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全部话题 - 话题: pfpi3k
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o*******a
发帖数: 242
1
Nature. 2015 Apr 30;520(7549):683-7. doi: 10.1038/nature14412. Epub 2015 Apr
15.
A molecular mechanism of artemisinin resistance in Plasmodium falciparum
malaria.
Mbengue A1, Bhattacharjee S1, Pandharkar T1, Liu H2, Estiu G2, Stahelin RV3,
Rizk SS1, Njimoh DL4, Ryan Y1, Chotivanich K5, Nguon C6, Ghorbal M7, Lopez-
Rubio JJ7, Pfrender M8, Emrich S9, Mohandas N10, Dondorp AM11, Wiest O12,
Haldar K1.
Abstract
Artemisinins are the cornerstone of anti-malarial drugs. Emergence and
spread of resistanc... 阅读全帖
v**********m
发帖数: 5516
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Figure 3: Structural analyses of PfPI3K and human PI3K, with and without
artemisinin derived compounds (643 KB)
aSnapshots from 20ns MD simulations and chemical structure of
artelinic acid (top right), artemisone (bottom left) and deoxyartemisinin (
bottom right) bound to PfPI3K.
r********r
发帖数: 109
3
Are they inhibitors for Plasmodium falciparum phosphatidylinositol-3-kinase
(PfPI3K) or human-PI3K?

FDA
s******y
发帖数: 28562
4

文章里说是 phosphatidylinositol-3-kinase (PfPI3K)
一种脂分子的激酶。
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