v**********m
发帖数: 5516 | 1 Volume 134>>Issue 44 : Tuesday, October 7, 2014
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Excess postdocs causes quiet crisis
Well-educated trainees seen as source of cheap scientific labor
ByCarolyn Y. Johnson
THE BOSTON GLOBE
October 7, 2014
The life of the humble biomedical postdoctoral researcher was never easy:
toiling in obscurity in a low-paying scientific apprenticeship that can
stretch more than a decade. The long hours were w... 阅读全帖 |
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x********i
发帖数: 905 | 2 2016 Breakthrough Prize in Life Sciences
The Breakthrough Prize in Life Sciences honors transformative advances
toward understanding living systems and extending human life, with one prize
dedicated to work that contributes to the understanding of Parkinson’s
disease and neurodegenerative disorders.
Edward S. Boyden, Massachusetts Institute of Technology: for the development
and implementation of optogenetics – the programming of neurons to express
light-activated ion channels and pumps, so that... 阅读全帖 |
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b*****b
发帖数: 14 | 3 1.Ann Neurol. 1998 Jul;44(1):17-26.
Longitudinal study of cerebrospinal fluid levels of tau, A beta1-40, and A
beta1-42(43) in Alzheimer's disease: a study in Japan.
Kanai M
2.Neurobiol Aging. 2013 Oct;34(10):2441.e7-8. doi: 10.1016/j.neurobiolaging.
2013.04.012. Epub 2013 May 4.
Absence of A673T amyloid-β precursor protein variant in Alzheimer's disease
and other neurological diseases.
Ting SK
谢谢！
please email to:
[email protected]/* */
Thanks! |
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s*********n
发帖数: 128 | 4 http://link.springer.com/article/10.1007/s13361-014-1059-9
Herein, we developed two novel cysteine-based quantitative proteomics
workflows. The first method is cysteine-selective precursor dimethyl
labeling (cysDML). In this workflow, cysteinyl-peptides are captured on a
commercially available Thiopropyl Sepharose 6B resin and captured peptides
are labeled on resin with either light (–C2H6) or heavy (–13C2 2H6)
dimethyl tags [43]. CysDML appears to be a convenient, efficient, accurate,
and affor... 阅读全帖 |
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f*******9
发帖数: 74 | 5 我们用Orbitrap XL和Elite，一个代谢质谱的样本(MS1/2)，通常可以有5000 +/- 2000
的二级质谱MS2，然后对MS1 precursor ion进行peak identification之后，MS1 + MS2
+ RT的特征通常有>1000 个。
而和标品库对比之后，一般只能找到<50个化合物——这个数量取决于你的标品质量怎
样，覆盖度有多广。50是很高的数值了，我们与Thermo的msCloud标品库比较通常只能
找到个位数的化合物，和MassBank比较，发现的也很少，但我们自己的库，对植物比较
有针对性，就能找到很多。
如果做很多样本，那么能发现的特征就会增加，一倍以上吧。
然后还有很多没有MS2的离子，很多的峰非常明显，离子强度也高，不知道为什么没有
被裂解。实际上我分析过裂解的离子的强度，有相当数量的强度很低，在full scan里
面也不明显，有的甚至看上去是噪音。
不知道各大药厂是怎么利用LC-MS的，特别关心天然产物里面的应用，有谁来讲一讲？ |
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g*****x
发帖数: 3283 | 6
pico mole is enough, but this depends on how complex your sample is. If you
know what your target is, instead of doing shotgun proteomics, you can
develop a targeted method so the sensitivity can be improved by 5-10x.
For full cell lysate sample, if you wanna do ultra-deep discovery and
quantification, routinely you need to do fractionating (sec, iex, gelfree)
before digestion.
On current MS instrument, data-dependent acquisition can do dynamic or
static exclusion for the peptide precursors, so... 阅读全帖 |
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n********0
发帖数: 11 | 7 你说的dda 的exclusion list 效果能有多好呢?而且他要是定量的话，你的
housekeeping 蛋白都exclusive了 还怎么能相对定量?
应该是dia吧 data 全记录。
2. 用质谱做全细胞proteomics定量，信号是否很难解析？因为一些house keeping
For full cell lysate sample, if you wanna do ultra-deep discovery and
quantification, routinely you need to do fractionating (sec, iex, gelfree)
before digestion.
On current MS instrument, data-dependent acquisition can do dynamic or
static exclusion for the peptide precursors, so peptides from high-abundance
protein will not cover the signals from ... 阅读全帖 |
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d****i
发帖数: 360 | 8 Synthesis by AGET ATRP of degradable nanogel precursors for in situ
formation of nanostructured hyaluronic acid hydrogel. Bencherif, S.A.,
Washburn, N.R., Matyjaszewski, K. Biomacromolecules, Volume 10, Issue 9, 14
September 2009, Pages 2499-2507
Thanks a lot! |
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d****i
发帖数: 360 | 9 Synthesis by AGET ATRP of degradable nanogel precursors for in situ
formation of nanostructured hyaluronic acid hydrogel. Bencherif, S.A.,
Washburn, N.R., Matyjaszewski, K. Biomacromolecules, Volume 10, Issue 9, 14
September 2009, Pages 2499-2507
Thanks a lot! |
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q****i
发帖数: 6923 | 10 Title: POLYCARBOSILANE PRECURSORS FOR SILICON-CARBIDE
Author(s): SCHILLING CL, WESSON JP, WILLIAMS TC
Source: AMERICAN CERAMIC SOCIETY BULLETIN Volume: 62 Issue: 8 Pages:
912-915 Published: 1983
Times Cited: 81
q************[email protected] |
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l****u
发帖数: 3449 | 11 sent
hydrocarbon ion rearrangements in phenylborolanes under electron impact.
(1972-1999)
triphenylboroxin and its precursor phenylboronic acid. |
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d****i
发帖数: 360 | 12 Viability and differentiation of neural precursors on hyaluronic acid
hydrogel scaffold
Pan, L., Ren, Y., Cui, F., Xu, Q. 2009 Journal of Neuroscience Research 87
(14), pp. 3207-3220
e-mail: x**********[email protected] |
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b******3
发帖数: 62 | 13 A facile and high-yielding synthesis of symmetrical and unsymmetrical diaryl
alkynes using diethyl dichloromethylphosphonate as precursor.
Synthesis (1998), (3), 271-274.
My email address: c****[email protected]. Thank you very much. |
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f*******i
发帖数: 8492 | 14 Many thanks!!
Phytochemical Analysis
Volume 4 Issue 3, Pages 120 - 123
Published Online: 2 Mar 2007
Quantification of benzaldehyde and its precursors in montmorency cherry (Pru
nus cerasus L.) kernels
Amitabh Chandra, Muraleedharan G. Nair *
Department of Horticulture, Bioactive Natural Products Laboratory, Michigan
State University, East Lansing, Michigan 48824, USA
Received: 10 September 1992; Accepted: 6 December 1992
DIGITAL OBJECT IDENTIFIER (DOI)
10.1002/pca.2800040308 About DOI
Link:
htt |
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O*******f
发帖数: 926 | 15 过氧化物的precursor should be superoxide...good work, but also need more
work |
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n*******y
发帖数: 22 | 16 Are chlorinated phenols precursors of bleach plant dioxins?
Chemosphere, Volume 28, Issue 10, May 1994, Pages 1883-1894
C.E. Luthe, R.M. Berry, R.H. Voss
Occurrence of PCDDs and PCDFs in pulp and board products
Chemosphere, Volume 19, Issues 1-6, 1989, Pages 721-726
V.H. Kitunen, M.S. Salkinoja-Salonen
Give baozi, thanks!
My email address is p***********[email protected] |
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s*********n
发帖数: 68 | 21 Polymer Bulletin
Volume 35, Number 3, 291-297, DOI: 10.1007/BF00963126
Synthesis of poly(vinyl alcohol)s with narrow molecular weight distribution
from poly(benzyl vinyl ether) precursors
Clive Forder, Steven P. Armes and Norman C. Billingham
s*********[email protected]
Thanks a lot. |
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d****i
发帖数: 360 | 22 Polymer
Volume 13, Issue 10, October 1972, Pages 462-464
High polymers of acrylic and methacrylic esters of N-hydroxysuccinimide as
polyacrylamide and polymethacrylamide precursors
P. Ferrutia, A. Bettellia and Angelino Feréa
Thanks a lot! |
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d****i
发帖数: 360 | 23 Help me please! Thanks a lots!
Polymer
Volume 13, Issue 10, October 1972, Pages 462-464
High polymers of acrylic and methacrylic esters of N-hydroxysuccinimide as
polyacrylamide and polymethacrylamide precursors
P. Ferrutia, A. Bettellia and Angelino Feréa
Thanks a lot! |
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v******0
发帖数: 265 | 24 请问为什么ion trap不适合做precursor ion scan, MRM？而triple quatrople不适合
做identification呢？ |
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b*******g
发帖数: 1309 | 25 Ion trap 做ID 的优势 一个是 可以多级MSn, 另外一个是ion accumulation，灵敏度高
QQQ 适合MRM,linear range 比较广
其实如果硬要做precursor ion scan，并且用ion trap， 可以看看 AB 的QTRAP，结合
了两者的优势 QQ+linear ion trap |
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z****a
发帖数: 372 | 26 我想找metal precursors (e.g.Li3N),这种高温分解产生金属的化合物,或者是含Li,
Na的盐,高温分解生成金属的都可以....有没有阿,头都想大了 |
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m****q
发帖数: 118 | 27 【 以下文字转载自 Immigration 讨论区 】
发信人: mbdshq (mbdshq), 信区: Immigration
标 题: 审稿机会：金纳米粒子的制备和性质测量
发信站: BBS 未名空间站 (Wed Feb 8 00:05:46 2012, 美东)
用一种新的precursor salt制备的Au nanoparticle - pvp core-shell structure
表征手段：UV-Visible, FTIR, zeta potential, TEM.
有兴趣且有能力审稿的朋友请发站内信件：
注明是来自本贴
姓名
联系方式
科研单位及研究小组的link
如果有本人的publication list更好
本贴24小时有效
符合审稿条件的里面
先到先得
谢谢 |
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v*********r
发帖数: 184 | 28 那请问rayon做出来的是什么特性？
我看书上说可以通过调节stabilization,carbonation的条件来得到不同性质的碳纤维。
所以难道PAN就不能做高模，Pitch做高强么？
有什么特性是不管你如何做，最后得到碳纤维的性质就是和precursor相关的么？特别
是rayon做前身的？
因为在美国不生产了，书上提得很少。
谢谢！ |
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v*********r
发帖数: 184 | 29 那SEM或者TEM看得出来从不同precursor生成的 carbon fiber的区别吗？
另外有没有什么实验室可以做 tensile，thermal,electrical 表征的可以推荐一下？
对外收钱服务的那种。
谢谢！ |
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L****r
发帖数: 333 | 30 嘎tech化学 got Younan Xia, in 2011 he publsihed 11 Angewandte Chemie
International Edition.
(1) Silver nanocrystals with concave surfaces and their optical and surface-
enhanced Raman scattering properties
Xia, X.; Zeng, J.; McDearmon, B.; Zheng, Y.; Li, Q. and Xia, Y. Angewandte
Chemie International Edition 2011, 50, 12542-12546 (VIP article, highlighted
on the inside cover).
(2) Shape-controlled synthesis of copper nanocrystals in an aqueous solution
with glucose as a reducing agent and hexadecyl... 阅读全帖 |
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j********1
发帖数: 628 | 31 这𠆤好象比较浪费，一大半Pt都沉积在反应器壁和sopport上了。而且如果是真
正的ALD的话，一大半Pt会被抽走，底物表面的coverage可能只是sub-mono layer, 多
搞几个循环做到几𠆤纳米的话，Pt precursor的利用率会很低的。
化。 |
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S*****n
发帖数: 6055 | 32 现在催化剂做ALD只是demonstrate concept
真正要scale up的话，抽出来的Pt precursor循环利用是非常简单的事情 |
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q****i
发帖数: 6923 | 34 Synthesis and characterization of novel polycarbonate-polydimethylsiloxane
block copolymers with controlled block lengths and an alternating block
architecture
Annual Technical Conference of the Society of Plastics Engineers (2011),
69th, (Vol. 2), 1141-1145
Fluorine-containing poly(carbonate-block-siloxane) copolymers
Polymer Science, Series B (2012), 54, (1-2), 94-98
Research progress of hyperbranched polysiloxane (II)
Quick View Full Text
By Huang, Yan
From Xiandai Tuliao Yu Tuzhuang (2007), ... 阅读全帖 |
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z****r
发帖数: 245 | 35 我本来以为这种方法在scale up的时候precursor diffusion distribution会是一个问
题。如果能量产并能成本控制的话还是挺好的。 |
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S*****r
发帖数: 139 | 36 Design, Synthesis and ALD Assessment of Organometallic Precursors for
Semiconductor Applications
doi: 10.1149/06409.0233ecst
ECS Trans. 2014 volume 64, issue 9, 233-241
http://ecst.ecsdl.org/content/64/9/233.abstract
多谢了！！
Email：[email protected]
/* */ |
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s*****5
发帖数: 52 | 39 【 以下文字转载自 Biology 讨论区 】
发信人: shxm725 (晓晓), 信区: Biology
标 题: 问有关质谱ETD/CID decision tree的问题
发信站: BBS 未名空间站 (Tue Apr 28 18:11:47 2015, 美东)
问版上做质谱的行家，有重复过Josh coon几年前发表的那个ETD/CID decision tree的
方法吗?就是用ETD碎裂高电荷低M/Z的precursor,其他的用CID. 我最近在Orbitrap
Fusion上试图重复，发现ETD使CID的scan数也减少了很多，最后还不如只用CID。只用
ETD得到的蛋白数比CID少非常多，觉得可能是反应时间设的过长,但是设的短谱图质量
看起来很低。顺便求问如何优化ETD的参数及注意事项等，谢谢！ |
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a**u
发帖数: 8107 | 40 【 以下文字转载自 Wisdom 讨论区 】
发信人: airdragon77 (aid), 信区: Wisdom
标 题: Re: 全世界最大的维他命实验 (转载)
发信站: BBS 未名空间站 (Tue Dec 8 00:21:52 2009, 美东)
你倒真是独具慧眼,呵呵。希望你能读懂英文。
文中所说的实验显然就是下文所提到的，用到的吸烟者人数（２万９千），持续时间（
５到８年）都吻合；实验用到的也是维他命Ｅ和Ａ（β-carotene is a precursor to
vitamin A ）。不同的是，对结果的描述完全相反。
http://www.cancer.org/docroot/NWS/content/NWS_1_1x_Vitamin_E_and_Lung_Cancer_Risk.asp
Even though a large randomized trial of smokers in Finland found no benefit
from vitamin E against lung cancer, research suggests it may be t |
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t*****e
发帖数: 224 | 41 这是萨谬而森在AER发表的ECONOMISTS AND THE HISTORY OF IDEAS的关于马克思的节选。
其余的我有时间再整理贴出来。（只能找到扫描的pdf版本，不得不用OCR软件转化为文本
。。。）
Karl Marx. （from ECONOMISTS AND THE HISTORY OF IDEAS* By PAUL A. SAMUELSON
The American Economic Review, Vol 52, No. 1, pp. 1-18）
From the viewpoint of pure economic theory, Karl Marx can be regarded as a
minor post-Ricardian. Unknowingly I once delighted a southern university
audience: my description of Marx as a not uninteresting precursor (in Volume
2 of Capital) of Leontief's input- |
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发帖数: 1 | 42 小弟是刚毕业的硕士学生。在实验室主要是做Graphene solar cell的，有两年的实验
室经验，已经thesis答辩完，马上准备发paper。最近找工作找的快崩溃了，求相关的
公司的前辈，帮忙内推。
贴上我的工作经历。
• At UIC, my thesis research focus is to develop transfer-free
graphene-on-silicon heterojunction solar cells and plasmonics enhancement of
photo-conversion efficiency and received 1.5% PCE
• Tested and optimized critical parameters to solve graphene
quality problem via Raman, XPS, FESEM
• Monitored the parameters (pressure, temperature, precursor gas
flow ... 阅读全帖 |
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H***F
发帖数: 2501 | 43 刷题
小弟是刚毕业的硕士学生。在实验室主要是做Graphene solar cell的，有两年的实验
室经验，已经thesis答辩完，马上准备发paper。最近找工作找的快崩溃了，求相关的
公司的前辈，帮忙内推。
贴上我的工作经历。
• At UIC, my thesis research focus is to develop transfer-free
graphene-on-silicon heterojunction solar cells and plasmonics enhancement of
photo-conversion efficiency and received 1.5% PCE
• Tested and optimized critical parameters to solve graphene
quality problem via Raman, XPS, FESEM
• Monitored the parameters (pressure, temperature, precursor gas
f... 阅读全帖 |
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a*****a
发帖数: 1038 | 44 Keep in mind, only free chlorine reacts with DBP precursor, such as humic
acid, to produce TTHMs or HAA5s. The chlorine dioxide does not produce
these two DBPs above. However, the chlorine dixoide does produce its unique
byproduct, chlorite, which is in the EPA primary drinking water standard.
In the past 10 years, chlorite was found to be an effective inhibitor for
ammonia oxidizing bacteria (AOB) and nitrite oxidizing bacteria (NOB) growth
. It has been used for controlling nitrification in |
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M****s
发帖数: 6 | 45 MITsss,
PhD Environmental chemistry/applied chemistry (and some post-doc work on
microbiology )
方向：
Environmental chemistry: Activated carbon fiber (ACF) for wastewater
treatment through adsorption;
Preparation and characterization of environmentally friendly flocculant
based on natural polymers.
Application of Granular Activated Carbon (GAC) Filter for Control of
Disinfection-By-Product (DBP) Precursors and Trace Organic Contaminants;
Applied microbiology/environmental microbiology: bioreactors... 阅读全帖 |
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g*******g
发帖数: 1164 | 46 相应lazyworm的号召，我开个贴。希望大家跟帖。
需要审稿人的sdjm们站内联系志愿reviewer好了。
ID: Guaguadog, PhD. Environ. Eng. (Post-doc in U.S)
方向： environmental nanotechonology, biogeochemistry, environmental
toxicology, environmental chemistry, mercury contamination, life cycle
assessment.
soil remediation; groundwater remediation; solid and hazardous
waste management; subsurface/surface contamination hydrology
(modeling); environmental chemistry. NPs/colloids transport
曾为以下journals做过reviewer:
Bioresource Technology
Desalination... 阅读全帖 |
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M****s
发帖数: 6 | 47 MITsss,
PhD Environmental chemistry/applied chemistry (and some post-doc work on
microbiology )
方向：
Environmental chemistry: Activated carbon fiber (ACF) for wastewater
treatment through adsorption;
Preparation and characterization of environmentally friendly flocculant
based on natural polymers.
Application of Granular Activated Carbon (GAC) Filter for Control of
Disinfection-By-Product (DBP) Precursors and Trace Organic Contaminants;
Applied microbiology/environmental microbiology: bioreactors... 阅读全帖 |
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s*******1
发帖数: 146 | 48 ID: Guaguadog, PhD. Environ. Eng. (Post-doc in U.S)
方向： environmental nanotechonology, biogeochemistry, environmental
toxicology, environmental chemistry, mercury contamination, life cycle
assessment.
soil remediation; groundwater remediation; solid and hazardous
waste management; subsurface/surface contamination hydrology
(modeling); environmental chemistry. NPs/colloids transport
曾为以下journals做过reviewer:
Bioresource Technology
Desalination
Environmental Engineering Science
Environmental Interna... 阅读全帖 |
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o*********e
发帖数: 7 | 49 Just for anyone who might be interested, this is the abstract of the paper I
mentioned in previous post.
Study of directivity effect on electromagnetic emissions in the HF band as
earthquake precursors: Preliminary results on field observations
I. Stavrakas, M. Clarke, G. Koulouras G. Stavrakakisc and C. NomicosE-mail
The Corresponding Author
Abstract
This work focuses on the use of electromagnetic emissions (EM) in the HF
band as a warning event for earthquakes. EM at HF components 41 MHz and 4 |
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c*s
发帖数: 2145 | 50 it depends on what nano you want and their quality.
For metal NPs, I think it is pretty cheap.
For II-VI semiconductors, it depends on the synthesis method.
For example, by thiol molecules as stibilizer for CdTe, it cost only ~1/10 as
the cost by TOPO/metal organic precursors.
I would say, you can make a big money if you can produce inductrial scale,
high quality semiconductors. |
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