s******9
发帖数: 283 | 1 The peer review process at Science
http://www.publications.parliament.uk/pa/cm201011/cmselect/cmsc
1.Peer-reviewed scientific publications represent the primary useful archive
of scientific progress. Scientific publications have served other main
functions as well: They are a primary means of evaluating scientists and
institutions, and they have become a main pathway for informing the general
public about science, through coverage in the media and press releases (new
results are news). Peer-revi... 阅读全帖 |
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g****1
发帖数: 261 | 2 Good job!
http://www.futureoftech.msnbc.msn.com/technology/futureoftech/1
An artificial “brain” built by a 17-year-old whiz kid from Florida is able
to accurately assess tissue samples for signs of breast cancer, providing
more confidence to a minimally invasive procedure.
The cloud-based neural network took top prize in this year’s Google Science
Fair.
“I taught the computer how to diagnose breast cancer,” Brittany Wenger,
the Lakewood Ranch resident, told me today.
“And this is really importan... 阅读全帖 |
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l**********1
发帖数: 5204 | 3 人家各做一个residue 3D
Molecular Modeling 的话 还是可能的
//www.ncbi.nlm.nih.gov/pubmed/22448988
Crystal structures of Bcl-xL with 118 (PDB entry 2YXJ) and 4 were used to
model the binding poses of our designed compounds with Bcl-xL. In the
binding models, the structure of Bcl-xL in complex with 4 was superimposed
on that of Bcl-xL in complex with 1. The core scaffold of 4 then replaced
the 4′-chloro-2-methyl-1,1′-biphenyl group of 1 to generate the initial
binding model, which was then refined by a 1 ns mo... 阅读全帖 |
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v**********m
发帖数: 5516 | 5 http://m.f1000research.com/articles/3-291/v1
波士顿地区的千老联合会的报告，文章提到的问题非常典型和深刻，该文已经在圈内得
到了包括大佬们的极大肯定(恐惧)。
OPINION ARTICLE
Shaping the Future of Research: a perspective from junior scientists[v1;
ref status: approved 1, approved with reservations 1,http://f1000r.es/4ug]
Gary S. McDowell1*, Kearney T. W. Gunsalus2*, Drew C. MacKellar3, Sarah A.
Mazzilli4, Vaibhav P. Pai1, Patricia R. Goodwin5, Erica M. Walsh6, Avi
Robinson-Mosher7, Thomas A. Bowman8, James Kraemer9, Marcella L. Erb10, Eldi
Schoenfeld1... 阅读全帖 |
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发帖数: 1 | 6 Hum Gene Ther Methods. 2016 Nov 29.
A RAPID CELL EXPANSION PROCESS FOR PRODUCTION OF ENGINEERED AUTOLOGOUS CAR-T
CELL THERAPIES.
Lu TL1, Pugach O2, Somerville RP3, Rosenberg SA4, Kochenderfer JN5, Better
M6, Feldman SA7.
Abstract
The treatment of B cell malignancies by adoptive cell transfer (ACT) of anti
-CD19 chimeric antigen receptor T cells (CD19 CAR-T) has proven to be a
highly successful therapeutic modality in several clinical trials1-6
sup>. The anti-CD19 CAR T cell production met... 阅读全帖 |
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e****2
发帖数: 2723 | 7 第二版出台 也同时希望中国化学教授能表现出支持的态度，虽然事不关己，看在民族大义份上，务必团结
Should Mr. Sames apologize to these students being ruined by his fraud?
Mr Sames is a tenured Professor in chemistry department of Columbia University, he focused on his study in organic chemistry. During the past 10 years, he is considered by peers as a genius chemist and published a variety of research publications in high impact journals such as JACS and Angew. However, there is a scandal breaking out in 2003 that one of his student Sezen (a fem... 阅读全帖 |
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w*********s
发帖数: 2136 | 8 【 以下文字转载自 Parenting 讨论区 】
发信人: whiteclouds (/ 参考消息 /), 信区: Parenting
标 题: Fever medicines 'given to children too readily'
发信站: BBS 未名空间站 (Tue Mar 1 06:08:50 2011, 美东)
Fever medicines 'given to children too readily'
Health News, The Telegraph, Feb 28.
Parents should not dose up children who have a simple fever on regular
spoonfuls of paracetamol and ibuprofen, according to doctors who say that
doing so could put them at risk.
A misplaced "fever phobia" in society means parents too frequently us... 阅读全帖 |
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l*****a
发帖数: 119 | 9 Cost function shouble a subset of objective/goal function. Generally,
object/goal function can be minimize or maximize. However, we only want to
minimize the cost funtion, because it's our cost. |
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a****f
发帖数: 944 | 10 I want to minimize the energy E=f(p;...). p is a vector containing a set of
parameters.
I set initial values of each element in p based on some prior knowledge.
Then I use fmincon to find the optimal p that minimizes E.
Some elements in p are constrained in a range so I set the constraints
according to the syntax of fmincon.
The result is, the elements in p without constraints do not change (the same
as initial values), the elements that are initially in their constraints do
not change either, o |
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s*********2
发帖数: 37 | 11 Tianjin PSS team will be responsible for providing 24*7 user and production
support for Financial Markets applications for Standard Chartered Bank. The
selected person will be responsible for managing the support team that works
in shifts, handing over issues from one shift to the other.
KEY RESPONSIBILITIES/CHALLENGES:
• Responsible for stability of production environments
• Receive calls/remedy tickets for user and application issues and
trouble shoot them. Act as a facilitat... 阅读全帖 |
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c***u
发帖数: 843 | 12 现在有一个coplanar waveguide (CPW)，想把他的characteristic impedance做的比较
高（slightly
higher than 50 ohms），尽量minimize conductor loss,所以得把signal和ground之
间的间距做的比
较大，但是因为我们用来测量cpw的picoprobe的pitch比较小，所以在cpw的两端必须要
把这个间距降
低。但是降低间距的话，characteristic impedance就会降低，这样和probe之间就有
了一个
impedance mismatch。
大牛们觉得怎么在减小cpw间距的同时minimize loss？？简单的用一个linear taper可
以吗？
或者有什么文章可以推荐看看的？ 万分感谢！！！ |
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g*z
发帖数: 124 | 13 0.22uf is enough, you can even settle with smaller (0.1uF, 0.01uF), the key
problem here is how to get low ESL (parasitic inductance). component pins
have parasitic inductance, you need to minimize those parasitic inductance.
generally, the smaller the component size, the smaller the parasitic
inductance.
So in term of ground bounce minimizing,
0402 SMD > 0603 SMD >0805 SMD >1206 SMD >leaded caps.
5cm away from power pin is not close enough, but you can give it a try. If
you have commercial ... 阅读全帖 |
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I***a
发帖数: 704 | 14 1. 3.644 ns is the clock tree delay
" Info: + Longest clock path from clock "CLK" to source register is 3.644
ns "
http://www.altera.ru/Disks/Altera%20Documentation%20Library/literature/an/an123.pdf
page 3:
tCO = Clock Delay + Micro tCO + Data Delay
In my case;
Clock Delay = 3.644 ns (can be minimized by setting tCO constraint)
Micro tCO = 0.099 ns (intrinsic, cannot change)
Data Delay = 10.461 ns (can be minimized by setting tCO constraint, in RTL
no logic)
in total, tCO = 14.204 ns
2. rising... 阅读全帖 |
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b**********g
发帖数: 32 | 15
I am not an ADC person. For (2), generally, if one can
characterize statistical properties of quantization error,
which in your case may be dependent on the properties of u(z),
then it is possible to minimize the residual variance.
Alternatively, you can build a recursive filter to accomplish
your goal, although most RLS filters minimize error squared,
not absolute error - but you really want error squared, yes? |
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g****t
发帖数: 31659 | 16 谢谢回复.
例如y(t)=a*y(t-1)+b*y(t-2)+c*u(t)+d*u(t-1)
这样一个滤波器.
如果只知道u有界,字长8位,那种实现,能让
|理想的y-滤波器实际产生的y|的
min max或平方积分最小,这个问题我看了下文献,好像是没有答案的.
统计特性的结果有不少.但那个我觉得帮助不大.一来统计特性很难准确.一些
文章上的结论,对不准的统计特性是不是仍然有效,这个目前为止.二来,
data sheet上,我总不能说这个东西99%不会numerical blow up吧.
I am not an ADC person. For (2), generally, if one can
characterize statistical properties of quantization error,
which in your case may be dependent on the properties of u(z),
then it is possible to minimize the residual variance.
Alt... 阅读全帖 |
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c*******e
发帖数: 814 | 17 This is not an entry level job but I thought somebody might be
interested.
It is also posted on their website:
WWW.Ecolab.com
Title: Scientist Job Description
Ecolab is a leading provider of value-driven, sustainable water and
wastewater management solutions. Ecolab delivers comprehensive
solutions to meet the unique needs of our clients. Our systems use
cutting edge technology to provide the most effective and efficient
treatment available. Make your expertise work for you at Ecolab, the
soluti... 阅读全帖 |
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b*******n
发帖数: 61 | 18 For a real n dimension function(derivative up to any order) if you only have one local minimizer it must be the global minimizer.
Is this true??
The function is defined in the whole n-dim real space, not in a interval.
thanks |
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D*******a
发帖数: 3688 | 19 sufficient statistics is not unique
however, some ss are called "minimal" as they have minimal dimensions. |
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G****n
发帖数: 145 | 20 ALGORITHMICA, 2012; 62 (): 630
The Steiner Ratio Gilbert-Pollak Conjecture Is Still Open
Ivanov, AO; Tuzhilin, AA
Tuzhilin, AA (reprint author), Moscow MV Lomonosov State Univ, Fac Mech &
Math, Moscow, Russia.
分享到： 0
Abstract
The aim of this note is to clear some background information and references
to readers interested in understanding the current status of the Gilbert-
Pollak Conjecture, in particular, to show that A.O. Ivanov and A.A. Tuzhilin
were the first who understood the nature of the... 阅读全帖 |
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f***e
发帖数: 43 | 21 用不着软件，这个问题很简单, linear regression
写成一个objective function, minimize it, find the coefficient
y=, w, x a vector, <> inner product
minimize J=sum_i(y_i-)^2, i is the index of sample
take partial j/partial w =0,
w=(x^T x)^(-1)x^T y (T is the transpose)
(x^Tx)^(-1)x^T is also called pseudo inverse of x
多给包子,我给你发一个详细的求解过程。 |
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l******3
发帖数: 6 | 22 Guess your question is to solve
minimize f(D) over all D with eigenvalues equal to b1, b2,...bn.
Seems not a trivial problem.
You may try out the following method:
Let D0=diag[b1, b2,...,bn]. Your problem can then be rewritten as
minimize norm (R^T*D0*R*A*R^T*D0*R - a* Id) over all real number a,
rotation matrix R, where Id is the identity matrix and R^T is the transpose.
Then you may try to use the usual first-order condition...
The algebraic calculations are tedious but worth trying if this i |
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J*y
发帖数: 271 | 23 谢谢。也就是说为了计算容易一点。
其实minimize sum of squared distances 的同时，也 minimize sum of distances.
我可不可以说regression line 就是那条sum of vertical distances from points to
fitted line is the smallest.
deviation |
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f**e
发帖数: 350 | 24 你的解释不对，minimize sum of squared distances 不等于minimize sum of
distances，很容易找个反例。 |
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g**********l
发帖数: 9 | 25 name three vertices of the triangle as ABC from the top vertex and consider
a rectangle DEFG with D on AB, E,F on BC and G on CA.
Draw a line DH parallel to AC with H on BC. So the area of DEFG equal to
area of DHCG.
So the original problem is equivalent to minimize the sum of areas of ADG
and BHG, both of which are similar to ABC. If the length ratio AD/AB is x,
then the length ratio BD/AB=1-x. So the sum of areas of these two triangle
is x^2+(1-x)^2 times the area of ABC. So the minimal area a... 阅读全帖 |
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l******9
发帖数: 579 | 26 【 以下文字转载自 Statistics 讨论区 】
发信人: light009 (light009), 信区: Statistics
标 题: data clustering by vector correlation distance
发信站: BBS 未名空间站 (Wed Feb 26 11:17:21 2014, 美东)
I am working on data analysis.
Given a group of data vectors, each of them has the same dimension. Each
element in a vector is a floating point number.
V1 [ , , , … ]
V2[ , , , … ]
...
Vn [ , , , … ]
Suppose that each vector has M numbers. M can be 10000.
n can be 200.
I need to find out how to partition the n vector... 阅读全帖 |
|
L*m
发帖数: 235 | 27 统计了近十余年来中国大陆高校在四大刊物上的发文，有些是挂名的，但不管如何，还
是都统计了。全名单如下
Annals of Mathematics
A proof of Demailly’s strong openness conjecture
Qi'an Guan（关启安 北京大学） Xiangyu Zhou（周向宇 中科院）
A solution of an L2 extension problem with an optimal estimate and
applications
Qi'an Guan（关启安 北京大学） Xiangyu Zhou（周向宇 中科院）
Construction of Cauchy data of vacuum Einstein field equations evolving to
black holes
Junbin Li（黎俊彬 中山大学） Pin Yu（于品 清华大学）
Special test configuration and K-stability of Fano varieties
Chi Li(李驰 普林斯顿大学 现stony broo... 阅读全帖 |
|
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g*******e
发帖数: 110 | 29 the so called minimal invasive surgery in thyroid is actually making
incision from the chest or axillar to put scope in under the skin to operate
in the neck, which I think it is pushing too far. her nodule needs surgery,
if suspect malignancy, I don't know go for "minimal invasive is such a good
idea.
several point to make,
最关键的是这个部位最危险的是距离主动脉也比较近
the thyroid is miles away from the aorta, between them, there are skin, bone
, lung and pleura. it will take quit an effort to injure the aorta that |
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n***h
发帖数: 364 | 30 我还是认为A项选择是指：Minimal Change Disease。 但为什么选A?
Minimal Change Disease usually affects children,但这个患者都42了。 |
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w********g
发帖数: 447 | 31 Outsourcing M&A Year In Review
By Michael A. Martorelli
Several large outsourcing firms made important tuck-in acquisitions, many
mid-sized firms expanded their platforms with strategic acquisitions, and
one outsourcing firm successfully tapped the equity market for an Initial
Public offering (IPO). But the big stories in the pharmaceutical outsourcing
industry in 2009 involved seven “going private” transactions and fifteen
separate divestitures. During the past few years, both in these annual
r... 阅读全帖 |
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a*****r
发帖数: 63 | 32 最近在看LMM, 看了不少资料,反而把自己绕进去了,现在头脑僵硬看不懂Calibration这
块了. 急需牛人指点一二.
我的问题如下:
calibration我的理解就是用市场上的实际数据(比如swaption 价格),来估计
volatility,然后通过这个volatility来算模型推导出来的swaptioin 价格. 其中这个
volatility要能minimize error funciton.
然而: 1.为什么书上同时给出这个公式
sigmamodel_n_{^2}=(1/T_n) *Integral_0_{T_n}{sigma_n_{^2} } (也就是implied
volatility 在给定时间Tn内的平均值)
来计算模型中的sigma? 那这样的话,sigma不就是确定了吗? 怎么来minimize error
function呢?
2. implied volatility 和instantaneous volatility 有什么具体区别?
3. 市场数据是怎么来的? 难道不是根据这个模型算出来的吗?还是完全根据供求关系来
的?
4. smile 怎么 |
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j******0
发帖数: 162 | 33 minimize[原来的objective function + (绝对值相加-这个数）^2]
不过这样做效率也许不够高，
如果担心Constraint的满足程度，可以加权重
minimize[原来的objective function + 1000*(绝对值相加-这个数）^2] |
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s*******a
发帖数: 705 | 34 minimize maximal distance?
成的,如果按照我的方法,minimize他们的stdev,那么有可能会得到这么个结果 |
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f*******y
发帖数: 988 | 35 这个问题是常见问题
minimize 2p次方，慢慢增加p（整数）就可以了
2p是保证凸性
成的,如果按
照我的方法,minimize他们的stdev,那么有可能会得到这么个结果 |
|
p********0
发帖数: 186 | 36 I heard the contrary to "Historical volatility is better than implied". A
prominent prof mentioned in his class said he tried GARCH/ARCH/ARMA
everything, but turn out to use the implied volatility which is more
accurate than the historical one.
Assume Implied volatioity is 100 percent accurate, than by minimize the
implied volatility for a portfolio means the future volatility is minized.
In case error is big(predication power is weak) then minimize doesnot mean
anything useful. |
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g*****n
发帖数: 21 | 37 There's a book and each sentence consists of several words. How to find the
minimal set of words which can used by the reader to understand half of
total number of the sentences. Each sentence is readable if the reader know
all the words.
I can only think of brute force solution -- do word counting on every
possible collection of half number of sentences and choose the minimal. But
that's exponential C(n,n/2).
Any better solution?
Thanks |
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h*****g
发帖数: 21 | 38 There are infinite cards numbered 1-5. You construct a deck. Someone guesses
a value and draws a card. If they guessed correctly, they get the value.
What composition of the deck minimizes their expected value？
题目没看懂， 一个deck是5张还是不限张数还是infinite的全部。5张的话是随便取五
张还是要一到五俱全？
要是把题目改为： here are five cards numbered 1-5. You construct a deck.
Someone guesses a value and draws a card. If they guessed correctly, they
get the value. What composition of the deck minimizes their expected value？
就简单了。 |
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l******9
发帖数: 579 | 39 【 以下文字转载自 Statistics 讨论区 】
发信人: light009 (light009), 信区: Statistics
标 题: data clustering by vector correlation distance
发信站: BBS 未名空间站 (Wed Feb 26 11:17:21 2014, 美东)
I am working on data analysis.
Given a group of data vectors, each of them has the same dimension. Each
element in a vector is a floating point number.
V1 [ , , , … ]
V2[ , , , … ]
...
Vn [ , , , … ]
Suppose that each vector has M numbers. M can be 10000.
n can be 200.
I need to find out how to partition the n vector... 阅读全帖 |
|
J*****n
发帖数: 4859 | 40 【 以下文字转载自 JobHunting 讨论区 】
发信人: Jadeson (紫昂德帅), 信区: JobHunting
标 题: Need a Jr developer
发信站: BBS 未名空间站 (Thu Mar 12 11:18:29 2015, 美东)
Great C#.Net Developer position that is co-located with the Front Office
Securities business and is part of the global trading technology team. You
will have the opportunity to work on the real time trading platforms as well
as working closely with the traders to automate trading strategies. This
role is unique in that it is both Development and Ops focussed (on ... 阅读全帖 |
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k***g
发帖数: 7244 | 41 如果有intercept, 从实际的交易角度讲，会影响hedge ratio, hedge ratio 不
consistent 了，调换 y 和 x 后，新旧hedge ratio 不是互为倒数。因为不对称，
long /short 和short / long 本身就可以反被别人 arb 了。
所以通常会force zero intercept, 或者用 tls, minimize R^2上各点到 regression
line 的距离，而不是minimize residuals, 这样保证对称性。
feature
了. |
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d****i
发帖数: 11 | 42
minimize 6y1+4y2 subject to
2y1+y2>=3
3y1+y2>=4
y1>0, y2 free.
minimize y1+y2+y3+y4 subject to
y1+y3>=2
y1+y4>=3
y2+y3>=1
y2+y4>=2
all y's free (I think) |
|
d****z
发帖数: 9503 | 43 Firstly, there is NO minimal length in QM. A minimal length would mean a
maximum energy. There is clearly no up limit on energy in current QM. Why? For
any object you observe, you can always choose a reference frame which has a
relative speed of 0.9999999999999999999999c with respect to the object.
Current QM assumes the principle of relativity, which means it should describe
the physics in that frame the same way as in any other inertia frame. In that
frame, the energy of the object could be at |
|
c*****w
发帖数: 50 | 44 it is the "normal distribution" assumption that justifies to get MLE of E(Y|
X) from minimizing e'e. If the error term has a distribution other than
gaussian, you will end up with minimizing another metric f(e) that is not L2.
I am talking about OLS in the sense of statistics. Of course, you may have
your own sense to derive OLS. |
|
l*******l
发帖数: 204 | 45 There are two methods to find the "best" cut point using ROC.
1) the point on the ROC that minimize the distance to the point (0,1)
2) the point on the ROC that minimize the distance to the line y=1
Cheer |
|
a****g
发帖数: 53 | 46 是在一个minimize的问题里。求一个能minimize的矩阵。所以先需要定义一个矩阵之间
的距离，这样我可以控制什么时候停下来。
谢谢大家。 |
|
l******9
发帖数: 579 | 47 I am working on data analysis.
Given a group of data vectors, each of them has the same dimension. Each
element in a vector is a floating point number.
V1 [ , , , … ]
V2[ , , , … ]
...
Vn [ , , , … ]
Suppose that each vector has M numbers. M can be 10000.
n can be 200.
I need to find out how to partition the n vectors into sub-groups such that
each vector in one subgroup can be represented by a basic vector in the
subgroup.
For example,
W = union of V1, V2, V3 … Vn
Find subgroup i... 阅读全帖 |
|
a*i
发帖数: 1652 | 48 http://findarticles.com/p/articles/mi_m0EIN/is_2007_Feb_9/ai_n1
ARLINGTON, Tenn. -- First graph, second sentence of release dated Feb. 8,
2007 should read: Thursday, February 15 (sted Thursday, February 14).
The corrected release reads:
TENNIS LEGEND JIMMY CONNORS JOINS WRIGHT MEDICAL TO SHARE HIS EXPERIENCES OF
TOTAL HIP REPLACEMENT DURING AMERICAN ACADEMY OF ORTHOPEDIC SURGEONS'
MEETING
Wright Medical Group, Inc. (NASDAQ: WMGI), a global orthopaedic medical
device company, announced today that... 阅读全帖 |
|
l*******d
发帖数: 572 | 49 美国的医疗设备产业巨大，医疗设备领域中产品的多样化使它比美国的其他市场有更
大的增长潜力，全球近二分之一的医疗设备出自美国。同时，美国所消费的医疗设备产
品占全球出口量的近40%。从1989 年到2003 年，美国医疗器械和诊断产业的出口额逐
年上升，2003 年约为0.23 亿美元。2004 年美国医疗设备市场达到689 亿美元的销售
额，2005 年达到745 亿美元。
外科设备、外科和医学仪器、牙科设备是美国医疗设备公司三大主要产品。
在美国，尽管整个医疗设备行业中有大约6000 个医疗设备制造商，共有大约40 万的员
工，但约有80%的公司所雇用的员工不足50 人。这就意味着在医疗设备行业中大多数是
小型的公司。
2004年，美国共有17 家公司占据了医疗设备的大部分市场份额，而且每家公
司的年销售收入都超过5 亿美元，这17 家公司的总收入占整个行业总收入的65%左右。
为了达到扩展产品生产线、引进技术或者淘汰竞争者的目的，许多大的医疗设备生产厂
商一直在兼并一些较小的、更专业的医疗设备公司。例如，AbbottLabs 公司就以12 亿
美元购买了Th... 阅读全帖 |
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发帖数: 572 | 50 美国的医疗设备产业巨大，医疗设备领域中产品的多样化使它比美国的其他市场有更
大的增长潜力，全球近二分之一的医疗设备出自美国。同时，美国所消费的医疗设备产
品占全球出口量的近40%。从1989 年到2003 年，美国医疗器械和诊断产业的出口额逐
年上升，2003 年约为0.23 亿美元。2004 年美国医疗设备市场达到689 亿美元的销售
额，2005 年达到745 亿美元。
外科设备、外科和医学仪器、牙科设备是美国医疗设备公司三大主要产品。
在美国，尽管整个医疗设备行业中有大约6000 个医疗设备制造商，共有大约40 万的员
工，但约有80%的公司所雇用的员工不足50 人。这就意味着在医疗设备行业中大多数是
小型的公司。
2004年，美国共有17 家公司占据了医疗设备的大部分市场份额，而且每家公
司的年销售收入都超过5 亿美元，这17 家公司的总收入占整个行业总收入的65%左右。
为了达到扩展产品生产线、引进技术或者淘汰竞争者的目的，许多大的医疗设备生产厂
商一直在兼并一些较小的、更专业的医疗设备公司。例如，AbbottLabs 公司就以12 亿
美元购买了Th... 阅读全帖 |
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