N****f
发帖数: 25759 | 1 Some equally precious gems from their American colleagues:
* By the time she was admitted to the hospital, her rapid heart had
stopped and she was feeling much better.
* On the second day, the knee was better, and on the third day, it had
completely disappeared.
* The patient had waffles for breakfast and anorexia for lunch.
* She stated that she had been constipated for most of her life until
1989, when she got a divorce.
* Bleeding started in the rectal area and continued all the way ... 阅读全帖 |
|
g*******n
发帖数: 1188 | 2 有点多，找到几篇是几篇，都没access。。。大包子
//bow
Standard pharmacological treatment and new therapies for overactive bladder
Repeat intradetrusor injections of onabotulinum toxin a for refractory
idiopathic overactive bladder patients: a single-center experience.
Use of Combined Anticholinergic Medication and Sacral Neuromodulation in the
Treatment of Refractory Overactive Bladder
Posterior Tibial Nerve Stimulation in Patients Who Have Failed
Anticholinergic Therapy: Efficacy and Time to Response
Environmental ... 阅读全帖 |
|
p********3
发帖数: 5750 | 3 Re: 第一例文献报道，是中国上海医院报道的。
TIStudies on treatment of acute promyelocytic leukemia with arsenic trioxide
diagnosed and 47 relapsed acute promyelocytic leukemia patients.AUNiu C, Yan
H, Yu T, Sun HP, Liu JX, Li XS, Wu W, Zhang FQ, Chen Y, Zhou L, Li JM, Zeng
XY, Yang RR, Yuan MM, Ren MY, Gu FY, Cao Q, Gu BW, Su XY, Chen GQ, Xiong SM
, Zhang TD, Waxman S, Wang ZY, Chen Z, Hu J, Shen ZX, Chen SJSOBlood. 1999;
94(10):3315. Fifty-eight acute promyelocytic leukemia (APL) patients (11
newly diagnosed and 4... 阅读全帖 |
|
y***v
发帖数: 270 | 4 这是方的质疑文：
美国《泌尿学杂志》质疑“肖氏手术”
(2010-08-10 05:27:23)
美国《泌尿学杂志》最近登了“肖氏手术”在美国首批9个病人试验的结果，同时
刊登了两篇负面的编辑评论。特别指出该结果与肖传国所说的在中国的成功结果不符，
缺乏对照组，结果无统计学意义、自相矛盾，某些病人出现的改善可能是别的原因引起
的，该手术应该只用于探索性研究，如果迅速用于临床会有巨大的危险。
THE JOURNAL OF UROLOGY, Vol. 184, 702-708, August 2010
EDITORIAL COMMENTS
The authors present the first North American experience with lumbar to
sacral nerve rerouting for patients with spina bifida. The results from this
study and previous animal and clinical studies by Xiao clearly demonstrate
that n... 阅读全帖 |
|
y***v
发帖数: 270 | 5 这33个同行的信，你们看到过木有？ms都是肖同行
Open letter in support of Chuan-Guo Xiao, M.D. from the
International Academic Community
September 29, 2010
To all,
We have all had the pleasure of knowing Dr. Chuan-Guo Xiao for many years.
He is an internationally respected surgeon-scientist who has made major
advances in the development of neuroregeneration to restore voiding and
bowel function.
Dr. Xiao performed groundbreaking animal research in the United States,
demonstrating that a motor nerve that innervates the... 阅读全帖 |
|
h***a
发帖数: 312 | 6 http://www.aaemonline.org/gmopost.html
https://www.youtube.com/watch?v=eeW5yUSqdhY
American academy of enviromental medicine
Genetically Modified Foods
According to the World Health Organization, Genetically Modified Organisms(
GMOs) are "organisms in which the genetic material (DNA) has been altered in
such a way that does not occur naturally."1 This technology is also
referred to as "genetic engineering", "biotechnology" or "recombinant DNA
technology" and consists of randomly inserting geneti... 阅读全帖 |
|
x*****a
发帖数: 7797 | 7 A man is strolling past the mental hospital and suddenly remembers an
important meeting.
Unfortunately, his watch has stopped, and he cannot tell if he is late or
not. Then, he notices a patient similarly strolling about within the
hospital fence.
Calling out to the patient, the man says, "Pardon me, sir, but do you have
the time?"
The patient calls back, "One moment!" and throws himself upon the ground,
pulling out a short stick as he does. He pushes the stick into the ground,
and, pulling out ... 阅读全帖 |
|
w*p
发帖数: 16484 | 8 http://en.wikipedia.org/wiki/Medical_state
US practice[edit]
A wide range of terms are often used to describe a patient's condition. The
American Hospital Association advises physicians to use the following one-
word conditions in describing a patient's condition to those inquiring,
including the media.[1]
Undetermined[edit]
Patient awaiting physician and/or assessment.
Good[edit]
Vital signs are stable and within normal limits. Patient is conscious and
comfortable. Indicators are excellent.
Fai... 阅读全帖 |
|
d********f
发帖数: 43471 | 9 Hospital stocks tanked Thursday after another big chain warned Wall Street
that it won't meet third-quarter earnings expectations.
Community Health Systems said Wednesday after markets closed that patient
admissions fell about 2 percent at its established locations in the quarter,
and it saw a decrease in the percentage of people covered by commercial
insurance, which offers the best reimbursement. The Franklin, Tenn.-based
chain expects adjusted earnings for the quarter that ends Sept. 30 to be... 阅读全帖 |
|
z********6
发帖数: 852 | 10 古兰经有164处关于对异教徒发动圣战（jihad)的描述
The Koran's 164 Jihad Verses
K 2:178-179
Set 1, Count 1+2 [2.178] O you who believe! retaliation is prescribed for
you in the matter of the slain, the free for the free, and the slave for
the slave, and the female for the female, but if any remission is made to
any one by his (aggrieved) brother, then prosecution (for the bloodwit)
should be made according to usage, and payment should be made to him in a
good manner; this is an alleviation from your Lord and a mer... 阅读全帖 |
|
D*****r
发帖数: 6791 | 11 Letters from the Earth
When the Creator had finished thinking, He said, "I have thought. Behold!"
He lifted His hand, and from it burst a fountain-spray of fire, a million
stupendous suns, which clove the blackness and soared, away and away and
away, diminishing in magnitude and intensity as they pierced the far
frontiers of Space, until at last they were but as diamond nailheads
sparkling under the domed vast roof of the universe.
At the end of an hour the Grand Council was dismissed.
They left... 阅读全帖 |
|
T*******y
发帖数: 6523 | 12 en, I think I know what you mean, and there are a few things I want to
say a bit more.
1. All people die. There's no exception. It's a choice to die fearfully
without knowing the other side, or die peacefully knowing that this life
has a purpose. Many people don't know that there's such a choice.
At least based on what I read, both Brian Weiss and Byron Katie have
helped many dying patients to die peacefully with the knowledge that
it's not over. Brian is a doctor, who lost his first-born son 7 ... 阅读全帖 |
|
m*****n
发帖数: 5245 | 13 我的邮箱： m*****[email protected]
Kim HL, Seligson D, Liu X et al (2005) Using tumor markers to predict the
survival of patients with metastatic renal cell carcinoma. J Urol 173:1496–
1501
Mancuso A, Sternberg CN (2005) New treatments for metastatic kidney cancer.
Can J Urol 12(Suppl 1):66–70
Motzer RJ, Mazumdar M, Bacik J et al (1999) Survival and prognostic
stratification of 670 patients with advanced renal cell carcinoma. J Clin
Oncol 17:2530–2540
Fyfe G, Fisher RI, Rosenberg SA et al (1995) Results of... 阅读全帖 |
|
l**l
发帖数: 458 | 14 J Cardiovasc Surg (Torino). 2006 Feb;47(1):65-70.
Outcome after one-stage repair of tetralogy of Fallot.
Lee C, Lee CN, Kim SC, Lim C, Chang YH, Kang CH, Jo WM, Kim WH.
Source
Department of Cardiovascular Surgery, Sejong General Hospital, Sejong Heart
Institute, Bucheon, Kyungki-do, South Korea.
Abstract
AIM:
The purpose of this study was to evaluate the outcome after one-stage repair
of tetralogy of Fallot (TOF).
METHODS:
Between May 1997 and December 2002, 240 patients with a median age of 9
m... 阅读全帖 |
|
s********d
发帖数: 103 | 15 Alnylam and Ascletis collaborate to develop ALN-VSP for liver cancers in
China
US RNAi therapeutics specialties Alnylam Pharmaceuticals (Nasdaq: ALNY) and
Ascletis Pharmaceuticals, a privately held US-China joint venture
pharmaceutical company, have formed a strategic collaboration for the
development of ALN-VSP, a first-in-class, systemically delivered RNAi
therapeutic for the treatment of liver cancers including hepatocellular
carcinoma (HCC), a significant area of unmet need in China.
This co... 阅读全帖 |
|
l**********1
发帖数: 5204 | 16 cited from OX dot ac dot uk
6 gene sequencing test for cancer patients on the NHS
Health
Science 25 Mar 13
The first multi-gene test that can help predict cancer patients' responses
to treatment using the latest DNA sequencing techniques has been launched in
the NHS, thanks to a partnership between scientists at the University of
Oxford and Oxford University Hospitals NHS Trust.
The test detects mutations across 46 genes in cancer cells, mutations which
may be driving the growth of the cancer in... 阅读全帖 |
|
s********n
发帖数: 2939 | 17 现在这种例子越来越多了
http://www.nytimes.com/2014/06/05/health/in-first-quick-dna-tes
In a First, Test of DNA Finds Root of Illness
Joshua Osborn, 14, lay in a coma at American Family Children’s Hospital in
Madison, Wis. For weeks his brain had been swelling with fluid, and a
battery of tests had failed to reveal the cause.
The doctors told his parents, Clark and Julie, that they wanted to run one
more test with an experimental new technology. Scientists would search
Joshua’s cerebrospinal fluid for piece... 阅读全帖 |
|
l********y
发帖数: 2295 | 18 【 以下文字转载自 Pre_Resident_Club 俱乐部 】
发信人: lovelypony (pony), 信区: Pre_Resident_Club
标 题: case presentation 学习笔记
发信站: BBS 未名空间站 (Tue Feb 22 20:03:05 2011, 美东)
昨天第一次参加了由现任斑竹chipmunk和元老knockingdown主持的case presentation
，觉得收获很大，后面慢慢的把自己的学习笔记贴出来，后面的同学看了可以少犯些我
们犯过的低级错误，这样前辈们也可以省些力气。前辈们牺牲自己宝贵的私人时间，聆听我们支离破碎，毫无章法的presentation ，耐心细致的指出错误，提出建议，pony真的觉得没有更好的语言来表达自己的感激之情。就希望能抛砖引玉，大家能互帮互助，提高我们CMG的整体水平，这样前辈们的心思也算没有白花，希望大家都能来补充和指出错误，多谢了！
要present一个case，结构一定要完整。
1. CC: 第一句话永远是chief complaint，怎么样用一句话简明扼要的把CC说好了，还是要花大... 阅读全帖 |
|
s*h
发帖数: 1538 | 19 Many people will spend time as an observer. Few will do it well. First, know
the limits of the institution. Abide by these limits. There is nothing
worse than me reading a note in the chart from someone who I know is an
observer. I have to inform the attending that the observer cannot see or
chart on patients. The note has to be removed and sometimes risk management
has to be informed. Don’t overstep your boundaries. Many of the interns or
residents or attending don’t know the rules on observers... 阅读全帖 |
|
s*h
发帖数: 1538 | 20 内科各专科的竞争性
Ultra competitive: Gastroenterology, Allergy/Immunology (esp research based
programs)
Highly competitive: Cardiology, Heme/Onc
Less Competitive:Pulmonary, Critical Care, Rheumatology (Becoming more
competitive), General Medicine (Research based)
Not Competitive: ID, Endo, Nephrology, Geriatrics
I have seen good people not get GI and Cardiology spots. H/O is very
competitive, but there are many spots out there.
Important factors for fellowship application:
1. A great LOR from the PD
... 阅读全帖 |
|
s**********t
发帖数: 217 | 21 For neuro patient, again, you need to know the risk factors. The details of
HPI, esp the sequences of the symptoms are very important in neuro patient.
If the patient has CVA in the past, you need to know the patient's function
status, the left over symptoms from last stroke. Are there any tests
doppler, MRI/MRA have been done in the past. Does the patient on any
preventive meds for recurrent stroke or not.
For neurosurgery patient, it depends on cases. Neruomascular or brain mass.
For neuromas... 阅读全帖 |
|
l********y
发帖数: 2295 | 22 【 以下文字转载自 Pre_Resident_Club 俱乐部 】
发信人: lovelypony (pony), 信区: Pre_Resident_Club
标 题: Tips for IM interns
发信站: BBS 未名空间站 (Sun May 27 09:34:24 2012, 美东)
INTERNS: daily management (orders, consults, pages, calls); replete lytes
daily before rounds (check for renal failure first; if Cr up, run by
resident before ordering repletion); the groundwork to get stuff done and
care for patients
--> BEFORE ROUNDS: arrive by 6am (weekdays), get signout, review all labs
and test results, see all your patients... 阅读全帖 |
|
c*******m
发帖数: 25 | 23 我今天很有幸收到SleepyCoffee (让我叫她Dr. Coffee吧, 如果她不介意) 的电话。
我绝对是毕业很多年的啦（我比Dr. Coffee早几年医学院毕业，做了很多其他的事情，
现在又来忙着考版和申请住院医。反正是到处折腾，丰富人生阅历吧。）我很感谢Dr.
Coffee的热情帮助，而且她这样的性格的确对她的行医肯定非常有帮助。
言归正传，我也是今年在申请面试和Match。
一点个人简介：我毕业十好几年了，呵呵。。。Step 1 235+, Step 2 245+, CK CS 是
在去年和今年考的(1st attempt)。我同时申请两个专业（外加prelim),现在有十几个
IV，我去了三个IV。我的问题是我申请的专业有一些是advanced program（尤其是我很
想去的），可我的prelim IV只有三个。
我个人认为我的交流能力还是可以的，因为我的日常科研工作需要大量的交流（而且
我也工作很多年了）。我认为我IV最大的问题是进一步把我的以前的工作经验和临床更
具体的联系起来，特别是证明我的以前的经验会让我胜任住院医（尤其是PGY1 intern
）的工作。D... 阅读全帖 |
|
发帖数: 1 | 24 Difficult scenarios:
patient panicking ( I can’t breathe, etc) (Hi Ms, are you OK? can you come
and sit on the exam table, would that be more comfortable for you?) (one
thing we can do is to take a deep breath, can you follow me, breath in and
out slowly like this, in and out, in and out).
patient is suicidal. “Mr X, I would like you to stay in the hospital for
the time being so that I can run some tests. would that be Ok?”
patient crying ( give tissues. Do you need tissues? Mrs--, I am here to ... 阅读全帖 |
|
发帖数: 1 | 25 Difficult scenarios:
patient panicking ( I can’t breathe, etc) (Hi Ms, are you OK? can you come
and sit on the exam table, would that be more comfortable for you?) (one
thing we can do is to take a deep breath, can you follow me, breath in and
out slowly like this, in and out, in and out).
patient is suicidal. “Mr X, I would like you to stay in the hospital for
the time being so that I can run some tests. would that be Ok?”
patient crying ( give tissues. Do you need tissues? Mrs--, I am here to ... 阅读全帖 |
|
G*******4
发帖数: 117 | 26 对下面的三个问题，不是十分清楚，想听听大家的意见。Any suggestion will be
GREATLY appreciated.
1. a female Muslim patient does not want a male healthcare provider. what
does the nurse do?
A. tell the male healthcare provider the patient's feeling
B. find a femle healthcare provider
我的问题是，护士可以换医生？？？How?
2. a 86 years old patient cannot sleep. what does the nurse do?
A. back massage
B. administer analgesics prn
C. no naps daytime
86 的病人经得住back massage么？ 他们不是thin skin, easy to be bruised的么？
另外，86岁的病人是不是经常这里痛那里痛的？为什么不是因为痛才失眠... 阅读全帖 |
|
h******q
发帖数: 865 | 27 don't remember where did I find this (maybe here?) but something interesting:
Delegation:
NURSING ASSISTANT
- ADLs/Noninvasive
- Assist
- Remind/Reinforce: usually reminds pt. TO do something rather than HOW to
do it (skills previously taught by other health care professional or
precaution measures)***
* Usually in regards to ADLs (hygiene, nutrition, ambulating, skin care),
turning, repositioning, cough deep breathe ROM *
- Special positioning-- requires initial education by RN -- assistant wil... 阅读全帖 |
|
l**n
发帖数: 60 | 28 I find seeing 4 puts an hour for a 12 hr day highly unlikely (in a clinic
setting). You have charts to review, meds, histories and then there is the
interaction with the patients. If the patients were muzzled and not allowed
to talk maybe you could poke your head in the door and be out to the next
patient. Perhaps put all the patients in the same room and pass out
prescriptions. Plus the charting!! I am fast and can be in and out of most
rooms in a few minutes, but then I have a few patients who... 阅读全帖 |
|
s********d
发帖数: 103 | 29 Alnylam and Ascletis collaborate to develop ALN-VSP for liver cancers in
China
US RNAi therapeutics specialties Alnylam Pharmaceuticals (Nasdaq: ALNY) and
Ascletis Pharmaceuticals, a privately held US-China joint venture
pharmaceutical company, have formed a strategic collaboration for the
development of ALN-VSP, a first-in-class, systemically delivered RNAi
therapeutic for the treatment of liver cancers including hepatocellular
carcinoma (HCC), a significant area of unmet need in China.
This co... 阅读全帖 |
|
y**3
发帖数: 267 | 30 Lz need understand how Time is calculated. Here Time is a duration, not a
time point.
For example, for a study which needs recuit 100 lung cancer patients in a
medical center.The whole study duration is set 5 years. Suppose the starting
time point fr computing Time is the date when the patient is diagnosed lung
cancer( they are different for different patients), the event time point is
the patient dies of lung cancer(censor=1 as in the model statement LZ gave)
. At the date of the study closes,... 阅读全帖 |
|
s**********8
发帖数: 25265 | 31 Investigator's brochure
From Wikipedia, the free encyclopediaJump to: navigation, search
Some of this article's sections are empty. Please add content to empty
sections. (May 2011)
This article needs additional citations for verification. Please help
improve this article by adding reliable references. Unsourced material may
be challenged and removed. (September 2009)
The Investigator's Brochure (IB) is a comprehensive document summarizing the
body of information about an investigational product ... 阅读全帖 |
|
b*w
发帖数: 2062 | 32 some protective practice:
Documentation, documentation, documentation is key. We had a representation
from our malpractice carrier come out and review our charting. This was a
service they offered free of charge. She picked 10 random charts and read
through them, found no serious errors but made some suggestions about
wording or detail.
You need to document any patient complaints and your response to them. For
example, I documented my patient's pain and that she was not using the pain
medication... 阅读全帖 |
|
b*w
发帖数: 2062 | 33 some protective practice:
Documentation, documentation, documentation is key. We had a representation
from our malpractice carrier come out and review our charting. This was a
service they offered free of charge. She picked 10 random charts and read
through them, found no serious errors but made some suggestions about
wording or detail.
You need to document any patient complaints and your response to them. For
example, I documented my patient's pain and that she was not using the pain
medication... 阅读全帖 |
|
b******a
发帖数: 704 | 34 Happy Chinese New Year!
Here is what I recently read online. Very interesting topic from MAYO CLINIC !
PUBLIC HEALTH RELEVANCE: Clear cell renal cell carcinoma (ccRCC) is the most
lethal form of kidney malignancy, killing nearly 13,000 patients annually.
Current treatment options for metastatic ccRCC are limited as evident in 2
year survival rates of 10-20%. Advancing ccRCC patient care centers around
several areas including better methods for identifying patients at high risk
for metastatic rel... 阅读全帖 |
|
m********4
发帖数: 607 | 35 Afib is one of major risk factors to cause stroke. It is common to see pts
with afib in both hospital and clinic. How to manage pts with afib w/o
stroke?
*Thank eastlake to contribute Anticoagulation question.
http://www.mitbbs.com/article_t/Medicalpractice/31165.html
I would recommend the following paper to read.
* A new landscape for stroke prevention in atrial fibrillation: focus on new
anticoagulants, antiarrhythmic drugs, and devices.
Stroke. 2011 Nov;42(11):3316-22. Epub 2011 Oct 13.
A... 阅读全帖 |
|
b******a
发帖数: 704 | 36 Another intersting case
A Window of Opportunity
Sandra J. Bliss, M.D., Richard H. Moseley, M.D., John Del Valle, M.D., and
Sanjay Saint, M.D., M.P.H.
N Engl J Med 2003; 349:1848-1853 November 6, 2003
--Just in case you don't have access to NEJM:
The diagnosis of herpetic hepatitis was made ante mortem in fewer than 25
percent of published cases.6,8 The definitive diagnosis of HSV hepatitis is
based on liver biopsy, which shows parenchymal necrosis, characteristic
viral inclusions, and nuclear ch... 阅读全帖 |
|
b******a
发帖数: 704 | 37 Lampl, C. and K. Yazdi (2002). "Central pontine myelinolysis." Eur Neurol 47
(1): 3-10
The etiology and pathogenesis of this disorder are unclear and will be
discussed. Chronic alcoholism is still the most common underlying condition
of CPM patients. In the literature, 174 cases of CPM have been reported in
alcoholics since 1986, which is equivalent to an incidence of 39.4%.
Likewise, 95 cases of CPM following the correction of hyponatremia have been
documented since 1986 (21.5%). The role of h... 阅读全帖 |
|
d**********0
发帖数: 13081 | 38 Metastatic adenocarcinoma is a cancer arising in glandular tissue that
spreads to other regions of the body. This type of cancer can be highly
aggressive in some cases, and there are a number of treatment options
available to manage it. Patients diagnosed with metastatic adenocarcinoma
typically work with an oncologist, a physician who focuses on cancer care,
and they may see nuclear medicine specialists, as well as other medical
specialists during the course of their treatment.
Adenocarcinomas ... 阅读全帖 |
|
J*********l
发帖数: 1185 | 39 连接有问题。
Flexible bronchoscopy as a valuable tool in the evaluation of persistent
wheezing in children.
Erkan Cakir, Refika Hamutcu Ersu, Zeynep Seda Uyan, Sedat Oktem, Bulent
Karadag, Okan Yapar, Ozge Pamukcu, Fazilet Karakoc, Elif Dagli
Division of Pediatric Pulmonology, Marmara University, Istanbul, Turkey.
International journal of pediatric otorhinolaryngology (impact factor: 0.85)
. 10/2009; 73(12):1666-8. DOI:10.1016/j.ijporl.2009.08.016
Source: PubMed
ABSTRACT Persistent wheezing is a commo... 阅读全帖 |
|
d********e
发帖数: 239 | 40 Stress echo with treadmill test has better diagnostic value than the
treadmill test. Plus, it is safer for patient since patient will have
baseline EKG and echo done first. Patient can not start the exercise test if
the baseline echo or EKG shows some new abnormalities. Patient may need
angiogram instead. It depends.
It is not uncommon that patients EKG's shows late changes during the
exercise test or recovery time when patient has some coronary artery
blockage. So echo images are more reliable ... 阅读全帖 |
|
h***a
发帖数: 312 | 41 来自主题: Medicalpractice版 - GMO http://www.aaemonline.org/gmopost.html
https://www.youtube.com/watch?v=eeW5yUSqdhY
American academy of enviromental medicine
Genetically Modified Foods
According to the World Health Organization, Genetically Modified Organisms(
GMOs) are "organisms in which the genetic material (DNA) has been altered in
such a way that does not occur naturally."1 This technology is also
referred to as "genetic engineering", "biotechnology" or "recombinant DNA
technology" and consists of randomly inserting genet... 阅读全帖 |
|
l*h
发帖数: 4124 | 42 when I said I would advise against coming to the US, it was based on your
statement 前段时间到北京治疗，但是病情还是比较严重. if you truly want to
bing the patient to the US, consider a few things including the following.
1. where was the tumor? how big was it? how well was the patient doing at
the time of diagnosis? what was her Karnofsky score? what was the extent of
her resection? how well was she doing after the first surgery? what other
treatment has been given?
2. what is the expectation of the patient and he... 阅读全帖 |
|
f**d
发帖数: 768 | 43 这是一本计算神经科学的优秀著作，全文拷贝这里（图和公式缺），有兴趣的同学可以
阅读
如需要，我可以分享PDF文件（－－仅供个人学习，无商业用途）
From Computer to Brain
William W. Lytton
From Computer to Brain
Foundations of Computational Neuroscience
Springer
William W. Lytton, M.D.
Associate Professor, State University of New York, Downstato, Brooklyn, NY
Visiting Associate Professor, University of Wisconsin, Madison
Visiting Associate Professor, Polytechnic University, Brooklyn, NY
Staff Neurologist., Kings County Hospital, Brooklyn, NY
In From Computer to Brain: ... 阅读全帖 |
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p***o
发帖数: 714 | 45 by pennbrook@168
好久没有正经写点东西了, 今天说说rheumatoid arthritis.
Inappropriate inflammatory cell response is associated with autoimmune
diseases, a spectrum of disorders in which the immune system malfunctions
and causes the body to attack its own organs, tissues, and cells.
The body's own immune system attacks a joint's synovial membrane, which
becomes inflamed, secretes fluid, and the cartilage becomes rough and pitted.
Rheumatoid arthritis大家应该都知道, 基本上每个药出来都是blockbuster.
现在的几种主要治疗方法是:
1. NSAID: 象Pf... 阅读全帖 |
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d*****c
发帖数: 23 | 46 有人hold吗？公司的研发还在继续，Multikine的三期可能快开始了。
我转封CVM头的信。现在股价短期适中。
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CEL-SCI Corporation Releases Letter to Shareholders
VIENNA, VA, July 7, 2009 – The following letter is being released by CEL-
SCI Corporation (NYSE AMEX: CVM) to its shareholders:
Dear Fellow Shareholders:
Recently we have been hearing a great deal about the pandemic caused by the
H1N1 swine flu. You may think to yourself, this is no big deal since it
does not seem that serious and, look what happened to bird flu - it
disappear... 阅读全帖 |
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c****e
发帖数: 749 | 47 是指这个吗？
"In PN400-301 (n=434), 21% patients taking VIMOVO experienced erosive
gastritis, as compared to 37% taking EC naproxen. Among patients taking
VIMOVO, 18% experienced gastritis, as compared to 13% taking EC naproxen,
and 16% of the patients reported dyspepsia, as compared to 30% taking EC
naproxen. 2% of patients taking VIMOVO experienced erosive duodenitis as
compared to 14% taking EC Naproxen. In PN400-302 (n=420), incidences of
erosive gastritis were reported by 18% patients taking VIMO... 阅读全帖 |
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n****e
发帖数: 1677 | 48 我先写点，以后有新的东西再补充，另外还有些数据要斟酌，有保留的看吧。
obesity的药，FDA有明确的guideline http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm071612.pdf,里面详细列举了clinical trials的design,和要求，其中包括patient size, duration,还有safety等等，简单的说，phase III要至少4500人一年，safety对于obesity的药尤其重要，因为obesity不是life threatening,而且要长期使用。主要的safety concern是心血管疾病，还有就是精神疾病比如depression。
现在来看vvus和arna的药：
vvus的叫Qnexa，是low dose phentermine and topiramate, phentermine是1959年FDA
批准的，到现在也没有efficacy和safety的data,唯一的数据是1990年的Fen-p... 阅读全帖 |
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