnetic field and therefore align
themselves along the magnetic field lines.
这句话有没有毛病？为什么要odd number proton？odd number neutron 不行吗？ |
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t*******e
发帖数: 216 | 28 作为色彩成像的物理本质，是不同的物体，对于自然光不同波长（频率）的吸收率不一
样，反射率也不一样；并且这个吸收率反射率在弱光情况下可以近似为常数，但是在强
光下，它们就随光强变化而变，这个也与物体的组成成分有关，万物皆不同。
我们知道自然光是什么色彩都有的，因此，你在特定光强下看到物体的色彩，是由物体
在吸收了特定自然光波长，并且反射了某些自然光波长所看的光波长综合效果，这就是
光色彩合成的原理。
以上是物理上的分析，但是如果设计到摄影，这个问题就变得有些主观了。因为每个人
的眼睛不同，在欣赏景色的时候心情不同，观察到的色彩也不同，很多人都会有种感觉
当心情极端不好的时候，世界都是灰色的。所以，你所说的逼真，一定要加个引号，这
取决与你希望你的作品表现什么样的心境，这就是所谓象由心生。
再说一下LCD，任何的发光电子元件，组成色彩的方式都是通过直接模仿物体反射到你
眼睛中的被频率选择吸收过的自然光，其方法就是用三原色来配比，由于数字化的位数
越来越高，因此可以配比的颜色层次就逐渐使得眼睛无法区分电子光学成像与实际自然
光成像的区别了，那么这就取决于你的LCD/LED/Plasma的显示... 阅读全帖 |
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k******6
发帖数: 7 | 29 Purpose
The Center for Nanophase Materials Sciences (CNMS) at Oak Ridge National
Laboratory (ORNL) is seeking a Postdoctoral Research Associate with
experience and expertise in organic spintronics, with a strong emphasis on
the design, fabrication and characterization of organic spintronic device.
The CNMS http://cnms.ornl.qov/ is a nanoscience research facility supported by the Office of Science, U.S. Department of Energy (DOE). The CNMS has a diverse spectrum of nanoscience activities includ... 阅读全帖 |
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l**n
发帖数: 67 | 30
I am a lay person here. What i mean is i have not heard of any
sound theory of the origin of big bang. A possible solution is given
by superstring theory. Suppose we are living in a 10-D universe and
six of them curled up into torus or loop or whatever so tiny that
probing them is practically impossible currently. "Before" the big bang
the other six dimensions are open and it is another perfect universe
maybe homogenous, maybe isotopic, i don't know. And the four dimension
we are living in curl |
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d****y
发帖数: 3 | 31 Sorry, Not now, no official reporting until now.
A professor in Japan found it. A research group in US has
confirmed it. Some research group is heading for to confirm
it. The rough chemical structure has identified. Moreover,
the isotopic effect is also proved, which mean this is a
conventional BCS superconductor.
I think this will be a great news in this year's coming
Match meeting of APS. |
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M*********m
发帖数: 2024 | 32 Correct several mistake for you. Customarily we use Z to indicate the proton
number of the element and it's called atomic number. For He and its isotopes,
Z=2.
Second, He3 atom obeys Fermi-Dirac statistics because the total spin of the
atom is an odd integer times 1/2. But for liquid He3, because of the strong
interaction between the atoms, there could be different excitation spectrum
other than the fermionic excitations. Above the transition temperature, the
quasi-particles in the He3 system is |
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c*****t
发帖数: 198 | 33 【 以下文字转载自 Biology 讨论区 】
发信人: compact (support), 信区: Biology
标 题: how to measure the spatial distribution of amino acids, like lysine
发信站: BBS 未名空间站 (Tue Jul 1 13:42:59 2008)
other than C14 isotope measurement. Thank you. |
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w*********s
发帖数: 2136 | 34 Veterans Today Exclusive: What To Do About the Radioactive Poison
April 11, 2011 posted by Bob Nichols · 115 Comments
Protect Yourself and Loved Ones – Not a Drill.
(San Francisco) – What we know:
1. The daily outflow of deadly radiation from Japan’s Four Chernobyl’d
Reactors increased Ten Times on March 31.
2. The Japanese Government in conjunction with GE and the American CIA
cut off information the next day.
3. Information has resumed and is “controlled”.
4. The March 31st Radioac... 阅读全帖 |
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w*********s
发帖数: 2136 | 35 【 以下文字转载自 NextGeneration 讨论区 】
发信人: whiteclouds (/ 参考消息 /), 信区: NextGeneration
标 题: Re: 提醒注意： 地表自来水，乳制品，海鲜受污染最重。 (转载)
发信站: BBS 未名空间站 (Tue Apr 19 08:21:16 2011, 美东)
Veterans Today Exclusive: What To Do About the Radioactive Poison
April 11, 2011 posted by Bob Nichols · 115 Comments
Protect Yourself and Loved Ones – Not a Drill.
(San Francisco) – What we know:
1. The daily outflow of deadly radiation from Japan’s Four Chernobyl’d
Reactors increased Ten Times on March 31.
2. The Japanese Gov... 阅读全帖 |
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h*h
发帖数: 18873 | 36 Most mammals reach adulthood within months and die in their teens or 20s.
Not so with humans and other primates, which take years to become adults,
then live for decades and reproduce infrequently.
Now researchers are reporting that a reason for the disparity may lie in
metabolic rates. According to a new study in Proceedings of the National
Academy of Sciences, primates burn about half as many calories per day as
mammals of comparable size — and not simply because the other mammals are
more act... 阅读全帖 |
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A*********y
发帖数: 3 | 37 偶尔逛到这个网站，看到开了医疗技师版，很高兴。希望和大家交流实用信息
长话短说，移民加拿大， 以前文科专业，全部抛弃，从头开始学新专业。 选了医学放
射专业里的核医学 nuclear medicine, 实习毕业了以后，多伦多附近工作难找，因为
isotope 的短缺，这个分支其实在缩水。 为了尽快得到工作经验，在安省温莎的医院
拿到 cover maternity leave 的一年合约，搬家到那里住了一年。 期间经常去底特律
Shopping,好开心。但是未婚夫在多伦多附近，还得想办法回去。
毕业后立即申请在线的核磁专业，边工作，边继续读。期间因换工作又搬家到里多伦
多更近一些的小镇，但是真是太小了，只有五万人口，虽然这次工作是长期的，但是只
有part time,像这种工作，工资依靠每周做的小时数，part time 每周只有三天，工资
勉强维持生活：（ 但是有请我妈来旅游了三个月，也算尽孝心。
课程读好后在医院的核磁共振部实习，实习好了立刻搬家，搬到离多伦多很近的区域。
很幸运马上拿到了个offer, 离家很近，开车一刻钟，虽然还是part time, 但是每周的
工作小时数... 阅读全帖 |
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z**l
发帖数: 1192 | 38 下面的分析好象有道理:
Epidemiologically, are not the factors you have raised direct evidence of
the impact of potassium/caesium and Calcium/Strontium ionic replacement?
Four points:
1. Perhaps more so than any other sea creature, K and Ca are the critical
minerals for starfish. Starfish have complex K and Ca exchange, uptake and
shedding mechanisms.
2. Sr and Cs are notorious Ca and K emulators respectively.
3. A single Sr90 or Cs137 atom resident in a starfish for a few days would
release enough energy t... 阅读全帖 |
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