z*t
发帖数: 863 | 1 你想要常规的三个subpopulation(monocyte, neutrophil, lymphocyte)的percentage
还是绝对数？
或者要macrophage或者特殊的t细胞subpopulation? |
|
f******g
发帖数: 1003 | 2 首先，我还是要说，我不是做结构的。为了回答你的问题，我在google搜索两个关键词
protein structure, drug discovery,得到很多结果，我把维基的链接放在这里，你可
以看看
http://en.wikipedia.org/wiki/Drug_design
里面举例如下，
A particular example of rational drug design involves the use of three-
dimensional information about biomolecules obtained from such techniques as
X-ray crystallography and NMR spectroscopy. Computer-aided drug design in
particular becomes much more tractable when there is a high-resolution
structure of a target protein bound to a potent ligand. ... 阅读全帖 |
|
s**********e
发帖数: 2888 | 3 记得去年在Science上面看到报道，现在都已经快批准了，牛。
http://news.yahoo.com/us-regulators-fast-track-novel-leukemia-t
Washington (AFP) - US regulators on Monday put an experimental immunotherapy
agent on the fast track to market approval, after 89 percent of leukemia
patients in early trials saw their cancers disappear.
The personalized immunotherapy known as CTL019 was developed by the
University of Pennsylvania and was designated a "breakthrough therapy" by
the US Food and Drug Administration.
That means the experi... 阅读全帖 |
|
n*********s
发帖数: 552 | 4 Establishment and characterization of a bank of cytotoxic T lymphocytes for
immunotherapy of epstein-barr virus-associated diseases.
July/August 2004 - Volume 27 - Issue 4
多谢！有包子。 |
|
f******g
发帖数: 1003 | 5 老的T细胞如果不被新生取代的话，容易生成tumor。
Cell competition is a tumour suppressor mechanism in the thymus
Cell competition is an emerging principle underlying selection for cellular
fitness during development and disease. Competition may be relevant for
cancer, but an experimental link between defects in competition and
tumorigenesis is elusive. In the thymus, T lymphocytes develop from
precursors that are constantly replaced by bone-marrow-derived progenitors.
Here we show that in mice this turnover is regula... 阅读全帖 |
|
j***x
发帖数: 1469 | 6 1.EARLY T LYMPHOCYTE PROGENITORS
Annual Review of Immunology
Vol. 14: 29-47 (Volume publication date April 1996)
DOI: 10.1146/annurev.immunol.14.1.29
Ken Shortman and Li Wu
====================================
2.The majority of immature fetal thymocytes can be induced to proliferate to
IL-2 and differentiate into cells indistinguishable from mature natural
killer cells.
The Journal of ImmunologyDecember 15, 1993 vol. 151 no. 12 6645-6656
Please send to l************[email protected] |
|
|
s******9
发帖数: 283 | 8 Immuno-sequencing方向挺好，但需要等待好些方向的技术突破才能变成大规模的应用
。现在办公司能否快速成长关键在于摘取low-hanging fruit，比如检测tumor-
Infiltrating lymphocytes。 |
|
P******r
发帖数: 966 | 9 PD-L1或者B7-H1在发现之初，两个小组给出了截然不同的结果。日本的小组说PD-L1抑
制T细胞的增值和细胞因子的释放
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member
leads to negative regulation of lymphocyte activation.
而Lieping Chen小组最早发现的时候说是刺激T细胞的增殖和细胞因子的释放：
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation
and interleukin-10 secretion
这样截然不同的结果有可能是分别在不同条件下都成立吗？还是说有一方错了？ |
|
S******D
发帖数: 29 | 10 如果从肿瘤组织中分离出一些T细胞，现在知道大部分是CD8+，怎样能确定T cell
clone或者T cell antigen？还有通过什么实验可以确定lymphocyte是促进肿瘤发展还
是抑制肿瘤发展？
谢谢！ |
|
b*******1
发帖数: 16 | 11 岗位一：吴虹课题组博士后工作人员 （2名）
主要职责：
1）独立开展科研工作，动手进行体内外实验；
2）协助PI负责实验室研究课题的设计和开展；
3）参与科研基金撰写；
4）协助培养研究生。
招聘条件：
1）品学兼优，身体健康，年龄在40岁以下；
2）近年来在国内外获得分子生物学、细胞生物学、肿瘤遗传学、药理学等相关专业博
士学位；
3）至少具备一项以下领域内的工作经验和文献发表：
a. 独立运用细胞和动物模型进行肿瘤药物的机理研究
b. 在分子生物学和细胞生物学领域有深厚的知识背景；
c. 在蛋白质分析、核酸分析和细胞生长分析等相关技术方面有丰富的经验；
d. 对治疗癌症的药物疗效和安全性评价方面有强烈的兴趣和研究背景 ；
4）有较强的团队合作精神，沟通协调能力强，动手能力强，工作细心，积极主动，能
持之以恒；
聘用待遇：
本职位将为你提供在生物学领域极具竞争力和创造性的工作机会。博士后工作人员薪酬
标准按照北京大学生命科学院和北大-清华生命科学中心相应规定及个人工作经验及能
力确定。
联系方式：
有意者请将本人应聘材料电子文档发至以下联络方式（请在应聘材料及邮件主题上注明
：姓名 ... 阅读全帖 |
|
s****9
发帖数: 932 | 12 帮朋友贴个广告，job description见下。
We have an opening for a talented Senior Research Associate (temporary
position) to join Discovery Immunology department at Genentech/Roche. The
successful candidate will utilize molecular biology, biochemistry, and in
vivo animal models, as well as cutting edge techniques to understand the
autoimmune pathogenesis pathways in inflammatory bowel diseases (IBD). The
project is to support a late-stage clinical trial with animal mechanism of
action study. Animal handlin... 阅读全帖 |
|
e****l
发帖数: 115 | 13 Adv Exp Med Biol. 2013;792:193-214. doi: 10.1007/978-1-4614-8051-8_9.
Molecular biomarkers in chronic lymphocytic leukemia.
Malek S
please send to [email protected]
/* */
Thanks so much! |
|
j***x
发帖数: 1469 | 14 Noel, S., et al. (2015). "T Lymphocyte-Specific Activation of Nrf2 Protects
from AKI." J Am Soc Nephrol 26(12): 2989-3000.
please send to: [email protected]
/* */
Thanks in advance. |
|
j***x
发帖数: 1469 | 15 T Lymphocyte–Specific Activation of Nrf2 Protects from AKI
Sanjeev Noel, Maria N. Martina, Samatha Bandapalle, Lorraine C. Racusen,
Haranatha R. Potteti, Abdel R.A. Hamad, Sekhar P. Reddy, and Hamid Rabb
JASN December 2015 26: 2989-3000; published ahead of print August 20, 2015,
please send to: [email protected]
/* */
thx |
|
s******a
发帖数: 134 | 16 The Avram Laboratory at University of Florida is seeking a postdoc or a
visiting Ph.D. student researcher. Our laboratory focuses on transcriptional
control of effector lymphocytes in autoimmunity. Our recent work has been
published in many high-impact journals, such as Immunity, J Clin Invest, and
J Exp Med. We are seeking candidates who are self-motivated and career-
oriented to join an exciting highly interactive research team. Interested
candidates are encouraged to contact Dr. Avram by e-m... 阅读全帖 |
|
l*******i
发帖数: 153 | 17 专利已经被法国人申请了：
Title： ENGINEERING MAMMALIAN GENOME USING DNA-GUIDED ARGONAUTE INTERFERENCE
SYSTEMS
Pub. No.: WO/2015/140347 International Application No.
: PCT/EP2015/056113
Publication Date: 24.09.2015 International Filing Date: 23.03.
2015
IPC:
C12N 15/113 (2010.01), C12N 15/90 (2006.01)
Applicants: CELLECTIS [FR/FR]; 8 Rue de la Croix Jarry F-75013 Paris (FR)
Inventors: VALTON, Julien; (US).
DUCHATEAU, Philippe; (FR)
Agent: ZACCO ... 阅读全帖 |
|
l********9
发帖数: 28 | 18 With liquid biopsy, you can check many things, like circulating tumor DNA,
circulating tumor cells and lymphocytes, assuming you are also getting tumor
biopsies. |
|
c**********n
发帖数: 177 | 19 不管怎么样，病人总是还活着吧，除了一个已经beta2M缺失了。Beta2M缺失这个也算一
个对照了，只有MHC production完全受阻以后疫苗才没用。所有参与trial的人都是
chemo，check point用了一圈没用，最后才死马当活马医来参加疫苗trial。
几点thoughts：
1. 德国组给RNA，哈佛组给peptide，个人觉得给RNA更好。哈佛组给的peptide都是15-
30mer，而且属于exogenous antigen, 对于classI MHC来说太长,并且classI MHC主要
是present endogenous的antigen peptide。哈佛组的结果也是主要激活CD4 细胞，而
CD8细胞激活的比较少。
2. 这个方法基本给之前狂热追逐Tumor infiltrating Lymphocyte的各路大牛小牛们浇
了盆冰凉冰凉的水。参看一下，有多少关于高通量测paired alpha beta single cell
sequence的文章就知道了。
3. 文章里面的技术基本都可以外包给公司，产业化和规模化都很容易。此处飘过一句
话：2... 阅读全帖 |
|
发帖数: 1 | 20 我没有太仔细的读，不过文章里说这俩个trails里大部分的患者都是肿瘤已经切除，体
内没有detectable tumor的时候加入的。怎么能得出结论都是chemo,check point用了
一圈死马当活马医来的？
第二，德国的那个组2015年发的文章显示，这个antigen激活抗肿瘤免疫主要是靠MHC
class II 而不是class I.Mutant MHC class II epitopes drive therapeutic immune
responses to cancer.Nature. 2015 Apr 30;520(7549):692-6. doi: 10.1038/
nature14426. Epub 2015 Apr 22.
你说的“这个方法基本给之前狂热追逐Tumor infiltrating Lymphocyte的各路大牛小
牛们浇
冲突啊？
最后，如果这个技术被大量应用，并且都外包到公司，是不是会给千老提供一个出坑的
好机会呢？毕竟里面生物信息分析和一些技术的操作设计到人的生命，估计公司不会放
心去交给小本去干吧？？
15- |
|
|
|
m********8
发帖数: 314 | 23 这篇论文的提法是co-stimulatory molecule that may be involved in the negative
regulation of cell-mediated immune responses.能算作是“误认为PD-L1(B7-H1)是
抑制T细胞增殖”的论断吗？
https://www.nature.com/articles/nm1299_1365
摘要：The B7 family members B7-1 and B7-2 interact with CD28 and constitute
an essential T-cell co-stimulatory pathway in the initiation of antigen-
specific humoral and cell-mediated immune response. Here, we describe a
third member of the B7 family, called B7-H1 that does not bind CD28,
cytotoxic T-lymphoc... 阅读全帖 |
|
m********8
发帖数: 314 | 24 将B7-H1更名为PD-L1的论文作者众多。这篇论文里Honjo用极为技巧的写法并突出了自
己是这篇论文的代表。第一作者Freeman当时可不是学生。
G.J. Freeman, A.J. Long, and Y. Iwai contributed equally to this work. C.R.
Wood and T. Honjo share senior authorship.
Gordon J. Freeman, Andrew J. Long, Yoshiko Iwai, Karen Bourque, Tatyana
Chernova, Hiroyuki Nishimura, Lori J. Fitz, Nelly Malenkovich, Taku Okazaki,
Michael C. Byrne, Heidi F. Horton, Lynette Fouser, Laura Carter, Vincent
Ling, Michael R. Bowman, Beatriz M. Carreno, Mary Collins, Clive R. Wood,
Tasuku Ho... 阅读全帖 |
|
j********1
发帖数: 17 | 25 标题: A NEW GENERATION OF CA-2+ INDICATORS WITH GREATLY IMPROVED
FLUORESCENCE PROPERTIES
作者: GRYNKIEWICZ, G; POENIE, M; TSIEN, RY
来源出版物: JOURNAL OF BIOLOGICAL CHEMISTRY 卷: 260 期: 6 页: 3440-
3450 出版年: 1985
被引频次: 17,738
2. 标题: CALCIUM HOMEOSTASIS IN INTACT LYMPHOCYTES - CYTOPLASMIC FREE
CALCIUM MONITORED WITH A NEW, INTRACELLULARLY TRAPPED FLUORESCENT INDICATOR
作者: TSIEN, RY; POZZAN, T; RINK, TJ
来源出版物: JOURNAL OF CELL BIOLOGY 卷: 94 期: 2 页: 325-334 出版年:
1982
被引频次: 2,269
3. 标题: |
|
u**s
发帖数: 384 | 26 Title:Serum metabolome analysis by 1H-NMR reveals differences between
chronic lymphocytic leukaemia molecular subgroups
Author:D A MacIntyre, B Jiménez, E Jantus Lewintre, C Reinoso Martín, H
Schäfer, C García Ballesteros, J Ramón Mayans, M Spraul, J García-
Conde and A Pineda-Lucena
Journal:Leukemia 24, 788-797 (April 2010) | doi:10.1038/leu.2009.295
Link:http://www.nature.com/leu/journal/v24/n4/full/leu2009295a.html
Thanks! |
|
h******d
发帖数: 4761 | 27 是我没仔细？！那我就都贴过来大家看吧
Can an Ancient Healing System practiced for thousands of years be useful
in the modern cancer care setting? The National Cancer Institute says YES!
Acupuncture has demonstrated benefit to cancer patients in the following
areas:
Pain Management: managing pain related to tumors, surgery, chemotherapy,
radiation and inflammation.
Immune System Modulation: increases blood cell production and enhances
Natural Killer Cells and Lymphocytes which leads to increased immune
response |
|
h******d
发帖数: 4761 | 28 是我没仔细？！那我就都贴过来大家看吧
Can an Ancient Healing System practiced for thousands of years be useful
in the modern cancer care setting? The National Cancer Institute says YES!
Acupuncture has demonstrated benefit to cancer patients in the following
areas:
Pain Management: managing pain related to tumors, surgery, chemotherapy,
radiation and inflammation.
Immune System Modulation: increases blood cell production and enhances
Natural Killer Cells and Lymphocytes which leads to increased immune
response... 阅读全帖 |
|
n*p
发帖数: 1253 | 29 ☆─────────────────────────────────────☆
qingxi (作为兔子一定要长得呆) 于 (Fri Jul 16 17:37:01 2010, 美东) 提到:
引言：
我曾经在mitbbs论坛发了有关妈妈的信息，http://www.mitbbs.com/article/ChineseMed/12563569_3.html 说西医正在谋杀我妈妈，受到很多人的指责，现在就让事实来说话。
我的妈妈胃癌晚期手术后化疗吃的东西全部呕掉，连水都喝不了，我们明智的放弃了痛苦的西医，转为中医治疗。在中医的治疗下，我妈妈再没有受任何罪，既不痛苦又恢复超快。一个月就能够逛街，做全家人的饭，两个多月诸症俱消，心情舒畅。最近看到买买提上很多绝望的人在发
兹瞬×饲笾急富ǖ羲谢睿以埠退且谎淖叩搅巳松淖畹凸取Ｋ煌氖牵笔蔽矣兄幸骄憷植康呐笥衙歉业闹С趾妥８＃易约阂布嵝胖幸侥芄话崖杪杈然乩础Ｎ艺夥菪⑿奶炜闪梦矣龅搅撕靡缴以说淖吖戳恕Ｎ腋庑┤朔⒐ㄒ樗强粗幸剑
有人搭理我，因为没有人相信。所以要把这个帖子发出来，让大家看一看我和妈妈共同经历的这个真实的故事。
我经妈妈同意，贴... 阅读全帖 |
|
b**s
发帖数: 589 | 30 http://microbiology.medicine.dal.ca/people/hoskin/labtech.htm
SCID mice and SCID-human mice (p. 524-525; Fig. 23-1)
* SCID mice fail to develop mature T and B lymphocytes due to a failure in
VDJ recombination caused by defective recombinase enzymes. This defect renders
SCID mice severely immune deficient so they must be housed under sterile
conditions.
* SCID mice can be humanized in order to study the human immune system.
Portions of human fetal liver (a rich source of pluripotent stem |
|
l********z
发帖数: 810 | 31 A 42-year-old man has a temperature of 39.2°C (102.6°F) and mild jaundice
2 days after transfusion of packed red cell for the treatment of chronic
anemia. Laboratory studies show hyperbilirubinemia and a mild increase in
serum lactate dehydrogenase activity. Which of the followings will most
likely be observed on analysis of peripheral blood cells?
A) Complement protein C3bi bound to monocyte
B) Degranulated neutrophils
C) Erythrocyte ghosts
D) HLA-DR upregulation in circulating CD3+ T lymphocyt |
|
R****0
发帖数: 138 | 32 Lot of key words are missing in FA and make it hard to be fully understood.
For example, Step1 FA p325, the mechanism of Reye's syndrome
Aspirin metabolites (salicylates) inhibit β-oxidation by reversible
inhibition of mitochondrial enzyme (long-chain 3-hydroxyacyl-CoA
dehydrogenase).
p338, B lymphocytes migrates lo peripheral lymphoid tissue: follicles
of lymph nodes, white pulp of spleen, and Peyer’s patches (unencapsulated
lymphoid tissue).
You are welcomed to add more and more. |
|
h***a
发帖数: 312 | 33 1. During an experiment, the following data are obtained from an
anesthetized dog:
Mean glomerular capillary hydrostatic pressure (HPGC) 45 mmHg
Mean Bowman space hydrostatic pressure (HPBS) 12 mmHg
Mean glomerular capillary oncotic pressure (piGC) 23 mmHg
Mean Bowman space oncotic pressure (piBS) 0 mmHg
Coefficient of filtration (Kf) 3.0 (mL/min)/mmHg
Renal Blood Flow 200 mL/min
Hematocrit 40%
Filtration Fraction 25%
An IV infusion of AngII is administered for 60 minutes. Which of the
fol... 阅读全帖 |
|
s*******d
发帖数: 1079 | 34 学友MILK找到的这个FA ２０１１版 vs ２０１０版的详细对照，我觉得很有帮助，放
在这儿给大家做参考吧。
原文见 http://forums.studentdoctor.net/showthread.php?t=785943
Overall:
- FA 2011 corrects some of the 2010 errata
- FA 2011 has darker print and thicker pages
- FA 2011 increases the size of most figures/images (although only slightly)
- FA 2011 removes several images that are difficult to see/interpret
Behavioral Science:
p. 59-60 2010 (57-58 2011) -2011 reorganized a couple items into "Advance
directives" and got rid of "Good Samaritan Law.... 阅读全帖 |
|
p******3
发帖数: 318 | 35 I have a sad case.
I was rotating at a US #1/2 cancer center.
A 40 Yr old man came in due to HA. He was diagnosed with Burket's lymphoma
and had chemotherapy several weeks ago. his labs shows leukopenia that is
likely from the chemo. He had CT, MRI that are showed white matter changes
and some sinus wall thickening. I did an LP which showed several lymphocytes
. I asked the neurosurgery to perform a biopsy but they refused. My top 1
differential was Mucor. since i was only a starting second year... 阅读全帖 |
|
c*******s
发帖数: 399 | 36 interesting, lyphoma, chemo, lyphoma involvment vs mucor infection, sinus
wall thickening.
just wonder is there other way to test the spinal fluid for mucor infection
, or biopsy is the only way.
lymphocytes
no
the |
|
A*******s
发帖数: 9638 | 37 Great case. Pearls in this case include:
1. Immunosuppressed patients are vulnerable to fungus infection. When
headache is present, CNS infection should be considered, besides the
leptomeningeal carcinomatosis.
2. CSF neg does not necessorily R/O CNS infection.
3. CNS Mucor most likely comes from invasion of sinus mucor infection
directly. If that was the case, you might consult ENT instead of NSG. If
sinus mucor can be comfirmed, treat the sinusitis aggressively instead of
encephalitis.
4. Avoi... 阅读全帖 |
|
V*****G
发帖数: 337 | 38 Good case, progressing so fast.
lymphocytes
no
the |
|
f****g
发帖数: 41 | 39 在国内的亲戚被诊断为chronic lymphocytic leukemia，正在考虑来美国治疗。
请问各位版友在美国哪些医院的血液科或者治疗白血病比较厉害的，我们考虑先直接和
医院联系一下。
非常感谢！ |
|
i**********d
发帖数: 853 | 40 谢谢回复，我之所以问这个问题是因为：从外来抗原被注射入体内，到APC细胞把它和
MHC II的complex表达在细胞膜上之间有一些复杂的步骤，我个人认为这中间的过程是
解释这个题的关键所在。
基本步骤：
1. Exogenous antigens, such as viruses, are engulfed and placed in a
phagosome.
2. Lysosomes fuse with the phagosome forming a phagolysosome.
3. Protein antigens are degraded into a series of peptides.
4. MHC-II molecules are randomly synthesized in the endoplasmic reticulum;
since MHC is very complicated system and can form numerous different MHC II
molecules, in most time at least one MHC II ... 阅读全帖 |
|
h*******r
发帖数: 182 | 41 Many people would choose D, and I think this is a common logic--no MHCII,
then APC cannot present Ag. But one underlying fact most people missed is
that this deficiency (Bare lymphocyte) would leads to complete loss of CD4+
cells, one kind of rare SCID that will not respond to any foreign Ag
including microbes. There is no evidence that in such population one HLA
phenotype will increase its expression.
BTW, T cells are not APC.
Ag.
and |
|
w******y
发帖数: 4871 | 42 免疫方面查一下吧。
IgG, IgA, IgM, CH50, complete Lymphocyte subsets w/NK cell, mitogen test,
HIV.
And respiratory viral culture! CMV IgM antibody
阿 |
|
D******D
发帖数: 1159 | 43 续上集，step1成绩终于出来啦，勉强爬过260。再补充几点step1备考窍门。
http://www.mitbbs.com/article_t0/MedicalCareer/31511907.html
1. 这个窍门大家可能都知道，就是拿来一道题先看最后一句，或者后两句。主要原因
是可以省时间。因为有些 题前面讲了一堆东东，可最后滴问题跟前面一点关系都没有
，比如某人的了某病，然后给了某药，结果最后问你，这个药滴作用机理是什么，如果
你认认真真滴把题从头读到尾，那么 起码20秒滴时间就浪费掉了。还有些题前面描述
了很多东东，最后告诉你这个人得了什么病，然后问怎么治疗。。。所以碰到这种题，
如果你采取了偶滴办法，就可以省下不少时间^_^
2. 偶做题经常出低级错误，所以解决办法就是反复检查，可是想检查3遍时间肯定不够
啊，所以偶就把有可能出错滴题都label上，一般偶会label50%+滴题目。如果最后时间
足够，就全检查一遍，如果时间不够咋办，那就只检查重点喽。对于重点题目，偶滴
label办法是highlight，这样你就等于标记了两组题 ，一组是把握低于95%滴，一组是
把握低于... 阅读全帖 |
|
p******d
发帖数: 374 | 44 A four-year-old asian boy has fever ranging from 102 F to 104 F for more
than five days. Fever can be reduced by taking acetaminophen and ibuprophen
. Bilateral eyes are slightly pinkish. Lips are erythematous but no
fissure. Tongue and oropharynx are normal. No lymphadenopathy, extremity
swelling, and rash. Pediatric Transthoracic endocardiogram report shows no
abnormal findings except patent foramen ovale and physiological tricuspid
and pulmonary valve regurgitation. Blood culture negat... 阅读全帖 |
|
e****0
发帖数: 678 | 45 • leukemia
ALL AML CLL
child adult elderly
BM lymphoblasts 25%myeloblasts
lab Lymphocyte 5000, mature-appearing cells
• Osgood-schlatters disease
Adolescent male athletes
Traction apophysitis—quadriceps tendon put the traction on the
apophysis of the tibial tubercle where patellar tendon inserts.
A firm mass =heterotopic bone formation
Pain can be reproduced by extending the kne... 阅读全帖 |
|
f**********r
发帖数: 95 | 46 【 以下文字转载自 Medicine 讨论区 】
发信人: flyingbutter (flyingbuffer是我的马甲), 信区: Medicine
标 题: 帮妈妈的朋友问的，请熟悉Rheumatology的牛人帮忙看看，非常感谢
发信站: BBS 未名空间站 (Sat Jun 29 15:39:08 2013, 美东)
我有病人自述的病史 （在二楼）和全部的labs,不过很长，我试着写了个摘要在下面，
如果您需要更多的信息而且有时间，可以看看病人自己写的病史，我还可以把lab
tests发给您。
病人女，49岁。
家族史
母亲：2008年元月因突然双臂疼痛，由医院诊断为类风湿性关节炎，当时用激素治疗了
一个月，其它的药吃到当年的8月份停的，到当年的10月份基本治愈；之后一直自我感
觉良好，未在检查、治疗。直至2013年初，因发热去医院检查发现肺部感染并间质性改
变，白细胞、血小板减少，作进一步检查最后确诊为红斑狼疮，现服用美卓乐及羟氯喹。
弟弟：十六岁左右确诊罹患牛皮癣。
侄子：今年21岁，日前确诊罹患牛皮癣。
病史
1995年的4、5月份患带状疱疹（Herpes zoste... 阅读全帖 |
|
b****a
发帖数: 352 | 47 我实在受不了了，也顾不上批马甲，希望在国内当过医生的朋友指点我到底何去何从。
我想知道我这个情况是不是应该回国治疗更好。相知道国内医生会如果治疗。
我这个情况复杂，我希望讲清楚，谢谢你的耐心。
恳求版主不要删贴，我被折磨的快崩溃了。。真心希望得到多的意见。谢谢！
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
－－－－－－－
今年1月底，乳房剧痛 红肿，然后有肿块。很大。等约到医生做超声波就是2月中了，
但是当时肿块已经没有了。
等了1－2个月好像又有肿块，5月突然我觉得摸到很大一个（5cm 多）肿块，做了超声
波，医生 ""quite vascular, hypoechoic colletion, and more suspicious for
infection" STILL 建议biopsy。
biopsy pathology test 结果是 diagnosis is granulomatous mastitis.
granulation tissue with scattered granulomas that display central
n... 阅读全帖 |
|
j*******k
发帖数: 209 | 48 A 40-year-old woman comes to the physician because of "too much stress in my
life now." She describes feeling depressed and tense because of a recent
marital separation, a job change, the need to relocate to another city, and
the worsening of her 8-year-old son's asthma. Physical examination shows no
abnormalities. Laboratory studies are most likely to show which of the
following abnormalities?
A)Decreased lymphocyte reactivity to antigens
B)Decreased serum prolactin concentration
C)Increased se... 阅读全帖 |
|
s********o
发帖数: 21 | 49 29. A previously health 6 month old boy develops fever and severe paroxysmal
barking coughing. He has not had any immunizations. His leukocyte count is
30,000/mm3 (70% lymphocytes). Neutrophil chemotaxis and oxidative metabolism
are defective due to increased activity of which of the following enzymes?
A. adenylyl cyclase
B. MPO
C. NADPH oxidase
D. Phospholipase C
E. Protein Kinase C
论坛上不少人选A，并且说是B. Pertussis 感染，请问大家什么看法啊？
我自己觉得：
1. 如果确定是Pertussis感染，adenylyl cyclase （AC）的activity就会up-
regulated.... 阅读全帖 |
|
m****d
发帖数: 156 | 50 There still might be some reason that the doctor is considering disease
progression, for example, if the white cell baseline was 15k. See below.
Patients with chronic lymphocytic leukemia (chronic lymphoid leukemia, CLL)
do not need to be treated with chemotherapy until they become symptomatic or
display evidence of rapid progression of disease, as characterized by the
following:
Weight loss of more than 10% over 6 months
Extreme fatigue
Fever related to leukemia for longer than 2 weeks
Night sw... 阅读全帖 |
|
