a******u
发帖数: 211 | 1 Front Biosci. 2003 Jan 1;8:d369-91.
Mitogen-activated protein kinase pathways in redox signaling.
Torres M.
Please send it to e*********[email protected]
your help is greatly appreciated!!!!!!!!! |
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t********e
发帖数: 107 | 2 各位大牛:
1.Bilirubin chemistry and metabolism; harmful and protective aspects.
Vítek L, Ostrow JD.
2.Redox state, oxidative stress, and molecular mechanisms of protective and
toxic effects of bilirubin on cells.
3. The heme synthesis and degradation pathways: role in oxidant sensitivity.
Heme oxygenase has both pro- and antioxidant properties |
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s**l
发帖数: 11983 | 5 http://www.nature.com/nature/journal/v470/n7334/full/nature0981
An early Ediacaran assemblage of macroscopic and morphologically
differentiated eukaryotes
地球上最古老的「高等生命」到底是什么样子?人类已知的高等生命从什么时期开始演
化?英国的《自然》(Nature)杂誌在17日公佈了这一重大发现。
地球上的生命从无到有、从简单到复杂，其中的进化过程相当漫长。古生物学家认
为，在现今生物圈中，包括我们人类在内的所有肉眼可见的生命，几乎都是多细胞宏体
生物，也就是常说的「高等生命」，而多细胞宏体生物的出现是地球生命进化史上极为
重要的事件。
但是学术界一直认为地球没有早于5.8亿年前的「高等生命」，不过中国科学家在
安徽休甯县蓝田镇找到的「蓝田植物群」把高等生命起源向前推进了近4000万年。
「蓝田植物群」就在知名的景点黄山附近，出现在6亿多年前，展现了早期动物大规模
出现前夕的生命景观，是地球早期生命从简单向复杂进化过程中的重要环节。... 阅读全帖 |
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a********k
发帖数: 2273 | 6 JCR Year and Edition: 2010 Science
Abbreviated Journal Title ISSN {2010} Total Cites Impact Factor
5-Year Impact Factor Immediacy Index {2010} Articles Cited Half-
Life Eigenfactor Score Article Influence Score
CA-CANCER J CLIN 0007-9235 9801 94.262 70.216 8.667 18
3.8 0.04923 24.782
ACTA CRYSTALLOGR A 0108-7673 13944 54.333 24.717 0.629 70
6.2 0.04... 阅读全帖 |
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b******y
发帖数: 627 | 7 should be minimal. assume zero if you just use it for reducing agent for
protein purification. it is a different story if you are using it for redox
potential determination since it requires accuracy. |
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l**********1
发帖数: 5204 | 8 Bingo
人的血红细胞的生物钟韵律调控都可以不用DNA 的 transcription-translation feedback loops
各个血红细胞应该不会只有一套proteomics 不然生物钟韵律调控如何实现?
Nature. 2011 Jan 27;469(7331):498-
Circadian clocks in human red blood cells.
//www.ncbi.nlm.nih.gov/pubmed/21270888
full text link:
//www.dormivigilia.com/wp-content/uploads/2011/02/nature09702.pdf
Abstract
Circadian (～24 hour) clocks are fundamentally important for coordinated physiology in organisms as
diverse
as cyanobacteria and humans. All current models of the molecular circadi... 阅读全帖 |
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a****k
发帖数: 1130 | 9 J Bioenerg Biomembr. 2002 Dec;34(6):423-31.
Expression and characterization of recombinant human cytochrome c in E. coli.
Jeng WY, Chen CY, Chang HC, Chuang WJ.
Source
Department of Biochemistry, National Cheng Kung University College of
Medicine, Tainan 701, Taiwan.
Abstract
Cytochrome c is a heme protein involved in electron transfer, cell apoptosis
, and diseases associated with oxidative stress. Here we expressed human
cytochrome c in E. coli and purified it to homogeneity with a yield of 10... 阅读全帖 |
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A******y
发帖数: 2041 | 11 Just because we don't understand the process, does not mean it is cliche.
I haven't read the paper (I will), but I hope he mention redox signaling
such as glutathione modification, NO modification, etc. For example, NO
modified Hsp90 is selectively acute toxic to motor neurons. |
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d*****n
发帖数: 433 | 12 The 2013 Gordon Research Conference on OXIDATIVE STRESS AND DISEASE that
expands on the theme The Metabolic – Inflammatory Axis in Brain Aging and
Alzheimer’s Disease will be held April 14-19th, 2013 at the Les Diablerets
Conference Center, Les Diablerets, Switzerland.
The conference is designed from an interdisciplinary perspective to provide
discovery, translational, and clinical scientists with the latest findings
on bioenergetic deficits and activation of inflammatory responses, their
redox ... 阅读全帖 |
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A******y
发帖数: 2041 | 13 I hate the name of "anti-oxidant." Yes, NAC is an antioxidant. However, α
-Tocopherol chemically speaking is an oxidant. It's metabolite, duraquinone
, is likely the active form (pubmed Guy Miller). Btw, co-enzyme Q10 is an
oxidant, too. I will call vitamin E compunds "redox modulator," and I
believe they hit a very specific target. Btw, the ROS is likely the end
result of the death cascade, not the cause. |
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T******y
发帖数: 298 | 14 Hi ArtyArty,
Is there any difference between α-Tocopherol-acetate and α-tocopheryl
succinate on their redox modulation? Thank you so much!
Tankcity |
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y******8
发帖数: 1764 | 15 Abbreviated Journal Title ISSN {2012} Total Cites Impact Factor
5-Year Impact Factor Immediacy Index {2012} Articles Cited Half-
Life Eigenfactor Score Article Influence Score
CA-CANCER J CLIN 0007-9235 13722 153.459 88.55 27.04 25
3.3 0.0517 29.478
NEW ENGL J MED 0028-4793 245605 51.658 50.807 12.667 360
8 0.65776 21.494
REV MOD PHYS 0034-6861 35720 44.982 51.882 6.478 46 10
0.13048 32.634... 阅读全帖 |
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s****r
发帖数: 326 | 18 Anyone can help me get a pdf file for this paper? Tons of Thanks!!!
Antioxid Redox Signal. 2011 Jul 15;15(2):405-19. doi: 10.1089/ars.2010.3517.
Epub 2011 Feb 18.
Hydrogen sulfide: neurophysiology and neuropathology. |
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m******g
发帖数: 467 | 19 PNAS 14.05.13
推荐：
1. Microfluidic single-cell whole-transcriptome sequencing
稍微了解一下：
1. Evolutionary history of redox metal-binding domains across the tree of
life |
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z*t
发帖数: 863 | 20 你说的是agi-6628,早期的inhibitor?新的agi-221对r172k也适用，他们的cohort里有
一例R172k，也是有效果。idh1和idh2 WT基本就是不同功能...idh1在de novo lipid
synthesis和redox状态维持上更重要。只有neomphoric mutation功能是一致的。
Incyte这点是不错的，不过咱们算这些预期能占到市值的一半，MF,PV类的市场在
ruxolitinib的专利期内还是有2-4 billion的市值的。不过agios这个药celegene要全
部吃下来，最后估计agios会被celegene合并吧
lily |
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s**********t
发帖数: 680 | 21 Endoplasmic Reticulum Stress and Oxidative Stress in Cell Fate Decision and
Human Disease
Antioxidants & Redox Signaling
Stewart Siyan Cao1,2 and Randal J. Kaufman1
Published in Volume: 21 Issue 3: July 2, 2014
Link:
http://online.liebertpub.com/doi/abs/10.1089/ars.2014.5851
谢谢！
My Email： [email protected]
(function(){try{var s,a,i,j,r,c,l,b=document.getElementsByTagName("script");l=b[b.length-1].previousSibling;a=l.getAttribute('data-cfemail');if(a){s='';r=parseInt(a.substr(0,2),16);for(j=2;a.l... 阅读全帖 |
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P*******D
发帖数: 523 | 22 请教一下大家，我们最近develop了一个能在live cell里面定量glutathione的
fluorescent probe，大家有什么建议，可以回答什么important的biological
questions？
Invitrogen卖一个叫thioltracker violet的probe，但是这个不能定量，只能定性的看
一下GSH的变化。尽管GSH probe的文章都发烂了，也没有一个能在live cell里面定量
的。
我们develop了一个probe （ThiolQuant Green）可以很好的定量细胞里面的GSH (
reduced form only)。我们把这个probe用于confocal microscope和flow cytometry，
能很好的和cell lysate GSH measurement correlate.
相比起来redox GFP or YFP，ThiolQuant Green是直接测量reduced form GSH，而不是
measure GSSG GSH ratio。我们的probe potentially和roGFP c... 阅读全帖 |
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A******y
发帖数: 2041 | 23 It is very useful at monitoring cellular redox states and using microscopy,
you might be able to see if you are depleting specific GSH population (i.e.
mito vs cyto). Get a good price from invitrogen, you could be rich. |
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C*********u
发帖数: 811 | 24 相当有用啊，redox status，oxidative stress很多领域都用得到！ |
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l********n
发帖数: 260 | 25 Rank full journal title Total Cites IF
1 ca-a cancer journal for clinicians 18,594 115.84
2 new england journal of medicine 268,652 55.873
4 lancet 185,361 45.217
6 nature biotechnology 45,986 41.514
7 nature 617,363 41.456
12 nature materials 64,622 36.503
13 jama-journal of the american medical association 126,479 35.289
14 nature reviews immunology 28,938 34.985
15 nature nanotechnology 34,387 34.048
16 ... 阅读全帖 |
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a**y
发帖数: 464 | 26 Several postdoc positions are available in the group of Dr. Huiwang Ai at
the University of California, Riverside http://ailab.ucr.edu. The expertise of our lab is on protein engineering and fluorescent redox probes. Recently, our lab has explored new areas, including the biology and toxicology of oxidative stress, imaging of brain activities, and protein/peptide enzyme inhibitors.
We are looking for postdoctoral fellows with the following
expertise:
1. LC-MS/MS based proteomi... 阅读全帖 |
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发帖数: 1 | 27 求审稿机会，可以将简历发给您。谢谢！！
可给我发短信。
专注领域：
biochemistry, proteomics, cell biology, post-translational modifications,
signaling, redox biology, mitochondria, ER stress, diabetes,
neurodegeneration. |
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p******n
发帖数: 55 | 29 http://www.grc.org/amc.aspx
熟悉的名字不少啊
2016 Lecturers
◾Nieng Yan, Membrane Transport Proteins
◾Xiaowei Zhuang, Synaptic Transmission
◾Christopher J. Chang, Metals in Medicine
◾Mikhail Lukin, Quantum Science
2015 Lecturers
◾Karl Deisseroth, Amygdala in Health & Disease
◾David M. Sabatini, Lysosomal Diseases
◾Laura Kiessling, Carbohydrates
◾Gerbrand Ceder, Physical Metallurgy
◾Liang Fu, Superconductivity
2014 Lecturers
◾Kristi S. Anseth, Si... 阅读全帖 |
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b**m
发帖数: 91 | 30 Applications are invited for a postdoctoral position in Professor Guangwen
Zhou’s group at the Department of Mechanical Engineering, State University
of New York (SUNY), Binghamton. The appointment is initially for a duration
of one year, annually renewable up to three years. The project addresses the
atomistic mechanism of the redox reactions between metals and metal oxides
using surface science tools including variable-temperature ultrahigh vacuum
(UHV) scanning tunneling microscopy (STM), low... 阅读全帖 |
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b**h
发帖数: 55 | 31 同样的化合物在不同的溶剂下一班来说都回不一样的
我assume你这里的溶剂就是eletrolyte
特别是redox species有溶解化效应,
想想看，整个电极过程包括物质转移到电极上（diffussion, migration and convecti
on, etc)然后还有electrode kinetics.这些都在溶剂下进行的，当然和溶剂有关系 |
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y**********3
发帖数: 339 | 32 Introduction 1
Chapter 1 Solution
Chapter 2 the Halogens
Chapter 3 Structure of Matters
Chapter 4 Chemical Reaction Rates and Equilibrium
Chapter 5 Electrolyte Solution
Chapter 6 Coordination Compounds
Chapter 7 Oxidation-Reduction Reactions (Redox Reaction)
Chapter 8 the Group 6A and 5A Elements
Chapter 9 Introduction to Organic Compounds
Chapter 10 Alkanes
Chapter 11 Cycloalkanes
Chapter 12 Alkyl Halides
Chapter 13 Alcohols, Phenols and Ethers
Chapter 14 Aldehydes and Ketones
Chapter 15 Carbox |
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l******w
发帖数: 25 | 33 有个电化学的问题一直没有想明白。
我有一个石墨电极，放在葡萄糖溶液里。溶液里还有一个参比电极。我加了电压（比如
，0.5V),没有得到氧化电流，因为葡萄糖在石墨上氧化的速度太慢。现在我在石墨上修
饰了酶（可以转化葡萄糖），加同样的电压，得到了电流。我现在做了一个C-V，假设
得到了氧化-还原峰。
请问，这个氧化还原峰是酶的呢，还是葡萄糖的？如果我没有得到明显的氧化还原峰，
又是为什么了呢？
现在情况再复杂一点儿。假设，此酶转化葡萄糖的速度比较慢。于是我在溶液里又加了
一种redox物质A. A在电极上的反应速度几乎为零，但是可以很快的氧化葡萄糖，自己
变成A-。A-又可以很快的被酶还原成A.这样反应速度就快了。我做了相同的实验。也得
到了氧还峰。这个峰又是谁的呢？和上面的峰有何不同？ |
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l*****7
发帖数: 2844 | 34 Could you kindly get these two papers for me
http://www.rsc.org/publishing/journals/GC/article.asp?doi=b901127g
http://www.rsc.org/publishing/journals/GC/article.asp?doi=b815575e
Green Chem., 2009, 11, 810 - 815, DOI: 10.1039/b901127g
Deep oxidative desulfurization of fuels in redox ionic liquids based on iron
chloride
Huaming Li, Wenshuai Zhu, Yan Wang, Jingtong Zhang, Jidong Lu and Yongsheng
Yan
And Green Chem., 2009, 11, 883 - 888, DOI: 10.1039/b815575e |
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e****2
发帖数: 2723 | 35 根据它的REDOX 性质，首先一般是电子的TRANSFER， 前提是底物有容易失去电子的地
方，一般产物是夺氢产物， DDQ是这个体系最强的氧化剂。一个中国教授最近作这个不错。
Zhang, Y.
参考
Becker, H. In The Chemistry of Quinoid Compounds; Patai, S., Ed.; Wiley: New York, 1974; p 335. (b) Becker, H.; Turner, A. B. In The Chemistry of Quinoid Compounds; Patai, S., Rappoport, Z., Ed.; Wiley: New York, 1988; Vol. II, p 1351. (c) Xu, Y.-C.; Kohlman, D. T.; Liang, S. X.; Erikkson, C. Org. Lett. 1999, 1, 1599-1602. (d) Ying, B.-P.; Trogden, B. G.; Kohlman, D. T.; Liang, S. X.; Xu, Y.-C. |
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n*****g
发帖数: 4117 | 36 ☆─────────────────────────────────────☆
chouei (choei) 于 (Tue Jun 9 09:14:30 2009, 美东) 提到:
请问在测CV的时候，同样化合物采用不同溶剂的氧化电位值会不一样吗？
如果有内标的话，是不是结果（相对值）就跟溶剂无关了？
☆─────────────────────────────────────☆
blxh (kkk) 于 (Tue Jun 9 10:23:10 2009, 美东) 提到:
同样的化合物在不同的溶剂下一班来说都回不一样的
我assume你这里的溶剂就是eletrolyte
特别是redox species有溶解化效应,
想想看，整个电极过程包括物质转移到电极上（diffussion, migration and convecti
on, etc)然后还有electrode kinetics.这些都在溶剂下进行的，当然和溶剂有关系
☆─────────────────────────────────────☆
yugon (扫地大婶) 于 (Tue Jun |
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m******f
发帖数: 4352 | 37 这次doe说了，要使用redox active 矿石 |
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a***e
发帖数: 757 | 38 Anybody who can download from this journal, please help, many thanks.
Helvetica Chimica Acta
Volume 77 Issue 1, Pages 351 - 371, 2004
Organic Diodes Based on Redox-Polymer Bilayer-Film-Modified Electrodes
Wenyuan Zhao, Judith Marfurt, Lorenz Walder * |
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m******e
发帖数: 432 | 39 Dear all:
I need this reference badly. Could your bulls help up? Thanks a lot!
Jean-Luc Fillaut, Jorge Linares,Didier Astruc。Angew. Chem. Int. Ed. Engl.
1994, 33, 2460：Single-step six electron transfer in a heptanuclear complex:
isolation of both redox forms.
Could you please send the paper to my email address at h********[email protected]?
Thank you very much and have a nice day! |
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z****r
发帖数: 245 | 40 求篇国内中文文章，万方数据库收录的。不知道有哪位可以帮忙，请发到zimmerpeng@
gmail.com，有小包子相酬。谢谢。
钴电极在碱性溶液中氧化还原反应的现场共聚焦显微喇曼光谱研究
Studies on the Redox Reactions of Cobalt Electrodes in Alkaline Solution by
Using In-situ Confocal Microprobe Raman Spectroscopy
<<高等学校化学学报>>1999年 第20卷 第08期 第1276-1279页
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
作者: 南俊民, 杨勇, 尤金跨, 林祖赓
Author(s): Nan JM, Yang Y, You JK, Lin ZG |
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l**i
发帖数: 416 | 43 Journal of Electroanalytical Chemistry and Interfacial Electroch
Electron transfer through redox polymer films
Pages 377-381
C.P. Andrieux, J.M. Savéant |
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p******6
发帖数: 169 | 44 或者，有哪位大侠知道关于小分子的这种数据哪里可以查？ |
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s********n
发帖数: 235 | 47 Title: ELECTRON-ENERGY LEVELS IN SEMICONDUCTOR ELECTROCHEMISTRY
Author(s): GOMES WP; CARDON F
Source: PROGRESS IN SURFACE SCIENCE Volume: 12 Issue: 2 Pages: 155-215
DOI: 10.1016/0079-6816(82)90002-8 Published: 1982
Title: DIFFERENTIAL CAPACITANCE OF N-TYPE AND P-TYPE GALLIUM-ARSENIDE
ELECTRODE
Author(s): LAFLERE WH; CARDON F; GOMES WP
Source: SURFACE SCIENCE Volume: 44 Issue: 2 Pages: 541-552 DOI: 10.
1016/0039-6028(74)90136-8 Published: 1974
Title: APPLICATION OF KRAMERS-KRONI... 阅读全帖 |
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s***r
发帖数: 4013 | 50 参比电极用的是AG/AGCL
working电极是GLASSY CARBON
由于有很大的overpotential 所以峰会跑到+0.5-0.7左右，请问这个应该怎么克服？ |
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