c********r
发帖数: 1125 | 1 开始抬杠了是把。。
我的意思是“文章是很重要的”，前提是对于那些非牛校非牛老板的普通人来说，尤其
是国内的博士。未来的老板在面试前怎么真正的了解你？
如果发本帖求助的主角人脉很牛，有关系或者人就在美国比较容易见到申请的老板，还
用得着拜托朋友跑到MITBBS上来发帖么？
文章当然不是一切，这个本科生都懂。问题是在没有超越别人的学校牌子，人脉关系，
特殊技术以及忽悠套磁能力情况下，什么能真正让你从几十甚至几百的CV中脱颖而出？
综合素质高？ 外语能力好？独立研究能力？ 没有好的PUBLICATION的话恐怕连推荐信
这步都省了就直接扔垃圾箱了。
P.S 对于NEURON朋友的回复。
1）我没有说3篇JN不好，只是达不到CORI一般的POSTDOC的标准而已。（见下）
2）我至少知道有两个人，一个人1篇NEURON，一个人2篇JN+一篇略低的，投CORI实验室
连回信都没有。
3）你非较真我就跟你讨论CORI实验室博后的背景，你不要刻意找没有CNS的，我的意思
当然不是没有CNS没戏，而是很多人都有，你要是没有就要有其他的东西打动CORI。
她现在实验室博后6个，PHD期间文章如下(只... 阅读全帖 |
|
g*****h
发帖数: 32 | 2 评审是3月份,之后出来的当时肯定不能算.还有个要求就是中国人在国内发的文章,美国
人在美国发的文章是不算数的.
下面是rao lab 05年开始的文章,
1. Liu W, Liang X, Gong J, Yang Z, Zhang YH, Zhang JX and Rao Y. Social
regulation of aggression by pheromonal activation of Or65a olfactory neurons
in Drosophila. Nature Neuroscience, doi:10.1038/nn.2836, 2011 Jun. 19
这个文章是6月份出来的,当时用不上
2. Liu Y, Jiang Y, Si Y, Kim J-Y, Chen Z-F, and Rao Y (2011). Molecular
regulation of sexual preference revealed by genetic studies of 5-HT in the
brain of male mice. Nature 472:95... 阅读全帖 |
|
f*********l
发帖数: 116 | 3 GOOGLE一下，此公不算一个吗
李华顺，理学博士，教授，博士生导师。1999年获Washington 大学神经生物学博士，
1999-2005在加州大学旧金山分校作博士后，2005-2007年在乔治亚州医学院作助理教授
，2007年7月到四川大学任教授，发育干细胞所研究员兼所长。研究方向是不对称性细
胞分裂、细胞极性、神经突起分化、干细胞和肿瘤干细胞。李华顺博士的工作曾发表在
Development 124, 603-615 （1997）; Cell 96, 807-818, (1999); Neuron 23, 473-
85 (1999); Neuron 40, 1105-18 (2003); Genes Dev. 19:138-51 (2005); Nat
Neurosci. 10:819-27 (2007).
Huashun Li Laboratory
Huashun Li, PhD, MD, Doctoral Tutor ,received his PhD from Washington
University in St.Louis in 1999, did postdoc... 阅读全帖 |
|
m********a
发帖数: 239 | 4 Read it here: http://the-scientist.com/2011/08/31/puncturing-the-myth/
Puncturing the Myth
Purinergic signaling, not mystical energy, may explain how acupuncture works.
By Geoffrey Burnstock | August 31, 2011
4 Comments
According to traditional Chinese medical theory, acupuncture points are
situated on meridians along which qi, the vital energy, flows. However, I
have proposed a less mysterious neurophysiological mechanism to explain the
beneficial effects of this 2,000-year-old practice (Medica... 阅读全帖 |
|
d*****8
发帖数: 29 | 5 总结了一下其他学校青千的paper，希望大家能把以前两批的已经总结的也建个帖子，
可以给大家参考参考
北师大:
王占新(1977) Structure- Nature(Co-1st), Cell(Co-1st), Cell(2nd), JBC
第三军医大学:
谌小维(1980) Neuron- Nature, PNAS
叶丽林(1975) Immunity- Nat Biotech, PNAS(Co-1st), J Immunol
复旦大学:
王毅(1973) Signal transduction- PNAS, 同名太多
郑丙莲(1976) Plant small RNA- GD, Plant Cell
薛磊(1978) Neuron- Nature(Co-1st), J Neurosci, J Physiol
倪挺(1977) RNA transcription- Nat Method, Nat Protocol
华南农业大学:
李文涛(1973) Plant- Science, Genetics
南方科技大学:
胡健(1973) Structure- Nature
上... 阅读全帖 |
|
s****h
发帖数: 184 | 6 http://retractionwatch.wordpress.com/2011/09/28/you-can-do-that
You can do that? A massive correction in Nature, but no retraction
This past April, Amparo Acker-Palmer and colleagues published a study in
Nature, “Ephrin Bs are essential components of the Reelin pathway to
regulate neuronal migration.” Within a day of its publication, Nature
readers were raising questions about many of its figures. They started like
this:
Andy Gu said:
Looks like Fig 1a, the two middle figures are actuall... 阅读全帖 |
|
L*********y
发帖数: 322 | 7 Overall, your project sounds interesting. However, you might want to collect
more data or do far more in-depth analysis prior to submitting your story
to top journals. Below are my specific questions:
Where do you obtain this repellent? From plants or from insects?
Can you elaborate on what ecological impacts this repellent has? Can it be
used as insecticide?
If you are sure this repellent is a mixture instead of a pure chemical, can
you identify its chemical components by doing HPLC, per say?
已... 阅读全帖 |
|
p*****c
发帖数: 20445 | 8 Marc R. Freeman, Ph.D.
HHMI Early Career Scientist
University of Massachusetts Medical School
Neurons hog the attention, but our brains couldn’t operate without the
unassuming neural cells called glia. Marc Freeman is working to bring these
overlooked cells—which represent about 60 percent of brain cells—their
share of credit.
Freeman has been dissecting the role of glia in brain development, function,
and healing after injury, when glia hurry to the damaged area and devour
cellular debris to al... 阅读全帖 |
|
h*******o
发帖数: 4884 | 9 Adult neuronal culture is indeed very tricky. And most of what you get is
debris.
But to dissect out cerebral cortex is easy. By 软脑膜, do you mean meninges?
You can actually start from inside. Use a sharp pair of tweezers to snip out
the meniges on the outside, then flip open the hemisphere, there you will
be able to identify hippocampus and cerebral cortex. You can use tweezers to
snip out cortical pieces.
There will be a lot of debris (actually the majority of the fresh tissue
culture will be d... 阅读全帖 |
|
w******y
发帖数: 4871 | 10 我好多年没有做neuron培养了,neuron 和glia的大小上是有区别的吧.
neuron有axon and dendrite.
完了完了,第一年修的histology, neuroanatomy都忘掉了.....俺好几年不做动物实验
了,现在开始做人身上的实验了,要是半年后再出不了什么好结果,我就不干research了.
哦,那个"1"肯定是neuron,毕竟俺看了几年的猴脑切片,我以前的几位导师中有一位是做
电极插在活猴脑里的,还要事先训练猴子,猴子可聪明了,还会从我手心里拿东西吃.
你为什么要从化学转到生物上来啊? 化学不是不太难找工作的吗? |
|
d********n
发帖数: 15 | 11 看不到全文。但不怀疑数据的真实性，因为从道理上说是行得通的。但有两点比较关键。
1. 清除Abeta的药物（免疫方法或Bace1抑制剂）都已经出来，虽可以清除Abeta，但根
本就没有改善dementia的疗效。所以这样的研究不但临床应用可能性很低，而且又没有
疗效，别人觉得这样的研究毫无意义。
2. 没有一个老鼠模型是真正的Alzheimer。纯粹的Abeta高表达和形成plaque不导致
neuronal死亡，除非同时做Tau mutation。 这跟人为的其他方法杀死神经细胞没有什
么区别，所以和alzheimer就没什么关系。而且，tangle被怀疑只是neuron stress后期
的东西，不在早期起作用。就是说在AD被人脑内杀死neuron的根本就不是plaque和tau
的直接作用。所以，用所谓的AD老鼠模型其来做疗效只能是相当于体外模型，没有强有
力的说服力的。
早期清除Abeta肯定可以防止Alzheimer，这已是公认的事实。但疾病进程一旦启动，很
多pathway就开始了，（inflammation, ER, oxidative stress, bdnf depr... 阅读全帖 |
|
d********r
发帖数: 3279 | 12 My thoughts so far:
I think the "uniqueness" of using optogenetics in invertebrates, worms in
particular, is still essentially related to the general advantages of using
this model organism in the first place: transparent, small size, simple
nervous system and genetic screens.
For ephys analysis of synaptic function in dissected preps using
optogenetics, there is no big difference between worms and mice. For whole
animal behavioral studies under light stimulation, worms under a LED is a
lot eas... 阅读全帖 |
|
S******i
发帖数: 71 | 13 Distinct lineage-dependent structural and functional organization of the
hippocampus.
Xu HT, Han Z, Gao P, He S, Li Z, Shi W, Kodish O, Shao W, Brown KN, Huang K,
Shi SH.
Cell. 2014 Jun 19;157(7):1552-64. doi: 10.1016/j.cell.2014.03.067.
SDCCAG8 regulates pericentriolar material recruitment and neuronal migration
in the developing cortex.
Insolera R, Shao W, Airik R, Hildebrandt F, Shi SH.
Neuron. 2014 Aug 20;83(4):805-22. doi: 10.1016/j.neuron.2014.06.029. Epub
2014 Jul 31.
Cortical neurogenesi... 阅读全帖 |
|
V******t
发帖数: 444 | 14 他做博后期间发过cell？？
Publications
1.Jiang H, Guo W, Liang X, Rao Y (2005). Both the establishment and the
maintenance of neuronal polarity require active mechanisms: critical roles
of GSK-3beta and its upstream regulators. Cell 120:123-35. (Highlighted in
Science 307:646 (2005), and Nature Review Neuroscience 6:172-173(2005),
commented in Current Biology 15: R198-200)
2.Jiang H, Rao Y (2005). Axon formation: fate versus growth. Nat Neurosci.8:
544-6.
3.Ward ME, Jiang H, Rao Y (2005). Regulated formati... 阅读全帖 |
|
x*******t
发帖数: 3764 | 15 agree
不太理解国内所谓的分区。。一区，二区。。
和同事聊起来基本上也是和云中漫步差不多的分类 （neuroscience）
CNS
Neuron，Nature Neuro （其实有些人更愿意读这两个杂志），这个梯队IF基本没有啥
意义。
PNAS, Nat comm, eLife, Plos biology, Cell reports，jns，这些之间也有差别，比
如投稿难度，IF，但是基本都落在第三梯队。NC现在的IF十几分，都快接近Neuron了，
但是至少行业内认为能发neuron的一定是牛人，更不要说频频发neuron的，基本算大牛
了。如果申请grant需要IF撑场面，就NC了，elife的IF就算会升上去，也需要点时间估
计，况且还有降的可能性：（
are
neurosci
in |
|
a*******i
发帖数: 27 | 16 NATURE | NEWS Sharing
Chinese scientists row over long-sought protein that senses magnetism
Two universities ask journal to retract paper that allegedly violated a
collaboration agreement.
David Cyranoski
21 September 2015
Article toolsRights & Permissions
Neuroscientists in China say they have used magnetic fields to control
neurons and muscle cells in nematode worms (pictured), after identifying a
protein that senses magnetism.
A dispute has broken out at two of China’s most prestigious univer... 阅读全帖 |
|
a*******i
发帖数: 27 | 17 NATURE | NEWS Sharing
Chinese scientists row over long-sought protein that senses magnetism
Two universities ask journal to retract paper that allegedly violated a
collaboration agreement.
David Cyranoski
21 September 2015
Article toolsRights & Permissions
Neuroscientists in China say they have used magnetic fields to control
neurons and muscle cells in nematode worms (pictured), after identifying a
protein that senses magnetism.
A dispute has broken out at two of China’s most prestigious univer... 阅读全帖 |
|
t*******6
发帖数: 14 | 18 http://www.sciencenets.com/home.php?mod=space&uid=38&do=blog&id
清者自清浊者自浊：张生家实名批驳匿名谣言
【《科学伦理》编辑按：《科学伦理》发出公开调查引子和问卷后，收到张生家如下一
封来信。虽然《科学伦理》编辑以前未阅读张生家所指《知乎》网站的帖子，但有些匿
名者在《科学伦理》公开调查文章下的评论似乎已根据这些网上流传的帖子对张生家定
下了一个一贯作恶的坏人的印象。而张生家的这篇批驳却貌似真实而有力。为了帮助大
家辨别真伪，我们将这篇其实与张生家“抢发论文”和“掠夺成果”的控告无直接关系
的文章也公示出来，希望了解张生家的人也能出来真名说实话。】
《科学伦理》编辑:
知乎上一则针对我和我夫人叶菁进行人身攻击的极不负责任的帖子，捏造和歪曲了大量
我在德国和挪威工作时期的事情，对我们造成了巨大的人身和名誉上的伤害。我本来不
想花时间计较，但这样的行为已经逾越了基本的做人底线，作为当事人我必须站出来澄
清事实。
在国外工作这么多年，我总是坚持一个原则：尽力帮助中国人，我也尽最
大所能将我的实验小组的工作... 阅读全帖 |
|
N*********6
发帖数: 2302 | 19 人在国内，有11篇文章。有兴趣的PI, 请email me ：：[email protected]
/* */
谢谢！
1. Kang H, Cao S, Chen T, Jiang Z, Liu Z, Li Z, Xu Q, Lin Q, WeiS. The poor
recovery of neuromyelitis optica spectrum disorder is associated with a
lower level of CXCL12 in the human brain. J Neuroimm, 289:56-61, 2015.(co-
first author)
2. Chen T, Li Z, Jiang Z, Liu Z, Xu Q, Huang D, Lin Q, Wei.S (2015) Changes
of CXCL12, CXCL14 and PDGF levels in the brain of patients with idiopathic
demyelinating optic neuritis and neuromyeliti... 阅读全帖 |
|
j**h
发帖数: 126 | 20 nature.com
Sitemap
Register
Login
Nature
International weekly journal of science
Show searchMenu
Archive
Volume 544
Issue 7648
News
Article
NATURE | NEWS
Sharing
Compass protein attracts heap of criticism
Debate grows over a molecule implicated in animal navigation.
David Cyranoski
04 April 2017
Article tools
PDF
Rights & Permissions
George Grall/NGC
The red-spotted newt and many other animals can somehow sense Earth’s
magnetic field.
For decades, scientists have wondered how animals c... 阅读全帖 |
|
a******n
发帖数: 100 | 21 谢谢回复。我现在在研究一个问题：
https://ghr.nlm.nih.gov/gene/SCN8A
Most of these SCN8A gene mutations change a single protein building block (
amino acid) in the Nav1.6 channel. The mutations that cause SCN8A-related
epilepsy with encephalopathy result in altered channels that stay open
longer than usual, which increases the flow of sodium ions into neurons. The
persistently open channels abnormally increase electrical signals, which
can lead to excess activation (excitation) of neurons in the brain. This
incr... 阅读全帖 |
|
l******p
发帖数: 71 | 22 NBME 1 Block 2 question 25
A clone of cancer cells is resistant to vincristine, doxorubicin, and
dactinomycin but not to methotrexate and various alkylating agents. The
mechanism of resistance is most likely to involve
a) absence of superoxide dismutase
b) altered DNA polymerase
c) enhanced drug transport out of cell
d) inability to form polyglutamates
e) increased DNase
NBME 1 Block 2 question 42
A 49 yrs old man has a 1week history of shortness of breath ,with no fever ,
chills or cough.Breath... 阅读全帖 |
|
f**d
发帖数: 768 | 23 这个领域的最新进展，一篇很好的REVIEW，刚刚发表出来的
作者D.Debanne最近发表了不少这个方向的REVIEW文章
http://physrev.physiology.org/content/91/2/555.full
Axon Physiology
Dominique Debanne, Emilie Campanac, Andrzej Bialowas, Edmond Carlier,
and Gisèle Alcaraz
Institut National de la Santé et de la Recherche Médicale U.641 and
Université de la Méditerranée, Faculté de Médecine Secteur Nord,
Marseille, France
Next SectionAbstract
Axons are generally considered as reliable transmission cables in
which stable propagation occurs once an act... 阅读全帖 |
|
f**d
发帖数: 768 | 24 Gordon Shepherd
美国科学院院士，是能同时应用实验和理论模型方法来研究神经元、神经网络回路的
集大成者。目前耶鲁大学神经生物学教授。
他是早期致力于用计算模型来模拟神经元活动的科学家之一，曾和will rall合作奠定
了神经电缆理论。他早期对olfactory bulb的实验和理论研究是神经科学领域最早的研
究大脑系统回路的典范。也是最早对嗅觉信号的空间编码模式给出实验和理论研究的先
驱。
他是1993年构划‘人类脑计划’的主要人员，并几乎在同时推动了神经信息学的建立。
名扬天下的Neuron模型软件（http://www.neuron.yale.edu/neuron/）是Gordon，Michael Hines等最初提出并完善建成，目前几乎所有前沿领域的计算神经模型科学家们都或多或少在应用这个软件建立复杂3维结构的神经元模型。Gordon还是IBM BLUE BRAIN PROJECT的
评审委员会主席，而MICHAEL HINES是BLUE BRAIN PROJECT模型的首席顾问之一。
http://senselab.med.yale.edu/
他的实验室Sens... 阅读全帖 |
|
f**d
发帖数: 768 | 25 Published online 3 May 2011 | Nature | doi:10.1038/news.2011.264
News
Keeping memories sharp
Researchers home in on structures that help the brain avoid faulty
recall.
David Cyranoski
The specificity of memories relies on structures in the brain stopping
them from being triggered by unrelated events.EQUINOX GRAPHICS/SPL
Memories fade, events get conflated, names get attached to the wrong
faces, or, in the case of post-traumatic stress disorder, signals in
safe environments can mistakenly evoke e... 阅读全帖 |
|
h*******o
发帖数: 4884 | 26 That is not necessarily the case.
For metabolic coupling, glia are largely glycolytic relative to neurons. Yet
, they provide substrates for OXPHOS in neurons. Glia covert glucose to
pyruvate, then to lactate, which is transported to neurons and converted
back to pyruvate to enter into the TCA cycle and OXPHOS.
For more details, read Pierre Magistratti's review on glia-neuron metabolic
corss talk reviews.
For anti-oxidant capacity, glia are far more resistant to nitric oxide and
other ROS. They ... 阅读全帖 |
|
r***y
发帖数: 25 | 27 :-) It's been THE debate ever since the simulation of neural network started
structure of the neural network in living creatures. Canonical AI people
said no, we just need to replicate the functions, which is faster but hard
to generalize. Neuroscience people said yes, we have to, otherwise we couldn
't replicate such complicated, decent, and flexible network, which makes the
question always stuck at the level of functioning units -- protein, synapse
, or single neuron? Any connection map seems ... 阅读全帖 |
|
r***y
发帖数: 25 | 28 :-) It's been THE debate ever since the simulation of neural network started
structure of the neural network in living creatures. Canonical AI people
said no, we just need to replicate the functions, which is faster but hard
to generalize. Neuroscience people said yes, we have to, otherwise we couldn
't replicate such complicated, decent, and flexible network, which makes the
question always stuck at the level of functioning units -- protein, synapse
, or single neuron? Any connection map seems ... 阅读全帖 |
|
z****k
发帖数: 95 | 29 I see what you mean. Neuro-stem cell has been studied a lot, and my lab
actually plan neuro-stem cell on rats spinal cord. But when you talking bout
main function in cortex, the problem is even you have the new neuron, it's
not going to react with other old neuron well.
The analogy is if you have a book, some pages got tear off, and you insert
some new white paper in the book, it's not going to make any sense to the
whole. So, interaction with other neurons are the key in this term.
PSN are usua... 阅读全帖 |
|
J***b
发帖数: 76 | 30 The effect of dopamine on animal behaviors seems very complicated. Dopamine
may via D1 receptors stimulate "Go" neurons in the striatum to facilitate
the section of "Go" action in rewarding behaviors;simultaneously via D2
receptor suppress "No-Go" neurons to inhibit the section of "No-Go" actions.
So the net effect is "Go". This might be why dopamine is so powerful,
although none of dopamine receptors are ion channels. These receptors do not
mediate fast synaptic transmission.
However,naturally ... 阅读全帖 |
|
c******a
发帖数: 10623 | 31 哈哈，真是有人说的对啊，这前老公还是伯克利的AP，以前发的文章挂了好多她的名字
。。。。。。。。。。。。。。。。。。。。。。。。。。。
卡卡，这下这女滴真是出名乐
http://baolab.org/Pub.html
http://neuroscience.berkeley.edu/users/users_profile.php?id=66
1. Chen C, Kano M, Abeliovich A, Chen L, Bao S, Kim JJ, Hashimoto K,
Thompson RF and Tonegawa S. (1995). Impaired motor coordination correlates
with persistent multiple climbing fiber innervation in PKC-gama mutant mice.
Cell, 83, 1233-1242.
2. Chen L, Bao S, Kim JJ, Lockard J and Thompson RF. (1996). Impaired
classical eyebli... 阅读全帖 |
|
p*****c
发帖数: 20445 | 32 Science评价还是不错的，专门写了News：
Science 5 November 2010:
Vol. 330. no. 6005, p. 747
DOI: 10.1126/science.330.6005.747
News of the Week
Neuroscience:
China's Brain Mappers Zoom In on Neural Connections
Kristen Minogue
Anyone in business, and even just fans of The Apprentice, knows that
connections matter. Neuroscientists understand that, too, which is why a
research team in China has gone to great lengths to create the most detailed
three-dimensional map yet of all the connections between the neurons in... 阅读全帖 |
|
w*********g
发帖数: 30882 | 33 平井宪夫揭示日本核电业惊天内幕——素人造核电，豆腐渣工程
作者：蜀中行 更新时间：2011-3-16
设施配管1级技士平井宪夫(1997年1月因癌症逝世)生前的最后吶喊。
/来自中华网社区 club.china.com/
/来自中华网社区 club.china.com/
关于平井宪夫：
1997年1月逝世。设施配管1级技士，核电事故调查国民会议顾问，核电劳工救济中
心代表，北陆电力志贺核电厂停止诉讼原告特别辅佐人，东北电力女川核电停止诉讼原
告特别辅佐人，福岛二号核电厂三号机运转停止诉讼原告证人。「核电劳工救济中心代
表」在他仙逝后，因后继无人关闭
"我不是反核运动家。这20年来，我一直在核电厂工作。社会上有听不完的拥核反
核理论，但我只想在这里告诉大家：「所谓的核电厂是这样一回事。」大部份的人都不
知道核电内部的实际情形。希望大家有耐心把这篇文章读完。所谓核电，跟各位所想的
或许有点出入。在那里，每天都有遭受放射线污染的工人，以及严重的岐视产生。
我的专长，是负责大型化学工场的内部配管施工与维修。快30岁时，日本掀起了一
阵核电建设的... 阅读全帖 |
|
f***y
发帖数: 4447 | 34 http://www.cgsoft.org/2014/09/11/project-perception-neuron/
互联网、个人电脑、智能手机的发展历史告诉我们，技术的启发往往发生在专业级市场
，而技术的革命往往发生在消费级市场。 戴若犁在一次演讲中提到，动作捕捉市场是
一个传统的市场。但是，从 Neuron 这款 200 美元的动捕产品，即便放在中国，也不
算昂贵，许多人的收入足以负担得起。Neuron 很可能是第一款面向消费级市场的动捕
产品——它让动捕产品，从拍摄《阿凡达》、《加勒比海盗》等的电影棚，走向寻常百
姓的家里。 这背后的原因在于，诺亦腾所致力的“基于惯性传感器的动作捕捉技术”
，所采用的惯性传感器和手机上的惯性传感器很像，很容易开发出价格较低、又能达到
一定精度要求的产品。 |
|
x**s
发帖数: 185 | 35 这个摘要得算生物学领域相当有价值的了！
http://iovs.arvojournals.org/article.aspx?articleid=2404051
ARVO Annual Meeting Abstract | May 2005
Functional Expression of a Directly Light–Gated Membrane Channel in
Mammalian Retinal Neurons: A Potential Strategy for Restoring Light
Sensitivity to the Retina After Photoreceptor Degeneration
Z.–H. Pan; A. Bi; Y.–P. Ma; E. Olshevskaya; A.M. Dizhoor
看这几句话
“The Chop2–GFP–expressing retinal neurons exhibited robust membrane
depolarization in response to light stimulation and... 阅读全帖 |
|
t******l
发帖数: 10908 | 36 我觉得这不是主动的“猜”，这是 intuition。对于这个这个，得提一下最新潮的：
推 “mirror-neuron => object-permanence hypothesis”，这个 hypothesis 是：
（1）从小小娃的 peek-a-boo，到小娃的不硬背九九乘法表，到大娃的 AIME 欧氏几何
题，其底层的支撑，也许都是 object-permanence。而 object-permanence 在 neuro-
substrate 层面，也许就是 mirror neuron。
（2）从小小娃看扔球预知其轨迹，到大人 theory-of-mind 来 "know" 小小娃的
intention，其底层的支撑，也许都是 object-permanence。而 object-permanence 在
neuro-substrate 层面，也许就是 mirror neuron。 |
|
t******l
发帖数: 10908 | 37 如果这个 “mirror-neuron => object-permanence hypothesis” 成立，那么就容易
解释为啥小小娃 / 小娃，都不想太快知道答案了。
这个可能是为了 properly train 那些 mirror-neuron (类比 Cisco 路由器)，我们的
evolution 进化出一个机制来 discriminate direct causal-effect 的模式（因为这
个模式里，mirror-neuron 啥事都不用干）。而这个机制就是小小娃/小娃不希望大人
太早给答案，即使知道是 direct causal-effect。
如果再进一步假设的话，就算上一代知道是 direct causal-effect，但是 evolution
的优势更多的是在 adaptivity 而不是一点点 efficiency。而 evolution 永远无法确
信这种 direct causal-effect 将来是不是一定存在（挨过冰川期，比拿到藤校入学通
知书，更重要）。从这个角度看，evolution 让 neuro-plasticity outweigh ... 阅读全帖 |
|
J***b
发帖数: 76 | 38 A Postdoctoral Research Associate position is available immediately to study
synaptic transmission/plasticity and alcohol abuse at the Texas A&M Health
Science Center.
Research in the lab uses state-of-the-art technologies, including patch-
clamp recording from genetically identified neurons using transgenic animals
, optogenetics and pharmacogenetics, analysis of structural plasticity using
3-D reconstruction of single neurons in combination with behavioral
procedures. For more details, please ... 阅读全帖 |
|
B******y
发帖数: 110 | 39 Neuroscience Post-doc Position Available
Beijing Normal University
Applicants are invited for a postdoctoral position in Dr. Haidong Lu's lab
at Beijing Normal University. Dr. Lu’s lab uses optical imaging,
electrophysiology, and histological methods to study the neural mechanisms
underlying vision in non-human primates. Ongoing research projects include:
1. Anatomical connections among functional architectures in the monkey
visual cortex; 2. Functional roles of the motion sensitive neurons in t... 阅读全帖 |
|
s*****q
发帖数: 34 | 40 You will contribute to the development of computational models of Neuron
dynamics and how neurons encode memory. You are skilled in designing, coding
, testing and implementation of configuration changes to software that meet
both functional and technical requirements. You may also have some oversight
responsibility for the technology solution and may assist in the
development of the team. Your key responsibilities may include contributing
to the planning and analyzing of high-level software str... 阅读全帖 |
|
z****2
发帖数: 2 | 41 One or Two Postdoctoral positions are available (starting from August of
2010) in the laboratory of Dr. Yongjie Yang, to study the broad neuron to
astrocyte interaction, in particular, the roles of neuron to astrocyte
signaling in astrocyte development, the mechanisms/pathways of astrocyte
dysfunction in neurodegenerative diseases, such as motor neuron disease,
epilepsy, and Alzheimer’s diseases. This represents a very exciting and
important but less studied area in neurobiology field. The lab e |
|
p****n
发帖数: 2247 | 42 时间：11月9日星期六12:30-2:30pm.
地点：San Diego Downtown Convention Center
（目前决定的目标，需要今天小欧踩点并老徐致电警察局等相关部门之后才能确认）。
本周末Neuron Science的年会在那里召开，据估计参加会议人数大约有三万。因为San
Diego是旅游城市，随之而来旅游的家属应该也应该不少。抗议示威的影响可以传播的
范围将更广泛。
Q: 为什么选这个地点和时间？
A：我们抗议示威的目的是尽量提高这件事件的关注度，扩大影响。如果选择其它的地
点，我们所能面对的仅仅是经过那里的当地民众。而选择在Convention Center，即使
周六两个小时的时间经过的人数只有与会人数的十分之一，接到我们的flyer的并留心
关注的人再只有十分之一，那么也有三百人的影响度。上周六我们在Balboa Park有三
、四百人，但是接受我们宣传的有三、四百人吗？
瓜嫂查了一下，这次年会的报到时间是周六7:30am-5pm，Poster session开始于1pm，
第二天8:30am就有Special Lecture。所以周六这两个小时应该... 阅读全帖 |
|
h***a
发帖数: 1773 | 43 相当有参考价值
【 以下文字转载自 SanDiego 讨论区 】
发信人: papain (木瓜★桃谷第七仙之桃核仙★清华民工), 信区: SanDiego
标 题: 【119游行】时间、地点、诉求以及当前的任务
发信站: BBS 未名空间站 (Mon Nov 4 06:52:39 2013, 美东)
时间：11月9日星期六12:30-2:30pm.
地点：San Diego Downtown Convention Center
（目前决定的目标，需要今天小欧踩点并老徐致电警察局等相关部门之后才能确认）。
本周末Neuron Science的年会在那里召开，据估计参加会议人数大约有三万。因为San
Diego是旅游城市，随之而来旅游的家属应该也应该不少。抗议示威的影响可以传播的
范围将更广泛。
Q: 为什么选这个地点和时间？
A：我们抗议示威的目的是尽量提高这件事件的关注度，扩大影响。如果选择其它的地
点，我们所能面对的仅仅是经过那里的当地民众。而选择在Convention Center，即使
周六两个小时的时间经过的人数只有与会人数的十分之一，接到我们的flyer的并留心
关注的... 阅读全帖 |
|
O*******d
发帖数: 20343 | 44 Imidacloprid is a systemic insecticide which acts as an insect neurotoxin
and belongs to a class of chemicals called the neonicotinoids which act on
the central nervous system of insects with much lower toxicity to mammals.
The chemical works by interfering with the transmission of stimuli in the
insect nervous system. Specifically, it causes a blockage in the
nicotinergic neuronal pathway. This blockage leads to the accumulation of
acetylcholine, an important neurotransmitter, resulting in the ... 阅读全帖 |
|
g*b
发帖数: 60 | 45 Web of Science 上查得 Fu J and Yan SD 所合作的文章。其中 Yan SD 是大多数文章
的通信作者。
要查真相，为何不向这个通信作者写 email 询问呢？
Title: An intracellular protein that binds amyloid-beta peptide and mediates
neurotoxicity in Alzheimer's disease
Author(s): Yan SD; Fu J; Soto C; et al.
Source: NATURE Volume: 389 Issue: 6652 Pages: 689-695 Published: OCT
16 1997
Times Cited: 246 (from All Databases)
[ View abstract ] [ Hide abstract ]
2. Title: Amyloid-beta peptide-receptor for advanced glycation endproduct
interaction elicit... 阅读全帖 |
|
E*****m
发帖数: 25615 | 46 http://news.discovery.com/human/embryonic-stem-cells-trials.html?print=true
First Human Embryonic Stem Cell Trial Begins
The landmark trial could one day lead to a breakthrough in the treatment of
spinal cord injuries.
Thu Oct 14, 2010 11:50 AM ET | content provided by Karin Zeitvogel, AFP
Doctors have begun the first tests of human embryonic stem cells in patients
, treating a man with spinal cord injuries in a landmark trial of the
controversial process, the Geron Corporation said Monday.
The ... 阅读全帖 |
|
t*****r
发帖数: 142 | 47 也许吧。不过这样的大原则只是一句话，具体问题
的分析麻烦太多了。找你的说法，我也可以说牛顿
力学的精髓是f=ma,电动力学的精髓是麦克斯韦
方程，等等。但实际上你需要找出每个具体问题
的受力分析，场分布等等。我不知道你是不是能够
说出你自己设计的每一个neural network每个neuron具体
干什么的，就像每一个电路设计者一定说的出他设计
的每一个器件在电路中都会有什么作用一样。或者至少事先
对network architectue的选择有一套确定的方法，在你
Train之前就知道多一个neuron或者少一个neuron会有
什么不同 |
|
c****l
发帖数: 1086 | 48 I'm afraid you are wrong,lanceandfei. It's true that there are new new
arrived neurons in mammalian OB throughout whole life. However these new
neurons are generated in SVZ, then migrate through RMS to OB.
One pretty recent interesting finding is this SVZ-RMS-OB neurogenesis also
exists in human brain in which chain of neuron migration was thought to be
not present. (See cover paper of last week Science, groups from New Zealand
and Sweden)
Our lab is focusing on mechanism of tumorigenesis in bra |
|
n*********b
发帖数: 140 | 49 The level of adult neurogenesis appears to be inversely correlated with
evolution, i.e. humans have
much lower level of adult neurogenesis. This raises a question of what is
the negative effect of having
new neurons in adult life. If these neurons, if functional, replace more "
experienced" neurons, will adult
neurogenesis compromise the established memory? If the answer is yes, this
may, (sorry no scientist
can do their job without saying "may"), explain the observation of
evolutionarily dec |
|
