m***n
发帖数: 266 | 1 可能是这个问题太初级，大家不屑回答:-(
anyway, 找到个paper:
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
67A (1): 1-10 OCT 1 2003
用solvent evaporation把PLGA coat在stainless steel上。不知道这样做上去的
PLGA膜在steel substrate上的附着力有多强？ |
|
m***n
发帖数: 266 | 2 如果可以，什么方法？spin coating 行吗？
想把PLGA做surface modification. 多谢！ |
|
b**s
发帖数: 589 | 3 现在作monodisperse PLGA
particle的方法都是什么？普通的solution-precipitation的方法很不可靠。Spray
drier太贵，且分布宽。超声的方法最小也只能做到20 um.
另外要得到5 um的particle怎么分级比较好，用过滤的方法效率很低，离心也不好 |
|
c*******n
发帖数: 1648 | 4 I am a layman of bio stuffs, but how about phase separation method? For
example, say you got a median quality solvent for PLGA and their phase
diagram. You may manipulate conc.,temp, cosolvent, and other parameters of
kinetics of phase separation to get particle size that you want! |
|
d******6
发帖数: 276 | 5 HI blehum
I'd like review MS for JAPS.
pls see the following information. Many thanks
Ⅰ: PERSONAL INFORMATION
Name: Xiaoyi XU
Telephone Number: +1-(650)391-5991
E-mail Address: d******[email protected];
x**[email protected]
Address: Stanford University, School of Medicine
3801 Miranda Ave, Palo Alto, CA, 94304, US
Ⅱ: EDUCATION EXPERIENCE
YEAR INSTITUTION DEGREES /
2003.09-2006.06 Changchun Institute of Applie... 阅读全帖 |
|
d******6
发帖数: 276 | 6 我是做高分子化学药物控释，包括前药这个方向的，求审稿推荐。多谢
Ⅰ: PERSONAL INFORMATION
Name: Xiaoyi XU
Telephone Number: +1-(650)391-5991
E-mail Address: x**[email protected]
Address: Jilin University
Stanford University, School of
Medicine
3801 Miranda Ave, Palo Alto, CA, 94304, US
Ⅱ: EDUCATION EXPERIENCE
YEAR INSTITUTION DEGREES /
2003.09-2006.06 Changchun Institute of Applied Chemistry, Ph... 阅读全帖 |
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W*****s
发帖数: 684 | 7 Direct intracerebral delivery of carboplatin from PLGA microspheres against
experimental malignant glioma in rats Chen, W., He, J., Olson, J.J., Lu, D.
R. 1998 Drug Delivery: Journal of Delivery and Targeting of Therapeutic
Agents 5 (2), pp. 101-110 7
Carboplatin-loaded PLGA microspheres for intracerebral implantation: In
vivo characterization Chen, W., He, J., Olson, J.J., Lu, D.R. 1997 Drug
Delivery: Journal of Delivery and Targeting of Therapeutic Agents 4 (4), pp.
301-311
Thanks a lot... 阅读全帖 |
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W*****s
发帖数: 684 | 8 please get this paper for me. Thanks a lot!
A novel risperidone-loaded SAIB–PLGA mixture matrix depot with a reduced
burst release: effects of solvents and PLGA on drug release behaviors in
vitro/in vivo
Xia Lin, Shenshen Yang, Jingxin Gou, Mingming Zhao and Yu Zhang, et al.
Journal of Materials Science: Materials in Medicine, 2012, Volume 23, Number
2, Pages 443-455 |
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m***n
发帖数: 266 | 9 问题是PLGA有FDA许可，试验一种新的材料不是不可以，只是拿到FDA许可太花时间了吧。
boss觉得PLGA的deadly drawbacks在哪里呢？
materials |
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b**s
发帖数: 589 | 10 Acid generated through degradation of PLGA, I just speak from Tissue
engineering aspect. Most
people say that PLGA is popular only because it's FDA approved
。 |
|
c*w
发帖数: 50 | 11
Not exactly correct. PLA, PLGA and PLGA are hydrophibic, which makes the
implants or drug delivery devices opsonization in vivo. such shortcoming
results in a lot of work on the synthesis of Poly(ethylene glycol)-pLA
copolymers. |
|
c********9
发帖数: 65 | 12 来自主题: Macromolecules版 - 温敏性高分子 这个好像机械强度不太好?不容易降解?PLGA-PEG-PLGA是不是好些？这个能买到么，还
是得自己合成阿 |
|
b**********e
发帖数: 531 | 13 if your backgroud fits well. thanks a lot
Characterization of plasmid DNA location within chitosan/PLGA/pDNA
nanoparticle complexes designed for gene delivery
Abstract
Poly(D,L-lactide-co-glycolide, PLGA)-chitosan nanoparticles are becoming an
increasingly common choice for the delivery of nucleic acids to cells for
various genetic manipulation techniques. These particles are biocompatible,
with tuneable size and surface properties, possessing an overall positive
charge that promotes complex for |
|
发帖数: 1 | 14 这支反政府武装缘何被印度当局视作最大威胁？
2018-03-23 00:15:01 来源：参考军事 责任编辑：董磊
核心提示：从目前的局势看，纳萨尔派在未来仍将是印度政府长期面临的“国内安全头
号威胁”。
参考消息网3月23日报道 近期，一则印度警察在巡逻时遭遇袭击的消息引发了关注。据
《印度斯坦时报》报道称，当地时间3月13日，印度中央预备警察部队（CRPF）在恰蒂
斯加尔邦苏克马区的一处森林执行巡逻任务时遭到突袭。在袭击中，一辆安全部队的防
地雷车被纳萨尔派反政府武装炸毁，造成9名士兵死亡，另有10人受伤。据印度安全部
队发言人透露，遇袭分队隶属于中央预备警察部队第212营。在该分队进入森林地带后
，反政府武装先引爆了预先埋设的多个简易爆炸装置，将一辆警方巡逻车炸毁。在遇袭
后，印度安全部队已经用直升机将伤员转移，截至目前双方未再发生交火。
值得注意的是，这一袭击事件并非孤立事件。仅在袭击发生地——恰蒂斯加尔邦，近期
便发生了多起印度安全部队与纳萨尔派反政府武装的冲突。在13日的袭击发生前，印度
中央预备警察部队在苏克马地区与反政府武装爆发了两次交火，并宣称打死10名武装分
子。在... 阅读全帖 |
|
d***u
发帖数: 118 | 15 急需审稿机会， 希望有人能提供帮助。 先谢谢了！！！ 国内博士毕业，有机化学不
对称合成。 现在美国一个没名气学校博后。我还做过离子液体，药物合成，抗菌的
polymer,以及poly(amido amine)for gene delivery. PLGA 微球合成。我会认真对待
每一篇稿件。 博士期间帮老板审过稿。 |
|
Q*****Y
发帖数: 741 | 16 这是他主页上的文章列表，每篇文章后面都列有影响因子，这种行为很奇葩。说明他很
在意影响因子，不干生物却甚于生物。在流体力学之外，他显然也打起了化学＋纳米＋
材料的主意，他喜欢被attention，追流行。有几篇文章nanoparticle, nanorod 是关
键词。这篇PRL的文章是他独立之后的有限的亮点文章，但却走的是nanopore（这里是
micron size)的路线，主要是实验数据总结，强的理论基础看不出来。可以预见，这哥
们儿去了南方科技大，一定会与那里的纳米灌水风气相结合，搞出很多他想要的高点数
文章来。
另，25篇文章中与其PhD 老板的文章有10篇，构成了他迄今为止有限文章引用数的绝大
部分。
1. Li, K. Krueger, W. Yang, H. Duan, and W. Deng*, Gas-focused Liquid
Microjets from a Slit, Physics of Fluids, 27, 032101 (10 pages) 2015. (IF=1.
9)
2. Zhao, W. Yang, C. Li, Z. Gao, B. Mi... 阅读全帖 |
|
d**********0
发帖数: 13081 | 17 这个学校是天才的摇篮， 300 中占了15名。。
The Harker School, San Jose, CA
Dixit, Shikhar, 17
Immunomodulation by Human Retinal Pigment Epithelial Cell Line ARPE-19
Jin, Andrew, 17
Shedding Light on Human Evolution: Machine Learning Algorithms for
Systematic
Genome-wide Discovery and Characterization of Adaptive Mutations
Kuditipudi, Rohith, 18
Network-based Integration of High Throughput Gene Expression and Methylation
Data
Lin, David, 17
Physical Properties and Evolution of
Lin, David, 17
Physical Properties an... 阅读全帖 |
|
d****i
发帖数: 360 | 18 Please help me with this paper! Thanks!
You can e-mail to l***[email protected]
International Journal of Pharmaceutics 379 (2), pp. 285-292
Characterization of endocytosis of transferrin-coated PLGA nanoparticles by
the blood-brain barrier
Chang, J., Jallouli, Y., Kroubi, M., Yuan, X.-b., Feng, W., Kang, C.-s., Pu,
P.-y., Betbeder, D. 2009 |
|
d***u
发帖数: 118 | 19 急需审稿机会， 希望有人能提供帮助。 先谢谢了！！！ 国内博士毕业，有机化学不
对称合成。 现在美国一个没名气学校博后。我还做过离子液体，药物合成，抗菌的
polymer,以及poly(amido amine)for gene delivery. PLGA 微球合成。我会认真对待
每一篇稿件。 博士期间帮老板审过稿。 |
|
Q*****Y
发帖数: 741 | 20 这是他主页上的文章列表，每篇文章后面都列有影响因子，这种行为很奇葩。说明他很
在意影响因子，不干生物却甚于生物。在流体力学之外，他显然也打起了化学＋纳米＋
材料的主意，他喜欢被attention，追流行。有几篇文章nanoparticle, nanorod 是关
键词。这篇PRL的文章是他独立之后的有限的亮点文章，但却走的是nanopore（这里是
micron size)的路线，主要是实验数据总结，强的理论基础看不出来。可以预见，这哥
们儿去了南方科技大，一定会与那里的纳米灌水风气相结合，搞出很多他想要的高点数
文章来。
另，25篇文章中与其PhD 老板的文章有10篇，够成了他迄今为止有限文章引用数的绝大
部分。
1. Li, K. Krueger, W. Yang, H. Duan, and W. Deng*, Gas-focused Liquid
Microjets from a Slit, Physics of Fluids, 27, 032101 (10 pages) 2015. (IF=1.
9)
2. Zhao, W. Yang, C. Li, Z. Gao, B. Mi... 阅读全帖 |
|
w******e
发帖数: 953 | 21 Manuscript title: "Hyaluronic acid decorated PLGA-PEG nanoparticles for
targeted delivery of SN-38 to ovarian cancer".
Author: Dr Palakurthi.
Journal: International Journal of Nanomedicine.
If you are interested, drop me your contact and short CV.I am have reviewed
too many for this journal. |
|
f*****m
发帖数: 425 | 22 感兴趣的同学请站内联系，留下姓名，联系方式，文章列表
谢谢 |
|
f********6
发帖数: 195 | 23 Journal: International Journal of Nanomedicine.
key words：tendon-bone healing; Nanofibrous membranes; polylactide-
polyglycolide (PLGA); collagen; 3D printing
站内信联系 |
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s**********8
发帖数: 25265 | 24 biocoat是coat啥的? PLA/PLGA based formulation吗? |
|
T*J
发帖数: 116 | 25 【 以下文字转载自 Biology 讨论区 】
发信人: TMJ (Temporomandibular Joint), 信区: Biology
标 题: BMES 2006 Abstract, help
发信站: BBS 未名空间站 (Tue Nov 13 19:35:34 2007)
那位能在网上下载BMES 2006的abstract啊。或者如果参加了2006的BMES,应该会有一个
光盘。里面应该有。 十万火急啊，谢谢。
Dr. Gemeinhat and Chuniang Guo attend the Biomedical Engineering Soceity
annual Meeting in Chicago, IL. Chunqiang presened a poster entitled "
Physicochemical interaction between DNA and chitosan-coated PLGA
nanoparticles".
Arpita Kadakia presented a poster, "Characterization of 3D |
|
d****i
发帖数: 360 | 26 【 以下文字转载自 Postdoc 讨论区 】
发信人: dududi (dududu,Sixth grade driver), 信区: Postdoc
标 题: Please help me with this paper! Thanks!
发信站: BBS 未名空间站 (Mon Sep 14 11:32:04 2009, 美东)
Please help me with this paper! Thanks!
You can e-mail to l***[email protected]
International Journal of Pharmaceutics 379 (2), pp. 285-292
Characterization of endocytosis of transferrin-coated PLGA nanoparticles by
the blood-brain barrier
Chang, J., Jallouli, Y., Kroubi, M., Yuan, X.-b., Feng, W., Kang, C.-s., Pu,
P.-y., Betbeder, D. 2 |
|
d****i
发帖数: 360 | 27 One paper please! Thanks a lot! E-mail: x**********[email protected]
Principles of encapsulating hydrophobic drugs in PLA/PLGA microparticles
Wischke, C., Schwendeman, S.P. 2008 International Journal of Pharmaceutics
364 (2), pp. 298-327 |
|
d****i
发帖数: 360 | 28 One paper please! Thanks a lot! E-mail: x**********[email protected]
Dual agents loaded PLGA nanoparticles: Systematic study of particle size and
drug entrapment efficiency
Song, X., Zhao, Y., Hou, S., Xu, F., Zhao, R., He, J., Cai, Z., (...), Chen
, Q. 2008 European Journal of Pharmaceutics and Biopharmaceutics 69 (2), pp
. 445-453 |
|
d****i
发帖数: 360 | 29 One more paper please! Thanks a lot! E-mail: x**********[email protected]
Synthesis and characterization of PLGA nanoparticles
Authors: Astete, Carlos E.; Sabliov, Cristina M.
Source: Journal of Biomaterials Science, Polymer Edition, Volume 17, Number
3, 2006 , pp. 247-289(43) |
|
b**********e
发帖数: 531 | 30 Let me know if you are familar and willing to review the following paper,
thanks
Preparation and Characterization of Self Emulsified Docetaxel
Abstract
The main goal of this work was to prepare a self-microemulsifying docetaxel
(Dtx) using PLGA, Tetraglycol, Labrasol, and Cremophor ELP. The prepared Dtx
-loaded SMES showed the size of the range of 80–90 nm with narrow size
distribution and the negative zeta-potential values. Its morphology was a
spherical shape by atomic force microscopy. In exp |
|
d****i
发帖数: 360 | 31 Please help me! Thanks a lot! E-mail: x**********[email protected]
A new double emulsion solvent diffusion technique for encapsulating
hydrophilic molecules in PLGA nanoparticles
Show Abstract Cohen-Sela, E., Chorny, M., Koroukhov, N., Danenberg, H.D
., Golomb, G. 2009 Journal of Controlled Release 133 (2), pp. 90-95 |
|
d****i
发帖数: 360 | 32 Please help me! Thanks a lot! E-mail: x**********[email protected]
Journal of Controlled Release
Volume 143, Issue 3, 10 May 2010, Pages 374-382
The effect of surface functionalization of PLGA nanoparticles by heparin- or
chitosan-conjugated Pluronic on tumor targeting |
|
|
d****i
发帖数: 360 | 34 Please help me! Thanks a lot! E-mail: x**********[email protected]
Carboplatin-loaded PLGA microspheres for intracerebral injection:
Formulation and characterization Chen, W., Lu, D.R. 1999 Journal of
Microencapsulation 16 (5), pp. 551-563 |
|
d****i
发帖数: 360 | 35 E-mail: x**********[email protected]
Journal of Controlled Release
Volume 105, Issues 1-2, 20 June 2005, Pages 68-76
Role of zinc in formulation of PLGA/PLA nanoparticles encapsulating
betamethasone phosphate and its release profile |
|
|
W*****s
发帖数: 684 | 37 Pharm Res. 2010 Oct;27(10):2063-74. . Epub 2010 Jul 29.
Development of PLGA-based injectable delivery systems for hydrophobic
fenretinide.
Wischke C, Zhang Y, Mittal S, Schwendeman SP.
doi: 10.1007/s11095-010-0202-y |
|
d***u
发帖数: 118 | 38 急需审稿机会， 希望有好心人能帮助。 先谢谢了！！！ 国内博士毕业，有机化学不
对称合成。 现在美国一个没名气学校博后。我还做过离子液体，药物合成，抗菌的
polymer,以及poly(amido amine)for gene delivery. PLGA 微球合成。我会认真对待
每一篇稿件。 博士期间帮老板审过稿。 |
|
b*o
发帖数: 47 | 39
里
coil
至
多谢讨论。我明白多月太自组装充当一个交联点，但另一个交联点呢？还是倾向于
micell aggregation, something like in the PEG-b-PLGA case. |
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b**s
发帖数: 589 | 40 PLGA and PHB are all gonna be phased out in the future (becuase they are
too expensive and have some deadly drawbacks), we are doing some new materials
instead, |
|
b***e
发帖数: 115 | 41 PLA sounds better than PHB
but, what are you doing ?
PLGA and PHB are all gonna be phased out in the future (becuase they are
too expensive and have some deadly drawbacks), we are doing some new materials
instead, |
|
b**s
发帖数: 589 | 42 You mean 3DP from MIT? they are using particles while we are using PLGA
latex materials which can solidify in room temperature and use just aqueous
media. Also 3DP is limited to one material. We have built a machine for MIT
before.Do you wanna buy one, then I can tell you more detail, heihei.
分
来 |
|
b**s
发帖数: 589 | 43 我都懒得反驳你，看了几篇文章就来对TE妄加评论。哈哈，不要生气。我就问一个简
单的问题：用PLGA为材料，要你做一个scaffold，必须满足时间(growth factor
controlled release)，空间(内部和外部)，组成,机械强度可以控制。还不能加热，不能
用有机溶剂。你现在能做的到吗？我现在可以说我们基本已经完成了这些指标。但我们从
不发文章,我认为发文章是很无聊的事情。你以为Harvard MedScool的文章惨不忍睹。人
家没有把好东西拿出来。首先你从文章来看一个行业的发展，就完全错误。发文
章都是要有经费(当然，混博士的除外)，而每个经费都是要有一个项目，而每个项目都是
有一个大背景的。我来给你分析一下。Tissue engineering的终极目的就是替换器官。那
好，人体都有什么器官？首先是皮肤。人工皮肤也是目前为止唯一成功的Tissue
engineering产品.再就是心脏，当时有个project叫“LIFE”，聚集了一大帮人，最后失
败了。MIT的人工肝脏，最后也失败了。
传递，压力3D控制是可以符合基本机械和化工原理的(虽然复杂得多， |
|
|
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b**s
发帖数: 589 | 46 I saw some microfluidics like cytometry can do it, but the fasted speed is
10 per second @@
what if I need 1000000000000000000 particles?
好 |
|
c*s
发帖数: 2145 | 47 simple, using 100000000000000000 microfluidics set up, then in second, you get
it :)
is
particle的方法都是什么？普通的solution-precipitation的方法很不可靠。Spray
不 |
|
c*******n
发帖数: 1648 | 48 Or block copolymer system? to get well defined particle size and morphology?
After that, cleave one block off to get particles:) |
|
|
c*w
发帖数: 50 | 50 来自主题: Macromolecules版 - 换种说法 what polydispersity means:分布宽？
if you devote some time in method 1, you could get something maningful. should
doing enough experiments to find the feeling of obtaining monodispersity PLGA
particles.some factors: the stirrer used, the beaker shape(high and slim one
better), surfactant concentration..
【 在 boss (养蜂人) 的大作中提到: 】
溶
高分子溶解在有机溶剂中，在超声波的作用下从微孔中inject到溶有surfactant
不 |
|
