y*****g
发帖数: 1822 | 1 游戏玩家破解蛋白质谜题，艾滋病研究有望获重大突破
仅用了三周时间，游戏玩家就解决了一个困扰科学家好几年的难题。一群玩家通过玩游
戏发现了一种蛋白质的结构，这种蛋白质在艾滋病毒生长过程中起到了至关重要的作用
。该发现标志着人类有望在艾滋病毒（HIV）和艾滋病（AIDS）研究领域获得重大突破
。这一成果刊登在《自然—结构与分子生物学》
在一款名叫Foldit的游戏中，玩家可以预测逆转录病毒蛋白酶的结构，这种酶在艾滋病
毒复制过程中起到了关键作用。从理论上讲，解开这种蛋白质的结构可以帮助科学家开
发阻止蛋白酶传布的药物。
“很多人尝试通过分子替代的方法解决M-PMV的晶体结构问题，但都失败了，于是我们
向蛋白质折叠游戏Foldit的玩家发起了挑战，让他们制作该蛋白质的精确模型。出人意
料的是，这些玩家制作的模型质量很高，可成功地用于分子替代和结构判断。这种更准
确的结构为设计抗逆转录病毒药物提供了新的见解。”
人类具有空间推理能力，这是计算机所不擅长的。游戏则提供了一个框架，把计算机和
人类的优势整合到一起。Foldit首席设计师Seth Cooper说到。
这项通过Foldit取得的突破不... 阅读全帖 |
|
d*********9
发帖数: 30 | 2 家具房间出租. The house near to University of Maryland and FDA. Walk to bus
stations for bus to Silver Spring Metro station, UMCP and Washington DC. It
is about 1 mile to UMCP shuttle 108(PMV line) in Powder Mill Road. Walk to
FDA office (0.8 mile) in New Hampshire Ave. It is about one mile to Shopping
mall, Restaurants and Supermarket.
Furnished rooms have big windows. Washer and dryer, central air condition
and heating in the house, Free Parking space. FIOS internet is available to
be shared.
single... 阅读全帖 |
|
d*********9
发帖数: 30 | 3 Furniture room for rent in a single house. The house locates in a quiet,
safe and beautiful community. The house near to University of Maryland and
FDA office.
1. Walk to bus stations for bus to Silver Spring Metro station, UMCP and
Washington DC.
2. About 1 mile to UMCP shuttle 108(PMV line) in Powder Mill Road. Walk to
FDA office (0.8 mile) in New Hampshire Ave.
3. About one mile to Shopping mall, Restaurants and Supermarket.
4. Free washer and dryer,
5. Central air condition and heating in th... 阅读全帖 |
|
d*********9
发帖数: 30 | 4 楼上二楼房间出租,房间采光好，有家具近 Silver Spring, FDA USDA UMCP. The
house locates in a quiet, safe and beautiful community. The house near to
University of Maryland and FDA office.
1. Walk to bus stations for bus to Silver Spring Downtown Metro station,
2. C8 bus from house to University of Maryland, UMCP.
3. About 1 mile to UMCP shuttle 108(PMV line) in Powder Mill Road to UMCP.
4. Walk to FDA office (0.8 mile) in New Hampshire Ave.
5. About one mile to two Shopping malls, Restaurants and Supermarket.
6. Fre... 阅读全帖 |
|
d*********9
发帖数: 30 | 5 Furniture room for rent in a single house. The house locates in a quiet,
safe and beautiful community. The house near to University of Maryland and
FDA.
1. Walk to bus stations for bus to Silver Spring Metro station, UMCP and
Washington DC.
2. About 1 mile to UMCP shuttle 108(PMV line) in Powder Mill Road. Walk
to FDA office (0.8 mile) in New Hampshire Ave.
3. About one mile to Shopping mall, Restaurants and Supermarket.
4. Free washer and dryer,
5. Central air condition and heat... 阅读全帖 |
|
d*********9
发帖数: 30 | 6 Two rooms for rent with simple furniture in a single house are available now
. One big room and a middle sized room. The house locates in a quiet, safe
and beautiful community. The house near to University of Maryland and FDA.
Walk to bus stations for bus to Silver Spring Metro station, UMCP and
Washington DC. It is about 1 mile to UMCP shuttle 108(PMV line) in Powder
Mill Road. Walk to FDA office (0.8 mile) in New Hampshire Ave. It is about
one mile to Shopping mall, Restaurants and Supermarket... 阅读全帖 |
|
d*********9
发帖数: 30 | 7 家具房间出租. The house near to University of Maryland and FDA. Walk to bus
stations for bus to Silver Spring Metro station, UMCP and Washington DC. It
is about 1 mile to UMCP shuttle 108(PMV line) in Powder Mill Road. Walk to
FDA office (0.8 mile) in New Hampshire Ave. It is about one mile to Shopping
mall, Restaurants and Supermarket.
Furnished rooms have big windows. Washer and dryer, central air condition
and heating in the house, Free Parking space. FIOS internet is available to
be shared.
single... 阅读全帖 |
|
d*********9
发帖数: 30 | 8 Furniture room for rent in a single house. The house locates in a quiet,
safe and beautiful community. The house near to University of Maryland and
FDA office.
1. Walk to bus stations for bus to Silver Spring Metro station, UMCP and
Washington DC.
2. About 1 mile to UMCP shuttle 108(PMV line) in Powder Mill Road. Walk to
FDA office (0.8 mile) in New Hampshire Ave.
3. About one mile to Shopping mall, Restaurants and Supermarket.
4. Free washer and dryer,
5. Central air condition and heating in th... 阅读全帖 |
|
d*********9
发帖数: 30 | 9 Furniture room for rent in a single house. The house locates in a quiet,
safe and beautiful community. The house near to FDA office and University of
Maryland.Bus to Silver Spring and Washington DC.
1. Walk to bus stations for bus to Silver Spring Metro station, UMCP and
Washington DC.
2. About 1 mile to UMCP shuttle 108(PMV line) in Powder Mill Road. Walk to
FDA office (0.8 mile) in New Hampshire Ave.
3. About one mile to Shopping mall, Restaurants and Supermarket.
4. Free washer and dryer,
5.... 阅读全帖 |
|
d*********9
发帖数: 30 | 10 Furnished Bedroom for rent in a single house. The house locates in a quiet,
safe and beautiful community. The house near to University of Maryland and
FDA.
1. Walk to bus stations for bus to Silver Spring Metro station, UMCP and
Washington DC.
2. About 1 mile to UMCP shuttle 108(PMV line) in Powder Mill Road. Walk to
FDA office (0.8 mile) in New Hampshire Ave.
3. About one mile to Shopping mall, Restaurants and Supermarket.
4. Free washer and dryer,
5. Central air condition and heating in the ho... 阅读全帖 |
|
d*********9
发帖数: 30 | 11 Furnished Bedroom for rent in a single house. The house locates in a quiet,
safe and beautiful community. The house near to University of Maryland and
FDA.
1. Walk to bus stations for bus to Silver Spring Metro station and
Washington DC.
2. About 1 mile to UMCP shuttle 108(PMV line) in Powder Mill Road. Walk to
FDA office (0.8 mile) in New Hampshire Ave.
3. About one mile to Shopping mall, Restaurants and Supermarket.
4. Free washer and dryer,
5. Central air condition and heating in the house,
6... 阅读全帖 |
|
d*********9
发帖数: 30 | 12 Furnished Bedroom for rent in a single house. The house locates in a quiet,
safe and beautiful community. The house near to University of Maryland and
FDA.
1. Walk to bus stations for bus to Silver Spring Metro station, UMCP and
Washington DC.
2. About 1 mile to UMCP shuttle 108(PMV line) in Powder Mill Road. Walk to
FDA office (0.8 mile) in New Hampshire Ave.
3. About one mile to Shopping mall, Restaurants and Supermarket.
4. Free washer and dryer,
5. Central air condition and heating in the ho... 阅读全帖 |
|
d*********9
发帖数: 30 | 13 Furnished Bedroom for rent in a single house. The house locates in a quiet,
safe and beautiful community. The house near to University of Maryland and
FDA.
1. Walk to bus stations for bus to Silver Spring Metro station, UMCP and
Washington DC.
2. About 1 mile to UMCP shuttle 108(PMV line) in Powder Mill Road. Walk to
FDA office (0.8 mile) in New Hampshire Ave.
3. About one mile to Shopping mall, Restaurants and Supermarket.
4. Free washer and dryer,
5. Central air condition and heating in the ho... 阅读全帖 |
|
d*********9
发帖数: 30 | 14 Furnished Bedroom for rent in a single house. The house locates in a quiet,
safe and beautiful community. The house near to University of Maryland and
FDA.
1. Walk to bus stations for bus to Silver Spring Metro station, UMCP and
Washington DC.
2. About 1 mile to UMCP shuttle 108(PMV line) in Powder Mill Road. Walk to
FDA office (0.8 mile) in New Hampshire Ave.
3. About one mile to Shopping mall, Restaurants and Supermarket.
4. Free washer and dryer,
5. Central air condition and heating in the ho... 阅读全帖 |
|
d*********9
发帖数: 30 | 15 楼上二楼房间出租,房间采光好，有家具近 Silver Spring, FDA USDA UMCP. The
house locates in a quiet, safe and beautiful community. The house near to
University of Maryland and FDA office.
1. Walk to bus stations for bus to Silver Spring Downtown Metro station,
2. C8 bus from house to University of Maryland, UMCP.
3. About 1 mile to UMCP shuttle 108(PMV line) in Powder Mill Road to UMCP.
4. Walk to FDA office (0.8 mile) in New Hampshire Ave.
5. About one mile to two Shopping malls, Restaurants and Supermarket.
6. Fre... 阅读全帖 |
|
d*********9
发帖数: 30 | 16 家具房出租. furnished room for rent in a single house. The house locates in
a quiet, safe and beautiful community. Walk to FDA office (0.8 mile) in New
Hampshire Ave. Close to University of Maryland. Walk to bus stations for bus
to Silver Spring Metro station, UMCP and Washington DC. It is about 1 mile
to UM shuttle 108(PMV line) in Powder Mill Road. It is about one mile to
Shopping Center, Restaurants.
Furnished room with big windows, Free in house washer and dryer, Central air
condition and heating... 阅读全帖 |
|
d*********9
发帖数: 30 | 17 Furniture room for rent in a single house. The house locates in a quiet,
safe and beautiful community. The house near to University of Maryland and
FDA.
1. Walk to bus stations for bus to Silver Spring Metro station, UMCP and
Washington DC.
2. About 1 mile to UMCP shuttle 108(PMV line) in Powder Mill Road. Walk
to FDA office (0.8 mile) in New Hampshire Ave.
3. About one mile to Shopping mall, Restaurants and Supermarket.
4. Free washer and dryer,
5. Central air condition and heat... 阅读全帖 |
|
d*********9
发帖数: 30 | 18 Silver Spring Maryland 雅房出租 近 FDA and 马里兰大学. 房間有供應床、桌、椅
等家具. C8 Metro Bus 可載你到馬里蘭大學內。
房子是在一個安靜而且安全的地區,步行到 FDA 办公室 (0.8 mile) in New Hampshire
Ave.
Close to University of Maryland. Walk to bus stations for bus to Silver
Spring Metro station, UMCP and Washington DC.
It is about 1 mile to UM shuttle 108(PMV line) in Powder Mill Road. It is
about one mile to two shopping Center, Restaurants.
1. Furnished room,
2. Free in house washer and dryer,
3. Central air condition and heating,
4. Free Parking s... 阅读全帖 |
|
d*********9
发帖数: 30 | 19 Silver Spring Maryland 雅房出租 近 FDA and 马里兰大学. 房間有供應床、桌、椅
等家具. C8 Metro Bus 可載你到馬里蘭大學內。
房子是在一個安靜而且安全的地區,步行到 FDA 办公室 (0.8 mile) in New Hampshire
Ave.
Close to University of Maryland. Walk to bus stations for bus to Silver
Spring Metro station, UMCP and Washington DC.
It is about 1 mile to UM shuttle 108(PMV line) in Powder Mill Road. It is
about one mile to two shopping Center, Restaurants.
1. Furnished room with two big windows,
2. Free in house washer and dryer,
3. Central air condition and heati... 阅读全帖 |
|
B******1
发帖数: 9094 | 20 A widely-accepted idea is that work and play cannot possibly be used in the
same sentence. Indeed, whoever thought they were must have heard wrong.
Work is something you do so that you have enough money for a decent method
of recreation. However, that is not always the case, as studies have shown
that interest in one’s subject quickens the rate of learning, which is true
if you think about it. If you find something intriguing, you would, at
any rate, be keener to learn about it. If you believe i... 阅读全帖 |
|
|
t******g
发帖数: 17520 | 22 Using a game called Foldit, gamers build enzyme models that may be crucial
to understanding how many diseases do their damage. Scientists couldn’t
solve the crystal structure of the M-PMV retroviral protease for more than
10 years. Gamers solved it in 10 days. Zoran Popovic is one of the
conceptual designers of Foldit - a kind of 3 dimensional Tetris.
http://www.msnbc.msn.com/id/44668197/ns/local_news-new_orleans_ |
|
s*m
发帖数: 40 | 23 相关的内容很多，Google一下又很多，我就长话短说，说说主流面板
TN：最普遍的，画质差点，视角小，反应最快(up to 2ms)，适合打游戏，不适合处理
照片
MVA：没用过，Bestbuy里看过Gateway 24寸的，画质不错，反映时间也可以，有JR GC
的可以从他们那里买Gate 24
PMV，三星的，各方面都不错，画质不是最好的，而且不便宜，Dell 2407就是用这个面
板，Samsung 215TW也是，
S-IPS，画质非常好，反映时间有点慢，不适合打游戏，代表Dell 2007WFP
AS-IPS，S-IPS的改进版，各方面都是最好的，就是太贵了。20寸的NEC 20WMGX2 要六
百多， |
|
d*****0
发帖数: 68029 | 24 【 以下文字转载自 Joke 讨论区 】
发信人: daemonself (mit行为艺术专业博士后导师), 信区: Joke
标 题: 网游玩家破解蛋白质结构 结果获得科学验证认可
发信站: BBS 未名空间站 (Wed Sep 21 01:01:05 2011, 美东)
网上玩玩游戏就可以在著名的英国《自然》系列学术刊物上发表论文？这听起来非常不
可思议，但《自然・结构和分子生物学》杂志近日发表了这样一篇有网络游戏玩
家署名的论文：《蛋白质折叠游戏玩家揭示一种单分子逆转录病毒蛋白酶的晶体结构》。
文中提到的蛋白质折叠游戏名为Foldit，是美国华盛顿大学研究人员开发的一款具有浓
厚科学色彩的网络游戏。游戏玩家要做的是，在给定一个目标蛋白质后，在遵守科学规
律的前提下，用氨基酸如搭积木一样把目标蛋白质“搭建”出来。
玩这个游戏其实不需要太多科学知识，只要遵守预先设定的规则就行。玩家每次游戏成
功都可获得积分，提升自己在游戏世界的知名度，碰到难题时还可以在网上和其他玩家
交流。
此次被破解结构的蛋白质名为M-PMV，是一种与猴类艾滋病病毒有关的蛋白质。科研人
员一直没能... 阅读全帖 |
|
d********f
发帖数: 43471 | 25 网上玩玩游戏就可以在著名的英国《自然》系列学术刊物上发表论文？这听起来非常不
可思议，但《自然・结构和分子生物学》杂志近日发表了这样一篇有网络游戏玩
家署名的论文：《蛋白质折叠游戏玩家揭示一种单分子逆转录病毒蛋白酶的晶体结构》。
文中提到的蛋白质折叠游戏名为Foldit，是美国华盛顿大学研究人员开发的一款具有浓
厚科学色彩的网络游戏。游戏玩家要做的是，在给定一个目标蛋白质后，在遵守科学规
律的前提下，用氨基酸如搭积木一样把目标蛋白质“搭建”出来。
玩这个游戏其实不需要太多科学知识，只要遵守预先设定的规则就行。玩家每次游戏成
功都可获得积分，提升自己在游戏世界的知名度，碰到难题时还可以在网上和其他玩家
交流。
此次被破解结构的蛋白质名为M-PMV，是一种与猴类艾滋病病毒有关的蛋白质。科研人
员一直没能探明它的具体结构。华盛顿大学研究人员于是把这个蛋白质设为目标，放入
Foldit游戏中。没过多久，就有玩家找出了可能的氨基酸组装方式。
华盛顿大学研究人员随之用X射线等对游戏玩家给出的结果进行了验证，发现这个玩出
的结果是准确的。于是在有关论文的作者中，出现了Foldit游戏中... 阅读全帖 |
|
f******b
发帖数: 1148 | 26 They are both managed by SM company but from my personal experience, the
managing philosophy is totally different.
PMV is relatively easy to apply and always has vacancies for new students
every fall. Sometimes we even have reference bonus for having friends sign
new lease there. But honestly it's not a 5-years long term option.
First of all, the community is not as safe as other SM apartments. Graduate
hills ( and Graduate gardens I assume) have blue emergency lamps which you
can directly talk |
|
P*****s
发帖数: 166 | 27 Available on Aug 1, but early move is negotiable.
All utilities included! Nice roommates (both are UMD graduate students)
On UM shuttle route.
High speed internet ready to share.
Please message me or call 240-582-1018 if interested. |
|
|
m*****u
发帖数: 15526 | 29 新华社伦敦9月19日电(记者黄堃)在网上玩玩游戏就可以在著名的英国《自然》系列学
术刊物上发表论文？这听起来非常不可思议，但《自然·结构和分子生物学》杂志近日
发表了这样一篇有网络游戏玩家署名的论文：《蛋白质折叠游戏玩家揭示一种单分子逆
转录病毒蛋白酶的晶体结构》。 www.6park.com
文中提到的蛋白质折叠游戏名为Foldit，是美国华盛顿大学研究人员开发的一款具
有浓厚科学色彩的网络游戏。游戏玩家要做的是，在给定一个目标蛋白质后，在遵守科
学规律的前提下，用氨基酸如搭积木一样把目标蛋白质“搭建”出来。 www.6park.com
玩这个游戏其实不需要太多科学知识，只要遵守预先设定的规则就行。玩家每次游
戏成功都可获得积分，提升自己在游戏世界的知名度，碰到难题时还可以在网上和其他
玩家交流。 www.6park.com
此次被破解结构的蛋白质名为M-PMV，是一种与猴类艾滋病病毒有关的蛋白质。科
研人员一直没能探明它的具体结构。华盛顿大学研究人员于是把这个蛋白质设为目标，
放入Foldit游戏中。没过多久，就有玩家找出了可能的氨基酸组装方式。 www.6park.
com
华盛... 阅读全帖 |
|
