l****7
发帖数: 148 | 1 A 43-year-old man consults a physician because of progressively severe
fatigue developing over a period of about 3 months. On physical examination,
his skin and mucous membranes show a waxy pallor. Intraoffice hematocrit is
18%. Intraoffice peripheral blood smear shows cells of normal morphology in
all cell lines, but band form neutrophils and reticulocytes are nearly
absent. On specific questioning about possible toxic exposures, the man
reports using benzene frequently to clean his hands after |
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b****o
发帖数: 169 | 2 a male infant is referred to a urologist for bilateral hydronephrosis. the ureters are dilated from about 3 cm
above their insertion into the bladder to the renal pelvis. neither neutrophils nor bacteria are seen in the
urine. which of the following is the most likely cause of obstruction?
a. benign primary tumor
B calculi
c chronic ureteritis
d metastatic tumor
e ureteropelvic junction |
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n***8
发帖数: 634 | 3 3.急性肾于肾炎， 控制感染最重要。 如果有血培养一项， 倒也可以考虑。
6.婴儿特有的， 名子望了， 和IMPETIGO 鉴别， 是ESINOPHILE ， 而不是
NEUTROPHILE. 不用治疗 |
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d****y
发帖数: 2180 | 4 大家讨论一下是那个答案合适
1. A 22-year-old man has a 36 hour history of pain and swelling of his
left testis. One week ago, he had mild dysuria and a urethral discharge.
Gram's stain of material from the urethra shows numerous neutrophils but
no organisms. The most likely cause of the patient's symptom is infection
with which of the following?
A) Chlamydia trachomatis
B) Cytomegalovirus
C) Eschenchia coil
D) Herpesvirus
E) Mumps virus
F) Neisseria gonorrhoeae
G) Trichomonas vaginalis |
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M********r
发帖数: 179 | 5 这道题我可以选出正确答案，但是有些地方还是有点含糊。比如pleural fluid正常的
cell number 是多少，正常
protein 含量是多少？为何此患者胸腔积液细胞含量如此高？
A 70 year old man comes to the emergency department because of shortness of
breath for 2 hours. He had
a myocardial infarction 2 years ago. A chest X-ray shows bilateral Kerley B
lines and bilateral pleural
effusions that are great on the right. If a thoracentesis were done,
laboratory studies would show
serum total protein 7g/dl
pleural fluid
specific gravity 1.008
total protein 1g/dl
leukocyte count... 阅读全帖 |
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b****5
发帖数: 504 | 6 请教：
A previously healthy 6-monthold boy is brought to the physician because of a
cough for 1 week, initially he had a low-grade fever, sneezing, congestion,
and runny nose, He then developed a dry intermittent cough, The parents now
note that with any startle the baby chokes and gasps, He has not had any
immunizations. Physical examination shows paroxysms of "machine gun" -like
coughing with a forced expiratory grunt at the end of coughing, Leukocyte
count is 30,0001mm3 (70% Iymphocytes). Neutro... 阅读全帖 |
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e****0
发帖数: 678 | 7 • leukemia
ALL AML CLL
child adult elderly
BM lymphoblasts 25%myeloblasts
lab Lymphocyte 5000, mature-appearing cells
• Osgood-schlatters disease
Adolescent male athletes
Traction apophysitis—quadriceps tendon put the traction on the
apophysis of the tibial tubercle where patellar tendon inserts.
A firm mass =heterotopic bone formation
Pain can be reproduced by extending the kne... 阅读全帖 |
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J*********4
发帖数: 1274 | 8 1.. Magnisium is required for secretion of PTH
2. don't know. Sorry.
Megaloblastic anemia=multi-lobulated neutrophil+macrocytic anemia
Alcohol inhibit folate acid absorption, also interfere with Heme synthesis.
---
I could be wrong on both. Welcome other experts! |
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j***e
发帖数: 62 | 9 1：Megaloblastic macrocytic anemia 是VitB12 或者叶酸缺乏引起。
2：Nonmegaloblastic macrocytic anemia 是由其他非VitB12 叶酸缺乏引起的大细胞
性贫血，如酒精性肝病。与前者区别：Macrocytes are round ，Hypersegmented
neutrophils are not present。Alcohol是此种类型最常见的原因。 |
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x******a
发帖数: 195 | 10 理论上，LZ说的那些影响DNA synthesis的药都会导致Megaloblastic macrocytic
anemia。只不过叶酸和B12缺乏是最常见的原因。DNA合成障碍会导致细胞核成熟受阻，
但同时RNA、细胞浆物质的合成会继续，细胞变大，形成megaloblast。这应该包括所有
lineage的blast。Hypersegmented neutrophils by definition并不是megaloblast，
跟巨大的RBC一样只是megaloblast的产物。
Nonmegaloblastic macrocytic anemia不是DNA合成受阻引起的，没有megaloblast形成
。通常由酒精（直接毒性）、红细胞膜障碍（肝病）、reticulocytosis（hemolysis）
等导致。如果酒精引起叶酸缺乏，则又会导致Megaloblastic macrocytic anemia。 |
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e***5
发帖数: 106 | 11 多谢君荷，我对关于magloblastic and macrocytic一直都没搞清楚过，再请教一下，
看我理解是否正确：1，magloblastic是专对于有骨髓抑制而言的，正因为骨髓抑制，
才会出现multi-lobulated neutrophil（发育不全？）。5FU若也引起骨髓抑制，那也
会引起magloblastic，所以这不是绝对的，当然真实情况可能发生几率较小。2，相对
于骨髓抑制，红细胞对DNA损伤比较敏感(可能是新成代谢比别的血细胞快？），所以有
些药物可引起macrocytic, 却还
没到magloblastic的程度。 |
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b****a
发帖数: 352 | 13 我实在受不了了，也顾不上批马甲，希望在国内当过医生的朋友指点我到底何去何从。
我想知道我这个情况是不是应该回国治疗更好。相知道国内医生会如果治疗。
我这个情况复杂，我希望讲清楚，谢谢你的耐心。
恳求版主不要删贴，我被折磨的快崩溃了。。真心希望得到多的意见。谢谢！
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
－－－－－－－
今年1月底，乳房剧痛 红肿，然后有肿块。很大。等约到医生做超声波就是2月中了，
但是当时肿块已经没有了。
等了1－2个月好像又有肿块，5月突然我觉得摸到很大一个（5cm 多）肿块，做了超声
波，医生 ""quite vascular, hypoechoic colletion, and more suspicious for
infection" STILL 建议biopsy。
biopsy pathology test 结果是 diagnosis is granulomatous mastitis.
granulation tissue with scattered granulomas that display central
n... 阅读全帖 |
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s********o
发帖数: 21 | 14 29. A previously health 6 month old boy develops fever and severe paroxysmal
barking coughing. He has not had any immunizations. His leukocyte count is
30,000/mm3 (70% lymphocytes). Neutrophil chemotaxis and oxidative metabolism
are defective due to increased activity of which of the following enzymes?
A. adenylyl cyclase
B. MPO
C. NADPH oxidase
D. Phospholipase C
E. Protein Kinase C
论坛上不少人选A，并且说是B. Pertussis 感染，请问大家什么看法啊？
我自己觉得：
1. 如果确定是Pertussis感染，adenylyl cyclase （AC）的activity就会up-
regulated.... 阅读全帖 |
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d******u
发帖数: 47 | 15 1, Your patient is a gravida 2 para 2 female with a complaint of a vaginal
discharge, vulvar irritation, and dysuria. Her symptoms have recurred 4
times within the past year. She had a recent urinary tract infection that
was treated with ciprofloxacin, but is in otherwise good health. She is
afebrile with normal vital signs, and pelvic examination reveals vulvar and
vaginal erythema with a thick white discharge in the vaginal vault. KOH prep
reveals pseudo hyphae. Which of the following treatmen... 阅读全帖 |
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t********s
发帖数: 374 | 16 1 Neutrophil (and macrophage)-synthesized molecules that are generated and
released during inflammation, directly causing local tissue injury and cell
death include (choose all that apply)
a leukotrienes
b proteases
c 0xygen-derived free radicals
d prostaglandins
e serotonin
2 A biopsy of a region of chronic inflammatory focus (such as the joints in
a patient with rheumatoid arthritis) is likely to show which cell types and
mediators (check all that apply)
a. cytokines
b beicosaboids
c lymphocyt |
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p*******g
发帖数: 2976 | 17 【 以下文字转载自 Biology 讨论区 】
发信人: albertsmwk (.)(.), 信区: Biology
标 题: 第一批“青年千人计划”生物类@publication列表@
发信站: BBS 未名空间站 (Thu Aug 18 15:04:16 2011, 美东)
花了一个小时，深深的鄙视一下自己的无聊行径！！
125 蔡亮 男 1980年11月 复旦大学 生命
科学 2007年12月毕业于[美国]北卡大学 [美国]加州大学旧金山分校 博士后
Cai L, Mostov K. Polarity is destiny. Cell. 2009 Nov 13;139(4):660-2. PubMed
PMID: 19914162; PubMed Central PMCID: PMC2900917.
Cai L, Makhov AM, Schafer DA, Bear JE. Coronin 1B antagonizes cortactin and
remodels Arp2/3-containing actin branche... 阅读全帖 |
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r*******n
发帖数: 51 | 20 Flonaw：家庭医生没说过我贫血，献血的时候说我的血红蛋白正常。
DIFFERENTIAL WBC'S:
NORMAL: Neutrophils, Lymphocytes, Monocytes, Eosinophils, Basophils,
Immunoglobulin A Serum, Immunoglobulin M Serum, Ceruloplasmin, Alpha 1
Antitrypsin TL
ABNOMAL: Immunoglobulin G Serum (High, 17.7, normal range:7.2-16.9) |
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I****a
发帖数: 407 | 21 Good job! That is the most likely diagnosis. Blow is the direct copy of
blood paper, How I treat hemophagocytic lymphohistiocytosis
1. Michael B. Jordan1,2,*,
2. Carl E. Allen3,*,
3. Sheila Weitzman4,
4. Alexandra H. Filipovich2, and
5. Kenneth L. McClain3
The diagnosis of HLH† may be established:
A. Molecular diagnosis consistent with HLH: pathologic mutations of PRF1,
UNC13D, Munc18-2, Rab27a, STX11, SH2D1A, or BIRC4
or
B. Five of the 8 criteria listed below are fulfilled:... 阅读全帖 |
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b******a
发帖数: 704 | 22 Case 12-2013 — An 18-Year-Old Woman with Pulmonary Infiltrates and
Respiratory Failure
N Engl J Med 2013; 368:1537-1545
Presentation of Case
Dr. James Sawalla Guseh (Medicine): An 18-year-old woman was admitted to
this hospital because of pulmonary infiltrates and respiratory failure.
The patient had been well until 3 weeks before admission, when fever and a
cough productive of white, nonbloody sputum developed. During the next week,
night sweats, extremely painful pharyngitis, pleuritic chest ... 阅读全帖 |
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b******a
发帖数: 704 | 23 In the clinical setting of infection, because patient with primary AIN has
normal bone marrow reserve, the increase in cell production and release from
bone marrow as the reactions to infection and the elevated stress hormone,
such as a corticosteroids, could predominantly exceeds the effect of
autoantibody binding.
In the late phase of infection, the cell number of neutrophils gradually
decreases due to cell apoptosis and reduced cell output and release. In AIN
patients, autoantibodies could q... 阅读全帖 |
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n*****j
发帖数: 261 | 24 【 以下文字转载自 NextGeneration 讨论区 】
发信人: wwwjobs (minimouse), 信区: NextGeneration
标 题: 求助: 6个月大婴儿肝衰竭 (转载)
发信站: BBS 未名空间站 (Fri Apr 12 07:11:51 2013, 美东)
发信人: wwwjobs (minimouse), 信区: Medicine
标 题: 求助: 6个月大婴儿肝衰竭
发信站: BBS 未名空间站 (Fri Apr 12 05:39:14 2013, 美东)
我慢慢发细节，版主请帮助置顶几天。
宝宝生下来很健康。因为母乳不够，差不多1周大的时候全部营养来自于奶粉。开始几
天similac液体奶，很快就全部是enf的固体奶粉，milk-based.这时候一切正常。除了
，非常容易吐奶，需要很多关心外，吃和拉还行。
还行就是按照医生的说法，其实我们一直觉得孩子把把有些太软。1个多月后，孩子重
量还行，闹得更厉害，吐奶更频繁，于是我们改用sensitive的配方奶粉。孩子清况好
了不少，体重及各方面数据都正常。
3个月前后，孩子的把把开始很稀了，次数更... 阅读全帖 |
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t******9
发帖数: 270 | 25 不知道你是否需要把下面的翻译成中文，试着翻译了一下。
infection 感染
metabolic disease 代谢性疾病
obstruction 梗阻（这里可能指胆道梗阻）
oncologic 肿瘤
autoimmune 自身免疫性疾病
neurologic status.. 神经系统状态
4/9 22:10
rdw 19.0h 红细胞分布宽度
monocytes, abs 2970h 单核细胞绝对数
bands,abs 1080h 不成熟白细胞绝对数
abs neutrophil ct cal 20250h 中性粒细胞绝对数
polys,% 71h 中性粒细胞百分比
monocytes,% 11h 单核细胞百分比
raw reticulocyte count 5.73h 网织红细胞计数百分比
hct corrected retic count 3.9h 根据血容量而修正的网织红细胞计数百分比
sodium level 134L 血钠水平
phosphorus serum 3.4L 血磷水平
white blood cell count 27h 白细胞... 阅读全帖 |
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h*******3
发帖数: 54 | 26 不知道为什么添加附件没有成功，贴上请大家看看
Potassium 5.2 H 3.4-4.7
BUN/CR 32 H 7-30
hemato crit 38.7 H 31.2-37.8
Hemoglobin 13.1 H 10.2-12.7
IM Grans% AUTO 1.1 H 0.0-0.5
IM GRANS ABS AUTO 0.15 H 0.00-0.03
MCH 29.0 H 23.7-28.6
MCV 85.8H 72.3-85.0
MONOCYTE%AUTO 11.5 H 4.0-9.0
MONOCYTE ABS ATUO 1.62 H 0.30-1.20
NEUTROPHIL ABS,AUTO 7.38 H 2.00-7.10
WBC 14... 阅读全帖 |
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b****a
发帖数: 352 | 27 我实在受不了了，也顾不上批马甲，希望这里的医生指点我到底何去何从。我这个情况
复杂，我希望讲清楚，谢谢你的耐心。
今年1月底，乳房剧痛 红肿，然后有肿块。很大。等约到医生做超声波就是2月中了，
但是当时肿块已经没有了。
等了1－2个月好像又有肿块，5月突然我觉得摸到很大一个（5cm 多）肿块，做了超声
波，医生 ""quite vascular, hypoechoic colletion, and more suspicious for
infection" STILL 建议biopsy。
biopsy pathology test 结果是 diagnosis is granulomatous mastitis.
granulation tissue with scattered granulomas that display central
neutrophili aggregates
然后医生让我等他自己好。
等到10月份还是没有消，我就要pcp给我看了specialist
她说很concern 让我做MRI ， MRI 显示enhancement 就做了2个地方的biopsy.
... 阅读全帖 |
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