t*******r
发帖数: 22634 | 1 另外 epigenetic 观点似乎是认为娃小时候的环境不仅仅 rewire brain，而且还可能
决定 turn on/off 某些 gene。。。 |
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m**x
发帖数: 8454 | 2 肖氏手术国外临床试验情况
作者：羽矢
肖传国对国外医生吹嘘肖氏手术是中国各大医院每天都做的常规手术，成功率接近
90%，国外几家机构因此上当受骗而进行或准备进行临床试验。反过来，肖又在国内歪
曲国外试验情况欺骗公众和媒体、做虚假宣传诱骗患者。例如，肖雇凶落网前谎称美国
最初9个病人的3年结果“9个大便功能都正常了，7个小便正常了”，出狱后吹嘘“美国
病人的结果比我们中国的还好”。
目前，德国Tubingen大学和美国Beaumont医院的先期试验已经结束。除Beaumont一
年结果外，尚无同行评议论文发表，但长期试验结果现已公布。其中，德国8例脊髓损
伤患者全部失败，无一能通过刺激皮肤引发排尿，“无一达到自主排尿的试验目标”，
结果与肖以前报告的“完完全全不同”。美国2例脊髓损伤患者也都“无改善”，包括
2006年底试验开始时FoxNews等新闻机构铺天盖报道过的瘫痪大学生KevinBryant。美国
9例脊柱裂一年后“无一能完全自主控尿”，被同行专家评价为“临床疗效与肖此前所
报告的截然不同”；三年后也并非肖传国曾谎称的“9个大便功能都正常了，7个小便正
常了”，而是2例失访、“6... 阅读全帖 |
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G****o
发帖数: 124 | 3 肖氏手术国外临床试验情况
2012年03月24日 17:10:07分类：未分类
肖氏手术国外临床试验情况
作者：羽矢
肖传国对国外医生吹嘘肖氏手术是中国各大医院每天都做的常规手术，成功率接近
90%，国外几家机构因此上当受骗而进行或准备进行临床试验。反过来，肖又在国内歪
曲国外试验情况欺骗公众和媒体、做虚假宣传诱骗患者。例如，肖雇凶落网前谎称美国
最初9个病人的3年结果“9个大便功能都正常了，7个小便正常了”，出狱后吹嘘“美国
病人的结果比我们中国的还好”。
目前，德国Tubingen大学和美国Beaumont医院的先期试验已经结束。除Beaumont一
年结果外，尚无同行评议论文发表，但长期试验结果现已公布。其中，德国8例脊髓损
伤患者全部失败，无一能通过刺激皮肤引发排尿，“无一达到自主排尿的试验目标”，
结果与肖以前报告的“完完全全不同”。美国2例脊髓损伤患者也都“无改善”，包括
2006年底试验开始时FoxNews等新闻机构铺天盖报道过的瘫痪大学生KevinBryant。美国
9例脊柱裂一年后“无一能完全自主控尿”，被同行专家评价为“临床疗效与肖此前所
报告的截然不同”；三年后也... 阅读全帖 |
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t******n
发帖数: 2939 | 4 ☆─────────────────────────────────────☆
boilingsnow (沸腾的雪) 于 (Tue Mar 27 09:08:22 2012, 美东) 提到:
教主拉的屎总是时不时被教徒捡去吃。
全世界泌尿学界专业人士都不知道肖氏手术是非原创的，却被教主发现了！
☆─────────────────────────────────────☆
locarno (May the Force be with you) 于 (Tue Mar 27 09:18:51 2012, 美东) 提到:
即便你说的是真的，又怎么样？现在几乎说有新的医疗方式/药物，都是先动物实验，
难道这和你理解的常识/科学又不一致了？
☆─────────────────────────────────────☆
garnetcrow (kikicoco) 于 (Tue Mar 27 09:36:42 2012, 美东) 提到:
肘粉都是这种智障，现在有几个手术是发明最初就在人身上做，一次成功的？
☆─────────────────────────────... 阅读全帖 |
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u***************r
发帖数: 11227 | 5 发信人： thethird(三儿), 信区： GenderEquality
标题： 每次跟老公吵架都会去读关于两性/婚姻/亲密关系的科普书
发信站： BBS未名空间站(Tue Aug 29 09:04:42 2017,GMT)
我每次跟老公吵架都会去读关于两性/婚姻/亲密关系的科普书，目前已经读了十本了。
然后有人问，看了十本还吵，是不是证明看这些书没有用？
其实是这样的——读书的用处不在于防止吵架。每个人都是独特的独立个体。人跟人之
间有些分歧是无法“彻底解决”的，是永恒的吵架导火索。很多时候你能做的，是接受
这些问题将永远存在，然后带着这些问题继续生活。
读书的用处在于，读之前我觉得“明明我对他错他为什么不改好气喔”。
读之后我觉得“嗯我自己还是有很多可以改进的地方的。但是仍然是我对他错。他为什
么错还不改呢？因为他蠢啊。”（←此处推荐阅读跟亲密关系无关的卡罗尔·塔夫里斯
的《错不在我》）
一般想到这里，你就能带着平和的心情微笑了。
然后你还会突然理解到佛跟菩萨的慈悲之心从何而来，因为他们眼中的众生都是傻X啊
……
P.S. 十本书书单如下——
· 莎伦·布雷姆《亲密关系》
· 马... 阅读全帖 |
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z*********n
发帖数: 94654 | 6 你们这些自恨
我随便google了一下就发现纽约地铁门成天夹人拖着走，除了好多事故了，死人也很多
不过，是87年的文章，哈哈
In the latest accident, a 69-year-old woman was attempting to get off a
Manhattan-bound E train when she was caught between the doors at the
Roosevelt Avenue station in Queens during the morning rush. The authority's
head of system safety, Albert Dzingelis, said the woman, Yolanda Abenante of
Elmhurst, Queens, suffered shoulder, neck and chest injuries. Dragged by
Train
Last week, a 60-year-old Manhattan man, Paul Ruud-Renault, was c... 阅读全帖 |
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e***h
发帖数: 2791 | 7 "Same Love"
(with Ryan Lewis)
(feat. Mary Lambert)
When I was in the third grade I thought that I was gay
'Cause I could draw, my uncle was, and I kept my room straight
I told my mom tears rushing down my face
She's like "Ben you've loved girls since before pre-k tripping, "
Yeah, I guess she had a point, didn't she?
Bunch of stereotypes all in my head.
I remember doing the math like, "Yeah, I'm good at little league"
A preconceived idea of what it all meant
For those that liked the same sex
Had... 阅读全帖 |
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l*****a
发帖数: 12 | 8 She got up early, when the Prussian blue of daybreak had yet to wane. She
shuffled around barefoot, waking him. He opened his eyes, his mind strangely
clear. Yet as he looked around the room, the sight of their studio
apartment startled him completely, as though he’d forgotten where he was.
For maybe twenty seconds, or maybe much longer, as it seemed, he rewired his
mind around the humming noise of the booming metropolis that permeated the
window pane. The noise had been subtle but unsettling an |
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D**N
发帖数: 1440 | 9 其实现代医学一直在努力把神经生理学和心理学联系起来，人的意识的发展跟大脑神经
元互相搭建联络关系密切，从出生到3岁，大概90%的神经联络就已经完成，也就是说该
个体的性格大体也已经决定了。遇到某种情境，大脑做什么反应，分泌什么化学物质，
从而产生的心理情绪和生理反应也都基本固定下来了。基因的力量就在于个体有先天性
生理倾向，影响大脑结构和功能，比如某种激素分泌偏少。
从这点看，“三岁看老”这句话很有道理，按弗洛伊德的说法，0--5岁的经历决定了人
一生的性格或心理特征，或抑郁，或快乐，或癫狂。但是，值得庆幸的是，现在发现，
成人主动控制自己的情绪，调整因某情境而产生的行动，可以逐渐改变大脑中的神经元
搭建结构(rewired), 这也是认知行为疗法的生理方面的证据或依据。所以，就算遗传
占了很大比重，就算幼时的经历造成了很多创伤，还是没有理由就此放弃。你有一个坏
的开始，并不意味着一定有一个坏的结束。希望，总是会有，甚至是你唯一拥有的东西
，但是它已足够美好，有了它，就能活下去。 |
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t*******n
发帖数: 4445 | 10 http://www.nytimes.com/2009/10/20/health/20mind.html
When Parents Are Too Toxic to Tolerate
By RICHARD A. FRIEDMAN, M.D.
You can divorce an abusive spouse. You can call it quits if your lover
mistreats you. But what can you do if the source of your misery is your own
parent?
Granted, no parent is perfect. And whining about parental failure, real or
not, is practically an American pastime that keeps the therapeutic community
dutifully employed.
But just as there are ordinary good-enough parents w... 阅读全帖 |
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N*******n
发帖数: 348 | 11 Interesting story from abcnews:
http://abcnews.go.com/Health/meditation-brain-rewire-study/stor
Sharon Salzberg said her mind might be very different if it weren't for
meditation, and new neurologic research suggests that she might be right.
Troubled by a traumatic, stressful childhood, Salzberg traveled to India as
a college student and discovered meditation. Not only did it help her deal
with her painful past, Salzberg said, but the practice helped change the way
her mind worked.
"I hadn't rea... 阅读全帖 |
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l***e
发帖数: 480 | 12 不是免费，但接近免费。
一个小时最贵的，不过1。2刀，不过一个汉堡。
自己买机器算，电费也差不多这么多吧。
何苦呢？
http://aws.amazon.com/ec2/#pricing
http://aws.amazon.com/ec2/
有空看看
The Big Switch: Rewiring the World, from Edison to Google
# Paperback: 304 pages
# Publisher: W.W. Norton & Co.; Reprint edition (January 19, 2009)
# Language: English
# ISBN-10: 0393333949
# ISBN-13: 978-0393333947 |
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a*****0
发帖数: 3319 | 13 非常感谢。我算了下，这房子才1800 sq ft, 室内最长距离也才34m, 是否cat6也够了
，不需cat6a？
我又called了comcast， 因为上次comcast technician说the dish network cable
inside the current house cannot run comcast, and I need to hire someone else
to rewire the cable line. But I found out the house has the RG6 cable,
which should work for either satellite or cable. The comcast technician who
came last Sunday was not knowledgeable.
Comcast technician would come again the coming Sat. Do I need to have the
activated cable outlet in the same plac... 阅读全帖 |
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n***w
发帖数: 2405 | 14 Title:Synaptic rewiring for topographic mapping and receptive field
development.
PMID:20176460
please send to n***[email protected]
Thank you. |
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h******y
发帖数: 1374 | 15 one possibility is that targeted drugs lead to a subpopulation of cells
which becomes resistant by acquiring new mutations, rewiring signaling
pathways, gaining addiction to other key molecules.
this is a very important field that warrants more investigation but the
underlying mechanisms could be quite complicate |
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h******y
发帖数: 351 | 16 Formerly Blind Children Shed Light on a Centuries-Old Puzzle
In 1688, an Irish polymath named William Molyneux wrote the English
philosopher John Locke a letter in which he posed a vexing question: Could a
blind person, upon suddenly gaining the ability to see, recognize an object
by sight that he'd previously known by feel? The answer has potentially
important implications for philosophers and neuroscientists alike. Now,
researchers working with a medical charity that provides surgery to restor... 阅读全帖 |
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X******n
发帖数: 914 | 17 synthetic biology只是一个工具，关键是看你想解决什么问题。很多方向是不需要工
科基础的，比如pathway rewiring。 |
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R******d
发帖数: 1436 | 18 多谢。我读了一下大牛的文章。
duplication致modularity形成的部分，AB也是引用他人的文章。
似乎没有homomeric duplication或interaction rewiring，就不可能得到modularity
。仅仅duplication部分是不够的。 |
|
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h***0
发帖数: 248 | 20
我看一个文章说,在众多molecula network中
transcriptional regulation还有phosphorylation是rewiring最快的两个
比蛋白序列的上的变化快
所以我觉得从dna,蛋白序列上找到真正起到作用的差异的几率很小,噪音太多了
同意你说的,RNA-seq, ChIP-seq, 还有proteomics的数据更可信,也更能反应真实情况 |
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P****d
发帖数: 564 | 21 Plasticity and rewiring? |
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P****d
发帖数: 564 | 22 Plasticity and rewiring? |
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s******a
发帖数: 472 | 23 http://www.cell.com/molecular-cell/fulltext/S1097-2765(11)00331
Fifty Years after Jacob and Monod: What Are the Unanswered Questions in Molecular Biology?
=====================================================================
Tomorrow's Molecular Biology
Marc W. Kirschner
Harvard University
Today, the term molecular biology has a rather prosaic sound. After all,
there is little in contemporary biology that isn't molecular. It's hard to
remember that 50 years ago, molecular biology was distinctly ... 阅读全帖 |
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k****o
发帖数: 589 | 24 部分同意楼主观点。NGS提供更加可靠的数据，对癌症诊断治疗肯定有巨大推动作用的
。但是癌症治疗目前至少有这几个难点：
1. 很多癌症有多个靶点，target一个不光疗效有限，而且复发率偏高；
2. 癌症的亚型太多，而且有stage－specific signatures，这给分析NGS数据提出很大
挑战；
3. 癌症不光是突变在起作用。癌细胞的signaling pathway往往具有rewiring的能力，
而这样的行为很大程度上不受突变的支配；
4. 超大project立项前不光要在科学上证明可行性，还有诸多政策监管上的问题。另外
NGS数据分析不止一种方法，如何在那么多参与人员中达成共识也是个问题。
我对NGS在癌症领域的潜力还是有所保留。当年基因组测序前不也号称攻克癌症不是梦
吗，结果呢？未来20年内全面攻克癌症在我看来是不可能的任务。 |
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b****r
发帖数: 17995 | 25 1.我已经说了，类似治疗细菌感染，广谱，多抗联用
2.确实挑战巨大，所以我也提到了需要10多年多国合作。但是反正就是30亿个碱基，就
这么多
3.我不认为rewiring不受突变支配。你不妨举出你的例子
4.这个我同意。但是随着技术的发展，人力方面的限制会一年比一年少。就比如以前造
万里长城要几百年几百万人？现在造一样规模的长城，不用全国协调，找几个乡镇工程
队干个10多年也就搞定了 |
|
k****o
发帖数: 589 | 26
1. 抗生素和抗癌药没有很好的可比性。你指的广谱目前除了放疗和一些化疗药外没有
其他选择。即使是一大类癌症，目前市面上的往往也是不能通杀的。比如拿herceptin
去治triple negative breast cancer就不行。不过将来会不会有所谓广谱抗癌药也难
说，比如这篇已经进1期临床了：
http://clincancerres.aacrjournals.org/content/early/2012/06/26/
2. 加上不同族群的遗传背景，和不同阶段的肿瘤样本，工作量翻几番不是问题吧？
3. 我的观点是rewiring不全受突变支配。肿瘤细胞里的epigenetic modification，
gene deletion都可以引发signaling变化。 |
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g*********3
发帖数: 177 | 27 我本人并不是说NGS对cancer研究没用，只是说不会产生革命性的突破~
1）NGS穷举出mutation不会很难，这也是NGS牛逼的地方，但是真正找到driver很难
2）在function研究方面，无论是RNA-Seq还是ChIP-Seq说的都是一个故事：
transcription，一些初步的数据已经证实protein level翻译水平的贡献率大概是2/3,
另外我觉得NGS的定量分析和microarray一样很丑陋
3）我比较赞同进化的观点，因为cancer不能完全归功于mutation~ LS有两位在讨论
reprogrammed signal pathway~ 这个当然有mutation的例子，但是和mutation无关的
例子简直是太多了~ e.g.a lot of weird metabolism pathways will totally rewire
the epigenetic profiling. Some abnormal metabolites can change the pathway.
.....the interaction between dif... 阅读全帖 |
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b****r
发帖数: 17995 | 28 为什么说找到driving mutation有那么难。我一开始就讲了，现在是做不到，到时候只
要筛的病人，癌组织够多，真正的driving mutation总是会信号越来越强的。因为
driving mutation只要出现了，在它的子代细胞里基本上就总是在那里，类似于我们人
类最后都能用遗传方法追溯到我们唯一的那个母亲，lucy
function 方面的seq我认为不是根本道路。function的东西变化太多
关于你的第三点，首先epimutation也是NGS的强项。另外我不认为epimutation会是致
癌的主流。大部分epimutation根本就不稳定，它在自己那一代细胞里是会造成一些变
化，但你如何指望它都能一代代传下去，造成雪崩一样的本质改变-失去控制的癌变？
起码我没有看到什么好例子
3,
rewire
pathway. |
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G*****h
发帖数: 320 | 29 按大部分人的的思维放松来说，可以说基本如此。这么长时间的训练，足够 rewire 绝
大部分人的习惯性思路放松，尽管不能说是绝对的。 |
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p*****c
发帖数: 20445 | 30 Michael Rape, Ph.D.
University of California, Berkeley
Michael Rape’s love of science began in the basement of his parent’s house
, where he used to conduct rudimentary biochemistry experiments. Today, he
uses far more sophisticated methods to understand a complex process critical
to nearly all organisms: ubiquitylation. The term describes the attachment
of a regulatory protein called ubiquitin—named for its ubiquity—onto other
proteins. Ubiquitin tags communicate a wealth of information to the ... 阅读全帖 |
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E**********t
发帖数: 56 | 31 Xuebiao Yao, Dasheng Li and Gang Pei recently wrote an essay to Nature
Review in MCB Which is entitled “In focus: molecular and cell biology
research in China”. Here is the link: http://www.nature.com/nrm/journal/v14/n9/full/nrm3638.html In this article, they discussed the past, present and future of molecular and cell biology research in China. One part which interested me is the key MCB discoveries in China. Although most of the work are nice and likely solid work, few of them are breakthrough... 阅读全帖 |
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s***l
发帖数: 10 | 32 刚刚在研究这个领域的文章，看到这个guang-hui liu在cell research上出现了几次
，频率很高，就搜了一下，结果吓了一跳，尽然有14篇之多。这个肯定是中国干细胞界
的新星吧，不然，在10多分的杂志上随便灌水，这个面子可是不小呀。
1.Gametogenesis in a dish [1422-1425]
Ying Gu1, Guang-Hui Liu1,2 and Juan Carlos Izpisua Belmonte1,3
2.The dawn of angiogenesis modeling: regenerating vasculature from human
pluripotent stem cells [3-5]
Fei Yi1,*, Jing Qu1,2,*, Guang-Hui Liu1,2 and Juan Carlos Izpisua Belmonte1,
3
3.Huntington's disease: Dancing in a dish [1627-1630]
Kejing Zhang1,*, Fei Yi1,*, Guang-Hui ... 阅读全帖 |
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s******y
发帖数: 28562 | 33 【 以下文字转载自 Faculty 讨论区 】
发信人: sunnyday (胖头鱼。按斤卖就赚了), 信区: Faculty
标 题: NIGMS 要劫富济贫了
发信站: BBS 未名空间站 (Mon Jan 5 22:29:34 2015, 美东)
革命了革命了！
今天收到NIGMS director 的公开信，里面明白着说单个实验室不应该拿到超过三个R01
（除非是clinical research), 并明白指出这个动向的原因是：
1。在钱的总数有限的情况下，一个实验室拿到多的钱就会导致另外一个实验室拿到的
钱变少。
2。大实验室对博士后和研究生培养不利，因为导师的注意力被分散了。
3。从统计上来看，大实验室的成果并不和资金成正比
A Shared Responsibility
Dr. Jon LorschPosted by Dr. Jon Lorsch on January 5, 2015
Post a Comment
The doubling of the NIH budget between 1998 and 2003 affected nearly every
pa... 阅读全帖 |
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g*****j
发帖数: 1211 | 34 It is quite established now that major damage from diabetes is not
insulin resistance, not lack of insulin, but high blood glucose. This
is why controlling glucose is so important. It may appear not treating
the underlying cause, but it does work to prevent the devastating
consequence from diabetes.
Insulin is not the only treatment for type 2 diabetes. Actually for
type 2 diabetes, the recommended first treatment is diet and exercise.
Study has shown that they are as effective as metformin... 阅读全帖 |
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x***d
发帖数: 227 | 35 如果cable一段 是DB25 Female，能不能通过rewire把它变成 DB25 Male，然后接到另
一个 接口为DB25 Female的Device上 传输信号，
多谢！ |
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T******T
发帖数: 3066 | 36 I guess not much advantage other than ease of deployment and reach of mass
market. How many people are going to completely rewire their house or
apartment with CAT5, and sprinkle plugs evenly through out ? I guess not
many, hence why PLC is gaining popularity. |
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D******e
发帖数: 1085 | 37 You need to connect the dots.
Or I need to rewire my brain. |
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S******t
发帖数: 8388 | 38 祝大家保持健康活力.
Feeling sluggish? A few simple tricks can help you feel more awake.
1. Get an Energy Boost From Trying Something New
Recent research confirms what world travelers and adult-education addicts
already know: New experiences give you a rush. “We’ve known that when
people do something novel, the brain’s reward chemical, dopamine, is
released,” says Gregory Berns, M.D., a neuroscientist at Emory University,
in Atlanta, and the author of Satisfaction: The Science of Finding True
Fulfillment ... 阅读全帖 |
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C*****D
发帖数: 1299 | 39 来自主题: Medicalpractice版 - 止痛新方法 前几天，WSJ登了篇文章，讲最新研究显示，只要看loved ones' photo， 44% people
会疼痛减少。这是stanford 一个group 做出来的。这是个9mil grant， 有图有数据支
持的，不是瞎说的， called rewiring the brain to short circuit pain. The
principle is that perception of pain are highly determined by general health
, heredity, stress, anxiety, fear and depression.
以后大家牙痛肚子痛，就不要浪费钱去看医生，随身多带些照片即可。
以后要测爱不爱，就在牙痛时，把照片拿出，不痛，就是真爱；还痛，那就爱的不深，
dopamine 没分币。LOL |
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n***w
发帖数: 2405 | 40 It is logic to reason legally blind people may not have input to SCN which
interacts many other regions of the brain. Such loss may disturb the
endocrine system causing mood/emotion problems. But I don't think there is a
consensus over whether legally blind people have circadian rhythm or not.
I don' know the rewiring process after visual loss at the level of brain
cortex. I learned from many TV shows or movies that blind people have
superior hearing ability. LOL |
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f*******y
发帖数: 421 | 41 Today, IBM researchers unveiled a new generation of experimental computer
chips designed to emulate the brain’s abilities for perception, action and
cognition. The technology could yield many orders of magnitude less power
consumption and space than used in today’s computers.
In a sharp departure from traditional concepts in designing and building
computers, IBM’s first neurosynaptic computing chips recreate the phenomena
between spiking neurons and synapses in biolog... 阅读全帖 |
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f*******y
发帖数: 421 | 42 Today, IBM researchers unveiled a new generation of experimental computer
chips designed to emulate the brain’s abilities for perception, action and
cognition. The technology could yield many orders of magnitude less power
consumption and space than used in today’s computers.
In a sharp departure from traditional concepts in designing and building
computers, IBM’s first neurosynaptic computing chips recreate the phenomena
between spiking neurons and synapses in biolog... 阅读全帖 |
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c**e
发帖数: 3760 | 43 前阵子买了个二手的MB R500.
今天在dealer那里问如果换Xenon车灯多少钱。老头跟我说about 10 grand.
我问怎么会这么贵，他说要换整个head light assembly, rewire,
还要装什么leveling，以免车身不平等时候车灯射到对面人眼睛里
就算这些都加上，10 grand听着好离谱啊。
网上看见一些kit 100多，那些是xenon headlight么？ |
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B*******S
发帖数: 2379 | 44 XM radio/iphone connection
左边一大驼按钮rewire一下就好了 |
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