f*******3
发帖数: 122 | 1 RE: Applicant’s Name
To Whom It May Concern:
It gives me great pleasure to write this letter in support of Dr. XXX’s
research contributions to the field of ____________________.
I am Chair of Molecular Biology at the School of Biological Sciences at the
University of ____________________________. I have spent _______ years in
academic research, publishing approximately _________scientific publications
in peer-reviewed, internationally distributed journals, which have been
cited ________ tim... 阅读全帖 |
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m*******e
发帖数: 1598 | 2 BY TINA AMIRTHA8 MINUTE READ
This story contains interviews with Christian Kästner, assistant
professor at Carnegie Mellon University; Amy Hirotaka, state policy and
advocacy manager at Code.org; and Janet Siegmund, researcher at the
University of Passau.
In order to expose more students to computer science, 17 states have passed
legislation to create basic math and science requirements in the curriculum,
rather than count them as electives. But lawmakers in Texas have made
computer program... 阅读全帖 |
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H*****u
发帖数: 6 | 3 请帮忙获得此文献的PDF。不胜感激！
J Neuroimmune Pharmacol. 2008 Sep;3(3):143-9. Epub 2007 Dec 4.
Potentiation of HIV-1 expression in microglial cells by nicotine:
involvement of transforming growth factor-beta 1.
Rock RB1, Gekker G, Aravalli RN, Hu S, Sheng WS, Peterson PK.
Abstract
HIV-1 infection and nicotine addiction are global public health crises. In
the central nervous system, HIV-1 causes a devastating neurodegenerative
disease. It is well recognized that microglial cells play a pivotal role in
the neu... 阅读全帖 |
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c***s
发帖数: 70028 | 4 据报道，星形胶质细胞就像大脑中的微型胡佛电动吸尘器，当大脑连接变得薄弱和开始分裂时，它们将清除部分神经突触细胞。
据国外媒体报道，目前，科学家最新一项研究表明，当老鼠睡眠不足时，大脑将开始“自噬。”研究人员在实验室对老鼠进行了研究，发现当它们睡眠不足时，大脑中的“清除细胞”变得更加活跃，这些细胞叫做“星形胶质细胞”，就像是微型胡佛电动吸尘器，当大脑连接变得衰弱和分裂时，将开始清除神经突触细胞。
研究报告作者、意大利马尔凯理工大学米歇尔·贝雷西（Michele Bellesi）称，我们首次发现由于缺乏睡眠，神经突触部分被星形胶质细胞吞噬。该研究结果看似令人十分担忧，但实际上是一件积极的事情。
贝雷西说：“神经突触就像是老式家具，同时，它们可能需要更多的关注和清除。”但是他补充指出，睡眠不足可使大脑表现出不好的预兆，可能会引发阿尔兹海默症。对于睡眠不足的实验老鼠，叫做“小神经胶质细胞（microglials）”的大脑细胞仍处于活跃状态。
据国外媒体报道，目前，科学家最新一项研究表明，当老鼠睡眠不足时，大脑将开始“自噬。”研究人员在实验室对老鼠进行了研究，发现当它们睡眠不足时，大脑中的“清除... 阅读全帖 |
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k****z
发帖数: 1863 | 5 Yan, SD, Yan, S-F., Chen, X., Fu, J., Chen, M., Kuppusamy, P., Smith, M.A.,
Perry., G., Godman,G.C., Nawroth, P., Zweier, J.L., and Stern, D. Non-
enzymatically glycated tau in Alzheimer’s disease induces neuronal oxidant
stress resulting in cytokine gene expression and release of amyloid ß-
peptide. Nature Medicine, 1(7):693-699, 1995
Yan SD, Chen X, fu J, Chen M, Zhu H, Roher A, Slattery T, Nagashima M,
Morser J, Migheli A, Nawroth P, Goodmand G, Stern D, and Schmidt AM. RAGE in
Alzheimer... 阅读全帖 |
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k****z
发帖数: 1863 | 6 他妈怎么把它生出来的？
Yan, SD, Yan, S-F., Chen, X., Fu, J., Chen, M., Kuppusamy, P., Smith, M.A.,
Perry., G., Godman,G.C., Nawroth, P., Zweier, J.L., and Stern, D. Non-
enzymatically glycated tau in Alzheimer’s disease induces neuronal oxidant
stress resulting in cytokine gene expression and release of amyloid ß-
peptide. Nature Medicine, 1(7):693-699, 1995
Yan SD, Chen X, fu J, Chen M, Zhu H, Roher A, Slattery T, Nagashima M,
Morser J, Migheli A, Nawroth P, Goodmand G, Stern D, and Schmidt AM. RAGE ... 阅读全帖 |
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k****z
发帖数: 1863 | 7 发信人: pangduer (白飞飞), 信区: WaterWorld
标 题: Re: 傅瑾教授：已经把在哥大的学习经历说明和学位证书复印件提
发信站: BBS 未名空间站 (Mon Jul 23 14:03:45 2012, 美东)
对，这篇1997年的nature paper，列在第一位的yan shidu其实是唯一的通讯作者，列
在最后一位的本该是通讯作者的David Stern其实就是当时部门里的大牛。估计情况就
是David Stern是大老板，但是对这个project其实没啥贡献，然后是作为通讯作者的
Yan shidu是小老板，带领Fu Jin等一干人做出来的，才会有这样奇怪的authorship。
这样看来，Fu JIn实质上是真正干活的第一作者，凭这样一篇nature paper获得博士
也就没啥稀奇的了。Fu Jin是1999年拿的博士，1997年的paper正好对景。
凭什么方肘子要看学位证明人家就亮给这个傻逼看啊。他家菊花不是都拒绝出示学位证
明吗？人家Fu Jin教授把学位亮给学校看就好了，气死方教主及其教徒们！
Yan, SD, Yan, S-F., C... 阅读全帖 |
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k****z
发帖数: 1863 | 8 Yan, SD, Yan, S-F., Chen, X., Fu, J., Chen, M., Kuppusamy, P., Smith, M.A.,
Perry., G., Godman,G.C., Nawroth, P., Zweier, J.L., and Stern, D. Non-
enzymatically glycated tau in Alzheimer’s disease induces neuronal oxidant
stress resulting in cytokine gene expression and release of amyloid ß-
peptide. Nature Medicine, 1(7):693-699, 1995
Yan SD, Chen X, fu J, Chen M, Zhu H, Roher A, Slattery T, Nagashima M,
Morser J, Migheli A, Nawroth P, Goodmand G, Stern D, and Schmidt AM. RAGE in
Alzheimer... 阅读全帖 |
|
发帖数: 1 | 9 07 Nov 2019
Just as the clamor about Biogen’s seeking FDA approval for aducanumab with
one positive Phase 3 trial started to die down, a Chinese company garnered a
regulatory thumbs-up for its drug, also with one Phase 3 trial. On November
2, Shanghai Green Valley Pharmaceuticals announced that China’s National
Medical Product Administration (NMPA) had conditionally approved GV-971, aka
oligomannate, for the treatment of mild to moderate Alzheimer’s disease.
Full approval, expected to come in sp... 阅读全帖 |
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x***a
发帖数: 19 | 10 Check this website:
http://www.pharmtox.pharm.ku.edu/index.php?page=content:faculty
Shirley ShiDu Yan
Howard Mossberg
Distinguished Professor
(785) 864-3637
s******[email protected]
Find out more about the Yan Lab.
Dr. Yan received her M.D. from Fujian Medical University in 1983 and
completed Postdoctoral training at the Physicians & Surgeons College of
Columbia University in New York in 1993.
ChSelected Recent Publications
Yan, SD, Yan, S-F., Chen, X., Fu, J., Chen, M., Kuppusamy, P., Smith, M.A.,
Perry... 阅读全帖 |
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x***a
发帖数: 19 | 11 Dr. Yan received her M.D. from Fujian Medical University in 1983 and
completed Postdoctoral training at the Physicians & Surgeons College of
Columbia University in New York in 1993.
ShiDu Yan was a postdoc at Columbia in 90s. She stated very clearly in her
webpage. She is a very talented and productive researcher. FU Jin was
lucky to have opportunities to work with her therefore get her name included
in those papers.
http://www.pharmtox.pharm.ku.edu/index.php?page=content:faculty
FuJin has ne... 阅读全帖 |
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N*****m
发帖数: 42603 | 12 【 以下文字转载自 Military 讨论区 】
发信人: krzkrz (krzkrz), 信区: Military
标 题: 菊花党想想怎么把屎吃回去吧
发信站: BBS 未名空间站 (Mon Jul 23 14:12:37 2012, 美东)
发信人: pangduer (白飞飞), 信区: WaterWorld
标 题: Re: 傅瑾教授：已经把在哥大的学习经历说明和学位证书复印件提
发信站: BBS 未名空间站 (Mon Jul 23 14:03:45 2012, 美东)
对，这篇1997年的nature paper，列在第一位的yan shidu其实是唯一的通讯作者，列
在最后一位的本该是通讯作者的David Stern其实就是当时部门里的大牛。估计情况就
是David Stern是大老板，但是对这个project其实没啥贡献，然后是作为通讯作者的
Yan shidu是小老板，带领Fu Jin等一干人做出来的，才会有这样奇怪的authorship。
这样看来，Fu JIn实质上是真正干活的第一作者，凭这样一篇nature paper获得博士
也就没啥稀奇的了。Fu Ji... 阅读全帖 |
|
x***a
发帖数: 19 | 13 Check this website:
http://www.pharmtox.pharm.ku.edu/index.php?page=content:faculty
Shirley ShiDu Yan
Howard Mossberg
Distinguished Professor
(785) 864-3637
s******[email protected]
Find out more about the Yan Lab.
Dr. Yan received her M.D. from Fujian Medical University in 1983 and
completed Postdoctoral training at the Physicians & Surgeons College of
Columbia University in New York in 1993.
Selected Recent Publications
Yan, SD, Yan, S-F., Chen, X., Fu, J., Chen, M., Kuppusamy, P., Smith, M.A.,
Perry.,... 阅读全帖 |
|
s***a
发帖数: 384 | 14 J Neuropathol Exp Neurol. 2005 Sep;64(9):743-53.
Dynamic complexity of the microglial activation response in transgenic models
of amyloid deposition:
implications for Alzheimer therapeutics.
Morgan D, Gordon MN, Tan J, Wilcock D, Rojiani AM.
plz send to q*[email protected] |
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f******9
发帖数: 39 | 15 Neuropsychopharmacology. 2010 Jun;35(7):1550-9. Epub 2010 Mar 3.
Adenosine A1 receptors and microglial cells mediate CX3CL1-induced
protection of hippocampal neurons against Glu-induced death.
Lauro C, Cipriani R, Catalano M, Trettel F, Chece G, Brusadin V, Antonilli L
, van Rooijen N, Eusebi F, Fredholm BB, Limatola C.
PMID: 20200508
http://www.nature.com/npp/journal/v35/n7/full/npp201026a.html
Thanks in advance. Please send me to the email: f******[email protected] |
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j****x
发帖数: 1704 | 16 之前有报道骨髓移植的时候特意选择了一个CCR5缺陷的donor，结果顺带成功清除了HIV
，这在某种程度上也证实了了基于类似思路的基因治疗的设想。
HIV在体内除了CD4 T cell，当然还能感染其他细胞，比如DC细胞，microglial cells
。而且发现HIV能藏在brain中利用blood brain barrier保护自己。
你说的没错，如果消除的宿主细胞，病毒没处去了，自然就挂了。问题是，除非你能保
证100%无一遗漏的杀光光所有的病毒，或者之后新生成的T细胞都试HIV resistant的，
否则reinfection基本是很难避免的事情，再考虑到你说的以毒攻毒置之死地的策略，
这个风险就太大了 |
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d**l
发帖数: 1546 | 17 请问哪里有转基因的神经方面的细胞库？我要找的是一个转基因老鼠的。 谢谢 |
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S******9
发帖数: 2837 | 19 这个难道不是你选定一个研究的target基因的flox老鼠和Cre老鼠杂交以后就得到的？ |
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h*******o
发帖数: 4884 | 21 既然有transgenic mouse strain了， 那就把colony 建立起来，然后原代培养
astrocytes和microglia就行了啊
这个不是adult neuron培养，容易多了
如果你不要adult的， embryonic的neuron也好养 |
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h*******o
发帖数: 4884 | 23 别想了
可能性极小
找有那个老鼠colony的实验室合作算了 |
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l******a
发帖数: 3339 | 24 不知道你在说啥？Bexarotene的文章提出了一个新的假设，用FDA已经prove的drug证明
了这个假设，而且有直接的clinical的相关性，因为这个药是已经FDA批准的了。
“We reasoned that an RXR agonist would enhance normal Aβ clearance
mechanisms by activating PPARγ:RXR and LXR:RXR, inducing apoE expression,
facilitating Aβ clearance, and promoting microglial phagocytosis.”
这篇nano的文章没有任何全新的理论，都是已经prove的，而且文章并没能给出
nanoparticle有什么advantage other than just an alternative.。
我个人觉得这篇nano除非有大牛支持，并且从一个新的角度重写，不然根本投不到CNS
，因为不对口，没有任何新意。冲击一下nat med或者sci trans med还有可能，但我不
是这个field，不敢... 阅读全帖 |
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c***c
发帖数: 113 | 25 I have one postdoctoral position open starting from 9/1/2015 in the
University of Texas Health Science Center at Houston as my lab is moving to
there. We are looking for candidates with strong background of molecular
biology, especially with experience in management of conditional knockout
mice, and lenti/AA-virus transfection in vivo and in vitro. The position
will be supported by a newly-funded R01 grant (2015-2020), which is focused
on regulation of microglial activation in the context of st... 阅读全帖 |
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L*****n
发帖数: 6 | 26 One postdoctoral position will be open starting from 9/1/2015 at the
University of Texas Health Science Center at Houston as my lab is moving to
there. We are looking for candidates with a strong background of molecular
biology and/or immunology, preferably those with experience in flow
cytometry or middle cerebral artery occlusion (MCAO) modeling. Our lab
investigates cellular and molecular pathways underlying immune responses
after cerebral ischemic stroke, with a focus on regulation of micro... 阅读全帖 |
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L*****n
发帖数: 6 | 27 Dear my friends,
I have one postdoctoral position open starting from 9/1/2015 in the
University of Texas Health Science Center at Houston as my lab is moving to
there. We are looking for candidates with strong background of molecular
biology, especially with experience in management of conditional knockout
mice, and lenti/AA-virus transfection in vivo and in vitro. The position
will be supported by a newly-funded R01 grant (2015-2020), which is focused
on regulation of microglial activation in t... 阅读全帖 |
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