w******y
发帖数: 4871 | 1 NOVEL THERAPIES
Gene therapy — The identification of the gene responsible for the
dystrophinopathies led to initial excitement that transfer of a functioning
dystrophin protein (whether by transplanted myoblast or direct genetic
manipulation) may provide substantial benefit to or even "cure" affected
patients. Although myoblast transfer has been attempted in humans, the
results have thus far not been encouraging [47]. However, in one patient who
received a bone marrow transplant for severe combi... 阅读全帖 |
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d*i
发帖数: 9453 | 6 ☆─────────────────────────────────────☆
mkl (mkl) 于 (Wed Aug 29 14:32:47 2007) 提到:
'Mighty Mice' Made Mightier
Science Daily — The Johns Hopkins scientist who first showed that the
absence of the protein myostatin leads to oversized muscles in mice and men
has now found a second protein, follistatin, whose overproduction in mice
lacking myostatin doubles the muscle-building effect.
Comparison of body and muscle size between normal mice (left) and double
mutant mice lacking myostatin and ove |
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n********k
发帖数: 2818 | 8 not really, I just happen to know a bit....the myostatin is an amazing gene.
..I am just afraid this one is just
another hype like myostatin once was...left the field for ys, don't really
know the state of art now.... |
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t*******a
发帖数: 4055 | 9 世界反兴奋剂机构把基因组编辑技术列入“黑名单”
据日本共同社5日报道，世界反兴奋剂机构（WADA）汇总的关于2018年禁止药物名
单中，新加入了使用可自由改变遗传基因的基因组编辑技术的基因兴奋剂。该名单将从
明年1月1日起生效。
基因组编辑可有效改良目标基因，是在治疗疾病和改良食物品种应用上备受期待的
新技术。该技术被评价为生命科学研究领域的“诺贝尔奖级别”，正迅速推广。虽然尚
无报告例子，但由于该技术被视为也可用于增强肌肉力量等提升运动能力，存在以兴奋
剂为目的使用的担忧。迎接2020年东京奥运会和残奥会，开发检查方法等或成为课题。
WADA把来自外部的DNA和改变基因的细胞注入人体旨在提升运动能力的行为视为“
基因兴奋剂”，一直以来予以禁止。若使用基因组编辑，或能够更简单巧妙地起到兴奋
剂的作用，因此决定在名单中明文禁止。
通过使用可导致基因组编辑的药物等有可能能够增强肌肉力量和耐力。如果在受精
卵阶段进行基因组编辑，生出天生就具备较高运动能力的“人造宝宝”也并非不可能。
由于与自然产生的突变难以分辨，也有意见指出检查中难以辨别，导致“总有被... 阅读全帖 |
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a***a
发帖数: 40617 | 12 【 以下文字转载自 Fitness 讨论区 】
发信人: anoia (high estrogen man), 信区: Fitness
标 题: 这帮货都没后天workout，就是纯gene区别
发信站: BBS 未名空间站 (Tue Jul 24 15:15:58 2012, 美东)
myostatin gene mutation
dogs
cows
mice |
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d******0
发帖数: 22800 | 13 这样啊，那让那些科学家赶紧把这东西弄清楚点啊，投多点钱下去，这东西的商业用途
很大很广的。还有就是那个在sport gene里提到的Myostatin，double muscle的东西。 |
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l**********1
发帖数: 5204 | 14 预先打了伏笔了哈 Wo Kao Nature News
Performance enhancement: Superhuman athletes
Enhancements such as doping are illegal in sport — but if all restrictions
were lifted, science could push human performance to new extremes.
Helen Thompson
18 July 2012
Code breaking
Gene doping — enhancing performance by adding or modifying genes — has
been the subject of locker-room gossip for the past ten years. There are
plenty of natural mutations for which to wish. The Finnish cross-country
skier Eero Mäntyrant... 阅读全帖 |
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l**********1
发帖数: 5204 | 15 BGI or others just try
NGS with both blood samples Ye Shiwen and Katie Ledecky
plus below six athletes total 8 athletes
performance profiling”方法，将所有国际上
有名的现役游泳运动员的比赛成绩，进行profiling分析，发现最高分排名（也就是最
“anomalous”的排名）是：
1. Elizabeth Beisel
2. Michael Phelps
3. Rebecca Adlington
4. Ian Thorpe
5. Stephanie Rice
6. Allison Schmitt
while can find proof of her EPOR mutation which is identical to Finnish
cross-country skier Eero Mäntyranta
and also is different to former matchs any DNA samples Ge... 阅读全帖 |
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