y***e
发帖数: 6082 | 1 【 以下文字转载自 Internet 讨论区 】
发信人: yueke (小鱼儿), 信区: Internet
标 题: 最近电脑中了木马
发信站: BBS 未名空间站 (Sat Oct 21 17:04:13 2006), 站内
发信人: yueke (小鱼儿), 信区: Chemistry
标 题: 最近电脑中了木马
发信站: BBS 未名空间站 (Sat Oct 21 17:01:08 2006), 转信
这几天天天在修电脑，其实就是中了木马，运作很慢，好像都是些国内木马程序，昨天
下了个木马专杀的程序，关了硬盘监控，在安全模式下扫了个通宵，把全部硬盘加内存
扫了遍
，当时电脑没连网络，防火墙一直没跳出病毒信息，以为没事了，tnnd，刚刚一连网络
，又来了，这到底是木马没有扫干净，还是有人在攻击啊，我用的是McAFee防火墙，一
被攻击就是Trojan形式的PWS-Lineage.dll，PWS-Hook.dll的木马被检测到并且杀死的
信息跳出来，最可恶的是一堆W32/HLLP.Phili.ini的病毒刷屏一样的攻击E盘，也被监
测到并被杀死，到底怎么回事啊，电脑和网络高手 |
|
w*******h
发帖数: 29 | 2 现在被诺顿看出来得有木马Drondog, Downloader, 木马horse, 木马.webkit!html
Inforstealer. Onlinegame, Inforstealer.Gampass, Inforstealer.Wowcraft,
Inforstealer.Lineage, Bloodhound.Exploit.165
现在所有用的几个木马专杀工具和卡巴斯基都运行不了，IE 如果用 病毒和杀毒软件作
search 的 话就会被自动关掉，
请问这种情况是不是只有格盘重装系统了？ 还是有其他的办法？ 这种情况下用电脑
登陆邮箱或者msn 还安全吗？ 谢谢！ |
|
s********r
发帖数: 33 | 3 最近我的电脑中了很疯狂的毒，我的McAfee实时监控乱七八糟的跳出警示窗口, 导致我
根本无法用电脑工作了。用McAfee和Spybot都scan过了，没有任何有价值的信息。
具体表现有以下几种：
1，进程中出现奇怪的IEXPLORE.EXE，字母全部大写，有时有好几个IEXPLORE.EXE，占
用的mem usage会持续增长，我确定不是windows自带的ie浏览器，因为终止程序以后还
会不停的蹦出来。而且我已经卸载ie浏览器改用firefox，仍然有IEXPLORE.EXE在进程
中出现，症状跟用ie时一样。
2，进程中出现cmd.exe，占用CPU巨大，往往达到90%以上，可以终止，但会不定时再生
（机器没有重启的情况下）。
3，McAfee可以发现一些木马，如：PWS-Hook, PWS-Lineage，PWS-Legmir,New Malware
.j等等，但并不能完全清除他们，有些只能move，也不知道move到哪儿去了，还要做什
么后续工作。这些木马感染的都是浏览器程序，如firefox.exe, explorer.exe,
IEXPLORE.EXE。
电脑中毒我也快 |
|
d*****u
发帖数: 17243 | 4 http://www.zanhe.com/nature02878.pdf
下面作一个简介（转载）
今年九月，《自然，Nature》杂志刊登了文章：
“Genetic Evidence Supports Demic Diffusion of Han Culture”。
这里，对这篇文章做简单的介绍。
(一)中华远古大迁移
根据远古大迁移理论，三万年前非洲人进入中国的南方，然后向北方迁移。
参加中华北上大迁移的部族，只是南方部族的一部分。
江南的一些部族没有北上，江北缺少某些Y基因类型。但是后来，一些江南人来到北方。
所以至今江南的那些Y基因类型仍然比江北多。
(参见：Y-Chromosome Evidence for a Northward Migration of Modern
Humans into Estern Asia During the Last Ice Age
作者：来自复旦大学、上海二医大、中科院等单位。
Am. J. Genet. 65:1718-1724,1999)
(二)血统问题(Lineages)
mtDNA比较简单，在人类学中人们用mtDNA研究母系。
在讨论晋 |
|
b*******n
发帖数: 473 | 5 試著翻譯一小節，好玩。
I published Lineage Organisation in Southeastern China in 1958. It was an
attempt to bring together what I then knew about its subject, mainly from
published work, and to discuss the role of unilineal descent grouping in
China against the background of anthrpological theory. When I finished it I
knew it was not ended, for I was conscious of having failed to tap the
existing sources in Chinese and Japanese, and I was confident that my
exercise in the armchair anthropology of China wou... 阅读全帖 |
|
M****e
发帖数: 70 | 6 not too late to introduce goodies.
1. Draft genome of sea squirt C. intestinalis 298:2157
Ciona diverged prior to the genome-scale expansions that
occurred in the vertebrate lineage, and this work tries
to understand the origins of chordate and vertebrate by
comparison of genome of Ciona with other invertebrates and
invertebrates. The genome has ~16,000 predicted protein-
encoding genes which show strong similarity to other
invertebrates, which about 1/6 of them have a vertebrate
counterpart inv |
|
j******g
发帖数: 171 | 7 Pluripotency and Totipoteny has similar meaning if not the same, i.e.
differentiation potential of all lineages but not SC of all different cell
types. But some ppl prefer to use Totipotency for ESC.
As I mentioned before, some of the adult stem cells are NOT true stem cells,
coz they only have limited self-renewal ability and differentiation potential.
So it's probably more approtiate to call them progenitor cells. Most time the
Sci would like to blow they find xxx type of stem cells, however, |
|
O******e
发帖数: 4845 | 8 ☆─────────────────────────────────────☆
xfeng (風儿～長逝入君懷) 于 (Wed Jan 24 21:48:22 2007) 提到:
在multi-color调compensation的时候，是一定都要调到firstdecade以内，还是觉得保
证能分开就可以了呢？经常觉得如果调到所有events都在10以内，大部分events就都在
轴上了，不知道对不对？
今天做老鼠骨髓的multi-lineage：PE-CD3, PE-TxRed-B220, APC-Mac1, FITC-CD45.2
and PC5.5-CD45.1。发现，总是有PE-TxRed and PE， 或者PE-TxRed and APC double
positive的细胞。很清楚的population。不知道是我的compensation调的不够，还是FC
block的不完全。如果是FC block的问题，应该用多少抗体，block多久呢？
谢谢！！
☆─────────────────────────────────────☆
Kobune (Trou |
|
d*****r
发帖数: 2583 | 9 ☆─────────────────────────────────────☆
Statefarm (天道酬勤) 于 (Wed Feb 25 18:26:48 2009) 提到:
Volume 125, Issue 3, 5 May 2006, Pages 593-605
Homeodomain-mediated beta-catenin-dependent switching events dictate cell-
lineage determination.
Olson LE, Tollkuhn J, Scafoglio C, Krones A, Zhang J, Ohgi KA, Wu W, Taketo
MM, Kemler R, Grosschedl R, Rose D, Li X, Rosenfeld MG
☆─────────────────────────────────────☆
Statefarm (天道酬勤) 于 (Wed Feb 25 18:28:52 2009) 提到:
Volume 120, Issue 1, 14 January 20 |
|
a****d
发帖数: 1919 | 10 最新一期的Nature paper，reprogramming from fibroblasts to functional neurons
. 一样的套路，不过还是感觉很crazy！
Direct conversion of fibroblasts to functional neurons by defined factors
Thomas Vierbuchen1,2, Austin Ostermeier1,2, Zhiping P. Pang3, Yuko Kokubu1,
Thomas C. Südhof3,4 & Marius Wernig1,2
Abstract
Cellular differentiation and lineage commitment are considered to be robust
and irreversible processes during development. Recent work has shown that
mouse and human fibroblasts can be reprogrammed to a plurip |
|
p*****m
发帖数: 7030 | 11 周侨他们那个很酷 而且可能会很有用 但是这篇新文章能跨很遥远的lineage 这个还是
很有突破性的 |
|
a****d
发帖数: 1919 | 12 I thought the key factor here is the Chromatin remodeling protein. Crabtree
from Stanford has done really nice study to illustrate that different BAF
subunits specifically expressed in different stages of neural lineage.To
switch fibroblast to functional neuron, a large group of genes have to be re
-regulated, probably at the chromatin assembly/disassembly level. It would
be interesting to see if more related study can come up, basically combining
specific chromatin remodeling factor with cell f |
|
a**p
发帖数: 49 | 13 neuroscience department
named after him
if u read the famous book
师从天才
you know how mother ****ing his lineage is |
|
n********k
发帖数: 2818 | 14 watch out Rowitch DH, last times he came here and gave a very very nice talk
. I think he is gearing up to
dissect some of those with genetic and lineage tracing tools on astrocytes,
which were very nice and
impressive... |
|
r****r
发帖数: 379 | 15 挺喜欢骆的东西, his new cell paper
－－－－－－－－－
* Highlights
* The Q system offers repressible binary gene expression in flies and
mammalian cells
* Q-MARCM enables mosaic cell labeling and genetic manipulation
independently of GAL4
* Coupled MARCM independently labels and manipulates both progeny of a
cell division
* Intersecting Q and GAL4 systems refines transgene expression for
functional analyses
We describe a new repressible binary expression system based on the
regulatory genes f |
|
|
p******i
发帖数: 1092 | 17 是啊，我WSN这么多年，越来越体会到LINEAGE的重要性啊…… |
|
p*********8
发帖数: 1 | 18 Postdoctoral Position in Neural Stem Cell and Brain Tumorigenesis
A postdoctoral position is immediately available in the Zheng Laboratory at
Cold Spring Harbor Laboratory. This newly founded lab uses a range of in
vivo and in vitro approaches to study malignant gliomagenesis and its
relations to neural stem and progenitor lineage development (for more
information, please see - Cancer Cell 2010 17: 497; Nature 2008 455: 1129;
PNAS 2010 107: 6912). We are seeking a well-qualified and motivated
in |
|
e**s
发帖数: 856 | 19 Tapetal cell fate, lineage and proliferation in the Arabidopsis anther.
Feng X, Dickinson HG.
Development. 2010 Jul;137(14):2409-16.
PMID: 20570940 [PubMed - indexed for MEDLINE]
Related citations
2.Cell-cell interactions during patterning of the Arabidopsis anther.
Feng X, Dickinson HG.
Biochem Soc Trans. 2010 Apr;38(2):571-6. Review.
PMID: 20298223 [PubMed - indexed for MEDLINE]
Related citations
3.Packaging the male germline in plants.
Feng X, Dickinson HG.
Trends Genet. 2007 Oct;23(10):503-1 |
|
C********1
发帖数: 160 | 20 精妙，同赞！
其实我觉得CNS文章和K award的作用在于帮你拿到第二轮面试（也即Geneporter说
的chalk talk，一般3－10个candidate）的门票，之后如何能脱颖而出就在于1）
presentation skill，2）personality，3）scientific vision/potential，4）
lineage。（个人觉得这四点很难说有先后之分，关键看你申请的地方）
当然就像很多生物原理都不是绝对的一样，找工作也有很多例外，比如：
第一，小学校或是大学校的小department ，因为掏不起starting package，所以K
award，尤其是K99，反而变得非常重要。
第二，有些地方招人带有很强的目的性，比如特别需要做某一个specific领域甚至
技术的人（当然他们在广告里绝对不会告诉你）。我的大老板就刚招了一个AP，感觉跟
楼主背景很像，2篇一作CNS，二作三作N作的小文章也有一些，没有K award，没有很强
的派系背景。其他被刷掉的人当中比他背景强、paper还要好还要多的也大有人在，但
就招他的原因 |
|
a****d
发帖数: 1919 | 21 time lapse study of cell lineage is really powerful, and we sure need more
advanced tools to get into more details |
|
y******8
发帖数: 1764 | 22 Residency is for clinical practice, not for research. Nowdays, MDs have very
limited research experience. But before, when Collins received his
education, MDs ruled the biomedical research. In most medical institutions,
lineage inbred is a tradition. It is not hard at all to create some
independent fellow position in a hospital. |
|
a****d
发帖数: 1919 | 23 I don't think cancers are monoclonal, most times they are heterogeneous
population, and cancer can be derived by different cell lineages, at least
in some types of cancer.
Plus I don't think people in cancer stem cell field thought the "cancer stem
cell" have the ability to differentiate into multiple cell types. They are
more like cancer initiating cells per se.
differentiate |
|
H*****e
发帖数: 120 | 24 Wow, on the top list!
Well, I never expect to be on the top list. This reason is that I am not
here very often. Also apologize to those are discussing about the topic and
expect me to give my opinion.
I believe that the previous title regarding to someone retract her paper is
misleading. So it is necessary to clear some issue and have an opportunity
to draw more discussion. Now back to the stem cell issue not the Amy or
Carla although name may be mentioned but please ignore my own personal
... 阅读全帖 |
|
P*****a
发帖数: 629 | 25 hi, anyone knows who/where is conducting free genealogy research (genetic
based), like sending out my blood
sample, then they can reveal my ancestor lineage, thanks, very curious about
my family tree lately |
|
h*****G
发帖数: 113 | 26 By ectopic expression of only 4 transcription factors, terminal
differentiated somatic cells can be transformed to be iPS cells. My question
is that if iPS cells or ES cells can be directly programmed to a specific
somatic cell fate by a pool of lineage specific transcription factors
without usually used stepwise protocols. If yes, could you please show me
some of the references? If not, what do you think might be the problem? |
|
w*e
发帖数: 740 | 27 在再生医学里面，不一定非要用ES，IPS细胞
有时候用临近的，同一个LINEAGE的其他类型的细胞，直接通过几个因子就可以相互转换
好象胰腺里面搞的比较火热，DOUGLAS MELTON 08年的NATURE 就是类似的
还有 从ES细胞到终末分化的细胞，并不单单是转录因子的作用，
有时候细胞间的相互影响作用也很大
question |
|
h*****G
发帖数: 113 | 28 Thank you.
Lineage reprogramming is definitely very promising. As mentioned in another
post, it has been showed that fibroblast can be transformed to neuron
with only 3 TFs.
At the same time, direct programming from ES/iPS cells to somatic cells are
few. And I was not be able to find any publications. So was wondering if
someone can help me with some papers about direct programming from ES/iPS
cells to somatic cells with TFs, not stepwise extracellular signals.
Thanks.
转换 |
|
t****p
发帖数: 1504 | 29 These are good questions! I also thought about that.
Theoretically, directional differentiation is easier than reprogramming,
because the latter is not a natuarl process. There is no any reason that
transcription factors should not force cells to differentiate into specific
lineage, given the facts of iPS.
I don't think any lab has achieve this, though.
question |
|
g*********d
发帖数: 233 | 30 Genetic history of an archaic hominin group from Denisova Cave in
Siberia
David Reich, Richard E. Green, Martin Kircher, Johannes Krause,
Nick Patterson, Eric Y. Durand, Bence Viola, Adrian W. Briggs, Udo
Stenzel, Philip L. F. Johnson, Tomislav Maricic, Jeffrey M. Good,
Tomas Marques-Bonet, Can Alkan, Qiaomei Fu, Swapan Mallick, Heng
Li, Matthias Meyer, Evan E. Eichler, Mark Stoneking, Michael
Richards, Sahra Talamo, Michael V. Shunkov, Anatoli P. Derevi... 阅读全帖 |
|
i*****n
发帖数: 53 | 31 你的CRE没有 表达不够广泛吧。不是在所有lineage细胞里面都表达。因此有些细胞里
切掉了，有些没有切掉吧，最后导致mosaic 表达。 做一下IHC， 或者IF，看一下就知
道了。 |
|
b*******n
发帖数: 8420 | 32 研究有不少了吧。只是这种细胞目前还没lineage specific marker。 |
|
f*****Y
发帖数: 20 | 33 胚胎是一个比cell culture复杂的多的系统，需要很多signaling的协调才能正常的发
育。而ES cells只是胚胎的一个cell lineage的culture adaptation，是一个简单的多
的系统。比如说，cdx2 mutant embryo因为trophectoderm defect 无法存活(
embryonic lethal E3.5-5.5), 但是cdx2 ES cells 是可能的。还有nanog mutant
embryo is lethal，Nanog null ES cells 据说可以proliferate many passages. |
|
j**e
发帖数: 582 | 34 more retraction
Retraction
Oncogene (2011) 30, 2798; doi:10.1038/onc.2011.67
Selectively frequent expression of CXCR5 enhances resistance to apoptosis in
CD8+CD34+ T cells from patients with T-cell-lineage acute lymphocytic
leukemia
Z Qiuping, X Jie, J Youxin, W Qun, J Wei, L Chun, W Jin, L Yan, H Chunsong,
Y Mingzhen, G Qingping, L Qun, Z Kejian, S Zhimin, L Junyan and T Jinquan
Retraction to: Oncogene (2005) 24, 573–584; doi:10.1038/sj.onc.1208184;
published online 6 December 2004
This paper h... 阅读全帖 |
|
T*****n
发帖数: 274 | 35 谢谢，大受教宜。我的目标基因正是非常specific的表达在一个特定lineage
的特定发育阶段，其表达在RNA水平上受到调控，这也正是我猜测可能有microRNA
参与其中的原因。接下来准备去找找这个组织的miRNA profiling数据，还有
用你给的网站predict几个miRNA试试看。
关.
candidate |
|
c********r
发帖数: 1125 | 36 我实验室一个博后在woods hole暑假班跟tim有交流。
据说：
是非常nice得人，对senior和年轻学生都很友善。
真心喜欢科研，实验室现在方向有cell division和chemical genetic。实验室人不算
太多
手底下人出路不错，学生出息的也很多了，tarun kapoor做的跟他很多方向一致，
rising star啊。
另外他出身lineage很好，在细胞生物学界是top人物，跟着他混出路不可能差的。
严格说tim实验室追求方向多样化，（甚至物种多样化），但是还是传统的生物实验室
，不能算系统生物学实验室吧？ |
|
e******n
发帖数: 2 | 37 招聘行政助理、生物信息研究助理和博士后
清华大学医学院干细胞及表观遗传研究室 (August, 2011)
本实验室主要研究表观遗传调控机制在干细胞多能性、动物生长发育和癌变中的作用。
课题组研究背景：
http://www.tsinghua.edu.cn/publish/med/3157/2010/20101215191338
拟招聘实验室行政助理、生物信息研究助理和博士后各1 名。待遇参照清华大学标准，
提供有竞争力的薪酬（具体视个人情况而定）。
一、实验室行政助理1名：
工作职责：
1、协助管理实验室的日常运转，包括试剂、耗材和仪器订购及报修，各类文档和数据
的管理和备案;
2、 处理相关办公室事宜，包括科研经费管理、年度报告和学生工作。
3、辅助完成简单的生物学实验 （optional）。
资格要求：
1、 本科以上学历，年龄不限；具有生物、生物信息、计算机背景者优先;
2、 有较好的计算机操作能力、中文写作和打字能力; 较好的英语水平；
3、 具有较好的管理能力，善于沟通和交流，具有团队合作精神;
4、 具有极强的责任心，工作主动积极，办事利落、... 阅读全帖 |
|
a********k
发帖数: 2273 | 38 花了一个小时，深深的鄙视一下自己的无聊行径！！
125 蔡亮 男 1980年11月 复旦大学 生命
科学 2007年12月毕业于[美国]北卡大学 [美国]加州大学旧金山分校 博士后
Cai L, Mostov K. Polarity is destiny. Cell. 2009 Nov 13;139(4):660-2. PubMed
PMID: 19914162; PubMed Central PMCID: PMC2900917.
Cai L, Makhov AM, Schafer DA, Bear JE. Coronin 1B antagonizes cortactin and
remodels Arp2/3-containing actin branches in lamellipodia. Cell. 2008 Sep
5;134(5):828-42. PubMed PMID: 18775315; PubMed Central PMCID: PMC2570342.
Cai L, Makhov AM, Bear JE. F-actin... 阅读全帖 |
|
m*****u
发帖数: 15526 | 39 半固体培基主要目的是估计你的细胞样本中colony forming cells 的数量，功能和类
型。无论你用PBMC还是CD34,能形成colony的细胞只是其中一部分。根据colony的数量
，形态，大小，颜色可以知道血细胞红系，粒系，单核巨噬各系progenitor的分布和
colony形成能力。在液体培养中，所有分化的lineage都mix一起，和不能形成colony的细
胞也混在一起，这样这些就都无法判断。 |
|
m*****u
发帖数: 15526 | 40 我们似乎注重的方面不一样。半固体培养更着重看群体情况而不是单一细胞集落。比较
wt和mu各lineage分化情况，如果是我的话会把相同浓度的wt和mu cell做倍比稀释，每
个浓度都接种到methylcellulose,观察计数集落数量，大小，种类。然后按这些指标分
别统计比较，观察有否差异。如果集落本身就有重大区别，再看集落本身的情况。如果
你能得到一个高纯的细胞群体，colony forming cell的比例很高，随机看孔也不是不
可以。不过这种纯化富集本身就可能导致bias。 |
|
