t*******o 发帖数: 1464 | 1 在时下,这样的图很少见
http://stockcharts.com/h-sc/ui?s=MDVN&p=D&yr=0&mn=6&dy=0&id=p06273076886
Company: Medivation(MDVN Quote)
Drug: Dimebon for Alzheimer's disease.
Estimated Timing: March.
The phase III study of Dimebon in patients with mild to moderate Alzheimer's
disease is shaping up to be one of the biggest binary events in biotech
this year. Current Alzheimer's drugs are only moderately effective, so
Dimebon has the potential to be a billion dollar-plus blockbuster if it can
duplicate the positive ... 阅读全帖 |
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M**N 发帖数: 2 | 2 Medivation, Inc. seeks 2 biostatistics interns available for the summer of
2015. Internships will begin in May/June and last approximately 10-12 weeks.
The interns will be assigned specific projects and work under the guidance
of an experienced statistician to perform statistical analyses and/or
conduct statistical research in areas of interest. Interns must be thorough,
committed to completion, and willing to rapidly learn tools as needed to
get the job done. At the end of the internship, each ... 阅读全帖 |
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t*c 发帖数: 6929 | 4 除了中铁原来答应一亿美元给拉斯维加斯
一个私人赌场公司做可行性研究,那个Xpress
连创始人自己都不出钱,梦想拿联邦两千万美元
补助,申请给拒了两次。
同时默默无闻的华人David Hung创立的medivation公司,只有一个产品,只对部分前列
腺癌患者有效,就是
Xtandi, 目前该公司都被各大药厂追买,Sanofi
出到近百亿美元现金,连和medivation谈判的机会
都没有。
相反,在国内轰轰烈烈的高铁在美国几乎一个投资者
都没有,为何?市场机制的作用,没有市场而
又不适合美国国情的高铁根本没可能发展。
也就是说任何东西只要有一定规模的人群使用,
在美国不愁没钱没技术。
美国缺钱吗?看你问谁,如果是问美国政府,
他们从来没富裕过,当然没钱。如果你问美国的
市场和私人公司,那一直是全世界最大的资本市场,
也集中了世界上可调配现金存量最大的公司群。
只要你有好的东西,不愁没钱。有些热门的
startup 的融资,你出钱人家还不一定收,别人
还要看你的投资有没有长远规划和理念。 |
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a******g 发帖数: 13519 | 5 肖邛(中科院生物化学博士):格列卫应该用来嘲讽药厂,怎么就封神了?
在学界格列卫的发展史是被用来嘲讽诺华的短视和逐利的,怎么电影一出就封神了……
具体到格列卫,简要发展史如下:
1960年,David Hungerford发现在一类白血病人中多出一条染色体,他们把这类现象命
名为费城染色体。当时他们受到无数嘲讽,因为没人相信人会多一条染色体。
1970年,Janet Rowley发现这染色体是怎么出现的,他们发现是第9和第22号染色体发
生了重组,并且因为重组,bcr和abl两个基因融合到了一起,形成了一个新的酶。
图片来源:作者提供,下同
后来到了1990年,David Baltimore等人发现尽管这个新酶在常规致癌实验中不能让细
胞成癌,但是可以让血细胞变成白血病。以上的工作是决定性的,找到了致病的靶点,
好比修车工找到了车哪里出了问题。
接下来的工作是怎么修。这部分工作持续了30年,产生了两个拉斯克奖,完全是学界完
成的。一般来说大家都认为既然是这个酶导致了CML(观察者网注:慢性粒细胞白血病
),那么把这个酶关住,癌细胞就死掉了,这就叫靶向治疗。
而且治疗CML很容易,因为这... 阅读全帖 |
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w**z 发帖数: 8232 | 6 http://www.7x7.com/WorldDomination#/0
Obvious bias aside, the San Francisco Bay Area is one bad ass region. We
embody ingenuity and create products that people around the world love and
enjoy on a daily basis. You're all very welcome.
Though nothing more than a pen-sized dot on your average globe, a lot goes
down here. Brilliant engineering minds, vibrant recruiting teams, and young
CEOs are becoming a staple in the city—seriously, when else in history has
running a multi-million (sometimes bill... 阅读全帖 |
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r******o 发帖数: 1530 | 7 OMG, I have MDVN too, but I have $25 put in place, so I have my ass covered.
..
if you are interested, I think the downside is limited:
Elemer Piros, Ph.D., e****[email protected]
MEDIVATION INC. (MDVN: PRICE: $40.25; MARKET CAP: $1348.78; Market Perform)
- DIMEBON BITES THE DUST
Key Points
Medivation and Pfizer (PFE, Not Rated) announced that Dimebon failed to
show any sign of efficacy in a large Phase 3 trial
The companies should stop any further development activity for the drug,
in our view
Prost |
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y*****l 发帖数: 5997 | 8 Stocks to Watch at JPMorgan Healthcare Conference
By David Miller Jan 07, 2011 3:00 pm
Next week investors will congregate in California to discuss the future of
the biotech industry. Companies to watch include Exelixis, Medivation, and
Dendreon.
It’s the time of year for the JPMorgan (JPM) Healthcare Conference. The
conference, which runs Monday through Thursday next week in San Francisco,
is the surest place to see everyone in biotech each year. The size of the
crowd at the conference, held at... 阅读全帖 |
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y*****l 发帖数: 5997 | 9 Stocks to Watch at JPMorgan Healthcare Conference
By David Miller Jan 07, 2011 3:00 pm
Next week investors will congregate in California to discuss the future of
the biotech industry. Companies to watch include Exelixis, Medivation, and
Dendreon.
It’s the time of year for the JPMorgan (JPM) Healthcare Conference. The
conference, which runs Monday through Thursday next week in San Francisco,
is the surest place to see everyone in biotech each year. The size of the
crowd at the conference, held at... 阅读全帖 |
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G**8 发帖数: 1209 | 10 文明退步在人类历史上发生过非常多次。古希腊的dark age,希腊人把城市文明彻底忘
了,看到Mycenae的破石头城墙楞说是神迹。Rome Empire被野蛮人摧毁后,欧洲的
Medival Times更惨,用了1000年才终于文艺复兴(托突厥人的福,把Constantinople
破了,希腊和尚抱着“上古密集”逃到Florence);文艺复兴之前的欧洲在几大文明里
垫底(根本是野蛮人嘛),基督教五个教皇被更发达的阿拉伯文明灭了4个。蒙古人摧
毁阿拉伯文明也很彻底(在东方却相对很温柔)。
中华文明一直是连续的。几次野蛮人入关都没有彻底打断文明进程。象sea people入侵
,罗马陷落这样级别的文明浩劫,在东方没有发生过。 |
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B*S 发帖数: 1328 | 11 Medivation, Inc. (NasdaqGM: MDVN - News) shares fell 67% following the
release of disappointing phase III results on lead pipeline candidate
dimebon. The company, along with partner Pfizer, Inc. (NYSE: PFE - News),
suffered a huge setback when dimebon failed to achieve both its primary and
secondary endpoints in the CONNECTION study.
The phase III, multi-national, double-blind, placebo-controlled safety and
efficacy trial was conducted across 63 sites in North America, Europe, and
South America |
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w****r 发帖数: 245 | 12 大侠,分类都分好了,求神签
# Basic Materials, Agricultural Chemicals
AGU Agrium Inc.
AVD American Vanguard Corp.
CAGC China Agritech Inc.
CF CF Industries Holdings, Inc.
CGA China Green Agriculture, Inc.
CMP Compass Minerals International
COIN Converted Organics Inc.
IPI Intrepid Potash, Inc.
MON Monsanto Co.
MOS Mosaic Co.
NOEC New Oriental Energy & Chemical
POT Potas... 阅读全帖 |
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J********e 发帖数: 341 | 13 76.3% Biotechnology
14.4% Juno Therapeutics Inc JUNO $60.20 (18.19%) 4.6B --
14.2% Kite Pharma Inc KITE $74.13 (16.70%) 2.7B --
14.0% Celldex Therapeutics Inc. CLDX $32.57 (6.47%) 2.7B 20.7%
7.4% Isis Pharmaceuticals Inc. ISIS $77.19 (7.39%) 8.6B 47.9%
7.2% Incyte Corp. INCY $96.16 (4.24%) 15.9B 42.2%
7.2% Medivation Inc. MDVN $133.93 (1.32%) 10.3B 87.4%
4.5% Halozyme Therapeutics Inc. HALO $... 阅读全帖 |
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r*******e 发帖数: 60 | 14 http://www.ssfcareerevents.org/
Date: March 3, 2010
Time: 10am to 4pm
Location: South San Francisco Conference Center
Some of the companies attending:
Abbott
Affymetrix
Baxter
BioMarin
Boston Scientific
Catholic Healthcare West
Cepheid
FibroGen
Fluidigm
Genomic Health
Geron
Gilead
Impax Laboratories
Intuitive Surgical
MediImmune
Medivation
Live Leaf
Nektar
Novartis - Emeryville
Novartis - San Carlos
Pharmatech
ProGenTech
StemCells, Inc.
SuperGen
United Biosource
veracyte
XDx
Zeltiq Aesthetics
Go |
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k***n 发帖数: 11247 | 15 gee... you guys live in the medival age |
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a******2 发帖数: 42 | 16 在公司工作的前辈们好,我现在是PHD candidate,准备年底或者明年春天毕业。今年暑
假是最后一次找实习的机会。从去年开始就找实习(amgen, monsanto, genentech等等
),面试有几次,可能因为博士期间研究的对象不是人,最后都没拿到offer。我有很
多molecular biology, biochemistry, cell culture, assay, protein expression
and purification, proteomics analysis的经验,现在1,2,3,...n作文章有将近十篇
。希望大家如果组里需要招暑期Intern的,能帮助refer一下 (现在还没收到拒信的公
司有amris, bayer, biomartin, bolt threads, amgen, gliead, biogen, medivation
, genentech, regeneron等等)。先谢谢大家了! |
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e*********6 发帖数: 3453 | 17 你还至少有面试,我在生物公司一个面试都没有。
medivation |
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c*********r 发帖数: 1312 | 18 分享一点点自己的经验。把LinkedIn等找工作相关的网页建好。根据目标职位的关键词
去完善自己的skill set,简历里把该有的经验和关键词尽可能都填上。多拉一些人,
互相endorse最关键的技能。
一年多还有足够的时间去建立connection。有实习最好,没有也没关系。自己找点
summer course,workshop,或者工业界相关的training、会议,去强化一下目标职位
要求的技能,我觉得哪怕自己投资几百刀上千刀也是值得的。(我参加过一些生物信息
相关的培训,对后来的博后和可能的工作机会有很大帮助。不过和你的背景不太一样,
就删了。)
不管怎么样,早点开始准备,工作机会一定会有的。祝好运!
medivation |
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K***6 发帖数: 155 | 19 我最近刚面试结束,一个bolt threads 的scientist 职位,公司感觉潜力不错,但是
最后告诉我他们面试完所有的onsite 人选,挑花眼了,不知道需要招什么样的人,索
性决定不招了~~~
medivation |
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h******s 发帖数: 3420 | 20 我是说director of biostatistics 20万,分四年。programmer 要少。每年50%
refresh. 难道大家以为我说的是20万/year?
我们公司是billion 了。去再小的拿的多一点,去再大的拿的少一点。
NDA 的确股票涨的快,几倍,几十倍的一般是有platform, 不停的file 新药,像
biomarin, Jazz pharma,Gilead 什么的.
这边一般在大公司攒点经验就去小公司。一般人喜欢赌merger, 2016 去medivation,
pharmacyclics, 去了几个月公司就被收购,一个个笑呵呵的等退休。
今年大家去cancer, 只要跟cancer 相关的股票一个个呼呼的涨,过两天一看被收购了。
搞这行不去小公司去哪儿?大公司都是卖现成的药,要biostatistician 干嘛?很多在
大公司干了十几年的没摸过NDA 的,好多公司只有registry.
而且大公司不是药过期就是被小公司打败,也就是cash 多靠买小公司过日子。不裁员
就不错了。今年allergen 股票都跌一半了,那硅谷的小公司才刚phase ... 阅读全帖 |
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h******s 发帖数: 3420 | 21 我是说公司有个平台,不停file 新药,over years, 可以涨几十倍,只有一个药到不
了几十倍,几倍不错了。
至于medivation, all cash 买下来的,不是股票换股票。如果没太大好处,不会有这
么多Gilead 的人赶着马上被收购挤破头去吧。 |
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h******s 发帖数: 3420 | 22 我是说director of biostatistics 20万,分四年。programmer 要少。每年50%
refresh. 难道大家以为我说的是20万/year?
我们公司是billion 了。去再小的拿的多一点,去再大的拿的少一点。
NDA 的确股票涨的快,几倍,几十倍的一般是有platform, 不停的file 新药,像
biomarin, Jazz pharma,Gilead 什么的.
这边一般在大公司攒点经验就去小公司。一般人喜欢赌merger, 2016 去medivation,
pharmacyclics, 去了几个月公司就被收购,一个个笑呵呵的等退休。
今年大家去cancer, 只要跟cancer 相关的股票一个个呼呼的涨,过两天一看被收购了。
搞这行不去小公司去哪儿?大公司都是卖现成的药,要biostatistician 干嘛?很多在
大公司干了十几年的没摸过NDA 的,好多公司只有registry.
而且大公司不是药过期就是被小公司打败,也就是cash 多靠买小公司过日子。不裁员
就不错了。今年allergen 股票都跌一半了,那硅谷的小公司才刚phase ... 阅读全帖 |
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h******s 发帖数: 3420 | 23 我是说公司有个平台,不停file 新药,over years, 可以涨几十倍,只有一个药到不
了几十倍,几倍不错了。
至于medivation, all cash 买下来的,不是股票换股票。如果没太大好处,不会有这
么多Gilead 的人赶着马上被收购挤破头去吧。 |
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w***y 发帖数: 2537 | 24 【 以下文字转载自 Stock 讨论区 】
发信人: ll111 (Stealth), 信区: Stock
标 题: Events and ER for week August 2-6
发信站: BBS 未名空间站 (Sun Aug 1 22:47:17 2010, 美东)
Monday, Aug. 2
10 a.m.: ISM Manufacturing index on business activity in July, released by
the Institute for Supply Management.
10:15 a.m. Federal Reserve Chairman Ben Bernanke speaking on "challenges for
the economy and state governments."
4 p.m. Treasury Secretary Timothy Geithner speaking on the next steps for
financial reform.
Tuesday, Aug. 3
8:30 a.m.: P... 阅读全帖 |
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N***i 发帖数: 2063 | 25 【 以下文字转载自 Stock 讨论区 】
发信人: ll111 (Stealth), 信区: Stock
标 题: Events and ERs for week Aug 9-13
发信站: BBS 未名空间站 (Sat Aug 7 22:26:20 2010, 美东)
Monday, Aug. 9
Scheduled for around noon: President Obama to deliver remarks at University
of Texas in Austin.
No data scheduled.
Tuesday, Aug. 10
House returns for one day to vote on state aid bill.
9 a.m.: Federal Reserve's Federal Open Market Committee meets on interest
rate and monetary policy. Statement to be released at 2:15 p.m., at Fed
headquarters.
8... 阅读全帖 |
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v**********m 发帖数: 5516 | 26 You guys now are able to listen to these web-castings now. Enjoy it!
http://jpmorgan.metameetings.com/webcasts/healthcare11/ondemand
individual Company Presentations
A
Abbott
Abiomed Inc. (available to Feb. 5)
Ablynx N.V.
Accretive Health Inc.
Accuray Inc.
Acorda Therapeutics, Inc. (available to Feb. 11)
Actelion Ltd
Aetna Inc. (available to Feb. 8)
Affymetrix Inc.
Agilent Technologies Inc.
Albany Molecular Research Inc.
Alere Inc (available to Feb. 11)
Alexion Pharmaceuticals, Inc. (not availab... 阅读全帖 |
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v**********m 发帖数: 5516 | 27 You guys now are able to listen to these web-castings now. Enjoy it!
http://jpmorgan.metameetings.com/webcasts/healthcare11/ondemand
individual Company Presentations
A
Abbott
Abiomed Inc. (available to Feb. 5)
Ablynx N.V.
Accretive Health Inc.
Accuray Inc.
Acorda Therapeutics, Inc. (available to Feb. 11)
Actelion Ltd
Aetna Inc. (available to Feb. 8)
Affymetrix Inc.
Agilent Technologies Inc.
Albany Molecular Research Inc.
Alere Inc (available to Feb. 11)
Alexion Pharmaceuticals, Inc. (not availab... 阅读全帖 |
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f**********g 发帖数: 2252 | 28 BIO CEO Conference Live Blog: Day 1
By Adam Feuerstein 02/14/11 - 04:23 PM EST
quotes in this article:EXAS, MDVN, EXEL
http://www.thestreet.com/story/11005968/1/bio-ceo-conference-li
NEW YORK (TheStreet) -- Small and midsized biotech companies get a turn in
the investor spotlight this week as the 13th annual BIO CEO & Investor
Conference kicks off here this morning.
I'll be live-blogging from the BIO CEO conference over the next two days,
presenting news updates and analysis live from the pre... 阅读全帖 |
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f**********g 发帖数: 2252 | 29 BIO CEO Conference Live Blog: Day 1
By Adam Feuerstein 02/14/11 - 04:23 PM EST
quotes in this article:EXAS, MDVN, EXEL
http://www.thestreet.com/story/11005968/1/bio-ceo-conference-li
NEW YORK (TheStreet) -- Small and midsized biotech companies get a turn in
the investor spotlight this week as the 13th annual BIO CEO & Investor
Conference kicks off here this morning.
I'll be live-blogging from the BIO CEO conference over the next two days,
presenting news updates and analysis live from the pre... 阅读全帖 |
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m**k 发帖数: 18660 | 30 我们家书没什么系列。hehe.
我觉得小娃 历史 相对 还是有点 boring.
也就喜欢看看城堡阿,Medival Times的东西 |
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m**k 发帖数: 18660 | 31 谈不上请教阿。
看你要花多少钱,另外他们原来有没有lego,兴趣在什么方面。
最近没有deal. (前两天target有便宜些的,但是过去了)
5-7我觉得 救火车 7239不错,很景点。20+
creator 的house也可以.
如果喜欢toystory, TS3的几个也可以。
如果有钱。花$100买Medival Village..hehe |
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m**k 发帖数: 18660 | 35 基本建筑物都是 lego现成的set..hoho |
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c*******u 发帖数: 12899 | 36 正琢磨着你今儿该上FRIDAY LEGO了。你家到底多少LEGO块儿哪?
LEGO真应该付钱给你:) |
|
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q********y 发帖数: 615 | 38 can the bridge actually move?
any lego/toy that has elevators that actually move like an elevator?
my son loves elevators |
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m**k 发帖数: 18660 | 39 好眼力!very nice set indeed!
不算特别便宜,但是价格也还行。当然如果等可能再便宜10-20,不好说。 |
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q********y 发帖数: 615 | 40 真的吗?周末去lego store, 看见这个,卖107呢。当时就想,回来要下单
难道还会降? |
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m**k 发帖数: 18660 | 42 降,也是有可能。但是我觉得不会降太多,lego东西就是贵阿。 |
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m****y 发帖数: 3437 | 44 哦,KG不力,汗。。。
很牛的孩子,还是没推的,zeze |
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m**k 发帖数: 18660 | 45 这个lego和牛没关系阿。也不是都是他弄得。hiahia |
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m****y 发帖数: 3437 | 47 这里面要动到的脑筋,你肯定比俺懂啊。不牛的怎么能搞出来?!
虎父无犬子!
//你这是非要俺夸你才行?//run |
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m**k 发帖数: 18660 | 48
恩。这个名称叫 "draw bridge" ,可以活动的。
没见过,你是说上下的还是斜向上的?
上下的应该可以做。 |
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E*********e 发帖数: 10297 | 49 我就想知道一个问题
这每周一个PROJECT,是娃娃做的还是爸爸做的? |
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m**k 发帖数: 18660 | 50 大项目,是一起做的。
小的东西,一般是娃作的。hehe. |
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