T*G
发帖数: 600 | 1 If this is true, other more potent PI3K inhibitors would have stronger
effects. Many companies tried to screen lead from house-hold or existing FDA
libraries, many of them contain PI3K inhibitors, without success. Hard to
believe this paper describes the true mechanism of arteminsinin
Apr
RV3,
Lopez- |
|
r********r
发帖数: 109 | 2 Are they inhibitors for Plasmodium falciparum phosphatidylinositol-3-kinase
(PfPI3K) or human-PI3K?
FDA |
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y*****l
发帖数: 5997 | 3 http://seekingalpha.com/article/315312-biotech-companies-promis
Exelixis' (EXEL) advanced PI3K-delta research and development preclinical
program attracted Merck (MRK), known as MSD outside of the United States and
Canada. PI3K-delta is a therapeutic target that academic researchers and
the drug industry are racing to develop, therapeutic antagonists for both
inflammatory diseases and cancer. To get to the Exelixis program, Merck
agreed to pay $12 million in an upfront payment in addition to pot... 阅读全帖 |
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j********r
发帖数: 156 | 4 Generally, the kinases for T308 and S473 of Akt are PDK1 and mTOR complex 2
respectively. PI3K causes the production of PIP3 on the membrane, which then
binds to both Akt and PDK1 (which is assumed to be constitutively active).
So far there seems no direct evidence as to how mTORC2 is regulated. However
, inhibition of PI3K in most cases will lead to the suppression of
phosphorylation at S473.
Just curious, what is the evidence for PI3K-independent S473 phosphorylation
in your experiment? PI3K h... 阅读全帖 |
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e*******c
发帖数: 1479 | 5 我同意上位的观点，就是有可能在PI3K缺陷细胞或小分子抑制剂的情况下并没有完全
block其活性，我用了一个试验是在PI3K的p85缺陷细胞中检测到仍然有AKT473的调节，
但是否一定说明我这个调节是PI3K-independent的还为时过早。
为伊消的人憔悴。 |
|
e*******c
发帖数: 1479 | 6 我同意上位的观点，就是有可能在PI3K缺陷细胞或小分子抑制剂的情况下并没有完全
block其活性，我用了一个试验是在PI3K的p85缺陷细胞中检测到仍然有AKT473的调节，
但是否一定说明我这个调节是PI3K-independent的还为时过早。
为伊消的人憔悴。 |
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l**********1
发帖数: 5204 | 7 Please refer
Swedish Umeå Universitet. [2007] one PhD Dissertation
title:
Studies of phosphatidylinositol 3 kinase (PI3K) signaling pathway in
mammalian ovarian follicle activation and development
University dissertation from Umeå : Medicinsk kemi och biofysik
AUTHOR: Singareddy Rajareddy
KEYWORDS: oocyte; follicular development; P13K pathway; Medical Biochemistry
; medicinsk biokemi;
ABSTRACT: ignored and (iii) the overactivated follicles in p27-/- ovaries
are depleted in early adul... 阅读全帖 |
|
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i***s
发帖数: 39120 | 9 英国卡迪夫大学医学院研究证实，中国抗肿瘤创新中药养正消积胶囊可有效抑制肿瘤细胞侵袭转移。
对于恶性肿瘤患者而言，最可怕的莫过于肿瘤出现转移扩散，因为这意味着肿瘤病变已经发展到晚期，也是肿瘤治疗失败的重要原因之一。今天在第七届中国肿瘤学术大会上披露，国际权威学术杂志《抗癌研究》（Anticancer Research）刊发了英国卡迪夫大学关于中药抑制肿瘤转移的研究报告，在国际上引起广泛关注。
英国卡迪夫大学医学院研究证实，我国抗肿瘤创新中药养正消积胶囊可有效抑制肿瘤细胞侵袭转移。研究人员指出，在肿瘤细胞的侵袭转移过程中，磷酸肌醇 3－激酶/蛋白激酶 B（PI3K/AKT） 信号通路的过度激活起到了关键作用，养正消积胶囊可以显著干预 PI3K/AKT 通路，从而对乳腺癌、肠癌、前列腺癌、肺癌、胃癌和骨肉瘤等肿瘤细胞的黏附和迁移起到明显抑制作用，有效控制肿瘤的病变发展。
有关专家介绍，恶性肿瘤细胞非常容易从原发病灶上脱落，每克肿瘤组织每天可向血液中释放 300―400万个肿瘤细胞，脱落的肿瘤细胞随血液或淋巴流布全身，一旦条件成熟就会迅速生长，形成转移性病灶。控制肿瘤细胞的侵袭扩散是避免肿瘤恶... 阅读全帖 |
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i********n
发帖数: 171 | 10 请发简历及你想审稿的文章编号，可以多选。
同时提醒一下审稿人，请不要为了申绿卡而忽视了审稿质量，请大家珍惜下一次审稿机
会。
Please email to: [email protected]/* */
1. MiR-486-5p functions as a tumor suppressor and directly targets VEGFA
in human osteosarcoma
2. Novel quercetin derivative TEF induces ER stress and mitochondria-
mediated apoptosis in human colon cancer HCT-116 cells
3. Antioxidant, anti-microbial, anti-inflammatory and wound healing
effects of Artemisia campestris aqueous extract on rat
4. Identification of novel HDAC2 inh... 阅读全帖 |
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y***r
发帖数: 1845 | 11 没想到睡袋这么光明这么孝顺~~帮忙顶
我的个人看法是：首先要搞清楚高血压的原因。是家族遗传问题，还是伴随血糖产生的
，和胰岛素抗性是否有联系，心电图结果如何等。然后才能确定跑步是否有效。假如没
有什么特殊的原因，就是大多数人那样，活动少，饮食没有注意（比如米面特别多），
血脂也高一些，心脏机能弱，那么跑步应该会有一些效果。
有人专门做过这方面的研究，就是跑步是否可以改善高血压：
J Strength Cond Res. 2009 Nov;23(8):2331-8. doi: 10.1519/JSC.
0b013e3181bac418.
Effects of treadmill running and resistance exercises on lowering blood
pressure during the daily work of hypertensive subjects.
Mota MR, Pardono E, Lima LC, Arsa G, Bottaro M, Campbell CS, Simões HG.
Source
Laboratory of Ph... 阅读全帖 |
|
b******n
发帖数: 82 | 12 http://www.cell.com/abstract/S0092-8674%2810%2901180-3
The ER UDPase ENTPD5 Promotes Protein N-Glycosylation, the Warburg Effect,
and Proliferation in the PTEN Pathway
Min Fang, Zhirong Shen, Song Huang, Liping Zhao, She Chen, Tak W. Mak,
Xiaodong Wang
* Highlights
* The ER UDPase ENTPD5 is upregulated by AKT in PTEN mutant cells
* ENTPD5 hydrolyzes UDP to UMP to promote protein N-glycosylation
* ENTPD5, along with CMPK1 and AK-1, hydrolyze ATP to AMP, increasing
aerobic glycolys... 阅读全帖 |
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l**********n
发帖数: 240 | 13 Josef Martin Penninger
Most significant scientific contributions:
Our basic approach is to genetically manipulate and change genes in mice and
to
determine the effects of these mutations in development of the whole
organism and in
diseases. From these mutations we are trying to establish basic principles
of
development and basic mechanisms of disease pathogenesis. My laboratory
focuses on
heart diseases, autoimmune diseases and cancers, and bone diseases. On all
the listed
contributions below I ... 阅读全帖 |
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e*******c
发帖数: 1479 | 14 各位同仁，AKT308的磷酸化调控对于473的磷酸化有何作用？ PI3K通过PDK1调控着308
，然后如何作用于473的？auto磷酸化的作用？
我们发现一个非PI3K依赖性的473变化，该如何解释呢？谢谢 |
|
|
r******k
发帖数: 446 | 16 小弟最近看了看糖尿病的research。 发觉糖尿病人都是insulin resistance，然后
PI2k pathway是inactivation的。 那这不是跟癌症的pi3k pathway activation正相反？
而且如果治疗糖尿病的话，restore PI3k activation那不是很容易得癌症吗？
小弟不懂 忘大神们指点一二！ 谢谢！ |
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r******k
发帖数: 446 | 17 小弟最近看了看糖尿病的research。 发觉糖尿病人都是insulin resistance，然后
PI2k pathway是inactivation的。 那这不是跟癌症的pi3k pathway activation正相反？
而且如果治疗糖尿病的话，restore PI3k activation那不是很容易得癌症吗？
小弟不懂 忘大神们指点一二！ 谢谢！ |
|
l****y
发帖数: 486 | 18 而cancer metabolism的热跟这两点都关系没那么大，就第一点来说，整个cancer
metabolism里能抱的唯一大腿就是IDH（在癌症里有大量mutation的core component).
其实在发现IDH mutation前，这也是这个领域被人criticize的地方，就是：既然如此
重要，怎么没什么突变。IDH的出现让领域里的人如获至宝，但既变如此，这样的例子
还是太少了。
要说明的是，cancer metabolism是一个比较新（但其实也有上十年了）的领域，它里
面的leaders不是以前做传统metabolism的人，而是做 cancer signaling的人，所以这
些人把自己做的targets像PI3K, mTOR, Myc, P53什么的都说成是cancer metabolism里
的。这些targets在癌症里毫无疑问是非常重要的，但玩的太久了就不容易继续做了，
所以大家在这里换个角度可以继续研究。但这些不仅调控metabolism,也调控很多其他
东西（cell cycle, migration, genomic integrity, DNA ... 阅读全帖 |
|
l****y
发帖数: 486 | 19 而cancer metabolism的热跟这两点都关系没那么大，就第一点来说，整个cancer
metabolism里能抱的唯一大腿就是IDH（在癌症里有大量mutation的core component).
其实在发现IDH mutation前，这也是这个领域被人criticize的地方，就是：既然如此
重要，怎么没什么突变。IDH的出现让领域里的人如获至宝，但既变如此，这样的例子
还是太少了。
要说明的是，cancer metabolism是一个比较新（但其实也有上十年了）的领域，它里
面的leaders不是以前做传统metabolism的人，而是做 cancer signaling的人，所以这
些人把自己做的targets像PI3K, mTOR, Myc, P53什么的都说成是cancer metabolism里
的。这些targets在癌症里毫无疑问是非常重要的，但玩的太久了就不容易继续做了，
所以大家在这里换个角度可以继续研究。但这些不仅调控metabolism,也调控很多其他
东西（cell cycle, migration, genomic integrity, DNA ... 阅读全帖 |
|
o*******a
发帖数: 242 | 20 Nature. 2015 Apr 30;520(7549):683-7. doi: 10.1038/nature14412. Epub 2015 Apr
15.
A molecular mechanism of artemisinin resistance in Plasmodium falciparum
malaria.
Mbengue A1, Bhattacharjee S1, Pandharkar T1, Liu H2, Estiu G2, Stahelin RV3,
Rizk SS1, Njimoh DL4, Ryan Y1, Chotivanich K5, Nguon C6, Ghorbal M7, Lopez-
Rubio JJ7, Pfrender M8, Emrich S9, Mohandas N10, Dondorp AM11, Wiest O12,
Haldar K1.
Abstract
Artemisinins are the cornerstone of anti-malarial drugs. Emergence and
spread of resistanc... 阅读全帖 |
|
J********e
发帖数: 341 | 21 记得这个版上讨论过这篇文章，印象中有人说很难想象如果是抑制PI3K，其他很多PI3K
的inhibitor没被发现和使用 |
|
t*******o
发帖数: 1464 | 22 EXEL June5-7
Presentations Featuring XL184 (MET, VEGF, RET)
* Oral presentation: Data from a phase 2 study of XL184 in patients with
progressive glioblastoma will be presented on Saturday, June 5, 2010 from 5
* Oral presentation: Long-term results in a cohort of medullary thyroid
cancer patients in a phase 1 study of XL184 will be presented in a clinical
science symposium on Monday, June 7 at 10:45-11:00AM (Abstract #5502).
* Poster discussion: Data from a phase 1b/2 study of XL184 ... 阅读全帖 |
|
c****e
发帖数: 1628 | 23 【 以下文字转载自 Biology 讨论区 】
发信人: HFNO (H5N1 禽流感), 信区: Biology
标 题: 孔老千 zz
发信站: BBS 未名空间站 (Mon Feb 3 16:30:35 2014, 美东)
理砖科的论文，是和别处不同的。多是第一作者为主要的砖工，后边几个帮忙的
，再后边几个打酱油的，最后挂上老板的名字是为通讯作者。做工的人，PhD毕业之后
，往往先做一两轮postdoc，攒几篇paper，然后去找教职——这是二十年前的事，现在
要做到四五轮——有了大paper，后面找postdoc便有底气；倘若有了CNS，便可从AP做
起谋个PI当了，如果有几篇CNS，或者已经当上AP，A/P，那兴许就能评千人锦衣还乡了
。但多数的砖工，智商情商拙计，大抵没有这么顺利。只有牛人，才能当上老板push别
人干活。
我从大二起，便在村口的文理学院砖厂里打杂。老板说，too young na... 阅读全帖 |
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t*******a
发帖数: 4055 | 24 最新诺奖预测出炉：华裔女科学家、美国科学院院士张远成热门
澎湃新闻记者 王盈颖
2017-09-21 20:43 来源：澎湃新闻
字号
张远
一年一度的诺贝尔奖是学术界最大的盛事之一。随着2017年诺贝尔奖公布的时间进入一
个月倒计时，陆续有机构开始“押宝”谁会是今年的得主。
当地时间9月20日，科睿唯安（原汤森路透知识产权与科技事业部）公布了最新的“引
文桂冠奖”，预测了22位可能在今年或未来，获得生理学或医学、物理、化学、经济学
诺贝尔奖的学者。
其中，华裔科学家、美国匹兹堡大学医学院病理学特聘教授张远（Yuan Chang）和其丈
夫、同为匹兹堡大学教授的帕特里克·摩尔（Patrick S. Moore）一同上榜生理学或医
学领域的“引文桂冠奖”。上榜原因是这对“夫妻档”科学家一起发现了卡波济氏肉瘤
相关疱疹病毒（KSHV），又名人类疱疹病毒（HHV8）。
张远1959年出生于中国台湾。除了KSHV/ HHV8病毒，她和摩尔还与他人一同发现了引起
梅克尔细胞癌的梅克尔多元癌细胞病毒（MCV）。2012年，张远当选美国科学院院士。
此外，俄罗斯物理学家Rashid A. Sunya... 阅读全帖 |
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j****d
发帖数: 123 | 25 key words
drugs -
AZD4547
lucitanib
AXL1717
BGJ398
BKM120
genes -
EGFR
KRAS
PI3K
FGFR1
websites -
51qiji
yuaigongwu
inspire
good luck.
PS -
Unless for participating in NIH clinical trials, don't come to the US |
|
g****e
发帖数: 1426 | 26 TGTX: bought in at 5.7. Promising oncology company developing two drugs for
B-cell cancers – Leukemia and Lymphoma:
TG-1101 – Novel Glycoengineered, Anti-CD20 monoclonal antibody
Same class as Rituxan®, which has ~$7BB WW Sales
Enhanced ADCC profile for increased potency similar to Gazyva® (GA101)
Single agent activity demonstrated in CLL and NHL in Phase 1/2 studies
TGR-1202 – Novel PI3Kδ inhibitor
Same class as Idelalisib and IPI-145
Currently in Phase 1 dose escala... 阅读全帖 |
|
g****e
发帖数: 1426 | 27 TGTX: bought in at 5.7. Promising oncology company developing two drugs for
B-cell cancers – Leukemia and Lymphoma:
TG-1101 – Novel Glycoengineered, Anti-CD20 monoclonal antibody
Same class as Rituxan®, which has ~$7BB WW Sales
Enhanced ADCC profile for increased potency similar to Gazyva® (GA101)
Single agent activity demonstrated in CLL and NHL in Phase 1/2 studies
TGR-1202 – Novel PI3Kδ inhibitor
Same class as Idelalisib and IPI-145
Currently in Phase 1 dose escala... 阅读全帖 |
|
c********r
发帖数: 562 | 28 EXEL:
The company has the best line up of MAPK pathway inhibitors
Its pipeline is very complementary to ROCHE's, is a speculated target for
ROCHE.
Its MEK inhibitor cobimetinib is the best in class, and has shown good
results in combination with ROCHE's RAF inhibitor and PI3K inhibitor
Its market cap is only 700 million, a bargain for a biotech with a drug
already approved to market
etc etc. |
|
N******s
发帖数: 10555 | 29 ☆─────────────────────────────────────☆
chemmaster (chemmaster) 于 提到:
EXEL:
The company has the best line up of MAPK pathway inhibitors
Its pipeline is very complementary to ROCHE's, is a speculated target for
ROCHE.
Its MEK inhibitor cobimetinib is the best in class, and has shown good
results in combination with ROCHE's RAF inhibitor and PI3K inhibitor
Its market cap is only 700 million, a bargain for a biotech with a drug
already approved to market
etc etc.
☆───────────────────────────... 阅读全帖 |
|
f*******1
发帖数: 1308 | 30 INCY还是相当猛的，有批了的药 JAK1/JAK2 inhibitors (Jakafi), 还有Iclusig (BCR
-ABL),另外在小分子抑制剂（JAK, PI3K, LSD1,FGFR, PIM,BRD...)和Immunotherapy(
IDO1, PD-1, ARG, OX40, GITR...)还有一堆很有意思的pipeline,针对各种肿
瘤的。 |
|
h******5
发帖数: 19 | 31 审稿机会：Title: Activation of PI3K/Akt/NF-B pathway is involved in
the toxicity of aristolochic acid I in renal epithelial cells
International Immunopharmacology 影响因子2.7， 申请绿卡够用了：）， 如有兴趣
，请快回复 |
|
h******5
发帖数: 19 | 32 审稿机会：Title: Activation of PI3K/Akt/NF-B pathway is involved in
the toxicity of aristolochic acid I in renal epithelial cells
International Immunopharmacology 影响因子2.7， 申请绿卡够用了：）， 如有兴趣
，请快回复 |
|
g**********y
发帖数: 423 | 33 新闻里面有引用我的话：
The finding could greatly improve patient care with the development of a
genetic test to classify tumors and match them to the therapies that offer
the best outcomes.
"In terms of clinical treatment, there are two promising findings from our
research," Rozen said. "One is that 5-FU has been particularly effective
against metabolic- subtype tumors, and the second is that drugs targeting
the PI3K−AKT−mTOR pathway may be particularly effective against
mesenchymal-subtype can... 阅读全帖 |
|
c**********l
发帖数: 32 | 34 PI3K/Akt pathway in hepatocellular carcinoma
关于 CSF， miRNA |
|
i********n
发帖数: 171 | 35 1.Anti-diabetic and anti-obesitic effects of aqueous extracts of
Yangkyuksanhwa-tang and its two major compositions on db/db mice
2.13-Methyltetradecanoic acid induces bladder cancer cell autophagy via ROS-
mediated PI3K/AKT and MAPK pathways
3.Ticagrelor inhibits oxLDL-induced migration of dendritic cells via miR-145
-5p mediated HSPA14 downregulation resulting in repressed atherogenesis
4.Co-delivery of IL17RB siRNA and doxorubicin by chitosan-based
nanoparticles for enhanced anticancer effica... 阅读全帖 |
|
i********n
发帖数: 171 | 36 send your CV if you think you are an expert in the field. [email protected]/* */
1. Curcumin-loaded Bioinspired Polymeric Nanosystem Enhances the Cell Cycle
Arrest and Cell Apoptosis in Colon Cancer Cells
2.Proliferation-enhancing effects of gastrodin on RSC96 Schwann cells by
regulating ERK1/2 and PI3K signaling pathways
3.MiR-489 suppresses proliferation and invasion of human bladder cancer
cells
4.Combination treatment with Rhizoma Paridis and Rhizoma Curcuma longa
extracts and 10-hydro... 阅读全帖 |
|
i********n
发帖数: 171 | 37 Please send your CV to [email protected]/* */ with selected MS#. 请务必认真审稿并及
时提交意见，谢谢
1. Iptakalim induces mitochondria-dependent apoptosis in hypoxic rat
pulmonary arterial smooth muscle cells
2. Fyn-related kinase expression predicts favorable prognosis in patients
with cervical cancer and suppresses malignant progression by regulating
migration and invasion
3. The Protective effect of Citrus limon essential oil on Hepatotoxicity
and nephrotoxicity induced by aspirin in rats
4. ... 阅读全帖 |
|
i********n
发帖数: 171 | 38 有审稿意愿的请发送你的CV到[email protected]/* */并告知你希望审稿的文章编号
请有时间愿意多审几篇的也可以，只要你能保证质量，之前有些审稿人有些敷衍，希望
大家能认真对待。谢谢合作。
1. Comparative assessment of cytotoxic effect of Cuban and Brazilian
propolis in human laryngeal epidermoid carcinoma cells
2. Role of PI3K/AKT/mTOR signaling pathway in ostearthritis by regulating
articular chondrocytes autophagy in rats
3. CREB knockdown inhibits growth and induces apoptosis in human pre-B
acute lymphoblastic leukemia cells through inhibition of prosurvival sig... 阅读全帖 |
|
c***r
发帖数: 73 | 39 收到两篇review邀请，我现在已经不需要了，有意者请尽快给我站内信，如果背景符合
，我回信推荐给editor。烦请信中包括你工作的领域，姓名，工作单位，email等信息
，或者你的profile， 谢谢！
第一篇：
Manuscript title: "Role of PI3K/AKT signaling pathway in migraine mechanism"
.
Journal: Neuropsychiatric Disease and Treatment.
In an effort to expedite the review process, would you please click on the
link below to advise your willingness or otherwise. If you agree to review
this manuscript we would appreciate receiving your comments by 03 Sep 2016.
第二篇：
NEOPLASMA.
The submission is en... 阅读全帖 |
|
b**********5
发帖数: 1 | 40 Jimmy Fund Auditorium, Harvard Medical School Boston, 35 Binney Street, MA,
02115
9:00am – 9:20am Registration and Light refreshment
9:30 am – 9:45 am Opening Remarks
Dr. Edward Benz
CEO, Dana-Farber Cancer Institute, Harvard Medical School
(Facilitator: Dr. Jin Zhang)
Technology innovation drives development in Medicine
(Facilitator: Dr. Shirley Liu)
9:45 am – 10:30 am Life at the Single Molecule Level.
Dr. Xiaoliang Xie
Mallinckrodt Professor, Department of Chemistry & Chemical Biolog... 阅读全帖 |
|
g********0
发帖数: 6201 | 41 【 以下文字转载自 Biology 讨论区 】
发信人: HFNO (H5N1 禽流感), 信区: Biology
标 题: 孔老千 zz
发信站: BBS 未名空间站 (Mon Feb 3 16:30:35 2014, 美东)
理砖科的论文，是和别处不同的。多是第一作者为主要的砖工，后边几个帮忙的
，再后边几个打酱油的，最后挂上老板的名字是为通讯作者。做工的人，PhD毕业之后
，往往先做一两轮postdoc，攒几篇paper，然后去找教职——这是二十年前的事，现在
要做到四五轮——有了大paper，后面找postdoc便有底气；倘若有了CNS，便可从AP做
起谋个PI当了，如果有几篇CNS，或者已经当上AP，A/P，那兴许就能评千人锦衣还乡了
。但多数的砖工，智商情商拙计，大抵没有这么顺利。只有牛人，才能当上老板push别
人干活。
我从大二起，便在村口的文理学院砖厂里打杂。老板说，too young na... 阅读全帖 |
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O******e
发帖数: 4845 | 42 ☆─────────────────────────────────────☆
icecreamman (qiqi) 于 (Mon Sep 25 17:27:43 2006) 提到:
我不很看好时下的Targeted Therapy，迄今的clinical trial结果都不太好(Gleevec是
例外)，针对PI3K，MAPK，EGFR, Ras到B-Raf的各种药，或是毒性太大，或是无疗效。
我自己比较中意angiogenesis和cancer cell metabolism，因此看好VEGF，mTOR，AMPK
，HIF和glycolysis。
我倾向于把癌症看作是metabolic疾病，而不是genetic疾病。我猜测未来的突破也许会
来自elucidation of the metabolic basis of cell transformation and theparies
based on metabolic perturbation。今天来研究代谢，手段方法比三四十年前多了很
多，所以很可能会有意想不到的新发现。
从大的角度上说，我更认同中医对人体对疾病的理 |
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t****p
发帖数: 1504 | 44 thank you. this help a lot.
if the migration inhibitor is not specific, what will happen、
I saw a lot of inhibitors, such as mTOR or PI3K inhibtors, growth receptor
inhibitors, they are not cell type specific at all. I am confused how these
inhibitors can kill tumor cells at specific window.
a |
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t***s
发帖数: 163 | 45 其实是3个问题：
1. GSK的荧光底物筛选模型 是否是 假阳性
这个几乎是铁板钉钉的事实，4个实验室，5个不同模型全部证明
荧光底物结合SIRT1是假阳性
2. SIRT1能否作为糖尿病（衰老）的靶点
直接从酵母，果蝇跳跃到哺乳动物或人，现在证据不足
一篇SIRT1 gene KO， 几篇transgenic mice的结果
我个人觉得not convincing
3. resveratral及类似物是否直接target SIRT1
resveratral研究很多是hype，流行病学的研究结果
无法在临床试验中重复。
reveratrol的靶点太多（IKK,NFkB,AP1,COX,PI3K）
SIRT1只是最近才提上来的热点
考虑到荧光底物模型的不可靠性，我认为SIRT1是否
直接被resvatroal激活还要重新考虑
其他的类似物也要重新认识
Bottom line
GSK花了冤枉钱，现在还在死撑 |
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c**********r
发帖数: 109 | 46 phosphatidylinositol 3-kinase or Phosphoinositide 3-Kinase
which one is correct? |
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l**********n
发帖数: 240 | 47 Both are correct. But the latter is more commonly used. |
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q******g
发帖数: 3858 | 48 请帮忙找一下这篇文章，发到信箱q*****[email protected] 谢谢!
PI3K-AKT-mTOR pathway is dominant over androgen receptor signaling in
prostate cancer cells
Journal: Cellular Oncology
Issue Volume 32, Number 1-2 / 2010
Pages 11-27 |
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b******3
发帖数: 377 | 49 就一个Lewis C. Cantley挤牙膏挤牙膏一样，做一点发一点，其他人就旁边看，或者跟
着挂点文章。除了PI3K和新发现的PKM2就没啥了哇，将来怎么也就是很有限的几条
pathway有待发现，这是怎么回事？全都是临床的？ |
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K******S
发帖数: 10109 | 50 ft........
it's more complicated than just PI3K and PKM2,
Check out Hanahan & Weinberg's "hallmarks of cancer" review on CELL, yr 2000 |
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