d***3
发帖数: 181 | 1 Slc2a1 is Glut1, mainly expressed in liver, brain, and red blood cells.
Slc5a1 is Sglt1, which is the major transporter responsible for intestinal
glucose absorption. I don't think there is any Glut1 inhibitor on the market
. CNS side effect can be a major concern for Glut1 inhibition. Sglt1
inhibitors or Sglt1/Sglt2 dual inhibitors are being developed for diabetes
and obesity. Sglt2 (mainly in kidney) inhibitors are more advanced in
development. The primary indication for Sglt2 inhibition is di... 阅读全帖 |
|
