L**u
发帖数: 933 | 1 看看人家化学怎么转行的
看滑雪班的讨论，这个属于做的很牛很牛的了
【 以下文字转载自 Chemistry 讨论区 】
发信人: getjob (bright), 信区: Chemistry
标 题: 终于要走了
发信站: BBS 未名空间站 (Wed Jun 22 19:33:03 2011, 美东)
终于要转行了。
没了，才知道什么叫没了。走了，才知道再也回不来了。
今天最后一天。
我在NMR谱图上贴标签的时候，手写分子式，比任何时候都要认真。也许我以后一辈子
也不会在写天然产物的分子式了，呵呵。11个手性中心，3个顺反双键，两个环，还有
一个moiety 怕酸，另一个moiety怕碱。不算复杂，但也不好做。看着我的几大本子谱
图，几大本子实验记录，冰箱里一盒一盒的样品，无论以后他们怕酸，怕碱，怕光，怕
水，怕氧，不能久放，再也不关我的事了。
这么些年，我纯手工人肉过得柱子有两千根了吧。。。几年下来，发了三篇一区一作的
文章（mitbbs的热心读者请勿评论），有全合成，有方法学，还有全合成加方法学。写
到这里，真的眼泪要出来了。不为这些今后再也无人问津的所谓“科研成果... 阅读全帖 |
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l**********1
发帖数: 5204 | 2 sunny day
是专利的话 有基金可以负担没?
pls refer:
Spacer: As used herein, the term "spacer" (also referred to as "linker")
refers to a peptide sequence between two protein moieties in a fusion
protein. A spacer is generally designed to be flexible or to interpose a
structure, such as an alpha-helix, between the two protein moieties. A
spacer can be relatively short, such as the sequence Gly-Ala-Pro (SEQ ID NO:
4) or Gly-Gly-Gly-Gly-Gly-Pro (SEQ ID NO: 5), or can be longer, such as,
for example, 10-25 amino a... 阅读全帖 |
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g****b
发帖数: 143 | 3 终于要转行了。
没了，才知道什么叫没了。走了，才知道再也回不来了。
今天最后一天。
我在NMR谱图上贴标签的时候，手写分子式，比任何时候都要认真。也许我以后一辈子
也不会在写天然产物的分子式了，呵呵。11个手性中心，3个顺反双键，两个环，还有
一个moiety 怕酸，另一个moiety怕碱。不算复杂，但也不好做。看着我的几大本子谱
图，几大本子实验记录，冰箱里一盒一盒的样品，无论以后他们怕酸，怕碱，怕光，怕
水，怕氧，不能久放，再也不关我的事了。
这么些年，我纯手工人肉过得柱子有两千根了吧。。。几年下来，发了三篇一区一作的
文章（mitbbs的热心读者请勿评论），有全合成，有方法学，还有全合成加方法学。写
到这里，真的眼泪要出来了。不为这些今后再也无人问津的所谓“科研成果”，只为我
的曾经的t-butyl lithium的小火花（mitbbs的热心读者请勿评论），大瓶大瓶的HMPA
的蒸馏纯化，必须每次新鲜制备的硫醇，大量的Raney-Ni, azide, 和每每抬头从小窗
里望到的满天星斗。你懂的。
好，我不装13了。我不抒情了。不知道这一走是对是错。我只想以后的日子有... 阅读全帖 |
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k********k
发帖数: 5617 | 4 http://news. .net/immigration/2017/04/06/big5/1808258.html
100個單詞測出你的英文水平 快來測一測
www.creaders.net | 2017-04-06 09:33:06
這里是美國 | 0條評論 | 查看/發表評論
美國Heritage精心編輯了100個單詞。
他們認為這100個詞 能評測出美國高中畢業生的語言水平。
"我們選擇的單詞，如果你知道如何正確哂茫屈N你將在語言方面沒有問題。"
——《Heritage》主編Steven Kleinedler
那麼，你也來測一測吧!看這100個單詞，你認識幾個 ?
檢驗美國高中生英文水平的100個單詞:
abjure
abrogate
abstemious
acumen
antebellum
auspicious
belie
bellicose
bowdlerize
chicanery
chromosome
churlish
circumlocution
circumnavigate
deciduous
deleterious
diffident
enervate
enf... 阅读全帖 |
|
k********k
发帖数: 5617 | 5 http://news. .net/immigration/2017/04/06/big5/1808258.html
100個單詞測出你的英文水平 快來測一測
www.creaders.net | 2017-04-06 09:33:06 這里是美國 | 0條評論 | 查看/發表評論
美國Heritage精心編輯了100個單詞。
他們認為這100個詞, 能評測出美國高中畢業生的語言水平。
"我們選擇的單詞，如果你知道如何正確運用，那麼你將在語言方面沒有問題。"
——《Heritage》主編Steven Kleinedler
那麼，你也來測一測吧!看這100個單詞，你認識幾個 ?
檢驗美國高中生英文水平的100個單詞:
中英對照參考
abjure 發誓放棄
abrogate 廢除
abstemious 節省的 有節制的
acumen 聰明/敏銳
antebellum 戰爭前的
auspicious 吉利的
belie 掩飾/違背/使失望
bellicose 好戰的
bowdlerize 刪除文句 刪改
chicanery 欺詐/狡辯
chromosome 染色體
churlish 無... 阅读全帖 |
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d****g
发帖数: 7460 | 6 【 以下文字转载自 Military 讨论区 】
发信人: khabarovsk (伯力), 信区: Military
标 题: 100個單詞測出你的英文水平
发信站: BBS 未名空间站 (Thu Apr 6 13:11:42 2017, 美东)
http://news. .net/immigration/2017/04/06/big5/1808258.html
100個單詞測出你的英文水平 快來測一測
www.creaders.net | 2017-04-06 09:33:06
這里是美國 | 0條評論 | 查看/發表評論
美國Heritage精心編輯了100個單詞。
他們認為這100個詞 能評測出美國高中畢業生的語言水平。
"我們選擇的單詞，如果你知道如何正確哂茫屈N你將在語言方面沒有問題。"
——《Heritage》主編Steven Kleinedler
那麼，你也來測一測吧!看這100個單詞，你認識幾個 ?
檢驗美國高中生英文水平的100個單詞:
abjure
abrogate
abstemious
acumen
antebellum
auspicious
beli... 阅读全帖 |
|
S***A
发帖数: 40 | 7 DATE: Monday, April 7, 2014
TIME:
4:45 PM Registration
5:15 PM Professor Barry M. Trost, Tamaki Professor of Humanities and
Sciences, Stanford University, “The Alkyne Strategy For the Synthesis of
Bioactive Targets”
6:00 PM Networking and light dinner
7:00 PM Dr. Nicholas A. Meanwell, Executive Director, Medicinal
Chemistry, Bristol-Myers Squibb, “The Discovery of HCV NS5A Replication
Complex Inhibitors: Daclatasvir and Synergists”
PLACE: Knobbe ... 阅读全帖 |
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g***1
发帖数: 515 | 8 There has not been large-scale clinic research on this issue. However, most
physicians recommend Glucosamine as dietary supplement for better joint
health. My experience is that it helps quite a bit, especially after weight
training. We are not young anymore and need help repairing cartilage.
From Mayo Clinic info:
http://www.mayoclinic.com/health/glucosamine/NS_patient-glucosa
"Available evidence from randomized controlled trials supports the use of
glucosamine sulfate in the treatment of osteo... 阅读全帖 |
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t******c
发帖数: 2224 | 9 http://blog.sina.com.cn/s/blog_630cbe290100sel2.html
------------------------------------------------------
职业征象星的取法
命主有工作职业的状况：
一、针对水星、金星、火星三颗星体来论。火星给予肉体耐久力，水星给予智慧 金星
给予愉悦。
二、当水、金、火任一颗落在第十宫、第一宫与第七宫内。
且
a.具有essential dignities
b.没有被太阳燃烧
c.没有受阳光笼罩.
则该颗星体可为职业征象星。
三、若命盘中没有符合第二点，则观察MC的主宰星是否为水、金、火其中之一，且有
essential dignities。
因为
a.该星体peregrin... 阅读全帖 |
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a****e
发帖数: 173 | 10 Mine eye and heart are at a mortal war,
How to divide the conquest of thy sight;
Mine eye my heart thy picture's sight would bar,
My heart mine eye the freedom of that right.
My heart doth plead that thou in him dost lie,--
A closet never pierc'd with crystal eyes,--
But the defendant doth that plea deny,
And says in him thy fair appearance lies.
To 'cide this title is impanelled
A quest of thoughts, all tenants to the heart;
And by their verdict is determined
The clear eye's moiety and the dear |
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A***s
发帖数: 389 | 11 THE RAPE OF LUCRECE
TO THE
RIGHT HONORABLE HENRY WRIOTHESLY,
Earl of Southampton, and Baron of Tichfield.
The love I dedicate to your lordship is without end; whereof
this pamphlet, without beginning, is but a superfluous moiety.
The warrant I have of your honourable disposition, not the worth
of my untutored lines, makes it assured of acceptance. What I
have done is yours; what I have to do is yours; being part in
all I have, devoted yours. Were my worth greater, my duty would
show greater; mea |
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r****o
发帖数: 105 | 12 My lab happens to study one important type of O-glycosylation.
O-glycosylations are carbohydrates linked through hydroxyl groups of
serine or threonine of the protein. There are different types of
O-glycosylations. They have different functions.
(1)O-GalNAc(mucin type)
Originally, O-glycosylation only refers to this type. This type
of glycosylation has usually extended chains(but less branched than
N-glycans). The first carbohydrate moiety linking to the protein is
N-acetylgalactosa |
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h*******o
发帖数: 4884 | 13 If I remember correctly, moieties that naturally occurs cannot be patented
under the current US patent law.
You may patent the purification procedure but not the natural product. |
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h******y
发帖数: 351 | 14 RNA-RNA has a higher Tm than RNA-DNA, so you can use more stringent washing
in your in situ and get better background. In a nutshell, RNA probe is
better than DNA probe. Of course, your RNA probes should be free of any
RNase contamination.
Current commercially available DIG labeling kits is as sensitive as
radioactive labeling kits, although the advantage of using radioactive-
labeled probes is that you can do quantification analysis by densitometry.
The disadvantage of radioactive-labeled pro... 阅读全帖 |
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m****p
发帖数: 5 | 15 Molecular characterization of co-transcribed genes from Streptomyces tendae
Tü901 involved in the biosynthesis of the peptidyl moiety of the peptidyl
nucleoside antibiotic nikkomycin.
Bruntner C, Lauer B, Schwarz W, Möhrle V, Bormann C.
Mol Gen Genet. 1999 Aug;262(1):102-14.
http://www.ncbi.nlm.nih.gov/pubmed/10503541
m*****[email protected]
Many thanks! |
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d****i
发帖数: 360 | 16 Adsorption of protein on the surface of thermosensitive poly(methyl
methacrylate) microspheres modified with the N-(2-hydroxypropyl)
methacrylamide and 2-(methacryloyloxy)ethyl phosphorylcholine moieties
Journal of Polymer Science Part A: Polymer Chemistry
Volume 35, Issue 16, pages 3349–3357, 30 November 1997
E-mail to x**********[email protected] |
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s**********r
发帖数: 67 | 17 RT
Paper information:
Versatile Introduction of Azido Moiety into Oligonucleotides through Diazo
Transfer Reaction, Rémy Lartia, Pierre Murat, Pascal Dumy, and Eric
Defrancq, Org. Lett., 2011, 13 (20), pp 5672–5675
s**********[email protected]
THanks a lot!!!!!!!!! |
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w******e
发帖数: 953 | 18 Chen, F., Z. Jia, K.C. Rice, R.A. Reinhardt, K.W. Bayles and D. Wang, The
development of dentotropic micelles with biodegradable tooth-binding
moieties. Pharmaceutical Research, 2013. 30(11): p. 2808-2817. |
|
w******e
发帖数: 953 | 19 Chen, F., Z. Jia, K.C. Rice, R.A. Reinhardt, K.W. Bayles, and D. Wang, The
development of dentotropic micelles with biodegradable tooth-binding
moieties. Pharmaceutical Research, 2013. 30(11): p. 2808-2817. |
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f**********e
发帖数: 236 | 20 Do not get me wrong. First, my point is the danger of gold or silica is lower
relatively to CdSe. Who wants degraded Cd in the body? Secondly, the
nanoparicles are not necessarilly "non-degradable". With certain coating, they
might be able to be cleaned out by the body. Or they can be destoryed at
centain conditions, like low pH, high reductive conditions, etc. If they do
get degraded, Au or Si moieties are certainlly less toxic than Cd or Se or Hg
or Td. Anyway, I am not optimistic that metal |
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N**X
发帖数: 3 | 21 I guess you're talking about "post-streptococcal reactive arthritis (PSRA)"
and rheumatic heart disease seen in "rheumatic fever" since you mentioned
streptococcus. Both of them can be complicated by GAS pharyngitis,
presumably via cross-reactions of antibodies between M-protein moieties and
human tissues (the so-called molecular mimicry).
Also please be noted that the pathogenesis of autoimmune diseases involves a
triad of "triggering factors, susceptible hosts, and immune responses".
PSRA and ... 阅读全帖 |
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h*******o
发帖数: 4884 | 22 Again, you seem to quite lack basic knowledge of how FDA works.
FDA as a regulatory agency review your medical product profile, not provide
inspiration of your research and development activities.
The sponsor aims to test the efficacy and safety of a combo drug, then it is
a combo drug. Not necessary to test the efficacy and safety of each
components. Otherwise it will be multiple applications for multiple drugs.
In reality, there are cases that a few drugs were marketed first and later
on make ... 阅读全帖 |
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j*******1
发帖数: 266 | 23 “The sponsor aims to test the efficacy and safety of a combo drug, then it
is a combo drug. Not necessary to test the efficacy and safety of each
components. Otherwise it will be multiple applications for multiple drugs.”
I never said it necessary to test the efficacy and safety of each
components, I said that you need to test different combination from a few
NCEs in a single drug to find out safety and efficacy.
What we are debating is if development of a drug with a few NCEs costs more
or much... 阅读全帖 |
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h*******o
发帖数: 4884 | 24 Let me answer your question for the last time
It is not necessary to conduct human clinical trials on each active
ingredients if you only want the drug to work as a combo.
The ratio of active ingredients is determined in preclinical stage. As for
human dosage and formulation in clinical trials, it does not cost more than
drugs with a single moiety.
With that said, the exception is that the sponsors want to look at marketing
potential for each active ingredient separately, then your way of design... 阅读全帖 |
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j*******1
发帖数: 266 | 25 “It is not necessary to conduct human clinical trials on each active
ingredients if you only want the drug to work as a combo.”
Who said it necessary to conduct human clinical trials on each active
ingredients if you only want the drug to work as a combo, except you.
“The ratio of active ingredients is determined in preclinical stage. As for
human dosage and formulation in clinical trials, it does not cost more than
drugs with a single moiety.”
What is the purpose of phase II? The preclinical st... 阅读全帖 |
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h*******o
发帖数: 4884 | 26 I said the dosage and formulation trial for a multi-NCE drug does not cost
significantly more than a single moiety drug.
Is this your habit to distort what others said and attack?
用中文回你最后一次,
看来你不仅基础知识贫乏,理解能力也有限.
这个帖子里面谁在反复强调trial design要测试每一个NCE的dosage?
谁说因为有了multiple-NCE病人数量翻4倍到4000
又是谁告诉你不用clinical 直接就能上人体?
教育你一下
Phase I的主要目的是saefty和toxicity,找到MTD
Phase II一般的目的是扩大toxicity,并且做PK/PD,如果有条件可以看初始的efficacy
至于你认为我的水平不能理解你的issue,
我承认,要理解你的思维方式太难
给你个建议,要么踏踏实实去拿个regulatory science的学位,好好补补你的基本知识,
要么虚心的积... 阅读全帖 |
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f****w
发帖数: 947 | 27 这是我们这一周的NIW批准案例，大都是从Vermont而来供大家参考。下周我们会有详细的
分析。
Genetics. Ph.D. in 1999. Studies plasma C1 inhibitor bears sialy1 Lewis
related moieties and to select adhesion molecules. 11 publications. 7
recommendation letters. EB-2 NIW, Vermont, 12 months, no RFE.
Atmospheric Science, Ph.D. in 2001. Regional model application and monitoring
water resources over central and southwestern US and Mexico . Multi- year
simulation to provide the community with a climatological database. 14
publications. 6 recomm |
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