r**a
发帖数: 121 | 1 这个从一开始就有争论
好象最早的时候，有人认为是amino acid sensor
后来好多文章说不是
最近，一个cell文章，一个mol cell文章
都说明了Leucyl-tRNA Synthetase and TORC1 的联系
cell文章证明了他是一个GAP for Rag GTPase
看来这回是定论了 |
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m*p
发帖数: 226 | 2 lars2 is leucyl-tRNA synthetase 2, mitochondrial. 谁有这方面的背景？ 大量表
达或抑制表达会有什么样的反应？ 谢
谢！ |
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f****y
发帖数: 104 | 3 Looks it is related to longevity in worm. See this paper:
A systematic RNAi screen identifies a critical role for mitochondria in C.
elegans longevity.
Lee SS, Lee RY, Fraser AG, Kamath RS, Ahringer J, Ruvkun G.
Nat Genet. 2003 Jan;33(1):40-8. Epub 2002 Nov 25.
A classical genetic screen identified a mutation in the mitochondrial leucyl
-tRNA synthetase gene (lrs-2) that impaired mitochondrial function and was
associated with longer-lifespan. |
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m*p
发帖数: 226 | 4 还有人说lars2 mutation correlates with type ii diabetes。
leucyl |
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s*******2
发帖数: 598 | 6 See below 1997 paper
Biochem J. 1997 Apr 1;323 ( Pt 1):233-7.
Actin is cleaved during constitutive apoptosis.
Brown SB, Bailey K, Savill J.
SourceDivision of Renal and Inflammatory Disease, Department of Medicine,
University Hospital, Nottingham NG7 2UH, UK.
Abstract
Proteases play an important role in the programme of cell death by apoptosis
but little is known of the substrates cleaved, particularly in constitutive
models of this type of cell death. Neutrophils spontaneously undergo
apoptosis ... 阅读全帖 |
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