F*********8
发帖数: 104 | 1 请问如何帮中国的亲戚在美国购买Rituximab?
我一个亲戚患淋疤瘤，在上海诊断和治疗。他化疗需要Rituximab。
请问一个问题，我如何在美国购买Rituximab？然后邮寄给他。多谢了。 |
|
x***m
发帖数: 1733 | 2 母亲确诊为 B淋巴细胞淋巴瘤，心急如焚。 急问北美购买美罗华 MABTHERA (
RITUXIMAB) and 楷莱 (Caelyx) 信息。
有其它特效药若能告知，同样感谢。 |
|
j******i
发帖数: 939 | 3 我不是做这个的，只是对immunotherapy感兴趣。参考文献：
Rituximab resistance
Rituximab has become a ubiquitous component of treatment regimens for
follicular non-Hodgkin lymphoma. Despite widespread clinical use, the
mechanisms by which tumor cells resist rituximab-mediated destruction remain
unclear. Rituximab relies in part on immune effector mechanisms for its
antitumor effect, and thus resistance may be mediated not only by intrinsic
tumor-cell alterations but also by the host immunological environment. In
this a... 阅读全帖 |
|
y*****l
发帖数: 5997 | 4 来自主题: _pennystock版 - SPPI Spectrum Pharmaceuticals Announces ZEVALIN(R) and Belinostat Abstracts to Be
Presented at the American Society of Clinical Oncology Annual Meeting
4 hours 16 minutes ago - BIZ via Comtex
BusinessWireSpectrum Pharmaceuticals (NasdaqGS: SPPI), a biotechnology
company with fully integrated commercial and drug development operations
with a primary focus in oncology, today announced ZEVALIN(R) (ibritumomab
tiuxetan) and Belinostat abstracts will be presented at the 2011 Annual
Meeting of the American... 阅读全帖 |
|
m*b
发帖数: 1421 | 5 单抗药物很早就出了Rituximab这么个明星产品
对后续的单抗药物研发推动作用太大了
但是其实后续出来的单抗都没有Rituximab效果好
Rituximab似乎是不多的几个可以治愈癌症的药物 |
|
r******g
发帖数: 600 | 6 实在不好意思，没表达清楚～！
我的意思是，Rituximab效果挺好的，Genetech挣了很多钱，但是专利明年15年就到期
了～ Genetech就会少挣很多钱！
这个时候，一群枪手开始帮genetech宣传 Rituximab的局限性，Rituximab的
resistance！ 然后，新一代的anti-CD20 抗体就会通过临床实验，并且，claim 新一
代药物没有那些局限性～！ 接着，继续挣钱
接着，等新一代的anti-CD20又expire了，CAR T cell therapy通过临床试验了，又开
始挣钱
business is business
这都是假设啊 |
|
l**x
发帖数: 296 | 7 (1)对于我叔叔的这种病情,主要的治疗手段是什么?
主要治疗方法：化疗 Intermediate-grade lymphoma (eg, diffuse large B cell) is
treated initially with rituximab plus cyclophosphamide, doxorubicin,
vincristine, and prednisone (R-CHOP)
(2)国内的治疗手段和水平和美国这边有什么不同?
基本上差不多，CHOP肯定在用，Rituximab 应该也在用，这个不肯定。
(3)有什么忙我可以在美国这边帮他做(比如药,保健品)?
保健品就算了吧。
(4)其他建议?
depends on the response to the chemotherapy,the prognosis may vary. |
|
I****a
发帖数: 407 | 8 Sorry to hear about your friend's condition.
There are a couple options available for her but before that she probably
needs a repeat lymph node biopsy to make sure she is still dealing with the
same disease. Follicular lymphoma can transform to more aggressive form and
that has to be excluded first. I have not seen the cytogenetics study of her
previous lymph node biopsy and that would be helpful if it is available. If
is is documented that she still has the same disease then there are at
least... 阅读全帖 |
|
d****9
发帖数: 517 | 9 "而且非霍奇金淋巴瘤弥漫大B细胞型也不是只用rituximab一个药"
请问除了rituximab，还有什么有效的药？即使是处方药也行，至少可以给朋友一点参
考信息。
这个朋友是我父母一辈的人，总得给点信息。
太谢谢了！ |
|
r******g
发帖数: 600 | 10 不懂别乱讲好吧～ Rituximab 几乎是一线临床抗癌 单抗中效果最好的了～ 我有朋友
，用rituximab痊愈的～ |
|
r******g
发帖数: 600 | 11 Car Therapy is very impressive and promosing. Cytokine storm syndromes were
potential problems for patients receiving CAR. In initial clinical trials,
administration of tocilizumab and enbrel was very effective.
Keep in mind that Gleevec from Novartis are expiring in 2 years. Rituximab
for treating patients with ALL-B cell is in phase III. Novartis businessmen
are trying to advertise a new promosing therapy to keep making more money.
To be honest, while CAR may not work as good as Gleevec or Rit... 阅读全帖 |
|
r******g
发帖数: 600 | 12 不好意思，我问的问题有点儿歧义。
我们可以这么分析
Rituximab 治疗 B cell lymphoma 基本上是神药了～ 这么多年来，genetech挣了不少
钱。 其实机制很简单，就是把病人体内 normal和malignant的B cell全部杀光，
targeting CD20.
Car T 目前最好的trial是 target CD19, 跟CD20机制类似，说到底就是 换汤不换药，
用transduced engineered T cell把CD19+的normal 和malignant B 细胞一起杀掉。目
前 clinical trial主要用于 B cell leukemia.
其实rituximab治疗B cell leukemia的效果很好，你去查一下clinical trial的结果，
naive patient 90% 的有效率～ 但是，pharma也没有很积极的把rituxan推向clinical
trial。原因是“rituxan现在很能挣钱，就让它继续挣，专利15年过期，再用于
leukemia挣钱” 或者“用car 挣钱？“
Car T这几年 副作... 阅读全帖 |
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t********e
发帖数: 931 | 13 Time杂志最近一期专辑。
1. Routine Care, Unforgettable Bills
When Sean Recchi, a 42-year-old from Lancaster, Ohio, was told last March
that he had non-Hodgkin’s lymphoma, his wife Stephanie knew she had to get
him to MD Anderson Cancer Center in Houston. Stephanie’s father had been
treated there 10 years earlier, and she and her family credited the doctors
and nurses at MD Anderson with extending his life by at least eight years.
Because Stephanie and her husband had recently started their own small
techn... 阅读全帖 |
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f******I
发帖数: 769 | 14
both are iv form meidcations given through iv infusion, don't think you
could get it from regular pharmacy store |
|
h***b
发帖数: 43 | 15 你母亲和我06年的病一样，这种瘤不幸中的万幸就是还有的治！
美罗华效果只要cd20指数在50%以上就非常非常好，cd20指数越高药效越好，一定要用
，如果医院里有朋友可以直接9折，如果认识做医药代表之类的朋友，能弄到7折。你在
美国直接买，不大可能的。 |
|
c*******n
发帖数: 1214 | 16 Does anyone know if the immune modification drugs can help? For example, the
Rituximab, or something like that? Any study on such topic? |
|
f****o
发帖数: 2770 | 17 ITP?
没有根治的药的。
发作从prednisone开始吃，无效的话
可以Nplate, Promacta, 切掉spleen,
rituximab, transfusion etc
不便宜 |
|
I****a
发帖数: 407 | 18 大夫说的基本没错，不过你转述错了，是割脾脏不是胰脏。免疫性质的血小板低下，割
脾后有50%的病人会痊愈。第一层疗法一般是短期大剂量激素治疗，如果复发，很多人
会推荐割脾，也有人会推荐Rituximab.
脾脏在某种意义上是一个免疫整合的器官，割掉后有1-2%的人可能会容易得一些细菌性
感染，有时致命，所以割之前都要打一些疫苗。 |
|
f****o
发帖数: 2770 | 19 first line R-CHOP
rituximab (Mab Thera)
Cyclosphophamide
Doxorubicin
Vincristine
Prednisone |
|
f****o
发帖数: 2770 | 20 ITP不管医院有没有经验
prednisone先来啊
这个病没有根治的本来就是idiopathic
Prednisone最便宜了
不管用就IVIG了
Rituximab
Nplate/Promacta国内能不能弄到呢 |
|
f****o
发帖数: 2770 | 21 ITP治不好的
只能定期检查血小板
低了吃药
steroid
IVIG
rituximab
Nplate/Promacta |
|
f****o
发帖数: 2770 | 22 自体干细胞移植不能叫做手术because it is not 手术, it's more like 化疗.
anyway, 自体干细胞移植 is not a cure for mantle cell lymphoma
may prolong remission
ur dad is 60
if you don't want to do 自体干细胞移植, you can do maintenance rituximab美罗
华 until disease relapse |
|
f****o
发帖数: 2770 | 23 你买不到的
不知道你朋友为什么要你问这样的问题
这些都是化疗注射药物
不是靠处方外卖的
医院直接注射的
而且非霍奇金淋巴瘤弥漫大B细胞型也不是只用rituximab一个药 |
|
l*h
发帖数: 4124 | 24 it appears there was GvHD, and now host vs graft.
rituximab is against B-cells, not T-cells. its use in rejection treatment is
off-label and efficacy is not well documented.
you might want to do a chimerism test at next bone marrow aspiration. it may
provide clues how to further treat her. |
|
f****o
发帖数: 2770 | 25 most ITP patients can expect a normal life expectancy
your daughter just need to follow with a hematologist throughout her life
there are multiple treatment options
steroids, IVIG, splenectomy, rituximab, Nplate/Promacta etc...
teach her how to protect herself from bleeding |
|
B****J
发帖数: 586 | 26 这么少见的病给得上了，不过俺觉着不用太担心，Splenectomy 应该是最有效的办法（
之一），你的这些 60-70% 数儿哪儿来的，指的是啥？俺的印象，割了脾以后，大概 2
/3 的人就没啥事儿了，还有些人需要用激素控制，或者 immunosuppressants 比如
Rapamycin，Cyclosporine,另外可以用 anti-CD20 的药，比如 Rituximab。干细胞移
植有人在研究，似乎还成熟，俺不太清楚。建议听医生的，人家最了解病情。
我的一个朋友患了自身免疫溶血性贫血，现在北京大学第一医院治疗。她现在靠输血维
持，同时在等待脾切除，这是她最后的希望了，可医生说只有70%成功率，网上查只有
60%成功率。所以我想帮她问问如果手术后效果不理想，来美国治疗有希望吗？是的话
，哪个医院这方面最强？ |
|
z****l
发帖数: 5282 | 27 ☆─────────────────────────────────────☆
Fulton (富二代) 于 (Fri Oct 26 21:25:43 2012, 美东) 提到:
看来最近Chase严打，为了保险起见，不要拿来扫货，不要重复买多次同样的东西，不要
全部集中5% category消费，不要别人billpay，不要转点买点给别人。做到这几点应该
可保命
☆─────────────────────────────────────☆
chopsuey (后海大傻鱼) 于 (Fri Oct 26 21:26:50 2012, 美东) 提到:
5% 应该没问题吧。
不要
☆─────────────────────────────────────☆
sioc (煎饼爱果子) 于 (Fri Oct 26 21:27:41 2012, 美东) 提到:
完了，我离关不远了
在staples连续买同一个打印机5次，神医还billpay两次
☆─────────────────────────────────────☆
Fulton (富二代) 于 ... 阅读全帖 |
|
e****e
发帖数: 931 | 28 "treat" or "no treat"? It depends on the philosophy of your physicians.
Our first physician was quite aggressive on treatments. We have tried three
regular ITP treatments (anti-D, IVIG and steroid). None of them has been
proved to be effective on my son. Besides, Anti-D and IVIG have some severe
side effects after injections. When the physician wanted to go ahead with
more aggressive treatments such as 6-mp or Rituximab, which basically knocks
out our bodies' ability to produce antibodies for on... 阅读全帖 |
|
l*******r
发帖数: 3799 | 29 这种immuotherapy drugs也不是新东西吧，97年Rituximab就有了。
如果你就靠你的1-4点就买这个股，那完全是赌博。 |
|
S***A
发帖数: 40 | 30 The Promising Future of Clinical Development in San Diego
Co-organized with UCSD Moores Cancer Center
Date
March 29, 2014 (Saturday), 8:30am to 1:00pm (Breakfast and lunch will be
provided.)
Location Institute of Americas, UCSD, 10111 North
Torrey Pines Road, La Jolla, CA 92037
Registration https://www.123signup.com/register?id=ddpvm
$20 for online registration (by March 27, 2014), $10 ... 阅读全帖 |
|
w*********g
发帖数: 10097 | 31 Rituximab，也就是你说的美罗华是第一代的anti-CD20靶向药了，现在已经有一些next
generation的类似药出来了
不过这个药是无区分的搞掉所有的CD20 positive的B cell,并不是cancer specific的 |
|
w***y
发帖数: 18 | 32 大家好，我想表达一些已商业化的蛋白或抗体如interferon或rituximab。请问怎样才
可以找到其基因序列来构建质粒。多谢！ |
|
c******a
发帖数: 267 | 33 anti-CD20 is a great medicine in treating lymphoma and B-CLL, and has become
the standard therapy for B cell lymphoma. But in this case, one of the
patients was treated by rituximab(anti-CD20) already and relapse occured, so
CAR approach was applied. |
|
a******e
发帖数: 1 | 34 http://en.wikipedia.org/wiki/Belimumab
Benlysta was approved by the U.S. Food and Drug Administration (FDA) for
treatment of SLE on March 9, 2011.
Belimumab (trade name Benlysta, previously known as LymphoStat-B)
or
Atacicept
Rituximab |
|
p**d
发帖数: 14 | 35 单抗不是小肽，150kDa左右,所以circulation time 要比小分子药物长很多，但是
delivery要差不少。(Rituximab的delivery问题要小些,因为lymphoma要比solid
tumors 更加accessible.)现在的单抗都是fully humanized, 不会有免疫反应。这个药
失败主要是因为pancreatic cancer太难治了,另外说明IGF1R 的singaling pathway不
是driver. |
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a*q
发帖数: 2109 | 36 本无意灌水，但今日与人争执，已然失言。本该就此打住，但又有若干事情不吐不快。
虑及话题已远离原帖，新开一贴于此。
某人执着于“正统”生物，而认为Engineering远不及Science。但实际上没有什么正统
不正统，有的只是理念的不同。对于Engineering的思路和Science的思路，每个人有自
己的偏好，每个系有自己的风格，每个学校有自己的传承，都不一样。所谓“正统”生
物，说得好听点应该叫传统生物，说的不好听一点就是有点过时的东西。
Science的核心是想回答一个“为什么”的问题，Engineering则可以完全不管原理，只
要新东西能够工作就行。这一点尤其体现在发展一个新方法、新工具的时候。iPS就是
一个例子，山中伸弥找到那四个转录因子能够改变分化了的细胞，但即使到现在我们都
不知道reprogramming的过程是怎么发生的。医学和药学的研究更是Engineering的思路
占主导，因为不知道的东西实在太多，但病是必须得治的。要把所有东西都搞清楚了再
开始治病就太迟了而且也是不现实的。青蒿素的抗疟机制现在还是完全不清楚，连它跟
疟原虫里面什么东西相互作用都不知道，但... 阅读全帖 |
|
a*q
发帖数: 2109 | 37 本无意灌水，但今日与人争执，已然失言。本该就此打住，但又有若干事情不吐不快。
虑及话题已远离原帖，新开一贴于此。
某人执着于“正统”生物，而认为Engineering远不及Science。但实际上没有什么正统
不正统，有的只是理念的不同。对于Engineering的思路和Science的思路，每个人有自
己的偏好，每个系有自己的风格，每个学校有自己的传承，都不一样。所谓“正统”生
物，说得好听点应该叫传统生物，说的不好听一点就是有点过时的东西。
Science的核心是想回答一个“为什么”的问题，Engineering则可以完全不管原理，只
要新东西能够工作就行。这一点尤其体现在发展一个新方法、新工具的时候。iPS就是
一个例子，山中伸弥找到那四个转录因子能够改变分化了的细胞，但即使到现在我们都
不知道reprogramming的过程是怎么发生的。医学和药学的研究更是Engineering的思路
占主导，因为不知道的东西实在太多，但病是必须得治的。要把所有东西都搞清楚了再
开始治病就太迟了而且也是不现实的。青蒿素的抗疟机制现在还是完全不清楚，连它跟
疟原虫里面什么东西相互作用都不知道，但... 阅读全帖 |
|
j******i
发帖数: 939 | 38 作为paper很cool。用到人体还是会要面对老问题：1）肿瘤异质性 2）免疫抑制等。但
即使效果有限，可能也能挣大钱，比如anti-CD20 Rituximab. |
|
s****9
发帖数: 932 | 39 Rituximab效果有限?
你不懂不要乱讲，first－line therapy for non-Hodgkin's lymphoma，救了不知道多
少人命。 |
|
j******i
发帖数: 939 | 40 你说的是事实。但是，Rituximab resistance 也是个很突出的问题，很多情况并没有
能够救人。 |
|
j******i
发帖数: 939 | 41 参考 Rituximab resistance. 我有同事就是做这个机制的。 |
|
r******g
发帖数: 600 | 42 来个假象，
rituximab的专利，明年就到期了！ 赶快把 局限性贴出来 和 扩大化，找一群
scientists当枪使 |
|
s****9
发帖数: 932 | 43 去看看Genentech的Obinutuzumab, GA101。
Rituximab升级版。 |
|
r******g
发帖数: 600 | 44 不好意思，Rituximab 16年过期～ 2年时间 |
|
|
u***e
发帖数: 611 | 46 楼主主要是考虑想呆在家人身边吧。年轻人一般hodgkin比较多，化疗加放疗应该也不
会太贵，如果你的保险不好，比如有些保险是封顶的，那在美国自己付的钱比国内多是
很有可能的。治疗方案都是标准的，国内外应该一样的。如果是NHL，rituximab非常贵
，如果这边的保险cover，就好很多。 |
|
l****n
发帖数: 64 | 47 There are some additional points in 2011 regarding
BEHAVIOUR SCIENCE
Sleep patterns in a depressed person
Sleep terror disorder
Ethical issues 3 additional points added
BIOCHEM
A few points added on in the Catecholamine synthesis reaction
EMBRYO
Types of error in organ morphogenesis
Descent of testes and ovaries
MICRO
Campylobactor jejuni
Vibrio cholera
Herpesviruses latency
Hepatitis chart modified
Pyrazinamide drug
HAART drugs details
Antiprotozoal chart
Antihelminthic chart
IMMUNO
TH1 & TH2 c... 阅读全帖 |
|
s*******d
发帖数: 1079 | 48 学友MILK找到的这个FA ２０１１版 vs ２０１０版的详细对照，我觉得很有帮助，放
在这儿给大家做参考吧。
原文见 http://forums.studentdoctor.net/showthread.php?t=785943
Overall:
- FA 2011 corrects some of the 2010 errata
- FA 2011 has darker print and thicker pages
- FA 2011 increases the size of most figures/images (although only slightly)
- FA 2011 removes several images that are difficult to see/interpret
Behavioral Science:
p. 59-60 2010 (57-58 2011) -2011 reorganized a couple items into "Advance
directives" and got rid of "Good Samaritan Law.... 阅读全帖 |
|
T*R
发帖数: 36302 | 49 Traditionally, the word "chemotherapy" is used to discuss drugs used to
treat cancer. That line blurs a bit because there are newer medications for
cancer that are not in the same classes of typical "cytotoxic"
chemotherapies. These new treatments, for example, monoclonal antibodies
like rituximab, don't cause the same side effects of older cancer treatments
. But they are frequently used in conjunction with traditional chemotherapy
and for ease of discussion are frequently called chemotherapy.
... 阅读全帖 |
|
d**o
发帖数: 618 | 50 Hairy cell leukemia, 虽然罕见，至少在美国医生都学过，是有药可治的。
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001618/
Treatment may not be needed for the early stages of this disease. Some
patients may need an occasional blood transfusion.
If treatment is needed because of very low blood counts, a variety of
chemotherapy drugs can be used. Drugs that may be used include cladribine,
pentostatin, and rituximab. |
|
