b*****e 发帖数: 1193 | 1 同学的小孩检测出得了这个病
墨蝶呤还原酶缺乏 sepiapterin reductase deficiency
国内医院给出的治疗方案是,用叫左旋多巴的药物。
这个病发病概率太低,200万分之一,很难验证治疗用药的合理性,没有医生懂这个病
。同学正在寻求2nd opinion。
不知版上有人知道这个病么? |
|
发帖数: 1 | 2 发病率低,不相信first opinion,怎么会觉得网上的2nd opinion就可信的
[在 bearjoe (bearjoe) 的大作中提到:]
:同学的小孩检测出得了这个病
:墨蝶呤还原酶缺乏 sepiapterin reductase deficiency
:国内医院给出的治疗方案是,用叫左旋多巴的药物。
:这个病发病概率太低,200万分之一,很难验证治疗用药的合理性,没有医生懂这个病
:。同学正在寻求2nd opinion。
:不知版上有人知道这个病么? |
|
m*****a 发帖数: 2160 | 3 同楼上
国内正规医院都不信,网上不明身份人的三言两语更没有可信的余地
如果不放心就来美国要第二意见,usnews上面靠前的儿童医院都可以
[在 bearjoe (bearjoe) 的大作中提到:]
:同学的小孩检测出得了这个病
:墨蝶呤还原酶缺乏 sepiapterin reductase deficiency
:国内医院给出的治疗方案是,用叫左旋多巴的药物。
:这个病发病概率太低,200万分之一,很难验证治疗用药的合理性,没有医生懂这个病
:。同学正在寻求2nd opinion。
:不知版上有人知道这个病么? |
|
f****n 发帖数: 67 | 4 【 以下文字转载自 Chemistry 讨论区 】
发信人: funren (funren), 信区: Chemistry
标 题: 有没有人测过E COLI中TMAO reductase的活性测定啊,求助
发信站: BBS 未名空间站 (Tue Nov 16 16:42:01 2010, 美东)
看了一些文章,方法都市引用1980年前的文章, 也没有介绍原理的,Google也找不到
,我按照一些文
章的方法用benzyl viologen和tmao做,就是做不出活性,也不知道哪里有问题, 有没
有人又详细
的方法和protocol的,谢谢了, |
|
K*F 发帖数: 120 | 5 请您转发 z******[email protected]
万分感谢!祝您身体健康,财源广进!
Biochim Biophys Acta. 1988 Apr 28;954(1):1-13.
The inducible trimethylamine-N-oxide reductase of Escherichia coli K12:
biochemical and immunological studies.
Silvestro A, Pommier J, Giordano G.
Source
Laboratoire de Structure et Fonction des Biomembranes, CNRS, Marseille,
France.
Abstract
The inducible trimethylamine-N-oxide reductase which migrates on non-
denaturing polyacrylamide gels with an RF of 0.22, has been purified from
the soluble fraction o... 阅读全帖 |
|
w***7 发帖数: 1637 | 6 宋的文章够了,experience不够让人信服。
宋的博士学位在中科院拿的,在us做了3-4 年postdoc。宋在us 待的时间太短,对美国
博士培养体制和科研体制先进之处了解得可能不够。一同面试院长的有几个candidate
文章比宋好。武大可能是看到宋在中科院当个官,搞个管理就把it请过来了。武大应该
找一个在美国拿个PhD,然后在us 做postdoc后海归的当院长。
宋自己的科研做得很好,但对宋领导一个院做出像样的改革,大幅提高整个院科研水平
不太看好。
http://www.bio.whu.edu.cn/News_reads.asp?cid=174&id=2574
学习经历:
1993-1997 南京大学生物科学与技术系,学士
1997-2002 中国科学院上海生命科学研究院生物化学与细胞生物学研究所,博士
主要工作经历与任职情况:
2002-2005 美国德克萨斯大学西南医学中心,博士后
2005-2014 中科院上海生命科学研究院生物化学与细胞生物学研究所,研究组长,研
究员,博士生导师,“百人计划”择优支持,“百人计划”终期评估优秀。分子生物学
国家重点实验室... 阅读全帖 |
|
w***7 发帖数: 1637 | 7 宋的文章够了,experience不够让人信服。
宋的博士学位在中科院拿的,在us做了3-4 年postdoc。宋在us 待的时间太短,对美国
博士培养体制和科研体制先进之处了解得可能不够。一同面试院长的有几个candidate
文章比宋好。武大可能是看到宋在中科院当个官,搞个管理就把it请过来了。武大应该
找一个在美国拿个PhD,然后在us 做postdoc后海归的当院长。
宋自己的科研做得很好,但对宋领导一个院做出像样的改革,大幅提高整个院科研水平
不太看好。
http://www.bio.whu.edu.cn/News_reads.asp?cid=174&id=2574
学习经历:
1993-1997 南京大学生物科学与技术系,学士
1997-2002 中国科学院上海生命科学研究院生物化学与细胞生物学研究所,博士
主要工作经历与任职情况:
2002-2005 美国德克萨斯大学西南医学中心,博士后
2005-2014 中科院上海生命科学研究院生物化学与细胞生物学研究所,研究组长,研
究员,博士生导师,“百人计划”择优支持,“百人计划”终期评估优秀。分子生物学
国家重点实验室... 阅读全帖 |
|
d****d 发帖数: 214 | 8 A conversation with Robert Lefkowitz, Joseph Goldstein, and Michael Brown
Ushma S. Neill and Howard A. Rockman
Published May 1, 2012
Today we shift the format of our Conversations with Giants in Medicine and
allow three of our most charismatic giants (Robert Lefkowitz, Joseph
Goldstein, and Michael Brown) to interview each other (Figure 1). Lefkowitz
(Duke University) is known for his seminal discoveries in understanding G
protein–coupled receptor function. The legendary partnership between Brow... 阅读全帖 |
|
w*********g 发帖数: 30882 | 9 同时质问金龙鱼:
(1)你们对自己加工抗草甘膦转基因大豆生产的金龙鱼转基因大豆油,是否对孟山
都抗草甘膦转基因大豆中必然存在的活的转基因片段进行了检测?
(2)如果进行了检测的话,检测的结果如何?为什么不向消费者告知来自抗草甘膦
转基因大豆的这种转基因片段对人类健康,特别对青少年、儿童、婴儿与孕妇及其胎儿
,造成一系列危害?
陈一文:转基因大豆脂肪酸含量比非转基因大豆的低不利健康
http://blog.sina.com.cn/s/blog_4bb17e9d0102dr56.html
国内学者检测发现:抗草甘膦转基因大豆的脂肪酸含量比非转基因大豆的低。食用
油脂的营养价值较大程度是取决于它的脂肪酸组成及其配比。中国优质非转基因传统大
豆油ω-6和ω-3脂肪酸的含量都较高。国外学者发现:抗草甘膦转基因大豆大量施用草
甘膦导致转基因大豆ω-6和ω-3脂肪酸的含量下降,对健康不利!深圳市计量质量检测
研究院对金龙鱼转基因大豆油的脂肪酸含量,特别是ω-6和ω-3脂肪酸含量,进行检测
了吗?与中国优质非转基因大豆相比的检测结果如何?
“抗草甘膦转基因大豆的脂肪酸含量比非转... 阅读全帖 |
|
c**********r 发帖数: 891 | 10 自己google一下Atorvastatin看看:
In the early 1950s, aware of the importance of cholesterol in cardiovascular
disease, scientists at Merck began researching how cholesterol was made in
the body. By 1956, they demonstrated that 3-hydroxy-3-methylglutaryl-
coenzyme A (HMG-CoA) was converted to mevalonic acid, a precursor of
cholesterol, by a particular enzyme named HMG-CoA reductase. This enzyme is
especially important in cholesterol synthesis, since it serves as the
slowest (i.e., the rate-limiting) ste... 阅读全帖 |
|
A*******s 发帖数: 9638 | 11 glutathione reductase deficiency can cause hemolytic anemia. There is also
a report regarding glutathione reductase deficiency induced hemolytic anemia
and pancytopenia. The triggers could be infection or meds.
Vit B2 is the treatment in this case.
http://www.nejm.org/doi/full/10.1056/NEJM197012032832304 |
|
y****g 发帖数: 36950 | 12 rs9332964 is a nonsynonymous change known as R227Q in the SRD5A2 gene. The
SRD5A2 gene encodes steroid 5-alpha-reductase, an enzyme which catalyzes the
conversion of testosterone in the body. Polymorphisms in SRD5A2 have been
implicated in several disorders of male sexual development such as
micropenis. The homozygous rs9332964(A;A) genotype has been observed in
several Japenese males with micropenis.
基因详情
参考文献
位点:rs9332964 基因名:SRD5A2
CC
Average
TT
Micropenis
CT
carrier for mutations linked t... 阅读全帖 |
|
l**********1 发帖数: 5204 | 13 if your boss (PI) post-tenured
s/he can try
R01 5 Series
pls refer,
2011-
5 series R01 most awarded section:
General Medical Sciences with key word:
next, only tick NIH
next, Fiscal Year: 2011
ps: 2012 and or 2013 records still not input that database.
then,
405 5R01GM026079-31 NIH Genetic Regulation Of Alcohol Metabolism
In Yeast Elton T. Young University Of Washington 2011 $467,636
406 5R01GM031105-30 NIH Genetic Analysis Of Genes Controlling A
Pos... 阅读全帖 |
|
Q*S 发帖数: 395 | 14 版大这张图信息量很大呀,不仅图示了脂类的主要代谢途径,而且还标出了几类降血脂
药物的药理,譬如 HMG CoA reductase inhibitor 就是目前主流 statin 类药物。
Ezetimibe 就是目前的二线降血脂药 Zetia, 其他的现在不太常用了。
如果说图中不足之处的话,就是脂类代谢的相对比例没有标出,左边的 Mevalonate
pathway 大概占 2/3, 右边的肠道内循环大概占 1/3 左右。 |
|
l**x 发帖数: 296 | 15 是。它属于HMR CoA Reductase inhibitor一类的药物,这类药物都可能造成肌痛,肌
肉无力。是这个药的副作用。
不清楚为什么医生说不用停。 |
|
f****o 发帖数: 2770 | 16 Surgery is reserved for patient with severe symptoms. If your dad hasn't
tried prescription drug therapy (alpha blocker, 5-alpha reductase inhibitor
etc), he should try pharmacological therapies first to control the symptoms.
50% of the men will all eventually have it.
Although surgery is potentially curative, it can result in significant
morbidity, including erectile dysfunction, retrograde ejaculation, urinary
incontinence, bleeding, or urinary tract infection.
English name is : Benign Prostat... 阅读全帖 |
|
m**********r 发帖数: 2099 | 17 你好!
这个药物主要成分Aldose reductase inhibitor,这类药物对糖尿病并发白内障有作用
,对非糖尿病造成的白内障好像并没有任何依据。更严重的是其中有几种药物在1996年
被FDA禁止出售,还是小心为好,因为白内障最终还可以手术治疗,如果用药后出现现
在未知的问题就得不偿失了。当然product liability是很赚钱的诉讼,非常受律师欢
迎。 |
|
n***a 发帖数: 1373 | 18 For over the counter, can try saw palmetto. Again, it probably won't help
much. For prescription medications, use Flomax or similar medications first,
if not working, can add 5 alpha reductase inhibitors. |
|
w******s 发帖数: 504 | 19 我LG的染色体也查了。
抗体作了:
lupus anticoagulant evaluation with reflex (PPT LA SREEN, HAXAGONAL PHASE,
DRVVT SCREEN, DRVVT CONFIRM, DRVVT 1:1 MIX, FACTOR V LEIDEN, SHARED ASSAY
COMPONENT)
results ok
下面也好像是抗体有有关的 :
MTHFR ( methylenetetrahydrofolate reductass ),
Reductase(MTHFR), DNA: positive for one copy of the C677T mutation
Thrombophilia : results ok
Antithrombin III activity : OK
protein C/S activity/Antigen; T4, free; TSH, 3RD generation;Hemoglobin Alc
all ok except for Protein S, activity value a li |
|
s*********u 发帖数: 2535 | 20 上个星期的面试(在U of Utah),当时感觉不太好,还在版上发过贴抱怨了一下。
回家后感觉拿不到offer了,又发了好些e-mail给其它的教授。这期间有一个MIT的教授
(JoAnne Stubbe,做ribonucleotide reductase)表示了相当的兴趣,要推荐信。因为
我博士期间在化学系做的bioinorganic的东西,背景还是接近的。她的e-mail里说我的
experiences nicely complement some of ongoing experiments in the lab。当时高
兴了一阵,正在准备要老板写推荐信。感觉有offer的机率不小。
但是昨天收到的e-mail,上个星期面试的教授给了offer。这个教授是在医学院,做的
是疾病相关的金属传递平衡方面的,算该领域内大牛,很偏生物,不过感觉能学到更多
的新东西。
现在正在考虑是不是应该继续申MIT的位置(当然还不知道能不能拿到offer)。担心的
是boston的生活太贵,因为有老婆和小孩,salt lake city是要便宜很多的。而且
Stubbe是出了名的push老太。但是名气 |
|
m**z 发帖数: 787 | 21 hihi,good to know you are about to graduate! Please check the mail I sent
上个星期的面试(在U of Utah),当时感觉不太好,还在版上发过贴抱怨了一下。
回家后感觉拿不到offer了,又发了好些e-mail给其它的教授。这期间有一个MIT的教授
(JoAnne Stubbe,做ribonucleotide reductase)表示了相当的兴趣,要推荐信。因为
我博士期间在化学系做的bioinorganic的东西,背景还是接近的。她的e-mail里说我的
experiences nicely complement some of ongoing experiments in the lab。当时高
兴了一阵,正在准备要老板写推荐信。感觉有offer的机率不小。
但是昨天收到的e-mail,上个星期面试的教授给了offer。这个教授是在医学院,做的
是疾病相关的金属传递平衡方面的,算该领域内大牛,很偏生物,不过感觉能学到更多
的新东西。
现在正在考虑是不是应该继续申MIT的位置(当然还不知道能不能拿到offer |
|
E*********r 发帖数: 4984 | 22 I think I am probably the best person to answer this question as one of my
projects at San Francisco General Hospital is to differentiate cholesterol
imbalance. There are two major routes for cholesterol accumulation in the
body.
The first one is through in vivo biosynthesis via a key enzyme called HMGCoA
reductase. Therefore, in order to lower cholesterol based on de novo
systhesis, a drug family called statins, is widely used because it inhibits
this key enzyme. Nowadays, measuring the conc... 阅读全帖 |
|
g****d 发帖数: 238 | 23 OAP 旗下 Journal of Drug Resistant Pathogen Research,无分非SCI哦,稿件情况
如下:
Title: In Vitro Activity of Iclaprim Against Methicillin-Resistant
Staphylococcus aureus Nonsusceptible to Daptomycin, Linezolid or Vancomycin
Abstract:
Iclaprim is a novel bacterial dihydrofolate reductase inhibitor in Phase 3
clinical development for the treatment of acute bacterial skin and skin
structure infections and hospital acquired bacterial pneumonia caused by
Gram-positve bacteria. Daptomycin, linezolid and vancomyci... 阅读全帖 |
|
x********i 发帖数: 66 | 24 两篇文章,找审稿人,先到先得。SCI 杂志, Journal of International Medical
Research, 1.4 分。感兴趣的请把个人资料发给我。谢谢。
1.Preventive treatments of patients with recurrent miscarriages and carrying
C677T methylenetetrahydrofolate reductase mutation: 5 years experience。
2. Antagonist/luteal-phase protocol in women with poor ovarian response |
|
k********u 发帖数: 2209 | 25 You know what is the best selling drug last year?
Lipitor, an inhibitor for HMG-CoA reductase, which inturn inhibits synthesis
of cholesterol.
http://en.wikipedia.org/wiki/Atorvastatin
Why you want to know this? Cholesterol problem?=P
function as
change?!
No.
cholesterols)?! |
|
p****y 发帖数: 23737 | 26 Recently, there has been a renewed interest in vegetarian diets. Today there
are countless books, cookbooks, and magazine articles promoting vegetarian
diets and providing guidance for those who wish to follow a meatless diet. A
Short Historical Perspective on Vegetarian Diets
In the past, many viewed vegetarianism as strange and faddish but
appropriately planned vegetarian diets are now recognized by many, including
the American Dietetic Association, as being nutritionally adequate, and
providi... 阅读全帖 |
|
h**********r 发帖数: 671 | 27 Title:
Reconstitution of the Isobutene-Forming Reaction Catalyzed by Cytochrome
P450 and P450 Reductase from Rhodotorula minuta: Decarboxylation with the
Formation of Isobutene
Biochemical and Biophysical Research Communications
Volume 201, Issue 2, 15 June 1994, Pages 516-522
doi:10.1006/bbrc.1994.1732
Thank you so much!
my email: m******[email protected] |
|
l**********1 发帖数: 5204 | 28 En
温习一下 其十一年前的豪言 啊
中国科学:显著的发展和严峻的挑战
——历史演变和现状比较
于2001年12月4日 1st version
饶毅
本文在简要回顾中国科学史的基础上,介绍一些近年研究的内容,肯定中国
科学令人乐观的进步,并讨论可能的意义。同时也指出,中国优秀论文总量仍不
到世界的百分之一,低于中国经济在世界所占的百分比、也不能适应中国持续发
展的要求。中国科学的规模需要相当程度的扩大、质量有待进一步提高。中国科
技还存在面临许多问题和挑战。
中国科学历史上的优秀例子
一个国家科学研究状况可以近似地由发表论文的情况所反映。以下,本文主
要从生命科学的研究来讨论中国科学的情况,一方面这是我有一定判断力的领域,
另一方面生命科学是科学技术最重要的组成部分之一,可以反映科学主流。讨论
中国论文发表情况前,先谈两个背景:中国科学的历史情况,优秀科学和著名杂
志的关系。
奠定中国生命科学研究是二、三十年代协和医学院生理系林可胜和生化系吴
宪。他们不仅自己研究出色,而且培养和带领了其他研究者。林可胜在胃肠道生
理和神经生理有优秀工作。1942年,他在中国当选为美国科学院外籍院士,是... 阅读全帖 |
|
b******k 发帖数: 2321 | 29 查查看 Merck当年为啥要去找HMG CoA reductase inhibitor? Hehe
cardiovascular
in
is |
|
j****1 发帖数: 81 | 30 Here is another abstract, because I have to write two abstracts for my
qualifying exam.
----------------------------------------------------------------------------
-------------
Not only are neural stem cells important in learning and memory, they are
also potential therapeutic approaches for neurodegenerative and other neural
pathological diseases. Adult neurogenesis occurs in the subventricular zone
(SVZ) of the lateral ventricle and subgranular zone (SGZ) in the
hippocampus (Suh et al., 2009... 阅读全帖 |
|
m******g 发帖数: 467 | 31 开学了,突然变得很有效率,脱离了颓废的圣诞假期感觉真好!
发布顺序有点乱,不过大概还是按照时间顺序的。
Science 13.12.06
推荐:
1. Genetic determinants and cellular constraints in noisy gene expression
Evidences for gene-specific v.s. genome-wide regulation
Mainly focused on yeast and E. coli
2. Functional Roles of Pulsing in Genetic Circuits
两篇都是Review, 不是我最喜欢的那类Review, 有点罗列的感觉
稍微了解一下:
1. Single-Cell Metabolomics: Analytical and Biological Perspectives
也是review,主要讲方法
小知识:
1. Playing Kissy with the Relatives
Who to select for cooperate
Surface rece... 阅读全帖 |
|
m******g 发帖数: 467 | 32 开学了,突然变得很有效率,脱离了颓废的圣诞假期感觉真好!
发布顺序有点乱,不过大概还是按照时间顺序的。
Science 13.12.06
推荐:
1. Genetic determinants and cellular constraints in noisy gene expression
Evidences for gene-specific v.s. genome-wide regulation
Mainly focused on yeast and E. coli
2. Functional Roles of Pulsing in Genetic Circuits
两篇都是Review, 不是我最喜欢的那类Review, 有点罗列的感觉
稍微了解一下:
1. Single-Cell Metabolomics: Analytical and Biological Perspectives
也是review,主要讲方法
小知识:
1. Playing Kissy with the Relatives
Who to select for cooperate
Surface rece... 阅读全帖 |
|
l****5 发帖数: 2968 | 33 下面很多papers,没有学校账户查不到了。请大家帮忙查一下吧。请发greenfast2013@
gmail.com
包子不多,不过由于文章很多,所以会发包子以表感谢的。万分感谢啊!
1) Effects of high electric field pulses on enzymes
2) Neuropharmacological investigations on muscimol, a psychotropic drug
extracted from Amanita muscaria
3) Extraction of BaChu mushroom polysaccharides and preparation of a
compound beverage
4) The effect of the high pressure homogenisation on the activity and
stability of a commercial neutral protease from Bacillus subtilis
5) Isolation o... 阅读全帖 |
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f****n 发帖数: 67 | 34 看了一些文章,方法都市引用1980年前的文章, 也没有介绍原理的,Google也找不到
,我按照一些文
章的方法用benzyl viologen和tmao做,就是做不出活性,也不知道哪里有问题, 有没
有人又详细
的方法和protocol的,谢谢了, |
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f******g 发帖数: 4 | 35 A 55-year-old woman comes to the physician because of increased facial hair
growth over the last 8 years. Menopause occurred at age 45. Laboratory
studies of the serum show:
Testosterone 80 ng/dL (N=20-90 ng/dL
Dehydroepiandrosterone sulfate 320 ug/dL (N=60-350 ug/dL)
Thyroid-stimulating hormone 0.8 uU/mL
Estradiol 20 pg/mL
Progesterone decreased
Which of the following is the most likely cause of the increased facial hair
growth?
A) Decreased 5-alpha reductase activity
B) Decreased adrenal andro... 阅读全帖 |
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y******7 发帖数: 17 | 36 The following is what I collected when I was a student doing capstone in a
local hospital. Not sure if it is useful.
Lidocaine topical is a amide-type local anesthetic. for production of
topical anesthesia, relief of pain associated with postherpetic neuralgia,
reduction of gagging during dental procedures, prevention and control of
urethral pain, anesthetic lubricant for endotracheal intubation, and relief
of hemorrhoidal pain.
Polyethylene glycol(Miralax) is a nonabsorbed solution used to trea... 阅读全帖 |
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U******m 发帖数: 423 | 37 选个好的题目真难,tnnd!
抗HIV,老的靶点已经做滥了,比如protease,nnrti做的也已经太多,integrase现在感
觉疗效不是很理想,好像只能配合用。capsid或许有前途,但现在问题还是很多。
抗肿瘤,老的靶点做不出东西了,新的靶点都是凑热闹。比如tubulin,bcl-2等,长远
上不是很看好,hdac的抑制剂好像也不怎么样,至于一些作用于PKC或TPK的目前好
像很好的一些药物,早晚要被淘汰。hsp90现在还比较看好,但是这个领域好像问题也
比较大...
心血管,降血压好像已经不是问题,降血脂好像hmg-coa reductase也还不错,statin
类还是在拼命赚钱,虽然可能有毒副作用,好像还没有好的靶点出来。
大家帮忙出个主意吧... |
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b*********n 发帖数: 2975 | 38 有主意的自己赠钱去了, 还给你出主意, 呵呵
选个好的题目真难,tnnd!
抗HIV,老的靶点已经做滥了,比如protease,nnrti做的也已经太多,integrase现在感
觉疗效不是很理想,好像只能配合用。capsid或许有前途,但现在问题还是很多。
抗肿瘤,老的靶点做不出东西了,新的靶点都是凑热闹。比如tubulin,bcl-2等,长远
上不是很看好,hdac的抑制剂好像也不怎么样,至于一些作用于PKC或TPK的目前好
像很好的一些药物,早晚要被淘汰。hsp90现在还比较看好,但是这个领域好像问题也
比较大...
心血管,降血压好像已经不是问题,降血脂好像hmg-coa reductase也还不错,statin
类还是在拼命赚钱,虽然可能有毒副作用,好像还没有好的靶点出来。
大家帮忙出个主意吧... |
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U******m 发帖数: 423 | 39 非statin类的hmg-coa reductase inhibitor可否有希望?现在statin类的副作用我怀
疑是statin类特异性的,摆脱这个骨架或许能避免这个副作用。长期用药的东东,有这
个副作用,谁心里不嘀咕啊? |
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R******d 发帖数: 5739 | 40
lipitor is one of the few drugs with low adverse effect even overdose. if
anyone abuse any drug for long time, s/he would be screw for sure. i think
it is possible to find non statin hmg-coa reductase inhibitor, but it is
very difficult to have the same efficacy and safety. that is why it is
still the best selling drug ah, but its patent is running off in a few years
, and Pfizr's stock will take another hit |
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a***e 发帖数: 315 | 41 eric zhou又没有可能是5-alpha reductase deficiency?or Micropenis? |
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A*******s 发帖数: 9638 | 42 What is Vitamin B12 level?
How about Glutathione Reductase Deficiency? |
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I****a 发帖数: 407 | 43 B12, folate level were normal. Urine/blood toxicology were non revealing.
I have never heard of glutathione reductase deficiency. Can it link
everything together? |
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b********p 发帖数: 45 | 44 不是我说话轻浮。是医生太看高自己了。你把治病看作是一个修车的过程的比喻非常恰
当。医生基本上也就是一个对车子的工作原理还不甚了了的技工,你说自己是总工程师
是大大的抬高自己了。要当汽车的总工程师,车上的每一个细节应该都知道清清楚楚。
你说医生是生命科学的领头羊简直是滑天下之大稽。医生的界定我觉得是一个观察者比
较合适。然后需要记住一些东西。医生的知识面其实很狭窄,然后能运用的手段也其实
很有限,在现在这个年头,基本上很难发现什么新的罕见病了,医生需要做的就是找方
抓药。生物体系的复杂是超越医生的想象了,等到真的出现什么问题,其实医生也没啥
办法。neurosurgeon够牛逼的了吧,让他打开一个生glioma的病人的脑子,然后都转移
了,他能有什么办法?有什么创造?那一个相反的例子,一种CML现在能变成一个可控
的慢性病,也是因为生物学家发现致病的mutation, 化学家合成针对这个kinase的
inhibitor, 然后能够deliver, 至于最初的医生当时发现这个疾病,但是却无可奈何的
心情很容易想象。至于医生的功能,就是观察者,只要是仔细一些的人,反正现在都是
做lab, ... 阅读全帖 |
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p****y 发帖数: 23737 | 45 http://www.vegetarian-nutrition.info/updates/vegetarian_diets_health_benefits.php
Recently, there has been a renewed interest in vegetarian diets. Today there
are countless books, cookbooks, and magazine articles promoting vegetarian
diets and providing guidance for those who wish to follow a meatless diet. A
Short Historical Perspective on Vegetarian Diets
In the past, many viewed vegetarianism as strange and faddish but
appropriately planned vegetarian diets are now recognized by many, includi... 阅读全帖 |
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