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全部话题 - 话题: olfactory
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b**o
发帖数: 5769
1
http://en.wikipedia.org/wiki/List_of_mnemonics_for_the_cranial_
As one author has noted, "Generations of biology and medical students have
relied on mnemonic (memory-aiding) phrases and ditties, ranging from
sublimely silly to the unprintably ribald, to help them remember the cranial
nerves..."[1]
The cranial nerves are:
I - Olfactory nerve
II - Optic nerve
III - Oculomotor nerve
IV - Trochlear nerve/pathic nerve
V - Trigeminal nerve/dentist nerve
VI - Abducens nerve
VII - Facial nerve
VIII - Ve... 阅读全帖
H********g
发帖数: 43926
2
烟也呛不醒,人(或者大部分人)睡着之后嗅觉就关掉了。
http://www.nbcnews.com/health/body-odd/can-smells-wake-us-deep-
……
“But the sense of smell may differ in that increasing intensity does not
appear to lead to awakening in deeper stages of sleep,” Freedom said.
In 1997, a study performed by the Irondale Fire and Rescue Service in
Irondale, Ala., found that among 10 adults who were snoozing in a medical
sleep lab, two of the subjects awoke when a smoke odor was introduced into
their room.
In 2004, at Brown University, re... 阅读全帖
P**********n
发帖数: 6311
3
You have just miss-counted the fact that olfactory system
is adaptive...

good!
q******r
发帖数: 6542
4
☆─────────────────────────────────────☆
Benbenxu (悠悠) 于 (Wed Aug 18 13:00:50 2010, 美东) 提到:
估计八成也还是冲着名去的吧。
反正,对俺,一个重要的原因就是,6个人的男生宿舍,住了10个人。
☆─────────────────────────────────────☆
GFeifei (Feifei) 于 (Wed Aug 18 13:04:55 2010, 美东) 提到:
啊?为了跟很多男人挤在一起住?
☆─────────────────────────────────────☆
visit (Just beat it, beat it) 于 (Wed Aug 18 13:06:20 2010, 美东) 提到:
爱好很独特
☆─────────────────────────────────────☆
glacierbeing (冰河生物) 于 (Wed Aug 18 13:11:33 2010, 美东) 提到:
悠悠口味很重
☆─────────────... 阅读全帖
h*i
发帖数: 3446
5
这种研究叫做嗅觉的心理物理学研究(olfactory psychophysics)。
在对感觉的研究中,对嗅觉的研究是最不成熟的。颜色视觉研究最多,人的颜色视觉是
三维的,这个比较清楚。 人的味觉是四维的,也比较清楚。但嗅觉比较糊涂,你可以
看看这个综述:http://vosshall.rockefeller.edu/reprints/KellerVosshallCB04.pdf
l*********i
发帖数: 332
6
版主好勤劳阿!!
还没等我解说一把。此贴天南海北扯了不少,本人感觉内容还是挺多,想稍稍总结一下。
从此贴楼主的连接,我去看了一下,美国科学院这个奖确实份量很重,是奖励各个领域
重大发现的。楼主也列出了
几个获得此奖的Nobel奖得主。
我在看Axel的过程中发现,axel得奖是93年,那个时候他刚刚发现嗅觉受体家族,对整
个嗅觉系统的组织还没有全
力投入,大家如果看过Axel获奖演说的话就会明白,Axel原来是跟嗅觉研究8杆子打不
找的,他就喜欢克隆基因,
克隆了无数的基因,比如CD4(好像,懒得查了,如果错了,抱歉),等等。而04年他
和Buck获奖的理由是,"for
their discoveries of odorant receptors and the organization of the olfactory
system"。 可见,光发现一个
超级基因家族,而不对其功能进行深入的研究,是没戏拿炸药奖的,至少没那么快,如
果Axel自从发现嗅觉基因家
族后,再也不碰,充其量到他80岁的时候,跟别人share一个关于嗅觉的炸药奖。
而我认为之所以他可以那么快的拿到,是因为他当
p*****m
发帖数: 7030
7
来自主题: Biology版 - 做果蝇电生理好做吗?
Rachel Wilson做的in vivo啊 她一个搞olfactory system的拿个isolated brain怎么
玩:)
O******e
发帖数: 4845
8
来自主题: Biology版 - linda buck 有点猛啊
刚开始还不太相信,后来去查了下,果真是全军覆没。
http://embargowatch.wordpress.com/2010/09/23/nobelist-linda-buck-retracts-two-studies-on-olfactory-networks-%E2%80%94-and-the-news-is-embargoed/
这种整法,回国了也是死路一条吧。胆子太大了。
p*******r
发帖数: 4048
9
来自主题: Biology版 - linda buck 有点猛啊
回国没事的,有这才能,会混得很好。

retracts-two-studies-on-olfactory-networks-%E2%80%94-and-the-news-is-
embargoed/
p*******r
发帖数: 4048
10
来自主题: Biology版 - linda buck 有点猛啊
这是出来捣浆糊的。
Linda文章中唯一和传统看法不一样的是, Olfactory Cortex 是 clustered, 不是完全
random. 没有这个,也就不成为nature文章了。
最近好几篇文章出来说,完全random.
l*******k
发帖数: 361
11
来自主题: Biology版 - linda buck 有点猛啊
Richard Axel在RU的postdoc retreat上的invited lecture讲的就是这个,连我这个完
全的神经门外汉都听得津津有味。这个老头还一直说science多么多么美,大家有机会
去enjoy这个,是多么多么幸福的一件事情,要积极地投身科学事业,可能只有到了他
那个层次才能真正enjoy science吧。
发信人: puppeteer (舟云), 信区: Biology
标 题: Re: linda buck 有点猛啊
发信站: BBS 未名空间站 (Fri Sep 24 10:59:56 2010, 美东)
这是出来捣浆糊的。
Linda文章中唯一和传统看法不一样的是, Olfactory Cortex 是 clustered, 不是完全
random. 没有这个,也就不成为nature文章了。
最近好几篇文章出来说,完全random.
g*********d
发帖数: 233
12
来自主题: Biology版 - 也谈Linda Buck的撤稿事件
During efforts to replicate and extend this work, we have been unable to
reproduce the reported findings.
Moreover, we have found inconsistencies between some of the figures and data
published in the paper and the original data.
We have therefore lost confidence in the reported conclusions.
http://www.nature.com/nature/journal/v452/n7183/full/nature06819.html
Nature 452, 120 (6 March 2008) | doi:10.1038/nature06819
Genetic tracing reveals a stereotyped sensory map in the olfactory cortex
Zhihua ... 阅读全帖
p*****m
发帖数: 7030
13
这个。。。张宏超过同代几乎所有华人生物学家的水平?这个说的有点太狠了吧。张同学这两年这两篇
cell委实不错,不过也只能说这个头开得很有意思(genetic screen for autophagy),至于能
不能做的很完整也得慢慢看。非要拿这个去和同代的年轻人比,老张能一定超过JHU的董欣中(Mrgs
family in pain and itch)和宋红军(adult neurogenesis);Stanford的沈康
(synaptogenesis);UCSD的王竞(olfactory coding);西南医学中心的刘庆华(RNAi)?更别说
这帮人前头还有大名鼎鼎的庄小威啊 老张拿什么和小薇同学比?

章超
n********k
发帖数: 2818
14
As you folks are discussing Cori, I happened to read his autobiography and
find it both interesting and enlightening:)))...BTW, it sounds Richard Axel
is a lot nicer than what I/we have heard...or in another word, his cruelty
is rooted in his obsession with science and indifference to humanity:))); As
well, it is pretty...he noted Cori but left his ex out...pretty human or
not human?
Autobiography
Richard AxelNew York City is my world. I was born in Brooklyn, the first
child of immigrant parents... 阅读全帖
p*****m
发帖数: 7030
15
来自主题: Biology版 - Where to Locate Taiwan?
lol 江安世的文章我是看过的好不好。。。另外 饶毅什么地方说他觉得ROC是可以得了
?他明明说的是ROC不行 一定要China lol
A Map of Olfactory Representation in the Drosophila Mushroom Body
Hui-Hao Lin1, 2, Jason Sih-Yu Lai1, 2, An-Lun Chin1, 2, Yung-Chang Chen3, 4
and Ann-Shyn Chiang1, 2, 3, 5, 6, ,
1 Institute of Biotechnology, National Tsing Hua University, Hsinchu 30013,
Taiwan, ROC
2 Department of Life Science, National Tsing Hua University, Hsinchu 30013,
Taiwan, ROC
3 Brain Research Center, National Tsing Hua University, Hsinchu 30013, Taiwa
... 阅读全帖
d*****r
发帖数: 2583
16
http://www.hhmi.org/news/popups/isrf_pop.html
2011 International Student Research Fellows
Institution Student Advisor Discipline
Boston University Wei Guo
China Barbara Shinn-Cunningham Systems and computational
neuroscience
Brandeis University Marcus Long
United Kingdom Lizbeth Hedstrom Protein degradation using chemical
biology
California Institute of Technology Andreas Hoenselaar
Germany Thanos Siapas Spatial mapping in the hippocampus using
virtual
reality... 阅读全帖
g*****h
发帖数: 32
17
来自主题: Biology版 - 饶毅在评院士的文章
评审是3月份,之后出来的当时肯定不能算.还有个要求就是中国人在国内发的文章,美国
人在美国发的文章是不算数的.
下面是rao lab 05年开始的文章,
1. Liu W, Liang X, Gong J, Yang Z, Zhang YH, Zhang JX and Rao Y. Social
regulation of aggression by pheromonal activation of Or65a olfactory neurons
in Drosophila. Nature Neuroscience, doi:10.1038/nn.2836, 2011 Jun. 19
这个文章是6月份出来的,当时用不上
2. Liu Y, Jiang Y, Si Y, Kim J-Y, Chen Z-F, and Rao Y (2011). Molecular
regulation of sexual preference revealed by genetic studies of 5-HT in the
brain of male mice. Nature 472:95... 阅读全帖
i****g
发帖数: 3896
18
来自主题: Biology版 - 饶毅在评院士的文章
饶毅全部在国内完成的工作:1 Cell, 1 Nature, 2 Nature Neuroscience。
Cell已经被引用220次了。这和同行比不够突出?
Title: Both the establishment and the maintenance of neuronal polarity
require active mechanisms: Critical roles of GSK-3 beta and its upstream
regulators
Author(s): Jiang H; Guo W; Liang XH; et al.
Source: CELL Volume: 120 Issue: 1 Pages: 123-135 DOI: 10.1016/j.cell
.2004.12.033 Published: JAN 14 2005
Times Cited: 220 (from Web of Science)
Title: Molecular regulation of sexual preference revealed by geneti... 阅读全帖
d****d
发帖数: 214
19
来自主题: Biology版 - 我来瞎评两句Bruce Beutler
Linda Buck was just a postdoc when she cloned olfactory receptor gene. That
did not hamper her to win the Nobel Prize.

change
d****d
发帖数: 214
20
来自主题: Biology版 - 我来瞎评两句Bruce Beutler
Linda Buck was just a postdoc when she cloned olfactory receptor gene. That
did not hamper her to win the Nobel Prize.

change
c**l
发帖数: 121
21
来自主题: Biology版 - paper help! Thanks a lot!
Science. 1972 Jan 7;175(4017):84-7.
Olfactory bulb units: activity correlated with inhalation cycles and odor
quality.
Macrides F, Chorover SL.
D*a
发帖数: 6830
22
你这都是paper啊,我自己搜olfactory system也能搜出来一堆啊。。。
l**********1
发帖数: 5204
23
来自主题: Biology版 - 求助:有关共聚焦的问题。
别理会那个ID
he/she 是和楼主的开题故意捣乱的 吧?
偶估计是wsn 让华人mm 给off 了 或者是wsnv 让
人家华人MM 给抢了未来的LD了。
比如:Linda Buck her case
please go to
http://www.mitbbs.com/article_t1/Biology/31638425_0_2.html
[ 37th floor
发信人: demoner (给我一块二向箔), 信区: Biology
标 题: Re: 有些女PI真可怕
发信站: BBS 未名空间站 (Fri Feb 24 18:40:55 2012, 美东)
Cori Bargman是美女又是天才,难怪Richar Axel不要Linda Buck...
她读PhD的时候就跟Bob Weinburg,参与发现Ras在Cancer中的作用,
她做博士后跟Bob Horvitz,发现nematodes在chemosensing的中作用,
后面就就跟Richar Axel谈恋爱,做faculty.
她从博士导师到博后老板到老公,全都是诺贝尔奖级别的人物.生物学圈子里面,还有
比... 阅读全帖
y**********n
发帖数: 478
24
不会,原始的那些生物没嗅觉吧
u**********d
发帖数: 573
25
来自主题: Biology版 - 有了解olfactory receptor表达的么
看起来非常有意思:几千个受体,但是每个细胞里面只表达一种;每个受体只由一个等
位基因表达,另一个关闭。有了解的八卦一下呗。
w***7
发帖数: 1637
26
source:http://bbs.netbig.com/thread-2491712-1-2.html
看了一下,今年不错啊,和清华并驾齐驱。
而且下半年我知道的还有两篇NS。
~~~~~~~~~~~~~~~~~
1.
Yuan W, Wu T, Fu H, Dai C, Wu H, Liu N, Li X, Xu M, Zhang Z, Niu T, Han Z,
Chai J, Zhou XJ, Gao S, Zhu B
Dense Chromatin Activates Polycomb Repressive Complex 2 to Regulate H3
Lysine 27 Methylation
Science, DOI: 10.1126/science.1225237, Aug. 24, 2012
2.
Liu B, Du H, Rutkowski R, Gartner A, Wang X
LAAT-1 Is the Lysosomal Lysine/Arginine Transporter That Maintains Amino
Acid Homeostasis
S... 阅读全帖
K**4
发帖数: 1015
27
来自主题: Biology版 - centrosome and centriole (转载)
基因治疗看起来很有希望
Nat Med. 2012:Gene therapy rescues cilia defects and restores olfactory
function in a mammalian ciliopathy model.
http://www.ncbi.nlm.nih.gov/pubmed/22941275

NPHP,
b******k
发帖数: 2321
28
来自主题: Biology版 - blog饶又放话了
Dopamine-mushroom body circuit regulates saliency-based decision-making in
Drosophila.
Zhang K, Guo JZ, Peng Y, Xi W, Guo A.
Science. 2007 Jun 29;316(5833):1901-4.
PMID: 17600217 [PubMed - indexed for MEDLINE]
Crossmodal interactions between olfactory and visual learning in Drosophila.
Guo J, Guo A.
Science. 2005 Jul 8;309(5732):307-10.
Choice behavior of Drosophila facing contradictory visual cues.
Tang S, Guo A.
Science. 2001 Nov 16;294(5546):1543-7.
三篇,挺不错了。。国内除了做结构的有几个发过三篇CNS的?
s******c
发帖数: 331
29
做neuroscience的大牛啊,Rockefeller的HHMI,Stanford的Kang Shen就是她实验室出
来的,老公是靠Olfactory receptors得诺奖的Richard Axel,今年刚拿了一个300w的
大奖,还是Obama的Brain Mapping Project的几个leading scientists之一,光环无限
啊。居然在Vogue上有个关于她的很长的采访,里面可以看到她对C elegans和
neuroscience的解释和介绍,针对的却是关心fashion的vogue的读者,真是不容易。
贴两张照片,气质美女,爱穿Michael Kors的衣服,有Christian Louboutin的
collection,文章里笑称拿了那个3M的大奖就可以买更多的Louboutin了(汗⊙﹏⊙b)
,女科学家们的榜样啊。
m******g
发帖数: 467
30
Science 14.03.21
推荐:
1. Highly Multiplexed Subcellular RNA Sequencing in Situ
稍微了解一下:
1. Epistasis and Allele Specificity in the Emergence of a Stable
Polymorphism in Escherichia coli
小知识:
1. From Parasitism to Mutualism: Unexpected Interactions Between a Cuckoo
and Its Host
Lower predation-induced falure due to repellent secretion by cuckoo chicks
2. Humans Can Discriminate More than 1 Trillion Olfactory Stimuli
t********n
发帖数: 64
31
Genome Analyses of Single Human Oocytes
Genome-Wide Detection of Single-Nucleotide and Copy-Number Variations of a
Single Human Cell
Probing Meiotic Recombination and Aneuploidy of Single Sperm Cells by Whole-
Genome Sequencing
Rare event of histone demethylation can initiate singular gene expression of
olfactory receptors
这是为了欢度圣诞么。。太霸道了
r*****m
发帖数: 3619
32
来自主题: Biology版 - Wang Jun这么狠了吗?
Results: 46
Select item 25597018
1.
Exome-wide Sequencing Shows Low Mutation Rates and Identifies Novel Mutated
Genes in Seminomas.
Cutcutache I, Suzuki Y, Tan IB, Ramgopal S, Zhang S, Ramnarayanan K, Gan A,
Lee HH, Tay ST, Ooi A, Ong CK, Bolthouse JT, Lane BR, Anema JG, Kahnoski RJ,
Tan P, Teh BT, Rozen SG.
Eur Urol. 2015 Jan 14. pii: S0302-2838(14)01396-7. doi: 10.1016/j.eururo.
2014.12.040. [Epub ahead of print]
PMID: 25597018 [PubMed - as supplied by publisher] Free Article
Related citations... 阅读全帖
s********9
发帖数: 132
33
Not in this field. Is the mechanism relatively clear now? Any ref?
Thanks,
L*******s
发帖数: 59
34
很怀疑是不是真的这种情况
S********l
发帖数: 8
35
教授给我回信问我是否愿意加入这个项目:
"Would you be interested if I offered you a project in neuro-computation. It
would offer you great experimental experience designing embedded
microelectrode experiments and using those to record electrical signals from
multiple neurons at once and then try to understand the dynamics that leads
to generation of patterns and intelligence in the brain, at this time, we
want to explore the olfactory system of the rat brain. It has both
experimental and theoretical components."
i**********d
发帖数: 853
36
首先声明:我的分数很普通,所以这个帖子也没有任何炫耀的意思,只是我在考前
,每天都来看看有没有考经,也经常拿自己的模考成绩和考经中的对照一下,看看自己
复习的效果,从前辈的考经中学到很多。所以,本贴得唯一目的是:希望能给还在准备
step1的朋友们一点提示,吸取我的教训,都考出一个好成绩。
正文:
我是8/06/2012考的Step1,昨天(8/29/2012)早上9:19am拿到成绩---242/85,还
好,和自己估计的成绩240 +/- 5基本一致。万分感谢我的家人的理解和支持,十分感
谢曾经一起学习的战友们和校友们的鼓励和帮助,感谢麦地版的前辈们的考经和经验介
绍。曾经许诺一旦成绩上了230,就写一篇考经,下面就把我的备考经历和一点心得体
会向麦地版的战友们作一汇报,也算是对自己这段人生的一个总结:
一、题库、模考及考试成绩+时间:
UW qBank: 正确率最早25%,考前80-90%
Kaplan qBank: 只做了解剖、遗传,没有统计正确率
Dec 18, 2011, Form3 --- 350
Feb 25, 2012, F... 阅读全帖
i**********d
发帖数: 853
37
Jeff的75条口诀:
1).
Chloramphenicol inhibits 50S peptidyltransferase.
喷着氯气的ram(羊)拦住(抑制) 50岁的亚裔太太搬家(转移)(50S亚基肽键转移酶)
Clindamycin & chloramphenicol block peptide bond formation.
克林顿用氯气 吓唬老婆 --> 防止太太贱(肽键)形成
Aminoglycosides bind 30S and inhibit formation of the initiation complex and
cause misreading of mRNA.
Amigo绑架了30S亚裔,抑制了她婚姻的起始,造成她男友的误读
Macrolides block translocation.
带着大沿帽子的人(城管?)挡道--> 不让别人换地方translocation
2).
下肢淋巴回流:
小隐隐于城外蝈蝈窝棚,大隐隐于城内富人水沟
(小隐收集小腿外侧淋巴液,注入腘窝;
大隐收集下肢内侧淋巴液,注入腹股沟;)
3)
imprinting diseas... 阅读全帖
i**********d
发帖数: 853
38
首先声明:我的分数很普通,所以这个帖子也没有任何炫耀的意思,只是我在考前
,每天都来看看有没有考经,也经常拿自己的模考成绩和考经中的对照一下,看看自己
复习的效果,从前辈的考经中学到很多。所以,本贴得唯一目的是:希望能给还在准备
step1的朋友们一点提示,吸取我的教训,都考出一个好成绩。
正文:
我是8/06/2012考的Step1,昨天(8/29/2012)早上9:19am拿到成绩---242/85,还
好,和自己估计的成绩240 +/- 5基本一致。万分感谢我的家人的理解和支持,十分感
谢曾经一起学习的战友们和校友们的鼓励和帮助,感谢麦地版的前辈们的考经和经验介
绍。曾经许诺一旦成绩上了230,就写一篇考经,下面就把我的备考经历和一点心得体
会向麦地版的战友们作一汇报,也算是对自己这段人生的一个总结:
一、题库、模考及考试成绩+时间:
UW qBank: 正确率最早25%,考前80-90%
Kaplan qBank: 只做了解剖、遗传,没有统计正确率
Dec 18, 2011, Form3 --- 350
Feb 25, 2012, F... 阅读全帖
i**********d
发帖数: 853
39
Jeff的75条口诀:
1).
Chloramphenicol inhibits 50S peptidyltransferase.
喷着氯气的ram(羊)拦住(抑制) 50岁的亚裔太太搬家(转移)(50S亚基肽键转移酶)
Clindamycin & chloramphenicol block peptide bond formation.
克林顿用氯气 吓唬老婆 --> 防止太太贱(肽键)形成
Aminoglycosides bind 30S and inhibit formation of the initiation complex and
cause misreading of mRNA.
Amigo绑架了30S亚裔,抑制了她婚姻的起始,造成她男友的误读
Macrolides block translocation.
带着大沿帽子的人(城管?)挡道--> 不让别人换地方translocation
2).
下肢淋巴回流:
小隐隐于城外蝈蝈窝棚,大隐隐于城内富人水沟
(小隐收集小腿外侧淋巴液,注入腘窝;
大隐收集下肢内侧淋巴液,注入腹股沟;)
3)
imprinting diseas... 阅读全帖
i**********d
发帖数: 853
40
来自主题: MedicalCareer版 - Steps口诀总结帖-2014
75条口诀:
1).
Chloramphenicol inhibits 50S peptidyltransferase.
喷着氯气的ram(羊)拦住(抑制) 50岁的亚裔太太搬家(转移)(50S亚基肽键转移酶)
Clindamycin & chloramphenicol block peptide bond formation.
克林顿用氯气 吓唬老婆 --> 防止太太贱(肽键)形成
Aminoglycosides bind 30S and inhibit formation of the initiation complex and
cause misreading of mRNA.
Amigo绑架了30S亚裔,抑制了她婚姻的起始,造成她男友的误读
Macrolides block translocation.
带着大沿帽子的人(城管?)挡道--> 不让别人换地方translocation
2).
下肢淋巴回流:
小隐隐于城外蝈蝈窝棚,大隐隐于城内富人水沟
(小隐收集小腿外侧淋巴液,注入腘窝;
大隐收集下肢内侧淋巴液,注入腹股沟;)
3)
imprinting disease: ch... 阅读全帖
i**********d
发帖数: 853
41
来自主题: MedicalCareer版 - Steps口诀总结帖-2014
75条口诀:
1).
Chloramphenicol inhibits 50S peptidyltransferase.
喷着氯气的ram(羊)拦住(抑制) 50岁的亚裔太太搬家(转移)(50S亚基肽键转移酶)
Clindamycin & chloramphenicol block peptide bond formation.
克林顿用氯气 吓唬老婆 --> 防止太太贱(肽键)形成
Aminoglycosides bind 30S and inhibit formation of the initiation complex and
cause misreading of mRNA.
Amigo绑架了30S亚裔,抑制了她婚姻的起始,造成她男友的误读
Macrolides block translocation.
带着大沿帽子的人(城管?)挡道--> 不让别人换地方translocation
2).
下肢淋巴回流:
小隐隐于城外蝈蝈窝棚,大隐隐于城内富人水沟
(小隐收集小腿外侧淋巴液,注入腘窝;
大隐收集下肢内侧淋巴液,注入腹股沟;)
3)
imprinting disease: ch... 阅读全帖
A*G
发帖数: 256
42
来自主题: Medicalpractice版 - 没有教不会的学生, 只有教不好的老师
WIKI:
The following structures are, or have been considered to be, part of the
limbic system:
Hippocampus and associated structures: Hippocampus:[4][5][6] Required for
the formation of long-term memories and implicated in maintenance of
cognitive maps for navigation.(according to this article, this part was
obviously changed, so...)
Amygdala:[4][5][6] Involved in signaling the cortex of motivationally
significant stimuli such as those related to reward and fear in addition to
social functions su... 阅读全帖
A*******s
发帖数: 9638
43
来自主题: Medicalpractice版 - 没想到养狗还可以测肺癌
interesting
Olfactory sense is as sophiscated as other special senses. I wonder if these
patients already received chemo/radiation therapy which could change the
body smell/odor.
f**d
发帖数: 768
44
请大家都顺便自我介绍一下自己的专业方向、特长、兴趣
以后大家可以互相请教、互相讨论问题
我先开始
计算神经科学+神经电生理
涉及脑区域:prefrontal cortex, visual cortex, olfactory bulb...

~~
f**d
发帖数: 768
45
请大家都顺便自我介绍一下自己的专业方向、特长、兴趣
以后大家可以互相请教、互相讨论问题
我先开始
计算神经科学+神经电生理
涉及脑区域:prefrontal cortex, visual cortex, olfactory bulb...

~~
p**q
发帖数: 6
46
来自主题: Neuroscience版 - Discussion
Based on two-photon imaging (Stettler DD and Axel R. Neuron 2009) and recent
tracing experiments (Sosulski DL, Nature. 2011), Axel concluded that no “
grandmother" neuron exsited for olfactory sensation/perception. Do you think
this is a valid conclusion/reseaonable hypothesis, or just an
overexplanation of data?
m***a
发帖数: 547
47
https://www.cell.com/abstract/S0092-8674%2813%2901350-0
If this is true, in the future we can treat some blood disease by smelling
specific odors or even personalized odors?
m****g
发帖数: 530
48
来自主题: _Harvard_Medical_School版 - 研究人员揭示产生长时记忆的分子机制
Wake Forest大学的研究人员在近期即将发行的《Neuroscience》杂志上发表了他们
的研究报告,他们发现了大脑是如
何产生长时记忆的。
据研究人员Hegde介绍,人们在极度愉快或悲伤时,对该场景的记忆就会非常
深刻。这是由于极端情绪引发了大脑内
去甲肾上腺素(norepinephrine)释放——该化学物质与肾上腺素有关,去甲肾上腺素能
够帮助记忆维持很长时间。
该研究以老鼠为动物模型,雄鼠和雌鼠在交配过程中释放一种气味,研究人员
研究了雌鼠在记忆这种气味时去甲肾上
腺素是如何发挥功能的。在雌鼠大脑的副嗅球(accessory olfactory bulb)神经回路中
,存储着对雄鼠气味的记忆。他们发
现,在老鼠交配时,去甲肾上腺素的释放会激活副嗅球中的蛋白激酶C-α(Protein
Kinase C alpha ,PKC-α)。在雌鼠内,
携带的雄鼠气味信息的谷氨酸(glutamate)与交配过程中释放的去甲肾上腺素相互作
用,能够引起雌鼠对雄鼠产生很强的
记忆。
Hegde介绍,该研究下一步计划是进一步了解PKC-
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