l*h
发帖数: 4124 | 1 this begs the question why he was operated on. there is no indication for
surgery if sclc is metastasized to the pleura. pleural metastasis is not
hard to see on CT.
the traditional view was surgery had no roles in the management of sclc.
with the improvement in early diagnosis and of surgical techniques, some
sclc can be operated on, which results in some improvement in outcomes. in
the US, fewer than 5% sclc patients are eligible for surgery.
i heard many late stage sclc patients are operated ... 阅读全帖 |
|
l*h
发帖数: 4124 | 2 choosing a treatment for SCLC requires relatively complete staging
information. i suggest you to ask an oncologist subspecializing in SCLC
whether the treatment response is good, whether radiation therapy should be
considered etc.
for SCLC, dealing with metastasis early is key to a longer survival. |
|
h********n
发帖数: 4079 | 3 既然来了, 就多说两句. 小细胞肺癌(small cell lung cancer, SCLC)主要是吸烟引起
的. 如果可以手术, 手术的预后取决于诊断的早晚, 或者说诊断的时候是什么期. 越是
晚期, 能做手术的可能性越小, 手术的预后越差.
目前的药物疗法对SCLC基本没有用. Iressa(易瑞莎)(gefitinib)是针对non-small
cell lung cancer (非小细胞肺癌)的, 不是针对SCLC的药.
楼主, 你应该到求医问药版去问问. 上面回帖的, 没有一个懂肺癌. |
|
w*l
发帖数: 43 | 4 1. 在美国癌症治疗大都有根据人群实验的结果推荐的方案， 除非加入人群实验中去接
受新的疗法。没有医生愿意独出心裁的。一线药多用platinum 组合。2. limited 和
extensive SCLC 方案略有不同， 比如在limigted SCLC病人中放化疗可以同上， 而放
疗可以在extensive SCLC 病人对化疗有反应后给。3. 亚洲人和西方人可能有些区别，
比如日本病人对cisplatin/ irinotecan 的反应比etoposide / cisplatin 好些， 但
在US病人中就没有发现这种不同。 |
|
D*******o
发帖数: 3229 | 5 在Wiki上看到的,这一段最后提到有关档案在2027年以前不许公开。希望2027年以后能
够让我们看到真相。
http://en.wikipedia.org/wiki/Martin_Luther_King,_Jr.#The_FBI_an
Having concluded that King was dangerous due to communist infiltration, the
FBI shifted to attempting to discredit King through revelations regarding
his private life. FBI surveillance of King, some of it since made public,
attempted to demonstrate that he also engaged in numerous extramarital
affairs.[191] Lyndon Johnson once said that King was a "hypocritical
preacher".[202]
R... 阅读全帖 |
|
s***l
发帖数: 11 | 6 那种类型的肺癌？小细胞（sclc)还是非小细胞型（NSCLC)？
如果是小细胞型的,先做化疗然后放疗，加或不加预防性头部照射；
如果是非小细胞类型的（包括鳞癌、腺癌、大细胞型），应该做全身检查后，明确分期，
I期、II期的根据患者身体状况先做手术，在考虑放、化疗，IIIA期可一先做新辅助化疗
，然后再手术，IIIB期、IV期的就直接考虑化疗了，有时候可根据情况加以放疗，以减轻
症状。
肺癌的预后都不好，sclc增长快，治疗效果好，但是易复发；nsclc对治疗反应不好。
目前全世界用的药物都差不多，癌症是一门新兴学科，全世界进展比较一致，在国内的大
医院医治，国际上能见得到的药物，基本上都能买到。
治疗肺癌，就是贵。
查
，
激 |
|
s***l
发帖数: 11 | 7 我刚刚回了一个关于肺癌的帖子，你可以看看。
另外关于你问的药物bufotanine，是一种肿瘤血管抑制因子，目前这类药物新研制的很多
，在美国和日本上市的Iressa，对非小细胞肺癌（nsclc)疗效比较确切，在中国也上市了
，但是很贵。
对于肺癌的治疗，晚期的患者，虽然化疗可以缓解症状，有效的药物也很多，但是预后都
很不好，想你朋友这种情况的，中位生存期也就8-12个月，也就是说，半年。所以化疗是
个双刃剑，最好的治疗和不治，理想的结果，可以延长生存期俩月。
如果家里钱多，可以先化疗，然后用用Iressa。
但是病理结果还没出来，如果病理结果出来了，是小细胞肺癌（sclc)，就另当别论，要
积极化疗，因为对于sclc化疗效果还是很好的。
的
的
也
失
有
有
在
害 |
|
l*h
发帖数: 4124 | 8 unfortunately the outcome of SCLC is grim. it responds well to chemotherapy
and radiation but the remission is usually short. 5 yr survival is ~20% for
limited SCLC. chemotherapy regimen should include a -platin as the major
ingredients. if it's limited stage, give concurrent radiation therapy to the
lung. if it responds well to chemo, do a whole brain irradiation, which
improves survival rate considerably. |
|
N*********6
发帖数: 2302 | 9 这两个有关系么？还是更早的美国历史？或者美美以外的历史？
关键词：1961年，Kennedy.. 1955年, Martin Luther King...
**
The term "affirmative action" was first used in the United States in "
Executive Order No.10925",[6] signed by President John F. Kennedy on 6 March
1961, which included a provision that government contractors "take
affirmative action to ensure that applicants are employed, and employees are
treated during employment, without regard to their race, creed, color, or
national origin."[7] In 1967, gender was added to the... 阅读全帖 |
|
r***e
发帖数: 2539 | 10 Thank everyone for the discussion!
As pineseed pointed out, too many topics were discussed here.
But my personal interests are:
1. what is the cell origin of different type of lung cancers?
2. does cell origin or mutation decide tumor types?
3. how to model different type of lung cancer?
HGTPase, it seems you are working in this field (more lung development than
lung cancer?), and I hope you can give your opinions. We can also discuss in
private mails for technique details.
1. ... 阅读全帖 |
|
T**********e
发帖数: 29576 | 11 所以即使是什么团队老爸写的，hh大可以不在乎，只要路线对了头，照样可以做时代领
头人。
回顾马丁·路德·金抄袭事件
刘 擎
1991年10月，我初到美国不久，就在《纽约时报》上读到有关马丁·路德·金博士
论文存在抄袭（plagiarism）的消息，当时感到的震惊无以名状。虽然早就过了崇拜偶
像的年龄，但这位民权运动的领袖、非暴力运动的倡导者、神学博士、魅力型牧师、诺
贝尔和平奖获得者、被邪恶势力暗杀的烈士，仍然是我心中不可亵渎的英雄，难以想象
他会与抄袭剽窃之类的行径有任何牵连。于是，凭借一个中国人“本能的”政治敏感，
自然地就生出一份警觉：这会不会是什么阴谋？会不会是右派势力和种族主义者制造的
污名化运动？存着这份怀疑，便开始关注这个事件的来龙去脉，却获得了一份意外的教
益。
事件的始末
马丁·路德·金于1968年4月被暗杀。无论是他在世的时候，还是他遇难之后的二
十年间，几乎没有人注意到他可能存在抄袭的嫌疑。唯一的例外是 Ira G. Zepp，他在
1971年完成的博士论文中指出，金的自传性作品《迈向自由》（Stride Toward
Freedom, 1958）抄袭了两部著名... 阅读全帖 |
|
D*********n
发帖数: 279 | 12 http://www.infoplease.com/spot/bhmtimeline.html
African-American History Timeline
A chronology of black history from the early slave trade through Affirmative
Action
by Borgna Brunner
1600s •
1700s •
1800–1850 •
1850–1900 •
1900–1950 •
1950–present
1619 Photograph of newspaper advertisement from the 1780s
Photograph of newspaper advertisement from the 1780s
The first African slaves arrive in Virginia.
1746 Lucy Terry, an enslaved person in 1746, becomes the earliest... 阅读全帖 |
|
z*******o
发帖数: 1794 | 13 国内的姨妈最近肺部不适，去医院（二线省会城市）检查身体各项指标均正常。照对肺
部照CT／B超等检测后发现有阴影，进一步取组织做免疫组化有了下面的诊断结果：
病理诊断：左上肺新生行2粒，共针头大小，镜下见多小灶核深染、胞浆少的细胞，免
疫组化：sclc(+),CD56(+),CK(+),EMA(+),LCA(_),Vim(--),Syn(--),TTF-1（+）符合肺
小细胞癌。
目前已经开始做化疗了，对此我有一些问题请教版上的同学：
姨妈目前64岁, 二十年前得过支气管扩张后来治愈。从来没有任何吸烟历史，
家中也没有任何人吸烟。目前的各种检测没有在身体其他部位发现有转移的迹象，身体
状态非常好，能吃能睡，上周还能背了一袋十几斤大米上5楼。目前根据免疫组化的结
果能否直接得出是小细胞肺癌么？为什么不是普通的肺癌？我也从事生物相关的研究，
很多时候免疫组化结果值得商榷。根据目前的结果直接开始做化疗是否有点操之过急？
姨妈从小对我关心很多，请大家多多指点，我代表她谢谢大家了。 |
|
l*h
发帖数: 4124 | 14 diagnosis of SCLC doesn't require IHC per se.
IHC is useful in atypical cases and in understanding biological
characteristics.
"我也从事生物相关的研究，很多时候免疫组化结果值得商榷。"
your thinking is kind of crooked. you have never seen how clinical IHC is
controlled. |
|
z*******o
发帖数: 1794 | 15 anyway, thanks for your words. How to confirm she has SCLC? |
|
l*h
发帖数: 4124 | 16 the histopathology description is a SCLC. isn't it sufficient? |
|
l*h
发帖数: 4124 | 17 this is a SCLC histopathology. there is no doubt once you see it. |
|
l*h
发帖数: 4124 | 18 well, without going into specifics related to this patient, SCLC looks this
way:
about 60-80% patients respond very well to chemotherapy. but the response is
usually short-lived (several months). after the disease returns, very
little can be done that shows meaningful efficacy.
what about the other ~20-40% that don't respond well to chemotherapy from
the beginning? we really don't have much up in our sleeves.
the physician-patient interaction in China is a big problem. when patient/
surrogate is... 阅读全帖 |
|
l*h
发帖数: 4124 | 19 well, without going into specifics related to this patient, SCLC looks this
way:
about 60-80% patients respond very well to chemotherapy. but the response is
usually short-lived (several months). after the disease returns, very
little can be done that shows meaningful efficacy.
what about the other ~20-40% that don't respond well to chemotherapy from
the beginning? we really don't have much up in our sleeves.
the physician-patient interaction in China is a big problem. when patient/
surrogate is... 阅读全帖 |
|
z******o
发帖数: 78 | 20 原来我爸已经做了6次化疗了。前四次都一样。
第五次化疗用了美罗华：600mg qd*1d, d0，奥沙利铂：176mg qd*1d, d1(维持四小时)
，阿糖胞苷：3.5g q12*1d d2(维持3小时)，地塞米松：20mg q12h*4d, d1-d4。
第六次化疗用了美罗华：600mg d0，地塞米松：20mg q12h*4d d1-d4，阿糖胞苷：3.5g
q12h*1d d3，顺铂：170mg qd*1d d1。
最近一次检查显示骨髓形态学基本正常，MRD示：1.0*10E-4/L，IgH重排阴性，胃镜示
：胃低隆起病变，慢性浅表性胃炎（活动期），活检病理示：套细胞淋巴瘤，免疫病理
：瘤细胞CD20，CD79a，CycinD1，CD5，Bc1-2弥漫阳性，Ki-67阳性（30%），CD3、
CD43、CD4、EMA、Bc1-6，SCLC、CK均阴性。查体：轻度贫血貌，余未见明显阳性体征
。心脏超声：升主动脉硬化，左室松弛性下降。腹部超声：肝脏囊肿。心电图：左心室
高电压。胃镜：贲门开合通畅，胃底见一粘膜隆起，约2.0*3.0cm，表面凹陷附着血痂
。皮肤巩膜无黄染，全身皮肤... 阅读全帖 |
|
m*****a
发帖数: 2160 | 21 摆脱大哥，你连患者是NSCLC还是SCLC都不知道，就说有特效药...
LZ你还是别听网上的了，去正规医院看病吧 |
|
h********n
发帖数: 4079 | 22 I am so glad to read your thought. I would like to discuss a little more.
to 1: the term of CSC is controversy, but what if I say: "In lung adenocarcinoma, there is a population of tumor cells whose potency (in vivo) is much higher than other population in the same tumor. It is important to study this population of cells. How about we call it tumor initiating cell?"
what is your opinion to my above thought?
to 4: I don't agree with you on this point. Most lung cancer model use SPC or CCSP or C... 阅读全帖 |
|
a**********2
发帖数: 3726 | 23 SCLC: chemo, bad prognosis.
NSCLC: prognosis and treatment depends on the stage. If end stage,
palliative care. |
|
j******t
发帖数: 788 | 24 最近家里传来噩耗, 爸爸在单位的年检中查出小细胞肺癌.姐姐马上带爸爸去了北京肿
瘤医院和301医院请专家会诊. 专家说癌细胞面积是0.5左右, 没有扩散, 骨扫描脑扫描
和其他器官检查都是阴性. 但是SCLC只有20%的两年存活率.我听了很绝望, 既然是早期
, 按这边的资料显示 应该有五年存活率. 想请教这里的专家, 看看能有多大的希望.以
下是病例报道. 麻烦那位懂行的医生帮我翻译成英语,我准备去当地的医院问一下,看一
看能不能把他接过来治疗.
跪谢了!
肉眼所见:
(气管下段右前壁)灰红碎组织一堆,总体积0.5cmx0,5cmx0.2cm.点布全(1)多.
病理诊断:
(气管下段右前壁)查见肿瘤,疑小细胞癌, 待免疫组化染色协助分析.
再发报告:
气管下段右前壁)小细胞癌, 免疫组化染色: PCX(+), BMA(+), CD56(+), Synu(+), CgA
(少数细胞+), TTF-I(+),P63(-). K167阳性率50% |
|
n**********9
发帖数: 120 | 25 Does anyone know which hospital is the best for SCLC treatment? Any new
promising treatment now? Thanks. |
|
p********a
发帖数: 5352 | 26 ☆─────────────────────────────────────☆
lwxzt (smallpp) 于 (Sat Dec 2 13:05:04 2006) 提到:
我有两组数据
id position
1 21223
2 31332
3 453267
4 14944
5 3321776
6 7209436
第二组数据是
Gene startposition endposition
FKBP5 20012 78332
CRH 333409 467431
TKC 6121707 7341880
CRHR1 2855 17661
SCLC 2021533 4412210
如果第一组数据中position在第二组数据的startposition和endposition之间，则将相
应的gene与第一组数据合并，结果应该是
id position gene
1 21223 FKBP5
2 31332 FKBP5
3 |
|
|
n**********9
发帖数: 120 | 28 Does anyone know which hospital is the best for SCLC treatment? Any new
promising treatment now? Thanks. |
|
n**********9
发帖数: 120 | 29 Does anyone know which hospital is the best for SCLC treatment? Any new
promising treatment now? Thanks. |
|
b*****h
发帖数: 3386 | 30 http://www.prweb.com/releases/2010PoniardPharmaceutical/01PARD/prweb3443814.htm
New York, NY (PRWEB) January 14, 2010 -
1. PARD will present additional data from their Phase 2 trial using
picoplatin in colorectal cancer (CRC) on January 24, 2010 at the ASCO 2010
Gastrointestinal Cancers Symposium in Orlando, Fla.
Present additional data from the Company's Phase 2 trial... in the first-
line treatment of patients with metastatic colorectal cancer (CRC) on Sunday
, January 24, 2010 at the ASCO 201... 阅读全帖 |
|
y*****9
发帖数: 43 | 31 感谢版主邀请，既然进来了，怎么也得贡献一点心得。这个就再这里首发了~~
这两个股票目前都还是低价股，但是都属于同一类股票。都是与血液肿瘤（癌症）相关
的BIO公司。
医药股的特点不是EPS，不是REV，（当然这些仍是成熟BIO的特点）对于研发阶段的BIO
，最重要的是它的实验数据（trial data).每次关键的data公布都会成为股价的催化剂。
SNTA: 最近两日的大涨都源自于本月底前后的data
Preliminary results from the GALAXY trial are expected in the second quarter
of 2012, and additional results from the GALAXY trial together with
preliminary results from the ALK+ lung cancer and breast cancer trials are
expected in the second half of 2012. In addition to the company-sponsored
tr... 阅读全帖 |
|
